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Job DescriptionP19174
Confidence100.00%DateWed May 9 17:43:44 BST 2012
Rank1Aligned Residues717
% Identity34%Templatec3ohmB_
PDB info PDB header:signaling protein / hydrolaseChain: B: PDB Molecule:1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase PDBTitle: crystal structure of activated g alpha q bound to its effector2 phospholipase c beta 3
Resolution2.70 Å

  Insertion relative to template
  Deletion relative to template
  Catalytic residue from the CSA
 
Detailed help on interpreting your alignment


   25....30.........40.........50.........60.........70.........80.........90.........100....
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Query Sequence  LCRSLEVGTVMTLFYSKKSQRPERKTFQVKLETRQITWSRGADKIEGAIDIREIKEIRPGKTSRDFDRYQEDPAFRPDQS
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Template Sequence  VVETLRRGSKFIKWDEETSSRNL. VTLRVDPNGFFLYWTGP. NMEVDTLDISSIRDTRTGRYARLPK. . . DPKIREVLEE
Template Known Secondary structure 



TT

S

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TTS

G.GG
GGGTTTS



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T
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   18.20.........30.........40 .........50....... ..60.........70.........80.. .......90..
 
   105....110..... ....120.........130.........140.........150.........160.. .......170.........180.
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Query Sequence  HCFVILYGMEF. RLKTLSLQATSEDEVNMWIKGLTWLMEDTLQAPTPLQIERWLRKQFY. . SVDRNREDRISAKDLKNML
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Template Sequence  KLMTVVSGPDPVNTVFLNFMAVQDDTAKVWSEELFKLAMNILAQNAS. . RNTFLRKAYTKLKLQVNQDGRIPVKNILKMF
Template Known Secondary structure  T
SSGGG
SSSS
T

..S

TTS
TT
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   102.......110.........120.........130.........140........ .150.........160.........170.........
 
   182 .......190.........200.........210.........220.........230.........240.........250.........
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Query Sequence  S. . QVNYRVPNMRFLRERLTDLEQRSGDITYGQFAQLYRSLMYSAQKTMDLPFLEASTLRAGERPELCRVSLPEFQQFLL
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Template Sequence  SADKKRVETALESCGLKFNRSESIRPDEFSLEIFERFLNKL. . CLRPDIDKILLEI. . . . . . GAKGKPYLTLEQLMDFIN
Template Known Secondary structure  GGGTTT


STT

GGG

..S

T......T

STT
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   180.........190.........200.........210.........220 .........230... ......240.........250.
 
   260........ .270.........280.........290.........300.........310.........320.........330..
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Query Sequence  DYQGELWAV. . . . . . . DRLQVQEFMLSFLRDPLREIEEPYFFLDEFVTFLFSKENSVWNSQLDAVCPDTMNNPLSHYWIS
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Template Sequence  QKQRDPRLNEVLYPPLRPSQARLLIEKY. EPNQQFLERDQMSMEGFSRYLGGEENGILPLEALDLSTD. MTQPLSAYFIN
Template Known Secondary structure  SS
TTS
TTTS



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TT
TSTTS
SS
SS
S
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S
GGG
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   252.......260.........270......... 280.........290.........300.........310........ .320.........
 
   333......340.........350.........360.........370. ........380.........390.........400.........410
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Query Sequence  SSHNTYLTGDQFSSESSLEAYARCLRMGCRCIELDCWDG. . PDGMPVIYHGHTLTTKIKFSDVLHTIKEHAFVASEYPVI
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Template Sequence  SSHNTYLTAGQLAGTSSVEMYRQALLWGCRCVELDVWKGRPPEEEPFITHGFTMTTEVPLRDVLEAIAETAFKTSPYPVI
Template Known Secondary structure 
BSSTTBSS
SS
B
STT




SSS



STTS

TTSS

S
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   330.........340.........350.........360.........370.........380.........390.........400.........
 
   411...... ..420.........430.........440.... .....450.........460.........470.........480.....
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Query Sequence  LSIEDHC. SIAQQRNMAQYFKKVLGDTLLTKPVEI. . . . SADGLPSPNQLKRKILIKHKKLAEGSAYEEVPTSMMYSEND
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Template Sequence  LSFENHVDSAKQQAKMAEYCRSIFGDALLIEPLDKYPLAPGVPLPSPQDLMGRILVKNKKRHTD. . . . . . . . . . . . . . . .
Template Known Secondary structure 


TTGGGB

S
BTTB
SSSS




TTTTTT






T................
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   410.........420.........430.........440.........450.........460.........470...
 
   486...490.........500.........510.........520.........530.........540.........550.........560.....
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Query Sequence  ISNSIKNGILYLEDPVNHEWYPHYFVLTSSKIYYSEETSSDQGNEDEEEPKEVSSSTELHSNEKWFHGKLGAGRDGRHIA
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Template Conservation  ................................................................................
Template Sequence  . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Template Known Secondary structure  ................................................................................
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   566...570.........580.........590.........600.........610.........620.........630.........640.....
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Query Sequence  ERLLTEYCIETGAPDGSFLVRESETFVGDYTLSFWRNGKVQHCRIHSRQDAGTPKFFLTDNLVFDSLYDLITHYQQVPLR
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Template Sequence  . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
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   646...650.........660.........670.........680.........690.........700.........710.........720.....
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Query Sequence  CNEFEMRLSEPVPQTNAHESKEWYHASLTRAQAEHMLMRVPRDGAFLVRKRNEPNSYAISFRAEGKIKHCRVQQEGQTVM
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Template Sequence  . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
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   726...730.........740.........750.........760.........770.........780.........790.........800.....
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Query Sequence  LGNSEFDSLVDLISYYEKHPLYRKMKLRYPINEEALEKIGTAEPDYGALYEGRNPGFYVEANPMPTFKCAVKALFDYKAQ
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Template Sequence  . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
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   806...810.........820.........830.........840.........850.........860.........870.........880.....
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Query Sequence  REDELTFIKSAIIQNVEKQEGGWWRGDYGGKKQLWFPSNYVEEMVNPVALEPEREHLDENSPLGDLLRGVLDVPACQIAI
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Template Sequence  . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
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   886...890.........900.........910.........920.........930.........940.........950.........960.....
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Query Sequence  RPEGKNNRLFVFSISMASVAHWSLDVAADSQEELQDWVKKIREVAQTADARLTEGKIMERRKKIALELSELVVYCRPVPF
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Template Sequence  . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . EGTASSEVNATEEMSTLVNYIEPVKF
Template Known Secondary structure  ......................................................TGGGTT




TT
SS



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   577..580.........590.........600..
 
   966...970.........980.........990.........1000.........1010.........1020.........1030.........1040.....
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Query Sequence  DEEKIGTERACYRDMSSFPETKAEKYVNKAKGKKFLQYNRLQLSRIYPKGQRLDSSNYDPLPMWICGSQLVALNFQTPDK
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Template Sequence  KSFEAARKRNKCFEMSSFVETKAMEQL. TKSPMEFVEYNKQQLSRIYPKGTRVDSSNYMPQLFWNVGCQLVALNFQTLDV
Template Known Secondary structure 

T
TT.SS


TT
TT




TTTT
S
B
TT

S
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   603......610.........620......... 630.........640.........650.........660.........670.........680.
 
   1046...1050.........1060.........1070... ......1080.........1090.........1100.........1110.........1120...
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Query Sequence  PMQMNQALFMTGRHCGYVLQPSTMRDEA. . FDPFDKSSLRGLEPCAISIEVLGARHLPKNGRGIVCPFVEIEVAGAEYDS
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Template Sequence  AMQLNAGVFEYNGRSGYLLKPEFMRRPDKSFDPFTEVIVDGIVANALRVKVISGQFLSDRK. . . VGIYVEVDMFGLPVDT
Template Known Secondary structure  TTGGG
S

GGGT
TT



TT
SS

TT


S

SS
...

SSTTT
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   682.......690.........700.........710.........720.........730.........740.. .......750........
 
   1124.. ...1130.........1140....... ..1150.........1160.........1170.........1180.........1190.........1200.
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Query Sequence  TKQ. KTEFVVDNGLNPVWPAKPFHF. QISNPEFAFLRFVVYEEDMFSDQNFLAQATFPVKGLKTGYRAVPLKNNYSEDLE
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Template Sequence  RRKYRTRTSQGNSFNPVWDEEPFDFPKVVLPTLASLRIAAFEEG. . . . GKFVGHRILPVSAIRSGYHYVCLRNEANQPLC
Template Known Secondary structure  B







SS
SSS
B




S
GGG
TT....TTTT



TTS
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   759760.........770.........780.........790.........800.. .......810.........820.........830....
 
   1202.......1210.........1220.........1230........
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Query Sequence  LASLLIKIDIFPAKENGDLSPFSGTSLRERGSDASGQ
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Template Sequence  LPALLIYTEASDYIPDDHQDYAE. . ALINPIKHVSLM
Template Known Secondary structure 


GGG..
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   835....840.........850....... ..860.........
 
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Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
 
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