Job Description P41240 Confidence 100.00% Date Thu Apr 26 09:28:47 BST 2012 Rank 5 Aligned Residues 423 % Identity 41% Template c2h8hA_ PDB info PDB header:transferase Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase src; PDBTitle: src kinase in complex with a quinazoline inhibitor Resolution 2.20 Å

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		14	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60	.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.
Predicted Secondary structure
Query SS confidence
Query Sequence		C	I	A	K	Y	N	F	H	G	T	A	E	Q	D	L	P	F	C	K	G	D	V	L	T	I	V	A	V	T	K	D	P	N	W	Y	K	A	K	N	K	V	G	R	E	G	I	I	P	A	N	Y	V	Q	K	R	E	G	V	K	A	G	T	K	L	S	L	M	P	W	F	H	G	K	I	T	R	E	Q	A	E
Query Conservation
Alig confidence																																																											.	.	.	.	.	.
Template Conservation																																																											.	.	.	.	.	.
Template Sequence		F	V	A	L	Y	D	Y	E	S	R	T	E	T	D	L	S	F	K	K	G	E	R	L	Q	I	V	N	N	T	E	G	D	W	W	L	A	H	S	L	S	T	G	Q	T	G	Y	I	P	S	N	Y	V	A	P	S	D	S	.	.	.	.	.	.	I	Q	A	E	E	W	Y	F	G	K	I	T	R	R	E	S	E
Template Known Secondary structure					S	S		B				S	S	S	B			B		T	T									S	S	S	S							T	T	T								G	G	G				T	T	S	.	.	.	.	.	.	G	G	G	S	T	T	B			S
Template Predicted Secondary structure																																																											.	.	.	.	.	.
Template SS confidence
		86	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120	.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.							.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.
		94	.	.	.	.	.			100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120	.	.						.	.	.	.	.	.	.	130	.	.	.	.		.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.
Predicted Secondary structure								.	.																								.	.	.	.	.													.
Query SS confidence								.	.																								.	.	.	.	.													.
Query Sequence		R	L	L	Y	P	P	.	.	E	T	G	L	F	L	V	R	E	S	T	N	Y	P	G	D	Y	T	L	C	V	S	C	.	.	.	.	.	D	G	K	V	E	H	Y	R	I	M	Y	H	.	A	S	K	L	S	I	D	E	E	V	Y	F	E	N	L	M	Q	L	V	E	H	Y	T	S	D	A	D	G	L	C	T
Query Conservation								.	.																								.	.	.	.	.													.
Alig confidence								.	.																								.	.	.	.	.													.
Template Conservation
Template Sequence		R	L	L	L	N	A	E	N	P	R	G	T	F	L	V	R	E	S	E	T	T	K	G	A	Y	C	L	S	V	S	D	F	D	N	A	K	G	L	N	V	K	H	Y	K	I	R	K	L	D	S	G	G	F	Y	I	T	S	R	T	Q	F	N	S	L	Q	Q	L	V	A	Y	Y	S	K	H	A	D	G	L	C	H
Template Known Secondary structure					T		T	T			T	T								S	S	S	T	T											T	T	T										B		.			S						T	T				S	S													T	T	S	S	S
Template Predicted Secondary structure
Template SS confidence
		160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180	.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.
		166	.	.	.	170	.	.	.	.	.	.	.	.	.	180	.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.		.	.	.	220	.	.	.	.	.	.	.		.	.	230	.	.	.	.	.	.	.	.	.	240	.	.	.
Predicted Secondary structure																																																					.												.
Query SS confidence																																																					.												.
Query Sequence		R	L	I	K	P	K	V	M	E	G	T	V	A	A	Q	D	E	F	Y	R	S	G	W	A	L	N	M	K	E	L	K	L	L	Q	T	I	G	K	G	E	F	G	D	V	M	L	G	D	Y	R	G	.	N	K	V	A	V	K	C	I	K	N	D	.	A	T	A	Q	A	F	L	A	E	A	S	V	M	T	Q	L
Query Conservation																																																					.												.
Alig confidence																	.	.																																			.												.
Template Conservation																	.	.
Template Sequence		R	L	T	T	V	C	P	T	S	K	P	Q	T	Q	G	.	.	L	A	K	D	A	W	E	I	P	R	E	S	L	R	L	E	V	K	L	G	Q	G	C	F	G	E	V	W	M	G	T	W	N	G	T	T	R	V	A	I	K	T	L	K	P	G	T	M	S	P	E	A	F	L	Q	E	A	Q	V	M	K	K	L
Template Known Secondary structure															S	S	.	.	S	S	T	T		S	B			G	G	G											S	S									T	T	T										T	T	S	S
Template Predicted Secondary structure																	.	.
Template SS confidence
		240	.	.	.	.	.	.	.	.	.	250	.	.	.	.			.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300	.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.
		244	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300	.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.
Predicted Secondary structure
Query SS confidence
Query Sequence		R	H	S	N	L	V	Q	L	L	G	V	I	V	E	E	K	G	G	L	Y	I	V	T	E	Y	M	A	K	G	S	L	V	D	Y	L	R	S	R	G	R	S	V	L	G	G	D	C	L	L	K	F	S	L	D	V	C	E	A	M	E	Y	L	E	G	N	N	F	V	H	R	D	L	A	A	R	N	V	L	V	S
Query Conservation
Alig confidence															.	.
Template Conservation															.	.
Template Sequence		R	H	E	K	L	V	Q	L	Y	A	V	V	S	.	.	E	E	P	I	Y	I	V	T	E	Y	M	S	K	G	S	L	L	D	F	L	K	G	E	T	G	K	Y	L	R	L	P	Q	L	V	D	M	A	A	Q	I	A	S	G	M	A	Y	V	E	R	M	N	Y	V	H	R	D	L	R	A	A	N	I	L	V	G
Template Known Secondary structure				T	T	B									.	.	S	S	S									T	T								S					T	T																							T	T				S			S	G	G	G
Template Predicted Secondary structure															.	.
Template SS confidence
		318	.	320	.	.	.	.	.	.	.	.	.	330			.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360	.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.
		324	.	.	.	.	.	330	.	.	.	.	.	.	.					.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360	.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.
Predicted Secondary structure																.	.	.	.
Query SS confidence																.	.	.	.
Query Sequence		E	D	N	V	A	K	V	S	D	F	G	L	T	K	.	.	.	.	E	A	S	S	T	Q	D	T	G	K	L	P	V	K	W	T	A	P	E	A	L	R	E	K	K	F	S	T	K	S	D	V	W	S	F	G	I	L	L	W	E	I	Y	S	F	G	R	V	P	Y	P	R	I	P	L	K	D	V	V	P	R	V
Query Conservation																.	.	.	.
Alig confidence																.	.	.	.
Template Conservation
Template Sequence		E	N	L	V	C	K	V	A	D	F	G	L	A	R	L	I	E	D	N	E	Y	T	A	R	Q	G	A	K	F	P	I	K	W	T	A	P	E	A	A	L	Y	G	R	F	T	I	K	S	D	V	W	S	F	G	I	L	L	T	E	L	T	T	K	G	R	V	P	Y	P	G	M	V	N	R	E	V	L	D	Q	V
Template Known Secondary structure		G	G	G							T	T	S	T	T	T								T	T		S	T	T	S		G	G	G	S																											T	T	T	T			S	S	T	T
Template Predicted Secondary structure
Template SS confidence
		396	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420	.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.
		400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420	.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.
Predicted Secondary structure
Query SS confidence
Query Sequence		E	K	G	Y	K	M	D	A	P	D	G	C	P	P	A	V	Y	E	V	M	K	N	C	W	H	L	D	A	A	M	R	P	S	F	L	Q	L	R	E	Q	L	E	H	I	K	T	H
Query Conservation
Alig confidence
Template Conservation
Template Sequence		E	R	G	Y	R	M	P	C	P	P	E	C	P	E	S	L	H	D	L	M	C	Q	C	W	R	K	E	P	E	E	R	P	T	F	E	Y	L	Q	A	F	L	E	D	Y	F	T	S
Template Known Secondary structure			T	T							T	T													T		S	S	G	G	G	S												T	S	S
Template Predicted Secondary structure
Template SS confidence
		476	.	.	.	480	.	.	.	.	.	.	.	.	.	490	.	.	.	.	.	.	.	.	.	500	.	.	.	.	.	.	.	.	.	510	.	.	.	.	.	.	.	.	.	520	.	.