Email l.a.kelley@imperial.ac.uk Description Q7KV33 Date Tue Jan 22 11:34:33 GMT 2013 Unique Job ID d95adb05d880fe9d

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 c2eo6A_ 99.9 31 PDB header:signaling protein Chain: A: PDB Molecule:b-cell linker protein; PDBTitle: solution structure of the sh2 domain from mouse b-cell2 linker protein blnk 2 c2hdxB_ 99.8 27 PDB header:signaling protein Chain: B: PDB Molecule:sh2-b ph domain containing signaling mediator 1 PDBTitle: crystal structure of the src homology-2 domain of sh2-b in2 complex with jak2 ptyr813 phosphopeptide 3 c2eo3A_ 99.8 27 PDB header:signaling protein Chain: A: PDB Molecule:crk-like protein; PDBTitle: solution structure of the sh2 domain from human crk-like2 protein 4 c3hizB_ 99.8 29 PDB header:transferase/oncoprotein Chain: B: PDB Molecule:phosphatidylinositol 3-kinase regulatory subunit PDBTitle: crystal structure of p110alpha h1047r mutant in complex with2 nish2 of p85alpha 5 d1mila_ 99.8 33 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 6 d2shpa2 99.8 27 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 7 d1fhsa_ 99.8 29 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 8 c2gsbA_ 99.8 30 PDB header:signaling protein Chain: A: PDB Molecule:ras gtpase-activating protein 1; PDBTitle: solution structure of the second sh2 domain of human ras2 gtpase-activating protein 1 9 c2hmhA_ 99.8 24 PDB header:cytokine regulator Chain: A: PDB Molecule:suppressor of cytokine signaling 3; PDBTitle: crystal structure of socs3 in complex with gp130(ptyr757)2 phosphopeptide. 10 c2eobA_ 99.8 28 PDB header:hydrolase Chain: A: PDB Molecule:1-phosphatidylinositol-4,5-bisphosphate PDBTitle: solution structure of the second sh2 domain from rat plc2 gamma-2 11 c3gqiB_ 99.8 28 PDB header:transferase/transferase inhibitor Chain: B: PDB Molecule:phospholipase c-gamma-1; PDBTitle: crystal structure of activated receptor tyrosine kinase in complex2 with substrates 12 c2kk6A_ 99.8 33 PDB header:transferase Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase fer; PDBTitle: solution structure of sh2 domain of proto-oncogene tyrosine-2 protein kinase fer from homo sapiens, northeast structural3 genomics consortium (nesg) target hr3461d 13 d1pica_ 99.8 26 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 14 d1qada_ 99.8 27 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 15 c2vifA_ 99.8 35 PDB header:signaling protein Chain: A: PDB Molecule:suppressor of cytokine signalling 6; PDBTitle: crystal structure of socs6 sh2 domain in complex with a c-kit2 phosphopeptide 16 c2crhA_ 99.8 26 PDB header:signaling protein Chain: A: PDB Molecule:vav proto-oncogene; PDBTitle: solution structure of the sh2 domain of human proto-2 oncogene protein vav1 17 d3c7ia1 99.8 28 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 18 d1a81e2 99.8 27 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 19 c2dlzA_ 99.8 17 PDB header:signaling protein Chain: A: PDB Molecule:protein vav-2; PDBTitle: solution structure of the sh2 domain of human protein vav-2 20 c2lqnA_ 99.8 25 PDB header:signaling protein Chain: A: PDB Molecule:crk-like protein; PDBTitle: solution structure of crkl 21 c1x6cA_ not modelled 99.8 26 PDB header:signaling protein Chain: A: PDB Molecule:tyrosine-protein phosphatase, non-receptor type PDBTitle: solution structures of the sh2 domain of human protein-2 tyrosine phosphatase shp-1 22 c2c9wA_ not modelled 99.8 27 PDB header:transcription regulation Chain: A: PDB Molecule:suppressor of cytokine signaling 2; PDBTitle: crystal structure of socs-2 in complex with elongin-b and2 elongin-c at 1.9a resolution 23 d1r1qa_ not modelled 99.8 23 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 24 d1ayaa_ not modelled 99.7 27 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 25 d1luia_ not modelled 99.7 27 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 26 c2ci8A_ not modelled 99.7 36 PDB header:translation Chain: A: PDB Molecule:cytoplasmic protein nck1; PDBTitle: sh2 domain of human nck1 adaptor protein - uncomplexed 27 d2shpa3 not modelled 99.7 29 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 28 c2dcrA_ not modelled 99.7 34 PDB header:transferase Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase fes/fps; PDBTitle: fully automated solution structure determination of the fes2 sh2 domain 29 d2oq1a1 not modelled 99.7 27 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 30 d1k9aa2 not modelled 99.7 30 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 31 c2dlyA_ not modelled 99.7 33 PDB header:transferase Chain: A: PDB Molecule:fyn-related kinase; PDBTitle: solution structure of the sh2 domain of murine fyn-related2 kinase 32 c2izvA_ not modelled 99.7 19 PDB header:transcription Chain: A: PDB Molecule:suppressor of cytokine signaling 4; PDBTitle: crystal structure of socs-4 in complex with elongin-b and2 elongin-c at 2.55a resolution 33 c2lctA_ not modelled 99.7 26 PDB header:signaling protein Chain: A: PDB Molecule:proto-oncogene vav; PDBTitle: solution structure of the vav1 sh2 domain complexed with a syk-derived2 doubly phosphorylated peptide 34 d1fu6a_ not modelled 99.7 27 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 35 d1csya_ not modelled 99.7 27 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 36 c2fo0A_ not modelled 99.7 33 PDB header:transferase Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase abl1 (1b isoform); PDBTitle: organization of the sh3-sh2 unit in active and inactive forms of the2 c-abl tyrosine kinase 37 d1jwoa_ not modelled 99.7 26 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 38 c1k9aB_ not modelled 99.7 27 PDB header:transferase Chain: B: PDB Molecule:carboxyl-terminal src kinase; PDBTitle: crystal structure analysis of full-length carboxyl-terminal2 src kinase at 2.5 a resolution 39 d1lkka_ not modelled 99.7 30 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 40 d2eyva1 not modelled 99.7 33 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 41 c1ka6A_ not modelled 99.7 27 PDB header:immune system Chain: A: PDB Molecule:sh2 domain protein 1a; PDBTitle: sap/sh2d1a bound to peptide n-py 42 c2knoA_ not modelled 99.7 29 PDB header:hydrolase Chain: A: PDB Molecule:tensin-like c1 domain-containing phosphatase; PDBTitle: nmr solution structure of sh2 domain of the human tensin like c12 domain containing phosphatase (tenc1) 43 c2y3aB_ not modelled 99.7 27 PDB header:transferase Chain: B: PDB Molecule:phosphatidylinositol 3-kinase regulatory subunit beta; PDBTitle: crystal structure of p110beta in complex with icsh2 of p85beta and2 the drug gdc-0941 44 d1a81a1 not modelled 99.7 22 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 45 d1opka2 not modelled 99.7 32 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 46 d2izva2 not modelled 99.7 19 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 47 d1a81e1 not modelled 99.7 22 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 48 d2oq1a2 not modelled 99.7 32 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 49 c2oq1A_ not modelled 99.7 28 PDB header:transferase Chain: A: PDB Molecule:tyrosine-protein kinase zap-70; PDBTitle: tandem sh2 domains of zap-70 with 19-mer zeta1 peptide 50 d1a81a2 not modelled 99.7 26 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 51 c2shpA_ not modelled 99.7 26 PDB header:tyrosine phosphatase Chain: A: PDB Molecule:shp-2; PDBTitle: tyrosine phosphatase shp-2 52 c2el8A_ not modelled 99.7 16 PDB header:signaling protein Chain: A: PDB Molecule:signal-transducing adaptor protein 2; PDBTitle: solution structure of the human stap2 sh2 domain 53 c2ekxA_ not modelled 99.7 31 PDB header:signaling protein Chain: A: PDB Molecule:cytoplasmic tyrosine-protein kinase bmx; PDBTitle: solution structure of the human bmx sh2 domain 54 d1d4ta_ not modelled 99.7 27 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 55 d1blja_ not modelled 99.7 30 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 56 d1rjaa_ not modelled 99.7 29 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 57 d2cs0a1 not modelled 99.7 26 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 58 d2c9wa2 not modelled 99.7 28 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 59 d1nrva_ not modelled 99.7 23 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 60 d1g83a2 not modelled 99.7 29 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 61 c2ysxA_ not modelled 99.7 34 PDB header:signaling protein Chain: A: PDB Molecule:signaling inositol polyphosphate phosphatase PDBTitle: solution structure of the human ship sh2 domain 62 c2ablA_ not modelled 99.7 32 PDB header:transferase Chain: A: PDB Molecule:abl tyrosine kinase; PDBTitle: sh3-sh2 domain fragment of human bcr-abl tyrosine kinase 63 d2fcia1 not modelled 99.7 28 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 64 c2ge9A_ not modelled 99.7 32 PDB header:transferase Chain: A: PDB Molecule:tyrosine-protein kinase btk; PDBTitle: solution structures of the sh2 domain of bruton's tyrosine2 kinase 65 d1f2fa_ not modelled 99.7 27 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 66 d1i3za_ not modelled 99.7 26 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 67 d1qcfa2 not modelled 99.7 30 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 68 d1jyra_ not modelled 99.7 30 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 69 c2augB_ not modelled 99.7 25 PDB header:signaling protein Chain: B: PDB Molecule:growth factor receptor-bound protein 14; PDBTitle: crystal structure of the grb14 sh2 domain 70 d1bkla_ not modelled 99.7 27 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 71 d1xa6a2 not modelled 99.7 19 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 72 c1x27F_ not modelled 99.7 29 PDB header:signaling protein Chain: F: PDB Molecule:proto-oncogene tyrosine-protein kinase lck; PDBTitle: crystal structure of lck sh2-sh3 with sh2 binding site of2 p130cas 73 c3mazA_ not modelled 99.7 19 PDB header:signaling protein Chain: A: PDB Molecule:signal-transducing adaptor protein 1; PDBTitle: crystal structure of the human brdg1/stap-1 sh2 domain in complex with2 the ntal ptyr136 peptide 74 c1y57A_ not modelled 99.7 28 PDB header:transferase Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase src; PDBTitle: structure of unphosphorylated c-src in complex with an inhibitor 75 d1o48a_ not modelled 99.7 29 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 76 c2h8hA_ not modelled 99.7 28 PDB header:transferase Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase src; PDBTitle: src kinase in complex with a quinazoline inhibitor 77 c1oplA_ not modelled 99.6 33 PDB header:transferase Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase; PDBTitle: structural basis for the auto-inhibition of c-abl tyrosine2 kinase 78 d1rpya_ not modelled 99.6 26 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 79 c2b3oA_ not modelled 99.6 25 PDB header:hydrolase Chain: A: PDB Molecule:tyrosine-protein phosphatase, non-receptor type PDBTitle: crystal structure of human tyrosine phosphatase shp-1 80 c1rqqC_ not modelled 99.6 29 PDB header:transferase/signaling protein Chain: C: PDB Molecule:adaptor protein aps; PDBTitle: crystal structure of the insulin receptor kinase in complex2 with the sh2 domain of aps 81 c3nhnA_ not modelled 99.6 30 PDB header:transferase Chain: A: PDB Molecule:tyrosine-protein kinase hck; PDBTitle: crystal structure of the src-family kinase hck sh3-sh2-linker2 regulatory region 82 d1cwea_ not modelled 99.6 31 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 83 d2qmsa1 not modelled 99.6 27 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 84 c2ozoA_ not modelled 99.6 29 PDB header:transferase Chain: A: PDB Molecule:tyrosine-protein kinase zap-70; PDBTitle: autoinhibited intact human zap-70 85 c1a81E_ not modelled 99.6 21 PDB header:complex (transferase/peptide) Chain: E: PDB Molecule:syk kinase; PDBTitle: crystal structure of the tandem sh2 domain of the syk kinase bound to2 a dually tyrosine-phosphorylated itam 86 c3gxxB_ not modelled 99.6 21 PDB header:transcription Chain: B: PDB Molecule:transcription elongation factor spt6; PDBTitle: structure of the sh2 domain of the candida glabrata2 transcription elongation factor spt6, crystal form b 87 c2dm0A_ not modelled 99.6 33 PDB header:transferase Chain: A: PDB Molecule:tyrosine-protein kinase txk; PDBTitle: solution structure of the sh2 domain of human tyrosine-2 protein kinase txk 88 c2eyyA_ not modelled 99.6 27 PDB header:signaling protein Chain: A: PDB Molecule:v-crk sarcoma virus ct10 oncogene homolog PDBTitle: ct10-regulated kinase isoform i 89 c4fl2A_ not modelled 99.6 24 PDB header:transferase Chain: A: PDB Molecule:tyrosine-protein kinase syk; PDBTitle: structural and biophysical characterization of the syk activation2 switch 90 c2c0iA_ not modelled 99.6 30 PDB header:transferase Chain: A: PDB Molecule:tyrosine-protein kinase hck; PDBTitle: src family kinase hck with bound inhibitor a-420983 91 c2cr4A_ not modelled 99.6 17 PDB header:signaling protein Chain: A: PDB Molecule:sh3 domain-binding protein 2; PDBTitle: solution structure of the sh2 domain of human sh3bp2 protein 92 c2dvjA_ not modelled 99.6 30 PDB header:signaling protein Chain: A: PDB Molecule:v-crk sarcoma virus ct10 oncogene homolog, PDBTitle: phosphorylated crk-ii 93 c2eyzA_ not modelled 99.6 26 PDB header:signaling protein Chain: A: PDB Molecule:v-crk sarcoma virus ct10 oncogene homolog PDBTitle: ct10-regulated kinase isoform ii 94 c3ps5A_ not modelled 99.6 28 PDB header:hydrolase, signaling protein Chain: A: PDB Molecule:tyrosine-protein phosphatase non-receptor type 6; PDBTitle: crystal structure of the full-length human protein tyrosine2 phosphatase shp-1 95 c1g83A_ not modelled 99.6 32 PDB header:transferase Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase fyn; PDBTitle: crystal structure of fyn sh3-sh2 96 c3qwxX_ not modelled 99.5 29 PDB header:signaling protein Chain: X: PDB Molecule:cell death abnormality protein 2; PDBTitle: ced-2 1-174 97 c3qwyA_ not modelled 99.5 29 PDB header:signaling protein Chain: A: PDB Molecule:cell death abnormality protein 2; PDBTitle: ced-2 98 d1uura3 not modelled 99.4 21 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 99 c3or8A_ not modelled 99.4 23 PDB header:transcription Chain: A: PDB Molecule:transcription elongation factor spt6; PDBTitle: a tandem sh2 domain in transcription elongation factor spt6 100 c1xa6A_ not modelled 99.3 19 PDB header:signaling protein Chain: A: PDB Molecule:beta2-chimaerin; PDBTitle: crystal structure of the human beta2-chimaerin 101 c2xp1A_ not modelled 99.3 28 PDB header:transcription Chain: A: PDB Molecule:spt6; PDBTitle: structure of the tandem sh2 domains from antonospora locustae2 transcription elongation factor spt6 102 c2dx0B_ not modelled 99.3 33 PDB header:hydrolase Chain: B: PDB Molecule:phospholipase c, gamma 2; PDBTitle: crystal structure of the n-terminal sh2 domain of mouse2 phospholipase c-gamma 2 103 d1bf5a3 not modelled 99.2 21 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 104 d1bg1a3 not modelled 99.1 19 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 105 c3cblA_ not modelled 98.8 40 PDB header:transferase Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase fes/fps; PDBTitle: crystal structure of human feline sarcoma viral oncogene homologue (v-2 fes) in complex with staurosporine and a consensus peptide 106 c1yvlB_ not modelled 97.5 29 PDB header:signaling protein Chain: B: PDB Molecule:signal transducer and activator of transcription PDBTitle: structure of unphosphorylated stat1 107 c1bf5A_ not modelled 97.3 28 PDB header:gene regulation/dna Chain: A: PDB Molecule:signal transducer and activator of transcription PDBTitle: tyrosine phosphorylated stat-1/dna complex 108 c1uusA_ not modelled 97.3 24 PDB header:signal transduction Chain: A: PDB Molecule:stat protein; PDBTitle: structure of an activated dictyostelium stat in its2 dna-unbound form 109 c2cblA_ not modelled 96.8 22 PDB header:complex (proto-oncogene/peptide) Chain: A: PDB Molecule:proto-oncogene cbl; PDBTitle: n-terminal domain of cbl in complex with its binding site2 on zap-70 110 c3bunB_ not modelled 96.7 22 PDB header:ligase/signaling protein Chain: B: PDB Molecule:e3 ubiquitin-protein ligase cbl; PDBTitle: crystal structure of c-cbl-tkb domain complexed with its2 binding motif in sprouty4 111 c1y1uA_ not modelled 96.3 23 PDB header:signaling protein Chain: A: PDB Molecule:signal transducer and activator of transcription 5a; PDBTitle: structure of unphosphorylated stat5a 112 c1bg1A_ not modelled 95.9 26 PDB header:transcription/dna Chain: A: PDB Molecule:protein (transcription factor stat3b); PDBTitle: transcription factor stat3b/dna complex 113 c2vpdA_ 95.4 28 PDB header:gene regulation Chain: A: PDB Molecule:pygopus homolog 1; PDBTitle: decoding of methylated histone h3 tail by the pygo-bcl9 wnt2 signaling complex 114 c3lqiA_ 94.7 24 PDB header:transferase Chain: A: PDB Molecule:mll1 phd3-bromo; PDBTitle: crystal structure of mll1 phd3-bromo complexed with h3(1-9)k4me22 peptide 115 c2kyuA_ 94.7 20 PDB header:transferase Chain: A: PDB Molecule:histone-lysine n-methyltransferase mll; PDBTitle: the solution structure of the phd3 finger of mll 116 c2xb1A_ 94.2 28 PDB header:transcription Chain: A: PDB Molecule:pygopus homolog 2, b-cell cll/lymphoma 9-like protein; PDBTitle: crystal structure of the human pygo2 phd finger in complex with the2 b9l hd1 domain 117 c3cwgA_ not modelled 93.0 30 PDB header:transcription Chain: A: PDB Molecule:signal transducer and activator of transcription PDBTitle: unphosphorylated mouse stat3 core fragment 118 d1wepa_ not modelled 92.1 31 Fold:FYVE/PHD zinc finger Superfamily:FYVE/PHD zinc finger Family:PHD domain 119 d1weva_ not modelled 89.5 26 Fold:FYVE/PHD zinc finger Superfamily:FYVE/PHD zinc finger Family:PHD domain 120 c2f6nA_ not modelled 88.0 22 PDB header:transcription Chain: A: PDB Molecule:bromodomain phd finger transcription factor; PDBTitle: crystal structure of phd finger-linker-bromodomain fragment2 of human bptf in the free form