Job Description P29349 Confidence 100.00% Date Tue Jan 22 11:46:53 GMT 2013 Rank 29 Aligned Residues 250 % Identity 61% Template c3jrlA_ PDB info PDB header:hydrolase Chain: A: PDB Molecule:oncogenic tyrosine phosphatase shp2; PDBTitle: crystal structure of the oncogenic tyrosine phosphatase shp2 complexed2 with a salicylic acid-based small molecule inhibitor Resolution 2.00 Å

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		242	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300	.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.
Predicted Secondary structure
Query SS confidence
Query Sequence		F	S	R	N	E	G	Y	K	Q	E	N	R	L	K	N	R	Y	R	N	I	L	P	Y	D	H	T	R	V	K	L	L	D	V	E	H	S	V	A	G	A	E	Y	I	N	A	N	Y	I	R	L	P	T	D	G	D	L	Y	N	M	S	S	S	S	E	S	L	N	S	S	V	P	S	C	P	A	C	T	A	A	Q
Query Conservation
Alig confidence																																																			.	.		.	.	.												.	.	.	.	.	.	.	.	.	.	.	.	.	.
Template Conservation																																																			.	.		.	.	.												.	.	.	.	.	.	.	.	.	.	.	.	.	.
Template Sequence		Y	S	R	K	E	G	Q	R	Q	E	N	K	N	K	N	R	Y	K	N	I	L	P	F	D	H	T	R	V	V	L	H	D	G	D	P	N	E	P	V	S	D	Y	I	N	A	N	I	I	M	.	.	P	.	.	.	K	K	S	Y	I	A	T	Q	G	C	L	.	.	.	.	.	.	.	.	.	.	.	.	.	.
Template Known Secondary structure						G	G	G	S	G	G	G	G	G	G		S	S	T	T					T	T	T	B					S			T	T	S	S			S			S						.	.		.	.	.												.	.	.	.	.	.	.	.	.	.	.	.	.	.
Template Predicted Secondary structure																																																			.	.		.	.	.												.	.	.	.	.	.	.	.	.	.	.	.	.	.
Template SS confidence
		263	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300	.	.	.	.	.	.	.	.	.	310	.			.				.	.	.	.	.	.	.	320	.	.	.
		322	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360	.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.
Predicted Secondary structure
Query SS confidence
Query Sequence		T	Q	R	N	C	S	N	C	Q	L	Q	N	K	T	C	V	Q	C	A	V	K	S	A	I	L	P	Y	S	N	C	A	T	C	S	R	K	S	D	S	L	S	K	H	K	R	S	E	S	S	A	S	S	S	P	S	S	G	S	G	S	G	P	G	S	S	G	T	S	G	V	S	S	V	N	G	P	G	T	P	T
Query Conservation
Template Conservation		.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.
Template Sequence		.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.
Template Known Secondary structure		.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.
Template Predicted Secondary structure		.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.
Template SS confidence
		402	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420	.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480	.
Predicted Secondary structure
Query SS confidence
Query Sequence		N	L	T	S	G	T	A	G	C	L	V	G	L	L	K	R	H	S	N	D	S	S	G	A	V	S	I	S	M	A	E	R	E	R	E	R	E	R	E	M	F	K	T	Y	I	A	T	Q	G	C	L	L	T	Q	Q	V	N	T	V	T	D	F	W	N	M	V	W	Q	E	N	T	R	V	I	V	M	T	T	K	E
Query Conservation
Alig confidence		.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.
Template Conservation		.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.
Template Sequence		.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	Q	N	T	V	N	D	F	W	R	M	V	F	Q	E	N	S	R	V	I	V	M	T	T	K	E
Template Known Secondary structure		.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	T	T	T											T	T								S		S
Template Predicted Secondary structure		.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.
Template SS confidence
																																																									335	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.
		482	.	.	.	.	.	.	.	490	.	.	.	.	.	.	.	.	.	500	.	.	.	.	.	.	.	.	.	510	.	.	.	.	.	.	.	.	.	520	.	.	.	.	.	.	.			.	.	530	.	.	.	.	.	.	.	.	.	540	.	.	.	.	.	.	.	.	.	550	.	.	.	.	.	.	.	.	.
Predicted Secondary structure																																																.	.
Query SS confidence																																																.	.
Query Sequence		Y	E	R	G	K	E	K	C	A	R	Y	W	P	D	E	G	R	S	E	Q	F	G	H	A	R	I	Q	C	V	S	E	N	S	T	S	D	Y	T	L	R	E	F	L	V	S	W	.	.	R	D	Q	P	A	R	R	I	F	H	Y	H	F	Q	V	W	P	D	H	G	V	P	A	D	P	G	C	V	L	N	F	L
Query Conservation																																																.	.
Alig confidence																																																.	.
Template Conservation
Template Sequence		V	E	R	G	K	S	K	C	V	K	Y	W	P	D	E	Y	A	L	K	E	Y	G	V	M	R	V	R	N	V	K	E	S	A	A	H	D	Y	T	L	R	E	L	K	L	S	K	V	G	Q	G	N	T	E	R	T	V	W	Q	Y	H	F	R	T	W	P	D	H	G	V	P	S	D	P	G	G	V	L	D	F	L
Template Known Secondary structure				T	T								S			T	T						T	T												S	S											T	T		S	S															S	S	S			S	S	T
Template Predicted Secondary structure
Template SS confidence
		360	.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420	.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.
		560	.	.	.	.	.	.	.	.	.	570	.	.	.	.	.	.	.	.	.	580	.	.	.	.	.	.	.	.	.	590	.	.	.	.	.	.	.	.	.	600	.	.	.	.	.	.	.	.	.	610	.	.	.	.	.	.	.	.	.	620	.	.	.	.	.	.	.	.	.	630	.	.	.	.	.	.	.	.	.
Predicted Secondary structure
Query SS confidence
Query Sequence		Q	D	V	N	T	R	Q	S	H	L	A	Q	A	G	E	K	P	G	P	I	C	V	H	C	S	A	G	I	G	R	T	G	T	F	I	V	I	D	M	I	L	D	Q	I	V	R	N	G	L	D	T	E	I	D	I	Q	R	T	I	Q	M	V	R	S	Q	R	S	G	L	V	Q	T	E	A	Q	Y	K	F	V	Y
Query Conservation
Alig confidence											.	.	.	.
Template Conservation											.	.	.	.
Template Sequence		E	E	V	H	H	K	Q	E	S	.	.	.	.	I	M	D	A	G	P	V	V	V	H	C	S	A	G	I	G	R	T	G	T	F	I	V	I	D	I	L	I	D	I	I	R	E	K	G	V	D	C	D	I	D	V	P	K	T	I	Q	M	V	R	S	Q	R	S	G	M	V	Q	T	E	A	Q	Y	R	F	I	Y
Template Known Secondary structure										T	.	.	.	.	S	T	T									S	S	S	S	S																				T	T	S													T	T	S	T	T		S		S
Template Predicted Secondary structure											.	.	.	.
Template SS confidence
		440	.	.	.	.	.	.	.	.					.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480	.	.	.	.	.	.	.	.	.	490	.	.	.	.	.	.	.	.	.	500	.	.	.	.	.	.	.	.	.	510	.	.	.	.	.
		640	.	.	.	.	.	.	.	.	.
Predicted Secondary structure
Query SS confidence
Query Sequence		Y	A	V	Q	H	Y	I	Q	T	L
Query Conservation
Alig confidence
Template Conservation
Template Sequence		M	A	V	Q	H	Y	I	E	T	L
Template Known Secondary structure
Template Predicted Secondary structure
Template SS confidence
		516	.	.	.	520	.	.	.	.	.

No model constructed - rank, confidence too low

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Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
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