Email l.a.kelley@imperial.ac.uk Description Q8IR23 Date Tue Jan 22 11:23:02 GMT 2013 Unique Job ID b35f2fb588505824

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 c3bxjB_ 100.0 24 PDB header:signaling protein Chain: B: PDB Molecule:ras gtpase-activating protein syngap; PDBTitle: crystal structure of the c2-gap fragment of syngap 2 d1wera_ 100.0 49 Fold:GTPase activation domain, GAP Superfamily:GTPase activation domain, GAP Family:p120GAP domain-like 3 c3fayA_ 100.0 17 PDB header:membrane protein Chain: A: PDB Molecule:ras gtpase-activating-like protein iqgap1; PDBTitle: crystal structure of the gap-related domain of iqgap1 4 d1nf1a_ 100.0 27 Fold:GTPase activation domain, GAP Superfamily:GTPase activation domain, GAP Family:p120GAP domain-like 5 c2b3oA_ 100.0 29 PDB header:hydrolase Chain: A: PDB Molecule:tyrosine-protein phosphatase, non-receptor type PDBTitle: crystal structure of human tyrosine phosphatase shp-1 6 c2shpA_ 100.0 32 PDB header:tyrosine phosphatase Chain: A: PDB Molecule:shp-2; PDBTitle: tyrosine phosphatase shp-2 7 c3ps5A_ 100.0 30 PDB header:hydrolase, signaling protein Chain: A: PDB Molecule:tyrosine-protein phosphatase non-receptor type 6; PDBTitle: crystal structure of the full-length human protein tyrosine2 phosphatase shp-1 8 c2oq1A_ 100.0 23 PDB header:transferase Chain: A: PDB Molecule:tyrosine-protein kinase zap-70; PDBTitle: tandem sh2 domains of zap-70 with 19-mer zeta1 peptide 9 c4fl2A_ 100.0 24 PDB header:transferase Chain: A: PDB Molecule:tyrosine-protein kinase syk; PDBTitle: structural and biophysical characterization of the syk activation2 switch 10 c2ozoA_ 100.0 24 PDB header:transferase Chain: A: PDB Molecule:tyrosine-protein kinase zap-70; PDBTitle: autoinhibited intact human zap-70 11 c3gqiB_ 100.0 31 PDB header:transferase/transferase inhibitor Chain: B: PDB Molecule:phospholipase c-gamma-1; PDBTitle: crystal structure of activated receptor tyrosine kinase in complex2 with substrates 12 c1a81E_ 100.0 26 PDB header:complex (transferase/peptide) Chain: E: PDB Molecule:syk kinase; PDBTitle: crystal structure of the tandem sh2 domain of the syk kinase bound to2 a dually tyrosine-phosphorylated itam 13 c2xp1A_ 99.9 16 PDB header:transcription Chain: A: PDB Molecule:spt6; PDBTitle: structure of the tandem sh2 domains from antonospora locustae2 transcription elongation factor spt6 14 c3or8A_ 99.9 18 PDB header:transcription Chain: A: PDB Molecule:transcription elongation factor spt6; PDBTitle: a tandem sh2 domain in transcription elongation factor spt6 15 c3hizB_ 99.9 23 PDB header:transferase/oncoprotein Chain: B: PDB Molecule:phosphatidylinositol 3-kinase regulatory subunit PDBTitle: crystal structure of p110alpha h1047r mutant in complex with2 nish2 of p85alpha 16 c2fo0A_ 99.9 23 PDB header:transferase Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase abl1 (1b isoform); PDBTitle: organization of the sh3-sh2 unit in active and inactive forms of the2 c-abl tyrosine kinase 17 c2ablA_ 99.9 25 PDB header:transferase Chain: A: PDB Molecule:abl tyrosine kinase; PDBTitle: sh3-sh2 domain fragment of human bcr-abl tyrosine kinase 18 c1k9aB_ 99.9 24 PDB header:transferase Chain: B: PDB Molecule:carboxyl-terminal src kinase; PDBTitle: crystal structure analysis of full-length carboxyl-terminal2 src kinase at 2.5 a resolution 19 c2lqnA_ 99.9 17 PDB header:signaling protein Chain: A: PDB Molecule:crk-like protein; PDBTitle: solution structure of crkl 20 c2gsbA_ 99.9 48 PDB header:signaling protein Chain: A: PDB Molecule:ras gtpase-activating protein 1; PDBTitle: solution structure of the second sh2 domain of human ras2 gtpase-activating protein 1 21 c1oplA_ not modelled 99.9 23 PDB header:transferase Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase; PDBTitle: structural basis for the auto-inhibition of c-abl tyrosine2 kinase 22 d2oq1a1 not modelled 99.9 26 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 23 c2eobA_ not modelled 99.9 25 PDB header:hydrolase Chain: A: PDB Molecule:1-phosphatidylinositol-4,5-bisphosphate PDBTitle: solution structure of the second sh2 domain from rat plc2 gamma-2 24 c1x27F_ not modelled 99.9 25 PDB header:signaling protein Chain: F: PDB Molecule:proto-oncogene tyrosine-protein kinase lck; PDBTitle: crystal structure of lck sh2-sh3 with sh2 binding site of2 p130cas 25 d2oq1a2 not modelled 99.9 22 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 26 c2y3aB_ not modelled 99.9 21 PDB header:transferase Chain: B: PDB Molecule:phosphatidylinositol 3-kinase regulatory subunit beta; PDBTitle: crystal structure of p110beta in complex with icsh2 of p85beta and2 the drug gdc-0941 27 c3nhnA_ not modelled 99.9 30 PDB header:transferase Chain: A: PDB Molecule:tyrosine-protein kinase hck; PDBTitle: crystal structure of the src-family kinase hck sh3-sh2-linker2 regulatory region 28 d1a81a1 not modelled 99.9 31 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 29 c2hdxB_ not modelled 99.9 24 PDB header:signaling protein Chain: B: PDB Molecule:sh2-b ph domain containing signaling mediator 1 PDBTitle: crystal structure of the src homology-2 domain of sh2-b in2 complex with jak2 ptyr813 phosphopeptide 30 c1y57A_ not modelled 99.9 26 PDB header:transferase Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase src; PDBTitle: structure of unphosphorylated c-src in complex with an inhibitor 31 d1a81e2 not modelled 99.9 25 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 32 c2h8hA_ not modelled 99.9 27 PDB header:transferase Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase src; PDBTitle: src kinase in complex with a quinazoline inhibitor 33 c2eo3A_ not modelled 99.9 26 PDB header:signaling protein Chain: A: PDB Molecule:crk-like protein; PDBTitle: solution structure of the sh2 domain from human crk-like2 protein 34 d2fcia1 not modelled 99.9 27 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 35 d1nrva_ not modelled 99.9 23 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 36 d1pica_ not modelled 99.9 22 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 37 c2c0iA_ not modelled 99.9 28 PDB header:transferase Chain: A: PDB Molecule:tyrosine-protein kinase hck; PDBTitle: src family kinase hck with bound inhibitor a-420983 38 c2eo6A_ not modelled 99.9 22 PDB header:signaling protein Chain: A: PDB Molecule:b-cell linker protein; PDBTitle: solution structure of the sh2 domain from mouse b-cell2 linker protein blnk 39 d1a81a2 not modelled 99.9 25 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 40 c2ysxA_ 99.9 32 PDB header:signaling protein Chain: A: PDB Molecule:signaling inositol polyphosphate phosphatase PDBTitle: solution structure of the human ship sh2 domain 41 d1a81e1 not modelled 99.9 30 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 42 d2shpa2 not modelled 99.8 29 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 43 d1fhsa_ not modelled 99.8 25 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 44 c2dlyA_ not modelled 99.8 25 PDB header:transferase Chain: A: PDB Molecule:fyn-related kinase; PDBTitle: solution structure of the sh2 domain of murine fyn-related2 kinase 45 c1g83A_ not modelled 99.8 29 PDB header:transferase Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase fyn; PDBTitle: crystal structure of fyn sh3-sh2 46 d1jwoa_ not modelled 99.8 28 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 47 d1csya_ not modelled 99.8 25 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 48 c2ci8A_ not modelled 99.8 30 PDB header:translation Chain: A: PDB Molecule:cytoplasmic protein nck1; PDBTitle: sh2 domain of human nck1 adaptor protein - uncomplexed 49 d3c7ia1 not modelled 99.8 26 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 50 c2crhA_ not modelled 99.8 16 PDB header:signaling protein Chain: A: PDB Molecule:vav proto-oncogene; PDBTitle: solution structure of the sh2 domain of human proto-2 oncogene protein vav1 51 c2dlzA_ not modelled 99.8 18 PDB header:signaling protein Chain: A: PDB Molecule:protein vav-2; PDBTitle: solution structure of the sh2 domain of human protein vav-2 52 d1opka2 not modelled 99.8 31 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 53 c1ka6A_ not modelled 99.8 23 PDB header:immune system Chain: A: PDB Molecule:sh2 domain protein 1a; PDBTitle: sap/sh2d1a bound to peptide n-py 54 d1k9aa2 not modelled 99.8 29 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 55 d1rjaa_ not modelled 99.8 28 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 56 c1x6cA_ not modelled 99.8 28 PDB header:signaling protein Chain: A: PDB Molecule:tyrosine-protein phosphatase, non-receptor type PDBTitle: solution structures of the sh2 domain of human protein-2 tyrosine phosphatase shp-1 57 d2izva2 not modelled 99.8 25 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 58 c2augB_ not modelled 99.8 25 PDB header:signaling protein Chain: B: PDB Molecule:growth factor receptor-bound protein 14; PDBTitle: crystal structure of the grb14 sh2 domain 59 c2lctA_ not modelled 99.8 17 PDB header:signaling protein Chain: A: PDB Molecule:proto-oncogene vav; PDBTitle: solution structure of the vav1 sh2 domain complexed with a syk-derived2 doubly phosphorylated peptide 60 d1qada_ not modelled 99.8 23 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 61 d2eyva1 not modelled 99.8 34 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 62 d1lkka_ not modelled 99.8 26 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 63 d1o48a_ not modelled 99.8 25 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 64 d1i3za_ not modelled 99.8 27 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 65 d1d4ta_ not modelled 99.8 25 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 66 c2ge9A_ not modelled 99.8 29 PDB header:transferase Chain: A: PDB Molecule:tyrosine-protein kinase btk; PDBTitle: solution structures of the sh2 domain of bruton's tyrosine2 kinase 67 d1ayaa_ not modelled 99.8 30 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 68 d1blja_ not modelled 99.8 28 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 69 c2dvjA_ not modelled 99.8 21 PDB header:signaling protein Chain: A: PDB Molecule:v-crk sarcoma virus ct10 oncogene homolog, PDBTitle: phosphorylated crk-ii 70 d2qmsa1 not modelled 99.8 20 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 71 d1bkla_ not modelled 99.8 34 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 72 c2kk6A_ not modelled 99.8 28 PDB header:transferase Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase fer; PDBTitle: solution structure of sh2 domain of proto-oncogene tyrosine-2 protein kinase fer from homo sapiens, northeast structural3 genomics consortium (nesg) target hr3461d 73 c2eyyA_ not modelled 99.8 26 PDB header:signaling protein Chain: A: PDB Molecule:v-crk sarcoma virus ct10 oncogene homolog PDBTitle: ct10-regulated kinase isoform i 74 d1mila_ not modelled 99.8 24 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 75 d1qcfa2 not modelled 99.8 27 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 76 d1luia_ not modelled 99.8 21 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 77 d1r1qa_ not modelled 99.8 26 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 78 c2hmhA_ not modelled 99.8 20 PDB header:cytokine regulator Chain: A: PDB Molecule:suppressor of cytokine signaling 3; PDBTitle: crystal structure of socs3 in complex with gp130(ptyr757)2 phosphopeptide. 79 d2shpa3 not modelled 99.8 37 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 80 c2knoA_ not modelled 99.8 29 PDB header:hydrolase Chain: A: PDB Molecule:tensin-like c1 domain-containing phosphatase; PDBTitle: nmr solution structure of sh2 domain of the human tensin like c12 domain containing phosphatase (tenc1) 81 c2c9wA_ not modelled 99.8 22 PDB header:transcription regulation Chain: A: PDB Molecule:suppressor of cytokine signaling 2; PDBTitle: crystal structure of socs-2 in complex with elongin-b and2 elongin-c at 1.9a resolution 82 c2el8A_ not modelled 99.8 19 PDB header:signaling protein Chain: A: PDB Molecule:signal-transducing adaptor protein 2; PDBTitle: solution structure of the human stap2 sh2 domain 83 c2dcrA_ not modelled 99.8 24 PDB header:transferase Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase fes/fps; PDBTitle: fully automated solution structure determination of the fes2 sh2 domain 84 c2eyzA_ not modelled 99.8 19 PDB header:signaling protein Chain: A: PDB Molecule:v-crk sarcoma virus ct10 oncogene homolog PDBTitle: ct10-regulated kinase isoform ii 85 d1f2fa_ not modelled 99.8 34 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 86 d1jyra_ not modelled 99.8 26 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 87 d1g83a2 not modelled 99.8 25 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 88 c2vifA_ not modelled 99.8 24 PDB header:signaling protein Chain: A: PDB Molecule:suppressor of cytokine signalling 6; PDBTitle: crystal structure of socs6 sh2 domain in complex with a c-kit2 phosphopeptide 89 d2cs0a1 not modelled 99.8 33 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 90 c2izvA_ not modelled 99.8 22 PDB header:transcription Chain: A: PDB Molecule:suppressor of cytokine signaling 4; PDBTitle: crystal structure of socs-4 in complex with elongin-b and2 elongin-c at 2.55a resolution 91 d1xa6a2 not modelled 99.8 25 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 92 d1fu6a_ not modelled 99.8 25 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 93 c2ekxA_ not modelled 99.8 24 PDB header:signaling protein Chain: A: PDB Molecule:cytoplasmic tyrosine-protein kinase bmx; PDBTitle: solution structure of the human bmx sh2 domain 94 d1rpya_ not modelled 99.8 19 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 95 c3mazA_ not modelled 99.8 15 PDB header:signaling protein Chain: A: PDB Molecule:signal-transducing adaptor protein 1; PDBTitle: crystal structure of the human brdg1/stap-1 sh2 domain in complex with2 the ntal ptyr136 peptide 96 c3qwxX_ not modelled 99.8 18 PDB header:signaling protein Chain: X: PDB Molecule:cell death abnormality protein 2; PDBTitle: ced-2 1-174 97 d1cwea_ not modelled 99.8 32 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 98 c1rqqC_ not modelled 99.8 22 PDB header:transferase/signaling protein Chain: C: PDB Molecule:adaptor protein aps; PDBTitle: crystal structure of the insulin receptor kinase in complex2 with the sh2 domain of aps 99 c3qwyA_ not modelled 99.8 18 PDB header:signaling protein Chain: A: PDB Molecule:cell death abnormality protein 2; PDBTitle: ced-2 100 c2dm0A_ not modelled 99.7 25 PDB header:transferase Chain: A: PDB Molecule:tyrosine-protein kinase txk; PDBTitle: solution structure of the sh2 domain of human tyrosine-2 protein kinase txk 101 d2c9wa2 not modelled 99.7 23 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 102 c3gxxB_ not modelled 99.7 22 PDB header:transcription Chain: B: PDB Molecule:transcription elongation factor spt6; PDBTitle: structure of the sh2 domain of the candida glabrata2 transcription elongation factor spt6, crystal form b 103 c2cr4A_ not modelled 99.7 21 PDB header:signaling protein Chain: A: PDB Molecule:sh3 domain-binding protein 2; PDBTitle: solution structure of the sh2 domain of human sh3bp2 protein 104 d2cjta1 99.7 20 Fold:C2 domain-like Superfamily:C2 domain (Calcium/lipid-binding domain, CaLB) Family:PLC-like (P variant) 105 d1gmia_ 99.7 29 Fold:C2 domain-like Superfamily:C2 domain (Calcium/lipid-binding domain, CaLB) Family:PLC-like (P variant) 106 c2fk9A_ 99.6 31 PDB header:transferase Chain: A: PDB Molecule:protein kinase c, eta type; PDBTitle: human protein kinase c, eta 107 c3m7fB_ 99.6 22 PDB header:signaling protein/ligase Chain: B: PDB Molecule:e3 ubiquitin-protein ligase nedd4; PDBTitle: crystal structure of the nedd4 c2/grb10 sh2 complex 108 c3l9bA_ not modelled 99.6 13 PDB header:membrane protein Chain: A: PDB Molecule:otoferlin; PDBTitle: crystal structure of rat otoferlin c2a 109 c2dx0B_ not modelled 99.6 32 PDB header:hydrolase Chain: B: PDB Molecule:phospholipase c, gamma 2; PDBTitle: crystal structure of the n-terminal sh2 domain of mouse2 phospholipase c-gamma 2 110 c2r09A_ 99.6 23 PDB header:signaling protein Chain: A: PDB Molecule:cytohesin-3; PDBTitle: crystal structure of autoinhibited form of grp1 arf gtpase exchange2 factor 111 c2d9zA_ 99.6 20 PDB header:signaling protein Chain: A: PDB Molecule:protein kinase c, nu type; PDBTitle: solution structure of the ph domain of protein kinase c, nu2 type from human 112 d2dyna_ 99.5 16 Fold:PH domain-like barrel Superfamily:PH domain-like Family:Pleckstrin-homology domain (PH domain) 113 d2fjla1 99.5 17 Fold:PH domain-like barrel Superfamily:PH domain-like Family:Pleckstrin-homology domain (PH domain) 114 d2coaa1 99.5 22 Fold:PH domain-like barrel Superfamily:PH domain-like Family:Pleckstrin-homology domain (PH domain) 115 c1xa6A_ not modelled 99.5 31 PDB header:signaling protein Chain: A: PDB Molecule:beta2-chimaerin; PDBTitle: crystal structure of the human beta2-chimaerin 116 d2cjsa1 99.5 21 Fold:C2 domain-like Superfamily:C2 domain (Calcium/lipid-binding domain, CaLB) Family:PLC-like (P variant) 117 c3kwtA_ 99.5 21 PDB header:metal binding protein Chain: A: PDB Molecule:munc13-1; PDBTitle: munc13-1 c2b-domain, calcium-free 118 d1qasa2 not modelled 99.5 17 Fold:C2 domain-like Superfamily:C2 domain (Calcium/lipid-binding domain, CaLB) Family:PLC-like (P variant) 119 c2q3xA_ not modelled 99.5 25 PDB header:transport protein Chain: A: PDB Molecule:regulating synaptic membrane exocytosis protein 1; PDBTitle: the rim1alpha c2b domain 120 c2nsqA_ not modelled 99.5 26 PDB header:ligase Chain: A: PDB Molecule:e3 ubiquitin-protein ligase nedd4-like protein; PDBTitle: crystal structure of the c2 domain of the human e3 ubiquitin-protein2 ligase nedd4-like protein