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Job DescriptionP29349
Confidence100.00%DateTue Jan 22 11:46:53 GMT 2013
Rank1Aligned Residues499
% Identity55%Templatec3ps5A_
PDB info PDB header:hydrolase, signaling proteinChain: A: PDB Molecule:tyrosine-protein phosphatase non-receptor type 6; PDBTitle: crystal structure of the full-length human protein tyrosine2 phosphatase shp-1
Resolution3.10 Å

  Insertion relative to template
  Deletion relative to template
  Catalytic residue from the CSA
 
Detailed help on interpreting your alignment


   5....10.........20.........30.........40.........50.........60.........70.........80....
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Query Sequence  RWFHPTISGIEAEKLLQEQGFDGSFLARLSSSNPGAFTLSVRRGNEVTHIKIQNNGDFFDLYGGEKFATLPELVQYYMEN
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Template Sequence  RWFHRDLSGLDAETLLKGRGVHGSFLARPSRKNQGDFSLSVRVGDQVTHIRIQNSGDFYDLYGGEKFATLTELVEYYTQQ
Template Known Secondary structure  S


SS



TT

SSSTTSTT
SS
SSSS

BSSTT
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   3......10.........20.........30.........40.........50.........60.........70.........80..
 
   85. ...90.........100.........110.........120.........130.........140.........150....
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Query Sequence  GE. LKEKNGQAIELKQPLICAEPTTERWFHGNLSGKEAEKLILERGKNGSFLVRESQSKPGDFVLSVRTDD. . . . . . . . .
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Template Sequence  QGVLQDRDGTIIHLKYPLNCSDPTSERWYHGHMSGGQAETLLQAKGEPWTFLVRESLSQPGDFVLSVLSDQPKAGPGSPL
Template Known Secondary structure  SS

B
SS

B




B




S

STTS



TT
SSSTT
SSSTTS
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   83......90.........100.........110.........120.........130.........140.........150.........160..
 
   155....160.........170.........180.........190.........200.........210.........220... ..
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Query Sequence  KVTHVMIRWQDKKYDVGGGESFGTLSELIDHYKRNPMVETCGTVVHLRQPFNATRITAAGINARVEQLV. . . . . . . . . KG
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Template Conservation   
 
  
        
     
 

  

  
   
 
   
 
  

     
 
           
            
Template Sequence  RVTHIKVMCEGGRYTVGGLETFDSLTDLVEHFKKTGIEEASGAFVYLRQPYYATRVNAADIENRVLELNKKQESEDTAKA
Template Known Secondary structure  B
GGG
BBSSSS

BSSS
B

TTS

B







GGG



SSS



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   163......170.........180.........190.........200.........210.........220.........230.........240..
 
   226...230..... ....240.........250.........260.........270.........280.........290... ......
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Query Sequence  GFWEEFESLQ. QDSRDTFSRNEGYKQENRLKNRYRNILPYDHTRVKLLDVEHSVAGAEYINANYIRLPT. . . . . DGDLYN
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Template Sequence  GFWEEFESLQKQEVKNLHQRLEGQRPENKGKNRYKNILPFDHSRVILQGRDSNIPGSDYINANYIK. . NQLLGPDENAKT
Template Known Secondary structure  GGGGG




TGGG
GGGGGG
S
SS



TTT

S

SSSTTTT..
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TT



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   243......250.........260.........270.........280.........290.........300........ .310.........320
 
   300.........310.........320.........330.........340.........350.........360.........370.........
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Query Sequence  MSSSSESLNSSVPSCPACTAAQTQRNCSNCQLQNKTCVQCAVKSAILPYSNCATCSRKSDSLSKHKRSESSASSSPSSGS
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Template Sequence  YIASQGCL. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
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   321.......
 
   380.........390.........400.........410.........420.........430.........440.........450.........
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Query Sequence  GSGPGSSGTSGVSSVNGPGTPTNLTSGTAGCLVGLLKRHSNDSSGAVSISMAEREREREREMFKTYIATQGCLLTQQVNT
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Template Sequence  . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . EAT
Template Known Secondary structure  .............................................................................TTT
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   329330.
 
   460.........470.........480.........490.........500.........510.........520....... ..530.......
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Query Sequence  VTDFWNMVWQENTRVIVMTTKEYERGKEKCARYWPDEGRSEQFGHARIQCVSENSTSDYTLREFLVSW. . RDQPARRIFH
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Template Sequence  VNDFWQMAWQENSRVIVMTTREVEKGRNKCVPYWPEVGMQRAYGPYSVTNCGEHDTTEYKLRTLQVSPLDNGDLIREIWH
Template Known Secondary structure  TT


S
SBSSSSBS



S

BT
TT
SSSS

S

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   332.......340.........350.........360.........370.........380.........390.........400.........410.
 
   538.540.........550.........560.........570.........580.........590.........600.........610.......
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Query Sequence  YHFQVWPDHGVPADPGCVLNFLQDVNTRQSHLAQAGEKPGPICVHCSAGIGRTGTFIVIDMILDQIVRNGLDTEIDIQRT
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Template Sequence  YQYLSWPDHGVPSEPGGVLSFLDQINQRQESLPHA. . . . GPIIVHSSAGIGRTGTIIVIDMLMENISTKGLDCDIDIQKT
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SSSS
S
S
TT
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SSSS
SS

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   412.......420.........430.........440...... ...450.........460.........470.........480.......
 
   618.620.........630.........640.........650........
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Query Sequence  IQMVRSQRSGLVQTEAQYKFVYYAVQHYIQTLIARKRAEEQ
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Template Sequence  IQMVRAQRSGMVQTEAQYKFIYVAIAQFIETTKKKLEVLQS
Template Known Secondary structure  TTSTTSS
STTTTTTS
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   488.490.........500.........510.........520........
 
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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
 
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Lawrence Kelley, Benjamin Jefferys 
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