Email l.a.kelley@imperial.ac.uk Description P29349 Date Tue Jan 22 11:46:53 GMT 2013 Unique Job ID ce9635f9a3e2e77d

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 c3ps5A_ 100.0 55 PDB header:hydrolase, signaling protein Chain: A: PDB Molecule:tyrosine-protein phosphatase non-receptor type 6; PDBTitle: crystal structure of the full-length human protein tyrosine2 phosphatase shp-1 2 c2b3oA_ 100.0 55 PDB header:hydrolase Chain: A: PDB Molecule:tyrosine-protein phosphatase, non-receptor type PDBTitle: crystal structure of human tyrosine phosphatase shp-1 3 c2shpA_ 100.0 75 PDB header:tyrosine phosphatase Chain: A: PDB Molecule:shp-2; PDBTitle: tyrosine phosphatase shp-2 4 c3sr9A_ 100.0 29 PDB header:hydrolase Chain: A: PDB Molecule:receptor-type tyrosine-protein phosphatase s; PDBTitle: crystal structure of mouse ptpsigma 5 c1yguA_ 100.0 26 PDB header:hydrolase Chain: A: PDB Molecule:leukocyte common antigen; PDBTitle: crystal structure of the tandem phosphatase domains of rptp2 cd45 with a ptyr peptide 6 c1larB_ 100.0 30 PDB header:hydrolase Chain: B: PDB Molecule:protein (lar); PDBTitle: crystal structure of the tandem phosphatase domains of rptp2 lar 7 c2jjdA_ 100.0 29 PDB header:hydrolase Chain: A: PDB Molecule:receptor-type tyrosine-protein phosphatase epsilon; PDBTitle: protein tyrosine phosphatase, receptor type, e isoform 8 c2nlkA_ 100.0 25 PDB header:hydrolase Chain: A: PDB Molecule:protein tyrosine phosphatase, receptor type, g variant PDBTitle: crystal structure of d1 and d2 catalytic domains of human protein2 tyrosine phosphatase gamma (d1+d2 ptprg) 9 d1wcha_ 100.0 38 Fold:(Phosphotyrosine protein) phosphatases II Superfamily:(Phosphotyrosine protein) phosphatases II Family:Higher-molecular-weight phosphotyrosine protein phosphatases 10 d1jlna_ 100.0 35 Fold:(Phosphotyrosine protein) phosphatases II Superfamily:(Phosphotyrosine protein) phosphatases II Family:Higher-molecular-weight phosphotyrosine protein phosphatases 11 c3s3fA_ 100.0 38 PDB header:hydrolase/hydrolase inhibitor Chain: A: PDB Molecule:tyrosine-protein phosphatase 10d; PDBTitle: crystal structure of the catalytic domain of ptp10d from drosophila2 melanogaster with a small molecule inhibitor vanadate 12 c2nz6A_ 100.0 40 PDB header:hydrolase Chain: A: PDB Molecule:receptor-type tyrosine-protein phosphatase eta; PDBTitle: crystal structure of the ptprj inactivating mutant c1239s 13 c2pa5A_ 100.0 36 PDB header:hydrolase Chain: A: PDB Molecule:tyrosine-protein phosphatase non-receptor type 9; PDBTitle: crystal structure of human protein tyrosine phosphatase ptpn9 14 d2shpa1 100.0 75 Fold:(Phosphotyrosine protein) phosphatases II Superfamily:(Phosphotyrosine protein) phosphatases II Family:Higher-molecular-weight phosphotyrosine protein phosphatases 15 d1fpra_ 100.0 55 Fold:(Phosphotyrosine protein) phosphatases II Superfamily:(Phosphotyrosine protein) phosphatases II Family:Higher-molecular-weight phosphotyrosine protein phosphatases 16 d1lara1 100.0 36 Fold:(Phosphotyrosine protein) phosphatases II Superfamily:(Phosphotyrosine protein) phosphatases II Family:Higher-molecular-weight phosphotyrosine protein phosphatases 17 d2f71a1 100.0 35 Fold:(Phosphotyrosine protein) phosphatases II Superfamily:(Phosphotyrosine protein) phosphatases II Family:Higher-molecular-weight phosphotyrosine protein phosphatases 18 c2bzlA_ 100.0 32 PDB header:hydrolase Chain: A: PDB Molecule:tyrosine-protein phosphatase, non-receptor type PDBTitle: crystal structure of the human protein tyrosine phosphatase2 n14 at 1.65 a resolution 19 c2vexA_ 100.0 36 PDB header:hydrolase Chain: A: PDB Molecule:tyrosine-protein phosphatase non-receptor type 1; PDBTitle: crystal strucutre of protein tyrosine phosphatase 1b in2 complex with an isothiazolidinone-containing inhibitor 20 c3i36A_ 100.0 40 PDB header:hydrolase Chain: A: PDB Molecule:vascular protein tyrosine phosphatase 1; PDBTitle: crystal structure of rat protein tyrosine phosphatase eta catalytic2 domain 21 c2oc3A_ not modelled 100.0 35 PDB header:hydrolase Chain: A: PDB Molecule:tyrosine-protein phosphatase non-receptor type PDBTitle: crystal structure of the catalytic domain of human protein2 tyrosine phosphatase non-receptor type 18 22 c2c7sA_ not modelled 100.0 40 PDB header:hydrolase Chain: A: PDB Molecule:receptor-type tyrosine-protein phosphatase kappa; PDBTitle: crystal structure of human protein tyrosine phosphatase2 kappa at 1.95a resolution 23 c2qdmA_ not modelled 100.0 38 PDB header:hydrolase Chain: A: PDB Molecule:tyrosine-protein phosphatase non-receptor type 7; PDBTitle: crystal structure of the heptp catalytic domain c270s/d236a/q314a2 mutant 24 c2qcjB_ not modelled 100.0 41 PDB header:hydrolase Chain: B: PDB Molecule:tyrosine-protein phosphatase non-receptor type PDBTitle: native structure of lyp 25 d1rpma_ not modelled 100.0 42 Fold:(Phosphotyrosine protein) phosphatases II Superfamily:(Phosphotyrosine protein) phosphatases II Family:Higher-molecular-weight phosphotyrosine protein phosphatases 26 d1larb1 not modelled 100.0 41 Fold:(Phosphotyrosine protein) phosphatases II Superfamily:(Phosphotyrosine protein) phosphatases II Family:Higher-molecular-weight phosphotyrosine protein phosphatases 27 d1yfoa_ not modelled 100.0 42 Fold:(Phosphotyrosine protein) phosphatases II Superfamily:(Phosphotyrosine protein) phosphatases II Family:Higher-molecular-weight phosphotyrosine protein phosphatases 28 c2bijA_ not modelled 100.0 40 PDB header:hydrolase Chain: A: PDB Molecule:tyrosine-protein phosphatase, non-receptor type 5; PDBTitle: crystal structure of the human protein tyrosine phosphatase2 ptpn5 (step, striatum enriched enriched phosphatase) 29 c3jrlA_ not modelled 100.0 61 PDB header:hydrolase Chain: A: PDB Molecule:oncogenic tyrosine phosphatase shp2; PDBTitle: crystal structure of the oncogenic tyrosine phosphatase shp2 complexed2 with a salicylic acid-based small molecule inhibitor 30 c2hy3A_ not modelled 100.0 42 PDB header:hydrolase Chain: A: PDB Molecule:receptor-type tyrosine-protein phosphatase gamma; PDBTitle: crystal structure of the human tyrosine receptor phosphate gamma in2 complex with vanadate 31 d1l8ka_ not modelled 100.0 38 Fold:(Phosphotyrosine protein) phosphatases II Superfamily:(Phosphotyrosine protein) phosphatases II Family:Higher-molecular-weight phosphotyrosine protein phosphatases 32 c1l8kA_ not modelled 100.0 38 PDB header:hydrolase Chain: A: PDB Molecule:t-cell protein-tyrosine phosphatase; PDBTitle: t cell protein-tyrosine phosphatase structure 33 c2h04A_ not modelled 100.0 43 PDB header:hydrolase Chain: A: PDB Molecule:protein tyrosine phosphatase, receptor type, b,; PDBTitle: structural studies of protein tyrosine phosphatase beta2 catalytic domain in complex with inhibitors 34 c2b49A_ not modelled 100.0 40 PDB header:hydrolase Chain: A: PDB Molecule:protein tyrosine phosphatase, non-receptor type 3; PDBTitle: crystal structure of the catalytic domain of protein tyrosine2 phosphatase, non-receptor type 3 35 c2qepA_ not modelled 100.0 39 PDB header:hydrolase Chain: A: PDB Molecule:receptor-type tyrosine-protein phosphatase n2; PDBTitle: crystal structure of the d1 domain of ptprn2 (ia2beta) 36 c2i75A_ not modelled 100.0 39 PDB header:hydrolase Chain: A: PDB Molecule:tyrosine-protein phosphatase non-receptor type 4; PDBTitle: crystal structure of human protein tyrosine phosphatase n4 (ptpn4) 37 c2g59B_ not modelled 100.0 39 PDB header:hydrolase Chain: B: PDB Molecule:receptor-type tyrosine-protein phosphatase o; PDBTitle: crystal structure of the catalytic domain of protein2 tyrosine phosphatase from homo sapiens 38 c3m4uB_ not modelled 100.0 31 PDB header:hydrolase Chain: B: PDB Molecule:tyrosine specific protein phosphatase, putative; PDBTitle: crystal structure of trypanosoma brucei protein tyrosine phosphatase2 tbptp1 39 d1lara2 not modelled 100.0 42 Fold:(Phosphotyrosine protein) phosphatases II Superfamily:(Phosphotyrosine protein) phosphatases II Family:Higher-molecular-weight phosphotyrosine protein phosphatases 40 c1g4wR_ not modelled 100.0 18 PDB header:signaling protein Chain: R: PDB Molecule:protein tyrosine phosphatase sptp; PDBTitle: crystal structure of the salmonella tyrosine phosphatase2 and gtpase activating protein sptp 41 c4az1B_ not modelled 100.0 31 PDB header:hydrolase Chain: B: PDB Molecule:tyrosine specific protein phosphatase; PDBTitle: crystal structure of the trypanosoma cruzi protein tyrosine2 phosphatase tcptp1, a potential therapeutic target for chagas'3 disease 42 d1p15a_ not modelled 100.0 40 Fold:(Phosphotyrosine protein) phosphatases II Superfamily:(Phosphotyrosine protein) phosphatases II Family:Higher-molecular-weight phosphotyrosine protein phosphatases 43 d1lyva_ not modelled 100.0 21 Fold:(Phosphotyrosine protein) phosphatases II Superfamily:(Phosphotyrosine protein) phosphatases II Family:Higher-molecular-weight phosphotyrosine protein phosphatases 44 d1g4us2 not modelled 100.0 22 Fold:(Phosphotyrosine protein) phosphatases II Superfamily:(Phosphotyrosine protein) phosphatases II Family:Higher-molecular-weight phosphotyrosine protein phosphatases 45 c3gqiB_ not modelled 100.0 31 PDB header:transferase/transferase inhibitor Chain: B: PDB Molecule:phospholipase c-gamma-1; PDBTitle: crystal structure of activated receptor tyrosine kinase in complex2 with substrates 46 c2oq1A_ not modelled 100.0 29 PDB header:transferase Chain: A: PDB Molecule:tyrosine-protein kinase zap-70; PDBTitle: tandem sh2 domains of zap-70 with 19-mer zeta1 peptide 47 c4fl2A_ not modelled 100.0 33 PDB header:transferase Chain: A: PDB Molecule:tyrosine-protein kinase syk; PDBTitle: structural and biophysical characterization of the syk activation2 switch 48 c2ozoA_ not modelled 100.0 30 PDB header:transferase Chain: A: PDB Molecule:tyrosine-protein kinase zap-70; PDBTitle: autoinhibited intact human zap-70 49 c1a81E_ not modelled 100.0 29 PDB header:complex (transferase/peptide) Chain: E: PDB Molecule:syk kinase; PDBTitle: crystal structure of the tandem sh2 domain of the syk kinase bound to2 a dually tyrosine-phosphorylated itam 50 c3or8A_ not modelled 100.0 20 PDB header:transcription Chain: A: PDB Molecule:transcription elongation factor spt6; PDBTitle: a tandem sh2 domain in transcription elongation factor spt6 51 c2xp1A_ not modelled 100.0 19 PDB header:transcription Chain: A: PDB Molecule:spt6; PDBTitle: structure of the tandem sh2 domains from antonospora locustae2 transcription elongation factor spt6 52 d1rxda_ not modelled 99.9 25 Fold:(Phosphotyrosine protein) phosphatases II Superfamily:(Phosphotyrosine protein) phosphatases II Family:Dual specificity phosphatase-like 53 d1v3aa_ not modelled 99.9 19 Fold:(Phosphotyrosine protein) phosphatases II Superfamily:(Phosphotyrosine protein) phosphatases II Family:Dual specificity phosphatase-like 54 d2shpa2 not modelled 99.9 69 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 55 c1x6cA_ not modelled 99.9 45 PDB header:signaling protein Chain: A: PDB Molecule:tyrosine-protein phosphatase, non-receptor type PDBTitle: solution structures of the sh2 domain of human protein-2 tyrosine phosphatase shp-1 56 c3rz2B_ not modelled 99.9 23 PDB header:hydrolase Chain: B: PDB Molecule:protein tyrosine phosphatase type iva 1; PDBTitle: crystal of prl-1 complexed with peptide 57 c3hizB_ not modelled 99.9 25 PDB header:transferase/oncoprotein Chain: B: PDB Molecule:phosphatidylinositol 3-kinase regulatory subunit PDBTitle: crystal structure of p110alpha h1047r mutant in complex with2 nish2 of p85alpha 58 d2oq1a1 not modelled 99.9 24 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 59 c2y3aB_ not modelled 99.9 27 PDB header:transferase Chain: B: PDB Molecule:phosphatidylinositol 3-kinase regulatory subunit beta; PDBTitle: crystal structure of p110beta in complex with icsh2 of p85beta and2 the drug gdc-0941 60 d3c7ia1 not modelled 99.9 26 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 61 c2eobA_ not modelled 99.9 24 PDB header:hydrolase Chain: A: PDB Molecule:1-phosphatidylinositol-4,5-bisphosphate PDBTitle: solution structure of the second sh2 domain from rat plc2 gamma-2 62 d2shpa3 not modelled 99.9 77 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 63 c2ci8A_ not modelled 99.9 33 PDB header:translation Chain: A: PDB Molecule:cytoplasmic protein nck1; PDBTitle: sh2 domain of human nck1 adaptor protein - uncomplexed 64 c2hdxB_ not modelled 99.9 20 PDB header:signaling protein Chain: B: PDB Molecule:sh2-b ph domain containing signaling mediator 1 PDBTitle: crystal structure of the src homology-2 domain of sh2-b in2 complex with jak2 ptyr813 phosphopeptide 65 d1ayaa_ not modelled 99.9 50 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 66 c2lqnA_ not modelled 99.9 19 PDB header:signaling protein Chain: A: PDB Molecule:crk-like protein; PDBTitle: solution structure of crkl 67 c2fo0A_ not modelled 99.9 25 PDB header:transferase Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase abl1 (1b isoform); PDBTitle: organization of the sh3-sh2 unit in active and inactive forms of the2 c-abl tyrosine kinase 68 d1a81a1 not modelled 99.9 29 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 69 c2eo6A_ not modelled 99.9 25 PDB header:signaling protein Chain: A: PDB Molecule:b-cell linker protein; PDBTitle: solution structure of the sh2 domain from mouse b-cell2 linker protein blnk 70 c2gsbA_ not modelled 99.9 27 PDB header:signaling protein Chain: A: PDB Molecule:ras gtpase-activating protein 1; PDBTitle: solution structure of the second sh2 domain of human ras2 gtpase-activating protein 1 71 d2oq1a2 not modelled 99.9 29 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 72 c2dlzA_ not modelled 99.9 24 PDB header:signaling protein Chain: A: PDB Molecule:protein vav-2; PDBTitle: solution structure of the sh2 domain of human protein vav-2 73 d1fhsa_ not modelled 99.9 31 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 74 d1a81e1 not modelled 99.9 27 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 75 d1nrva_ not modelled 99.9 33 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 76 c2crhA_ not modelled 99.9 24 PDB header:signaling protein Chain: A: PDB Molecule:vav proto-oncogene; PDBTitle: solution structure of the sh2 domain of human proto-2 oncogene protein vav1 77 c2dlyA_ not modelled 99.9 31 PDB header:transferase Chain: A: PDB Molecule:fyn-related kinase; PDBTitle: solution structure of the sh2 domain of murine fyn-related2 kinase 78 d1rjaa_ not modelled 99.8 36 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 79 d1pica_ not modelled 99.8 26 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 80 c3s4oB_ not modelled 99.8 18 PDB header:structural genomics, unknown function Chain: B: PDB Molecule:protein tyrosine phosphatase-like protein; PDBTitle: protein tyrosine phosphatase (putative) from leishmania major 81 c2lctA_ not modelled 99.8 26 PDB header:signaling protein Chain: A: PDB Molecule:proto-oncogene vav; PDBTitle: solution structure of the vav1 sh2 domain complexed with a syk-derived2 doubly phosphorylated peptide 82 c2ysxA_ not modelled 99.8 35 PDB header:signaling protein Chain: A: PDB Molecule:signaling inositol polyphosphate phosphatase PDBTitle: solution structure of the human ship sh2 domain 83 d1a81a2 not modelled 99.8 28 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 84 d1qada_ not modelled 99.8 30 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 85 d1a81e2 not modelled 99.8 33 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 86 c1oplA_ not modelled 99.8 25 PDB header:transferase Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase; PDBTitle: structural basis for the auto-inhibition of c-abl tyrosine2 kinase 87 d1blja_ not modelled 99.8 37 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 88 d1jyra_ not modelled 99.8 30 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 89 c2ge9A_ not modelled 99.8 28 PDB header:transferase Chain: A: PDB Molecule:tyrosine-protein kinase btk; PDBTitle: solution structures of the sh2 domain of bruton's tyrosine2 kinase 90 d1lkka_ not modelled 99.8 36 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 91 c1y57A_ not modelled 99.8 26 PDB header:transferase Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase src; PDBTitle: structure of unphosphorylated c-src in complex with an inhibitor 92 c1k9aB_ not modelled 99.8 27 PDB header:transferase Chain: B: PDB Molecule:carboxyl-terminal src kinase; PDBTitle: crystal structure analysis of full-length carboxyl-terminal2 src kinase at 2.5 a resolution 93 d2izva2 not modelled 99.8 22 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 94 d1d4ta_ not modelled 99.8 27 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 95 c2ablA_ not modelled 99.8 32 PDB header:transferase Chain: A: PDB Molecule:abl tyrosine kinase; PDBTitle: sh3-sh2 domain fragment of human bcr-abl tyrosine kinase 96 d1qcfa2 not modelled 99.8 34 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 97 d1bkla_ not modelled 99.8 30 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 98 d1opka2 not modelled 99.8 31 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 99 c1ka6A_ not modelled 99.8 25 PDB header:immune system Chain: A: PDB Molecule:sh2 domain protein 1a; PDBTitle: sap/sh2d1a bound to peptide n-py 100 d1o48a_ not modelled 99.8 30 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 101 c2eo3A_ not modelled 99.8 31 PDB header:signaling protein Chain: A: PDB Molecule:crk-like protein; PDBTitle: solution structure of the sh2 domain from human crk-like2 protein 102 d1jwoa_ not modelled 99.8 31 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 103 c2kk6A_ not modelled 99.8 27 PDB header:transferase Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase fer; PDBTitle: solution structure of sh2 domain of proto-oncogene tyrosine-2 protein kinase fer from homo sapiens, northeast structural3 genomics consortium (nesg) target hr3461d 104 d1csya_ not modelled 99.8 27 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 105 d2qmsa1 not modelled 99.8 32 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 106 d1g83a2 not modelled 99.8 32 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 107 c2el8A_ not modelled 99.8 18 PDB header:signaling protein Chain: A: PDB Molecule:signal-transducing adaptor protein 2; PDBTitle: solution structure of the human stap2 sh2 domain 108 c2vifA_ not modelled 99.8 27 PDB header:signaling protein Chain: A: PDB Molecule:suppressor of cytokine signalling 6; PDBTitle: crystal structure of socs6 sh2 domain in complex with a c-kit2 phosphopeptide 109 d1f2fa_ not modelled 99.8 29 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 110 d1r1qa_ not modelled 99.8 37 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 111 c2h8hA_ not modelled 99.8 26 PDB header:transferase Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase src; PDBTitle: src kinase in complex with a quinazoline inhibitor 112 d1i3za_ not modelled 99.8 34 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 113 c2augB_ not modelled 99.8 33 PDB header:signaling protein Chain: B: PDB Molecule:growth factor receptor-bound protein 14; PDBTitle: crystal structure of the grb14 sh2 domain 114 d1luia_ not modelled 99.8 34 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 115 d1ohea2 not modelled 99.8 26 Fold:(Phosphotyrosine protein) phosphatases II Superfamily:(Phosphotyrosine protein) phosphatases II Family:Dual specificity phosphatase-like 116 c3nhnA_ not modelled 99.8 35 PDB header:transferase Chain: A: PDB Molecule:tyrosine-protein kinase hck; PDBTitle: crystal structure of the src-family kinase hck sh3-sh2-linker2 regulatory region 117 c1x27F_ not modelled 99.8 36 PDB header:signaling protein Chain: F: PDB Molecule:proto-oncogene tyrosine-protein kinase lck; PDBTitle: crystal structure of lck sh2-sh3 with sh2 binding site of2 p130cas 118 d1xa6a2 not modelled 99.8 32 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 119 d1k9aa2 not modelled 99.8 29 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 120 c2dcrA_ not modelled 99.8 26 PDB header:transferase Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase fes/fps; PDBTitle: fully automated solution structure determination of the fes2 sh2 domain