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Job DescriptionP41240
Confidence100.00%DateThu Apr 26 09:28:47 BST 2012
Rank58Aligned Residues249
% Identity33%Templatec3d4qA_
PDB info PDB header:transferaseChain: A: PDB Molecule:b-raf proto-oncogene serine/threonine-protein kinase; PDBTitle: pyrazole-based inhibitors of b-raf kinase
Resolution2.80 Å

  Insertion relative to template
  Deletion relative to template
  Catalytic residue from the CSA
 
Detailed help on interpreting your alignment


   186...190.........200.........210.........220.........230.. .......240.........250.........260.
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Query Sequence  SGWALNMKELKLLQTIGKGEFGDVMLGDYRGNKVAVKCIKNDATAQA. . . . FLAEASVMTQLRHSNLVQLLGVIVEEKGG
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Template Sequence  DDWEIPDGQITVGQRIGSGSFGTVYKGKWHGD. VAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYS. . TKPQ
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B

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   448.450.........460.........470......... 480.........490.........500.........510.........520 ....
 
   262.......270.........280.........290.........300.........310.........320.........330.........340.
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Query Sequence  LYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASS
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Template Sequence  LAIVTQWCEGSSLYHHLHIIETK. FEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVLSG
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SGGGTTT


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   525....530.........540....... ..550.........560.........570.........580.........590.........600...
 
   342.......350.........360.. .......370.........380.........390.... .....400...... ...410...
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Query Sequence  TQDTGKLPVKWTAPEALREKK. . . FSTKSDVWSFGILLWEIYSFGRVPYPRIPLKD. VVPRVEKGYKMD. . . . APDGCPP
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Template Sequence  . . . . . . . SILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMT. GQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPK
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   616...620.........630.........640.........650. ........660.........670.........680.......
 
   414.....420.........430.........440......
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Query Sequence  AVYEVMKNCWHLDAAMRPSFLQLREQLEHIKTH
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Template Sequence  AMKRLMAECLKKKRDERPLFPQILASIELLARS
Template Known Secondary structure  T
SSGGGS

T
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   688.690.........700.........710.........720
 
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No model constructed - rank, confidence too low




Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
 
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Lawrence Kelley, Benjamin Jefferys 
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