Job Description P41240 Confidence 100.00% Date Thu Apr 26 09:28:47 BST 2012 Rank 2 Aligned Residues 439 % Identity 38% Template c2fo0A_ PDB info PDB header:transferase Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase abl1 (1b isoform); PDBTitle: organization of the sh3-sh2 unit in active and inactive forms of the2 c-abl tyrosine kinase Resolution 2.27 Å

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		1	.	.	.	.	.	.	.		.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60	.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.
Predicted Secondary structure										.
Query SS confidence										.
Query Sequence		M	S	A	I	Q	A	A	W	.	P	S	G	T	E	C	I	A	K	Y	N	F	H	G	T	A	E	Q	D	L	P	F	C	K	G	D	V	L	T	I	V	A	V	T	K	D	P	N	W	Y	K	A	K	N	K	V	G	R	E	G	I	I	P	A	N	Y	V	Q	K	R	E	G	V	K	A	G	T	K	L	S	L
Query Conservation										.
Alig confidence										.																																													.																		.	.	.	.	.	.
Template Conservation																																																							.																		.	.	.	.	.	.
Template Sequence		E	N	L	L	A	G	P	S	E	N	D	P	N	L	F	V	A	L	Y	D	F	V	A	S	G	D	N	T	L	S	I	T	K	G	E	K	L	R	V	L	G	Y	N	H	N	G	E	W	C	E	A	Q	T	.	K	N	G	Q	G	W	V	P	S	N	Y	I	T	P	V	N	S	.	.	.	.	.	.	L	E	K
Template Known Secondary structure		T	T	T	T			G	G	G	S		T	T					S	S		B				S	T	T	B			B		T	T										T	T	S	S							.	T	T							G	G	G				T	T	S	.	.	.	.	.	.	G	G	G
Template Predicted Secondary structure																																																							.																		.	.	.	.	.	.
Template SS confidence
		71	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120	.	.	.		.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140							.	.	.
		80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120	.	.	.	.	.	.	.	.	.	130	.	.	.	.		.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.
Predicted Secondary structure																																																									.
Query SS confidence																																																									.
Query Sequence		M	P	W	F	H	G	K	I	T	R	E	Q	A	E	R	L	L	Y	P	P	E	T	G	L	F	L	V	R	E	S	T	N	Y	P	G	D	Y	T	L	C	V	S	C	D	G	K	V	E	H	Y	R	I	M	Y	H	.	A	S	K	L	S	I	D	E	E	V	Y	F	E	N	L	M	Q	L	V	E	H	Y	T	S
Query Conservation																																																									.
Alig confidence																																																									.
Template Conservation
Template Sequence		H	S	W	Y	H	G	P	V	S	R	N	A	A	E	Y	L	L	S	S	G	I	N	G	S	F	L	V	R	E	S	E	S	S	P	G	Q	R	S	I	S	L	R	Y	E	G	R	V	Y	H	Y	R	I	N	T	A	S	D	G	K	L	Y	V	S	S	E	S	R	F	N	T	L	A	E	L	V	H	H	H	S	T
Template Known Secondary structure		S	T	T														T	S	S	S		T	T								S	S	S	T	T									T	T											T	T	S				S	S	T	T			B	S	S
Template Predicted Secondary structure
Template SS confidence
		144	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180	.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.
		159	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180	.	.		.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.			.	.	.	.	220	.	.	.	.	.	.	.	.	.	230		.	.	.	.
Predicted Secondary structure																										.																																		.	.																.
Query SS confidence																										.																																		.	.																.
Query Sequence		D	A	D	G	L	C	T	R	L	I	K	P	K	V	M	E	G	T	V	A	A	Q	D	E	.	F	Y	R	S	G	W	A	L	N	M	K	E	L	K	L	L	Q	T	I	G	K	G	E	F	G	D	V	M	L	G	D	Y	R	.	.	G	N	K	V	A	V	K	C	I	K	N	D	A	T	A	.	Q	A	F	L
Query Conservation																										.																																		.	.																.
Alig confidence																										.																																		.	.																.
Template Conservation
Template Sequence		V	A	D	G	L	I	T	T	L	H	Y	P	A	P	K	R	N	K	P	T	V	Y	G	V	S	P	N	Y	D	K	W	E	M	E	R	T	D	I	T	M	K	H	K	L	G	G	G	Q	Y	G	E	V	Y	E	G	V	W	K	K	Y	S	L	T	V	A	V	K	T	L	K	E	D	T	M	E	V	E	E	F	L
Template Known Secondary structure				T	T	S	S	S															S	S	S		S	S	T	T			B			G	G	G							S	G	G	G	T	T	S	S							G	G	G	T										T	T	S
Template Predicted Secondary structure
Template SS confidence
		224	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240	.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300	.	.	.
		235	.	.	.	.	240	.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300	.	.	.	.	.	.	.	.	.	310	.	.	.	.
Predicted Secondary structure
Query SS confidence
Query Sequence		A	E	A	S	V	M	T	Q	L	R	H	S	N	L	V	Q	L	L	G	V	I	V	E	E	K	G	G	L	Y	I	V	T	E	Y	M	A	K	G	S	L	V	D	Y	L	R	S	R	G	R	S	V	L	G	G	D	C	L	L	K	F	S	L	D	V	C	E	A	M	E	Y	L	E	G	N	N	F	V	H	R	D
Query Conservation
Alig confidence																							.
Template Conservation																							.
Template Sequence		K	E	A	A	V	M	K	E	I	K	H	P	N	L	V	Q	L	L	G	V	C	.	T	R	E	P	P	F	Y	I	I	T	E	F	M	T	Y	G	N	L	L	D	Y	L	R	E	C	N	R	Q	E	V	N	A	V	V	L	L	Y	M	A	T	Q	I	S	S	A	M	E	Y	L	E	K	K	N	F	I	H	R	N
Template Known Secondary structure													T	T	B								.		S	S	S	S									T	T		B								S		T	T	T	S																						T	T				S
Template Predicted Secondary structure																							.
Template SS confidence
		304	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.		.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360	.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.
		315	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.					.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360	.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390
Predicted Secondary structure																									.	.	.	.
Query SS confidence																									.	.	.	.
Query Sequence		L	A	A	R	N	V	L	V	S	E	D	N	V	A	K	V	S	D	F	G	L	T	K	.	.	.	.	E	A	S	S	T	Q	D	T	G	K	L	P	V	K	W	T	A	P	E	A	L	R	E	K	K	F	S	T	K	S	D	V	W	S	F	G	I	L	L	W	E	I	Y	S	F	G	R	V	P	Y	P	R	I
Query Conservation																									.	.	.	.
Alig confidence																									.	.	.	.
Template Conservation
Template Sequence		L	A	A	R	N	C	L	V	G	E	N	H	L	V	K	V	A	D	F	G	L	S	R	L	M	T	G	D	T	Y	T	A	H	A	G	A	K	F	P	I	K	W	T	A	P	E	S	L	A	Y	N	K	F	S	I	K	S	D	V	W	A	F	G	V	L	L	W	E	I	A	T	Y	G	M	S	P	Y	P	G	I
Template Known Secondary structure			S	G	G	G					G	G	G							T	T						S	S							T	T					G	G	G																													T	T	S			S	S	T	T
Template Predicted Secondary structure
Template SS confidence
		383	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420	.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.
		391	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420	.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.
Predicted Secondary structure
Query SS confidence
Query Sequence		P	L	K	D	V	V	P	R	V	E	K	G	Y	K	M	D	A	P	D	G	C	P	P	A	V	Y	E	V	M	K	N	C	W	H	L	D	A	A	M	R	P	S	F	L	Q	L	R	E	Q	L	E	H	I	K	T	H	E
Query Conservation
Alig confidence
Template Conservation
Template Sequence		D	L	S	Q	V	Y	E	L	L	E	K	D	Y	R	M	E	R	P	E	G	C	P	E	K	V	Y	E	L	M	R	A	C	W	Q	W	N	P	S	D	R	P	S	F	A	E	I	H	Q	A	F	E	T	M	F	Q	E	S
Template Known Secondary structure												T	T							T	T													T		S	S	G	G	G	S												T	S	S	S	S	S
Template Predicted Secondary structure
Template SS confidence
		463	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480	.	.	.	.	.	.	.	.	.	490	.	.	.	.	.	.	.	.	.	500	.	.	.	.	.	.	.	.	.	510	.	.	.	.	.	.	.	.	.