Email l.a.kelley@imperial.ac.uk Description P20936 Date Fri May 25 10:08:08 BST 2012 Unique Job ID 1e22fc0a085ba97b

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 c3bxjB_ 100.0 25 PDB header:signaling protein Chain: B: PDB Molecule:ras gtpase-activating protein syngap; PDBTitle: crystal structure of the c2-gap fragment of syngap 2 d1wera_ 100.0 100 Fold:GTPase activation domain, GAP Superfamily:GTPase activation domain, GAP Family:p120GAP domain-like 3 c3fayA_ 100.0 19 PDB header:membrane protein Chain: A: PDB Molecule:ras gtpase-activating-like protein iqgap1; PDBTitle: crystal structure of the gap-related domain of iqgap1 4 d1nf1a_ 100.0 32 Fold:GTPase activation domain, GAP Superfamily:GTPase activation domain, GAP Family:p120GAP domain-like 5 c2b3oA_ 100.0 31 PDB header:hydrolase Chain: A: PDB Molecule:tyrosine-protein phosphatase, non-receptor type PDBTitle: crystal structure of human tyrosine phosphatase shp-1 6 c3ps5A_ 100.0 30 PDB header:hydrolase, signaling protein Chain: A: PDB Molecule:tyrosine-protein phosphatase non-receptor type 6; PDBTitle: crystal structure of the full-length human protein tyrosine2 phosphatase shp-1 7 c2shpA_ 100.0 33 PDB header:tyrosine phosphatase Chain: A: PDB Molecule:shp-2; PDBTitle: tyrosine phosphatase shp-2 8 c3gqiB_ 100.0 33 PDB header:transferase/transferase inhibitor Chain: B: PDB Molecule:phospholipase c-gamma-1; PDBTitle: crystal structure of activated receptor tyrosine kinase in complex2 with substrates 9 c2oq1A_ 100.0 25 PDB header:transferase Chain: A: PDB Molecule:tyrosine-protein kinase zap-70; PDBTitle: tandem sh2 domains of zap-70 with 19-mer zeta1 peptide 10 c2ozoA_ 100.0 25 PDB header:transferase Chain: A: PDB Molecule:tyrosine-protein kinase zap-70; PDBTitle: autoinhibited intact human zap-70 11 c1a81E_ 100.0 26 PDB header:complex (transferase/peptide) Chain: E: PDB Molecule:syk kinase; PDBTitle: crystal structure of the tandem sh2 domain of the syk kinase bound to2 a dually tyrosine-phosphorylated itam 12 c2fo0A_ 99.9 21 PDB header:transferase Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase abl1 (1b isoform); PDBTitle: organization of the sh3-sh2 unit in active and inactive forms of the2 c-abl tyrosine kinase 13 c2gsbA_ 99.9 97 PDB header:signaling protein Chain: A: PDB Molecule:ras gtpase-activating protein 1; PDBTitle: solution structure of the second sh2 domain of human ras2 gtpase-activating protein 1 14 c2ablA_ 99.9 23 PDB header:transferase Chain: A: PDB Molecule:abl tyrosine kinase; PDBTitle: sh3-sh2 domain fragment of human bcr-abl tyrosine kinase 15 c1k9aB_ 99.9 21 PDB header:transferase Chain: B: PDB Molecule:carboxyl-terminal src kinase; PDBTitle: crystal structure analysis of full-length carboxyl-terminal2 src kinase at 2.5 a resolution 16 c1x27F_ 99.9 21 PDB header:signaling protein Chain: F: PDB Molecule:proto-oncogene tyrosine-protein kinase lck; PDBTitle: crystal structure of lck sh2-sh3 with sh2 binding site of2 p130cas 17 c1y57A_ 99.9 25 PDB header:transferase Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase src; PDBTitle: structure of unphosphorylated c-src in complex with an inhibitor 18 d2oq1a1 99.9 19 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 19 c3nhnA_ 99.9 29 PDB header:transferase Chain: A: PDB Molecule:tyrosine-protein kinase hck; PDBTitle: crystal structure of the src-family kinase hck sh3-sh2-linker2 regulatory region 20 c2h8hA_ 99.9 25 PDB header:transferase Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase src; PDBTitle: src kinase in complex with a quinazoline inhibitor 21 c1oplA_ not modelled 99.8 22 PDB header:transferase Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase; PDBTitle: structural basis for the auto-inhibition of c-abl tyrosine2 kinase 22 c2eobA_ not modelled 99.8 21 PDB header:hydrolase Chain: A: PDB Molecule:1-phosphatidylinositol-4,5-bisphosphate PDBTitle: solution structure of the second sh2 domain from rat plc2 gamma-2 23 c2c0iA_ not modelled 99.8 27 PDB header:transferase Chain: A: PDB Molecule:tyrosine-protein kinase hck; PDBTitle: src family kinase hck with bound inhibitor a-420983 24 c2eo6A_ not modelled 99.8 21 PDB header:signaling protein Chain: A: PDB Molecule:b-cell linker protein; PDBTitle: solution structure of the sh2 domain from mouse b-cell2 linker protein blnk 25 c3hizB_ not modelled 99.8 25 PDB header:transferase/oncoprotein Chain: B: PDB Molecule:phosphatidylinositol 3-kinase regulatory subunit PDBTitle: crystal structure of p110alpha h1047r mutant in complex with2 nish2 of p85alpha 26 c2dlyA_ not modelled 99.8 20 PDB header:transferase Chain: A: PDB Molecule:fyn-related kinase; PDBTitle: solution structure of the sh2 domain of murine fyn-related2 kinase 27 d1nrva_ not modelled 99.8 26 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 28 d3c7ia1 not modelled 99.8 27 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 29 d1rjaa_ not modelled 99.8 24 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 30 d1a81e2 not modelled 99.8 24 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 31 c1g83A_ not modelled 99.8 26 PDB header:transferase Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase fyn; PDBTitle: crystal structure of fyn sh3-sh2 32 d2shpa2 not modelled 99.8 33 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 33 d2oq1a2 not modelled 99.8 22 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 34 d1fhsa_ not modelled 99.8 24 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 35 c1ka6A_ not modelled 99.8 26 PDB header:immune system Chain: A: PDB Molecule:sh2 domain protein 1a; PDBTitle: sap/sh2d1a bound to peptide n-py 36 d1a81a1 not modelled 99.8 23 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 37 c2y3aB_ not modelled 99.8 26 PDB header:transferase Chain: B: PDB Molecule:phosphatidylinositol 3-kinase regulatory subunit beta; PDBTitle: crystal structure of p110beta in complex with icsh2 of p85beta and2 the drug gdc-0941 38 c2lqnA_ not modelled 99.8 26 PDB header:signaling protein Chain: A: PDB Molecule:crk-like protein; PDBTitle: solution structure of crkl 39 c2eo3A_ not modelled 99.8 29 PDB header:signaling protein Chain: A: PDB Molecule:crk-like protein; PDBTitle: solution structure of the sh2 domain from human crk-like2 protein 40 c2ysxA_ not modelled 99.8 27 PDB header:signaling protein Chain: A: PDB Molecule:signaling inositol polyphosphate phosphatase PDBTitle: solution structure of the human ship sh2 domain 41 d1csya_ not modelled 99.8 22 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 42 c1x6cA_ not modelled 99.8 28 PDB header:signaling protein Chain: A: PDB Molecule:tyrosine-protein phosphatase, non-receptor type PDBTitle: solution structures of the sh2 domain of human protein-2 tyrosine phosphatase shp-1 43 d1a81e1 not modelled 99.8 24 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 44 d1a81a2 not modelled 99.8 24 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 45 d1ayaa_ not modelled 99.8 35 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 46 d2fcia1 not modelled 99.8 27 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 47 d1i3za_ not modelled 99.8 20 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 48 d1jwoa_ not modelled 99.8 28 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 49 c2crhA_ not modelled 99.8 13 PDB header:signaling protein Chain: A: PDB Molecule:vav proto-oncogene; PDBTitle: solution structure of the sh2 domain of human proto-2 oncogene protein vav1 50 c2ci8A_ not modelled 99.8 25 PDB header:translation Chain: A: PDB Molecule:cytoplasmic protein nck1; PDBTitle: sh2 domain of human nck1 adaptor protein - uncomplexed 51 d1d4ta_ not modelled 99.8 28 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 52 c2dlzA_ not modelled 99.8 19 PDB header:signaling protein Chain: A: PDB Molecule:protein vav-2; PDBTitle: solution structure of the sh2 domain of human protein vav-2 53 d1blja_ not modelled 99.8 24 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 54 d1jyra_ not modelled 99.8 26 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 55 d1pica_ not modelled 99.8 25 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 56 d1o48a_ not modelled 99.8 26 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 57 d2qmsa1 not modelled 99.8 22 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 58 d1k9aa2 not modelled 99.8 27 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 59 c2ge9A_ not modelled 99.8 22 PDB header:transferase Chain: A: PDB Molecule:tyrosine-protein kinase btk; PDBTitle: solution structures of the sh2 domain of bruton's tyrosine2 kinase 60 d1gmia_ 99.8 26 Fold:C2 domain-like Superfamily:C2 domain (Calcium/lipid-binding domain, CaLB) Family:PLC-like (P variant) 61 d1opka2 not modelled 99.8 24 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 62 d1lkka_ not modelled 99.8 25 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 63 d2izva2 not modelled 99.8 18 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 64 c2knoA_ not modelled 99.8 21 PDB header:hydrolase Chain: A: PDB Molecule:tensin-like c1 domain-containing phosphatase; PDBTitle: nmr solution structure of sh2 domain of the human tensin like c12 domain containing phosphatase (tenc1) 65 d1r1qa_ not modelled 99.8 29 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 66 d1f2fa_ not modelled 99.8 25 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 67 d1qcfa2 not modelled 99.8 27 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 68 c2fk9A_ 99.8 26 PDB header:transferase Chain: A: PDB Molecule:protein kinase c, eta type; PDBTitle: human protein kinase c, eta 69 d2shpa3 not modelled 99.8 39 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 70 d1g83a2 not modelled 99.8 24 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 71 d1bkla_ not modelled 99.8 25 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 72 c2lctA_ not modelled 99.8 14 PDB header:signaling protein Chain: A: PDB Molecule:proto-oncogene vav; PDBTitle: solution structure of the vav1 sh2 domain complexed with a syk-derived2 doubly phosphorylated peptide 73 d2cjta1 99.8 19 Fold:C2 domain-like Superfamily:C2 domain (Calcium/lipid-binding domain, CaLB) Family:PLC-like (P variant) 74 d1luia_ not modelled 99.8 28 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 75 d2eyva1 not modelled 99.8 30 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 76 c2r09A_ 99.7 32 PDB header:signaling protein Chain: A: PDB Molecule:cytohesin-3; PDBTitle: crystal structure of autoinhibited form of grp1 arf gtpase exchange2 factor 77 c2el8A_ not modelled 99.7 20 PDB header:signaling protein Chain: A: PDB Molecule:signal-transducing adaptor protein 2; PDBTitle: solution structure of the human stap2 sh2 domain 78 d1rpya_ not modelled 99.7 24 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 79 c3m7fB_ 99.7 22 PDB header:signaling protein/ligase Chain: B: PDB Molecule:e3 ubiquitin-protein ligase nedd4; PDBTitle: crystal structure of the nedd4 c2/grb10 sh2 complex 80 d2cs0a1 not modelled 99.7 26 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 81 c1rqqC_ not modelled 99.7 25 PDB header:transferase/signaling protein Chain: C: PDB Molecule:adaptor protein aps; PDBTitle: crystal structure of the insulin receptor kinase in complex2 with the sh2 domain of aps 82 c2ekxA_ not modelled 99.7 22 PDB header:signaling protein Chain: A: PDB Molecule:cytoplasmic tyrosine-protein kinase bmx; PDBTitle: solution structure of the human bmx sh2 domain 83 d2dyna_ not modelled 99.7 16 Fold:PH domain-like barrel Superfamily:PH domain-like Family:Pleckstrin-homology domain (PH domain) 84 c2c9wA_ not modelled 99.7 18 PDB header:transcription regulation Chain: A: PDB Molecule:suppressor of cytokine signaling 2; PDBTitle: crystal structure of socs-2 in complex with elongin-b and2 elongin-c at 1.9a resolution 85 c2vifA_ not modelled 99.7 23 PDB header:signaling protein Chain: A: PDB Molecule:suppressor of cytokine signalling 6; PDBTitle: crystal structure of socs6 sh2 domain in complex with a c-kit2 phosphopeptide 86 d1mila_ not modelled 99.7 27 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 87 c2izvA_ not modelled 99.7 19 PDB header:transcription Chain: A: PDB Molecule:suppressor of cytokine signaling 4; PDBTitle: crystal structure of socs-4 in complex with elongin-b and2 elongin-c at 2.55a resolution 88 c3l9bA_ 99.7 17 PDB header:membrane protein Chain: A: PDB Molecule:otoferlin; PDBTitle: crystal structure of rat otoferlin c2a 89 c2d9zA_ 99.7 22 PDB header:signaling protein Chain: A: PDB Molecule:protein kinase c, nu type; PDBTitle: solution structure of the ph domain of protein kinase c, nu2 type from human 90 c2kk6A_ not modelled 99.7 33 PDB header:transferase Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase fer; PDBTitle: solution structure of sh2 domain of proto-oncogene tyrosine-2 protein kinase fer from homo sapiens, northeast structural3 genomics consortium (nesg) target hr3461d 91 d1fu6a_ not modelled 99.7 28 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 92 d1qada_ not modelled 99.7 27 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 93 c2dm0A_ not modelled 99.7 21 PDB header:transferase Chain: A: PDB Molecule:tyrosine-protein kinase txk; PDBTitle: solution structure of the sh2 domain of human tyrosine-2 protein kinase txk 94 c2dvjA_ not modelled 99.7 23 PDB header:signaling protein Chain: A: PDB Molecule:v-crk sarcoma virus ct10 oncogene homolog, PDBTitle: phosphorylated crk-ii 95 c2dcrA_ not modelled 99.7 30 PDB header:transferase Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase fes/fps; PDBTitle: fully automated solution structure determination of the fes2 sh2 domain 96 c2hmhA_ not modelled 99.7 17 PDB header:cytokine regulator Chain: A: PDB Molecule:suppressor of cytokine signaling 3; PDBTitle: crystal structure of socs3 in complex with gp130(ptyr757)2 phosphopeptide. 97 c3mazA_ not modelled 99.7 19 PDB header:signaling protein Chain: A: PDB Molecule:signal-transducing adaptor protein 1; PDBTitle: crystal structure of the human brdg1/stap-1 sh2 domain in complex with2 the ntal ptyr136 peptide 98 d2cjsa1 99.7 21 Fold:C2 domain-like Superfamily:C2 domain (Calcium/lipid-binding domain, CaLB) Family:PLC-like (P variant) 99 d2coaa1 not modelled 99.7 19 Fold:PH domain-like barrel Superfamily:PH domain-like Family:Pleckstrin-homology domain (PH domain) 100 c3qwxX_ not modelled 99.7 17 PDB header:signaling protein Chain: X: PDB Molecule:cell death abnormality protein 2; PDBTitle: ced-2 1-174 101 d2fjla1 99.7 22 Fold:PH domain-like barrel Superfamily:PH domain-like Family:Pleckstrin-homology domain (PH domain) 102 d1v88a_ not modelled 99.7 18 Fold:PH domain-like barrel Superfamily:PH domain-like Family:Pleckstrin-homology domain (PH domain) 103 c3a8qB_ 99.7 23 PDB header:signaling protein Chain: B: PDB Molecule:t-lymphoma invasion and metastasis-inducing PDBTitle: low-resolution crystal structure of the tiam2 phccex domain 104 d1cwea_ not modelled 99.7 26 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 105 c2eyyA_ not modelled 99.7 18 PDB header:signaling protein Chain: A: PDB Molecule:v-crk sarcoma virus ct10 oncogene homolog PDBTitle: ct10-regulated kinase isoform i 106 d1wg7a_ 99.7 26 Fold:PH domain-like barrel Superfamily:PH domain-like Family:Pleckstrin-homology domain (PH domain) 107 d1xa6a2 not modelled 99.7 24 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 108 d1x1ga1 99.7 25 Fold:PH domain-like barrel Superfamily:PH domain-like Family:Pleckstrin-homology domain (PH domain) 109 c2eyzA_ not modelled 99.7 29 PDB header:signaling protein Chain: A: PDB Molecule:v-crk sarcoma virus ct10 oncogene homolog PDBTitle: ct10-regulated kinase isoform ii 110 d1x1fa1 not modelled 99.7 18 Fold:PH domain-like barrel Superfamily:PH domain-like Family:Pleckstrin-homology domain (PH domain) 111 c3or8A_ not modelled 99.7 20 PDB header:transcription Chain: A: PDB Molecule:transcription elongation factor spt6; PDBTitle: a tandem sh2 domain in transcription elongation factor spt6 112 d2c9wa2 not modelled 99.7 18 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 113 c3qwyA_ not modelled 99.7 17 PDB header:signaling protein Chain: A: PDB Molecule:cell death abnormality protein 2; PDBTitle: ced-2 114 c2d9vA_ not modelled 99.7 19 PDB header:membrane protein Chain: A: PDB Molecule:pleckstrin homology domain-containing protein PDBTitle: solution structure of the ph domain of pleckstrin homology2 domain-containing protein family b member 1 from mouse 115 d1u5ea1 not modelled 99.7 25 Fold:PH domain-like barrel Superfamily:PH domain-like Family:Pleckstrin-homology domain (PH domain) 116 d1xx0a1 not modelled 99.7 32 Fold:PH domain-like barrel Superfamily:PH domain-like Family:Pleckstrin-homology domain (PH domain) 117 c3a8nA_ not modelled 99.7 22 PDB header:signaling protein Chain: A: PDB Molecule:t-lymphoma invasion and metastasis-inducing PDBTitle: crystal structure of the tiam1 phccex domain 118 d2coca1 not modelled 99.6 15 Fold:PH domain-like barrel Superfamily:PH domain-like Family:Pleckstrin-homology domain (PH domain) 119 c2xp1A_ not modelled 99.6 19 PDB header:transcription Chain: A: PDB Molecule:spt6; PDBTitle: structure of the tandem sh2 domains from antonospora locustae2 transcription elongation factor spt6 120 c2ys3A_ not modelled 99.6 21 PDB header:signaling protein Chain: A: PDB Molecule:unc-112-related protein 2; PDBTitle: solution structure of the ph domain of kindlin-3 from human