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Job DescriptionP19174
Confidence100.00%DateWed May 9 17:43:44 BST 2012
Rank3Aligned Residues673
% Identity36%Templatec2fjuB_
PDB info PDB header:signaling protein,apoptosis/hydrolaseChain: B: PDB Molecule:1-phosphatidylinositol-4,5-bisphosphate PDBTitle: activated rac1 bound to its effector phospholipase c beta 2
Resolution2.20 Å

  Insertion relative to template
  Deletion relative to template
  Catalytic residue from the CSA
 
Detailed help on interpreting your alignment


   25....30.........40.........50.........60.........70.........80.........90.. ......
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Query Sequence  LCRSLEVGTVMTLFYSKKSQRPERKTFQVKLETRQITWSRGADKIEGAIDIREIKEIRPGKTSRDFDR. . . . . . YQEDPA
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Template Sequence  VKAYLSQGERFIKW. DDETTVASPVILRVDPKGYYLYWTYQ. SKEMEFLDITSIRDTRFGKFAKMPKSQKLRDVFNMDFP
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.SSSSS

TTS
T.TS
GGGGGGS



STTTTST
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   13......20...... ...30.........40.........50.. .......60.........70.........80.........90
 
   99100.........110..... ....120.........130.........140.........150.........160. ........170.....
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Query Sequence  FRPDQSHCFVILYGMEF. RLKTLSLQATSEDEVNMWIKGLTWLMEDTLQAPTPLQIERWLRKQF. . YSVDRNREDRISAK
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Template Sequence  DNSFLLKTLTVVSGPDMVDLTFHNFVSYKENVGKAWAEDVLALVKHPLTANASRS. . TFLDKILVKLKMQLNSEGKIPVK
Template Known Secondary structure  T

GGGT
SSSSS
SSSST
T

..S

TTS
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   91........100.........110.........120.........130.........140..... ....150.........160........
 
   176...180..... ....190.........200.........210.........220.........230.........240.........250...
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Query Sequence  DLKNMLSQVN. . YRVPNMRFLRERLTDLEQRSGDITYGQFAQLYRSLMYSAQKTMDLPFLEASTLRAGERPELCRVSLPE
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Template Sequence  NFFQMFPADRKRVEAALSACHLPKGKNDAINPEDFPEPVYKSFLMSL. . CPRPEIDEIFTSY. . . . . . . . . . . . . MTKEH
Template Known Secondary structure  STT
TT


SSS

GGGS
TT..S



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B
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   169170.........180.........190.........200.........210..... ....220........ .230...
 
   254.....260.........270.........280.........290.........300.........310.........320.........330...
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Query Sequence  FQQFLLDYQGELWAVDRLQVQEFMLSFLRDPLREIEEPYFFLDEFVTFLFSKENSVWNSQLDAVCPDTMNNPLSHYWISS
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Template Sequence  LTKFINQKQRDQ. . . . . . . . . GLIDKY. EPS. . . . . . GQLSPEGMVWFLCGPENSVLAQDKLLLHHD. MTQPLNHYFINS
Template Known Secondary structure  TS


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B

STTS
SB
GGGGSS
S
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GGG
B
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   241........250.. ...... .260. ........270.........280.........290. ........300...
 
   334.....340.........350.........360.........370. ........380.........390.........400.........410.
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Query Sequence  SHNTYLTGDQFSSESSLEAYARCLRMGCRCIELDCWDG. . PDGMPVIYHGHTLTTKIKFSDVLHTIKEHAFVASEYPVIL
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Template Sequence  SHNTYLTAGQFSGLSSAEMYRQVLLSGCRCVELDCWKGKPPDEEPIITHGFTMTTDIFFKEAIEAIAESAFKTSPYPIIL
Template Known Secondary structure  BSSTTBSS
SSSS
B
TTT




TTTT



TTSS


TTTS

S
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   326...330.........340.........350.........360.........370.........380.........390.........400.....
 
   412..... ..420.........430.........440.... .....450.........460.........470.........480......
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Query Sequence  SIEDHC. SIAQQRNMAQYFKKVLGDTLLTKPVEI. . . . SADGLPSPNQLKRKILIKHKKLAEGSAYEEVPTSMMYSENDI
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Template Sequence  SFENHVDSPRQQAKMAEYCRTIFGDMLLTEPLEKFPLKPGVPLPSPEDLRGKILIKNKKEESGNLDEEEIKKMQSDEGT.
Template Known Secondary structure 



GGGB

S

TTS
SSTT




TTTTTT










TTTTTTTTTTTGG.
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   406...410.........420.........430.........440.........450.........460.........470.........480....
 
   487..490.........500.........510.........520.........530.........540.........550.........560......
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Query Sequence  SNSIKNGILYLEDPVNHEWYPHYFVLTSSKIYYSEETSSDQGNEDEEEPKEVSSSTELHSNEKWFHGKLGAGRDGRHIAE
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Template Conservation  ................................................................................
Template Sequence  . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
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   567..570.........580.........590.........600.........610.........620.........630.........640......
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Query Sequence  RLLTEYCIETGAPDGSFLVRESETFVGDYTLSFWRNGKVQHCRIHSRQDAGTPKFFLTDNLVFDSLYDLITHYQQVPLRC
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Template Sequence  . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
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   647..650.........660.........670.........680.........690.........700.........710.........720......
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Query Sequence  NEFEMRLSEPVPQTNAHESKEWYHASLTRAQAEHMLMRVPRDGAFLVRKRNEPNSYAISFRAEGKIKHCRVQQEGQTVML
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Template Sequence  . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
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   727..730.........740.........750.........760.........770.........780.........790.........800......
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Query Sequence  GNSEFDSLVDLISYYEKHPLYRKMKLRYPINEEALEKIGTAEPDYGALYEGRNPGFYVEANPMPTFKCAVKALFDYKAQR
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Template Sequence  . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
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   807..810.........820.........830.........840.........850.........860.........870.........880......
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Query Sequence  EDELTFIKSAIIQNVEKQEGGWWRGDYGGKKQLWFPSNYVEEMVNPVALEPEREHLDENSPLGDLLRGVLDVPACQIAIR
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Template Sequence  . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
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   887..890.........900.........910.........920.........930.........940.........950.........960......
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Query Sequence  PEGKNNRLFVFSISMASVAHWSLDVAADSQEELQDWVKKIREVAQTADARLTEGKIMERRKKIALELSELVVYCRPVPFD
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Template Sequence  . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . AGLEVTAYEEMSSLVNYIQPTKFV
Template Known Secondary structure  ........................................................GG





TT
SS




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   532.......540.........550.....
 
   967..970.........980.........990.........1000.........1010.........1020.........1030.........1040......
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Query Sequence  EEKIGTERACYRDMSSFPETKAEKYVNKAKGKKFLQYNRLQLSRIYPKGQRLDSSNYDPLPMWICGSQLVALNFQTPDKP
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Template Sequence  SFEFSAQKNRSYVISSFTELKAYDLL. SKASVQFVDYNKRQMSRIYPKGTRMDSSNYMPQMFWNAGCQMVALNFQTMDLP
Template Known Secondary structure 
T
TT.S

TT
TT





TT


B
TT

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   556...560.........570.........580. ........590.........600.........610.........620.........630....
 
   1047..1050.........1060.........1070.........1080.........1090.........1100.........1110.........1120......
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Query Sequence  MQMNQALFMTGRHCGYVLQPSTMRDEAFDPFDKSSLRGLEPCAISIEVLGARHLPKNGRGIVCPFVEIEVAGAEYDSTKQ
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Template Sequence  MQQNMAVFEFNGQSGYLLKHEFMRR. . . . . . . . . . . . . . . PTTLSITVISGQFLSERS. . . VRTYVEVELFGLPGDPKRR
Template Known Secondary structure  TTTGGG
S

GGGT
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S

SS
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TTS



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   635....640.........650......... 660.........670....... ..680.........690......
 
   1127..1130.........1140........ .1150.........1160.........1170.........1180.........1190.........1200...
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Query Sequence  . . KTEFVVDNGLNPVWPAKPFHFQ. ISNPEFAFLRFVVYEEDMFSDQNFLAQATFPVKGLKTGYRAVPLKNNYSEDLELA
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Template Sequence  YRTKLSPSTNSINPVWKEEPFVFEKILMPELASLRVAVMEEG. . . . NKFLGHRIIPINALNSGYHHLCLHSESNMPLTMP
Template Known Secondary structure 



SSS

SS
B







S
GGG
TT....TGGGB


TT

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   714.....720.........730.........740.........750..... ....760.........770.........780.........
 
   1204.....1210...
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Query Sequence  SLLIKIDIFP
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Template Sequence  ALFIFLEMKD
Template Known Secondary structure 
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   790.........
 
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Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
 
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Lawrence Kelley, Benjamin Jefferys 
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