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Job DescriptionB7YZT1
Confidence100.00%DateTue Jan 22 11:31:19 GMT 2013
Rank20Aligned Residues468
% Identity18%Templatec3cdzA_
PDB info PDB header:blood clottingChain: A: PDB Molecule:coagulation factor viii heavy chain; PDBTitle: crystal structure of human factor viii
Resolution3.98 Å

  Insertion relative to template
  Deletion relative to template
  Catalytic residue from the CSA
 
Detailed help on interpreting your alignment


   240.........250.........260.........270.........280 .........290... ......300....... ..310
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Query Sequence  NRMIPGPSIQVCENDKVVIDVENHMEGMEVTIHWHGIWQRG. . . . SQYYDGVPFVTQC. . PIQQGNTFRYQWTG. NAG. .
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Template Sequence  WMGLLGPTIQAEVYDTVVITLKNMAS. HPVSLHAVGVSYWKASEGAEYDDQTSQREKEDDKVFPGGSHTYVWQVLKENGP
Template Known Secondary structure  S

S
TT

B
SS.S



B
SSSB

TTS

B
S




TTS


TT





GGGS
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   68.70.........80.........90... ......100.........110.........120.........130.........140......
 
   311........320 .........330.........340.........350.........360.........370.........380
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Query Sequence  . . . . . . . . THFWHAHTGL. . QKLDGLYGSVVVRQPPSRDPNSHLYDFDLTTHIMLISDWLHEDAAERYPGRLAVNTGQDP
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Template Sequence  MASDPLCLTYSYLSHVDLVKDLNSGLIGALLVCREGSLAKEKTQTL. . . HKFILLFAVFDEGKS. . . . . . . WHSSARAWP
Template Known Secondary structure 
SSS
S

B
BSS

SS
STTTSSS


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   147..150.........160.........170.........180.........190.. .......200....... ..210......
 
   381........390.........400.........410.........420.........430.........440.. .......450........
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Query Sequence  ESMLINGKGQFRDPNTGFMTNTPLEIFTITPGRRYRFRMINAFASVCPAQVTIEGHGMTVIA. . TDGEPVHPVDVNTIIS
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Template Sequence  KMHTVNGY. . . . . . . . . . . VNRSLPGLIGCHRKSVYWHVIGMGTTPEVHSIFLEGHTFLVRNHRQASLEISPITFLTAQT
Template Known Secondary structure 



GGG
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TT







SSS




SS







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SSS


SS



SS


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   230....... ..240.........250.........260.........270.........280.........290........
 
   459460.........470. ........480... ......490...
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Query Sequence  FSGERYDFVISAD. . . . . . . . . . . . . . . . . . . . . . . . QPVGAYWIQLRG. . . . . . . . . . . . . . . . . . . . . LGECGIRRAQ
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Template Conservation                                                                                  
Template Sequence  LLMDLGQFLLFCHISSHQHDGMEAYVKVDSCPEEPKHPKTWVHYIAAEEEDWDYAPLVLAPDDRSYKSQYLNNGPQRIGR
Template Known Secondary structure 


SS








TT










SS







SS
S



SSSSTTTT
S
SSS

SS
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   299300.........310.........320.........330.........340.........350.........360.........370........
 
   494.....500.........510.........520... ......530.........540.........550.
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Query Sequence  QLAILRYARGPYQPASSPPTYDVGIPQGVI. . . . . . . . . . . . . . . . . . . . . . LNPLDAICDRKRADAVCVSNLKNAKKVD
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Template Conservation             
                 
      
        
                                  
Template Sequence  KYKKVRFMAYTDETFKTREAIQHESGILGPLLYGEVGDTLLIIFKNQASRPYNIYPHGITDVRPLYSRRLPKGVKHLKDF
Template Known Secondary structure 

SSSSTTSB



TTTTT



TT
SSS



S
SSS
S

STT
SSSSSS
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   422.......430.........440.........450.........460.........470.........480.........490.........500.
 
   552.......560.........570.........580.........590.........600.........610.........620.........630.
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Query Sequence  KGVLVERPDVKIFLPFRFFVYEPKALFIPNTYNRFLVVPSGDHLTSLVDEISYISPPAPPLSQIDDIPPEYFCNGDNRPP
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Template Sequence  PILPGEIFKYKWTVTVEDGPTKSDPRCLTRYYSSFVNMERDLASGLIGPLLICYKESVDQRGNQIMSDKRNVILFSVFDE
Template Known Secondary structure 


SS


GGGS

SSS
S

SSSTTT



SSSSSS
SS




G
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   502.......510.........520.........530.........540.........550.........560.........570.........580.
 
   632.... ...640.........650.........660.........670.......
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Query Sequence  NCGPN. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . CECTHMVDIPLGAIVEVVLVDEVQQVNLSHPFHLHGTAFYV
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Template Sequence  NRSWYLTENIQRFLPNPAGVQLEDPEFQASNIMHSINGYVFDSLQLSVCLHEVAYWYILSIGAQT. DFLSVFFSGYTFKH
Template Known Secondary structure  GG
TTTTTSS

TT


S
TSTTB
TT
S

B

TT
S

S.S


SS

B
S
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   582.......590.........600.........610.........620.........630.........640...... ...650.........660
 
   678.680.........690.........700.........710.........720.........730.........740.........750.......
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Query Sequence  VGLGRSPDKSIKKINLKHALELDQMGMLERHFSKPPLKDTIAVPNNGYVVIRFRADNPGYWLFHCHFLFHIVIGMNLIFH
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Template Sequence  K. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . MVYEDTLTLFPFSGETVFMSMENPGLWILGCHNSDFRNRGMTALLK
Template Known Secondary structure  T.................................TS
BS

SS




S
B


BS
TTTTTSB



BB
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   661 ........670.........680.........690.........700.......
 
   758.760...
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Query Sequence  IGTTAD
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Template Conservation 
   
 
Template Sequence  VSSCDK
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   708.710...
 
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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
 
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Lawrence Kelley, Benjamin Jefferys 
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