Job Description P20936 Confidence 35.68% Date Fri May 25 10:08:08 BST 2012 Rank 317 Aligned Residues 245 % Identity 18% Template c1e8zA_ PDB info PDB header:transferase Chain: A: PDB Molecule:phosphatidylinositol 3-kinase catalytic subunit; PDBTitle: structure determinants of phosphoinositide 3-kinase2 inhibition by wortmannin, ly294002, quercetin, myricetin3 and staurosporine Resolution 2.40 Å

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		595	.	.	.	.	600	.	.	.	.	.	.	.	.	.	610	.	.	.	.	.			.	.	.	.	620	.	.	.	.	.			.	.	.	.	630	.	.	.	.	.		.	.	.	.	640	.	.	.	.	.					.	.	.	.	650	.	.	.	.	.	.	.	.	.	660	.	.	.	.	.
Predicted Secondary structure																							.	.											.	.											.											.	.	.	.
Query SS confidence																							.	.											.	.											.											.	.	.	.
Query Sequence		S	L	V	L	H	I	E	E	A	H	K	L	P	V	K	H	F	T	N	P	Y	.	.	C	N	I	Y	L	N	S	V	Q	V	.	.	A	K	T	H	A	R	E	G	Q	N	.	P	V	W	S	E	E	F	V	F	D	.	.	.	.	D	L	P	P	D	I	N	R	F	E	I	T	L	S	N	K	T	K	K	S
Query Conservation																							.	.											.	.											.											.	.	.	.
Alig confidence																							.	.											.	.											.											.	.	.	.					.											.	.	.	.	.
Template Conservation																																																																		.											.	.	.	.	.
Template Sequence		R	V	K	I	R	G	I	D	I	P	V	L	P	R	N	T	D	L	T	V	F	V	E	A	N	I	Q	H	G	Q	Q	V	L	C	Q	R	R	T	S	P	K	P	F	T	E	E	V	L	W	N	V	W	L	E	F	S	I	K	I	K	D	L	P	K	.	G	A	L	L	N	L	Q	I	Y	C	.	.	.	.	.
Template Known Secondary structure											S					S	S													T	T															S														G	G	G			T	.	T										.	.	.	.	.
Template Predicted Secondary structure																																																																		.											.	.	.	.	.
Template SS confidence
		362	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420	.	.	.	.	.		.	.	.	.	430	.	.	.	.	.
		666	.	.	.	670	.	.	.	.	.	.	.	.	.	680	.	.	.	.	.	.	.	.	.	690	.	.												.	.	.	.	.	.	.	700	.	.	.	.	.	.	.	.	.	710	.	.	.	.	.	.	.	.					.	720	.	.	.	.	.	.	.	.	.	730
Predicted Secondary structure																													.	.	.	.	.	.	.	.	.	.	.																											.	.	.	.
Query SS confidence																													.	.	.	.	.	.	.	.	.	.	.																											.	.	.	.
Query Sequence		K	D	P	D	I	L	F	M	R	C	Q	L	S	R	L	Q	K	G	H	A	T	D	E	W	F	L	L	.	.	.	.	.	.	.	.	.	.	.	S	S	H	I	P	L	K	G	I	E	P	G	S	L	R	V	R	A	R	Y	S	M	E	K	I	M	.	.	.	.	P	E	E	E	Y	S	E	F	K	E	L	I
Query Conservation																													.	.	.	.	.	.	.	.	.	.	.																											.	.	.	.
Alig confidence		.	.	.															.										.	.	.	.	.	.	.	.	.	.	.																											.	.	.	.
Template Conservation		.	.	.															.
Template Sequence		.	.	.	L	L	Y	Y	V	N	L	L	L	I	D	H	R	F	.	L	L	R	R	G	E	Y	V	L	H	M	W	Q	I	S	G	F	N	A	D	K	L	T	S	A	T	N	P	D	K	E	N	S	M	S	I	S	I	L	L	D	N	H	P	I	A	R	A	E	M	P	N	Q	L	R	K	Q	L	E	A	I	I
Template Known Secondary structure		.	.	.									S	B		T	T	S	.		B										B							G	G	G	G						S		T	T	T	S
Template Predicted Secondary structure		.	.	.															.
Template SS confidence
					460	.	.	.	.	.	.	.	.	.	470	.	.	.		.	.	.	.	.	.	480	.	.	.	.	.	.	.	.	.	490	.	.	.	.	.	.	.	.	.	500	.	.	.	.	.	.	.	.	.	510	.	.	.	.	.	.	.	.	.	520	.	.	.	.	.	.	.	.	.	530	.	.	.	.	.
		731	.	.	.	.	.	.	.	.	740	.	.	.	.	.	.		.	.	.	750
Predicted Secondary structure																		.					.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.
Query SS confidence																		.					.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.
Query Sequence		L	Q	K	E	L	H	V	V	Y	A	L	S	H	V	C	G	.	Q	D	R	T	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.
Query Conservation																		.					.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.
Alig confidence																		.					.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.
Template Conservation
Template Sequence		A	T	D	P	L	N	P	L	T	A	E	D	K	E	L	L	W	H	F	R	Y	E	S	L	K	H	P	K	A	Y	P	K	L	F	S	S	V	K	W	G	Q	Q	E	I	V	A	K	T	Y	Q	L	L	A	R	R	E	V	W	D	Q	S	A	L	D	V	G	L	T	M	Q	L	L	D	C	N	F	S	D	E	N
Template Known Secondary structure			S		T	T	S													T					T	T		G	G	G						T	T	S		T	T													T	T		T					S										T	T	S	T	T
Template Predicted Secondary structure
Template SS confidence
		560	.	.	.	.	.	.	.	.	.	570	.	.	.	.	.	.	.	.	.	580	.	.	.	.	.	.	.	.	.	590	.	.	.	.	.	.	.	.	.	600	.	.	.	.	.	.	.	.	.	610	.	.	.	.	.	.	.	.	.	620	.	.	.	.	.	.	.	.	.	630	.	.	.	.	.	.	.	.	.
																																						751	.	.	.	.	.	.	.	.	760	.	.	.	.	.	.	.	.	.	770	.	.	.	.	.	.	.	.	.	780	.	.	.	.	.	.	.	.	.	790	.	.	.	.
Predicted Secondary structure		.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.
Query SS confidence		.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.
Query Sequence		.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	L	L	A	S	I	L	L	R	I	F	L	H	E	K	L	E	S	L	L	L	C	T	L	N	D	R	E	I	S	M	E	D	E	A	T	T	L	F	R	A	T	T	L	A
Query Conservation		.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.
Alig confidence		.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.																																							.	.	.	.	.	.
Template Conservation																																																																												.	.	.	.	.	.
Template Sequence		V	R	A	I	A	V	Q	K	L	E	S	L	E	D	D	D	V	L	H	Y	L	L	Q	L	V	Q	A	V	K	F	E	P	Y	H	D	S	A	L	A	R	F	L	L	K	R	G	L	R	N	K	R	I	G	H	F	L	F	W	F	L	R	S	E	I	A	Q	S	R	H	Y	Q	Q	R	F	.	.	.	.	.	.
Template Known Secondary structure											T	T																	G	G	G		S	S	S	S																																	T	T	T					.	.	.	.	.	.
Template Predicted Secondary structure																																																																												.	.	.	.	.	.
Template SS confidence
		640	.	.	.	.	.	.	.	.	.	650	.	.	.	.	.	.	.	.	.	660	.	.	.	.	.	.	.	.	.	670	.	.	.	.	.	.	.	.	.	680	.	.	.	.	.	.	.	.	.	690	.	.	.	.	.	.	.	.	.	700	.	.	.	.	.	.	.	.	.	710	.	.	.
		795	.	.	.	.	800	.	.	.	.	.	.	.	.	.	810	.	.	.	.	.	.	.	.	.	820	.	.	.	.	.	.	.	.	.	830	.	.	.	.	.	.	.	.	.	840	.	.	.	.	.	.	.	.	.	850	.	.	.	.	.
Predicted Secondary structure
Query SS confidence
Query Sequence		S	T	L	M	E	Q	Y	M	K	A	T	A	T	Q	F	V	H	H	A	L	K	D	S	I	L	K	I	M	E	S	K	Q	S	C	E	L	S	P	S	K	L	E	K	N	E	D	V	N	T	N	L	T	H	L	L	N	I	L	S	E	L
Query Conservation
Alig confidence
Template Conservation
Template Sequence		A	V	I	L	E	A	Y	L	R	G	C	G	T	A	M	L	H	D	F	T	Q	Q	V	Q	V	I	E	M	L	Q	K	V	T	L	D	I	K	S	L	S	A	E	K	Y	D	V	S	S	Q	V	I	S	Q	L	K	Q	K	L	E	N	L
Template Known Secondary structure										T	T	S																												S			S
Template Predicted Secondary structure
Template SS confidence
		714	.	.	.	.	.	720	.	.	.	.	.	.	.	.	.	730	.	.	.	.	.	.	.	.	.	740	.	.	.	.	.	.	.	.	.	750	.	.	.	.	.	.	.	.	.	760	.	.	.	.	.	.	.	.	.	770	.	.	.	.

No model constructed - rank, confidence too low

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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
© Structural Bioinformatics Group, Imperial College, London Lawrence Kelley, Benjamin Jefferys   Disclaimer Terms and Conditions