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Job DescriptionQ24145
Confidence100.00%DateTue Jan 22 11:35:34 GMT 2013
Rank1Aligned Residues544
% Identity35%Templatec4fl2A_
PDB info PDB header:transferaseChain: A: PDB Molecule:tyrosine-protein kinase syk; PDBTitle: structural and biophysical characterization of the syk activation2 switch
Resolution2.19 Å

  Insertion relative to template
  Deletion relative to template
  Catalytic residue from the CSA
 
Detailed help on interpreting your alignment


   4.....10.........20........ .30.........40.........50.........60.........70.........80..
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Query Sequence  DSDPMKWYHGNLSREAADELLKQGY. EDGTFLVRESSTAAGDFVLSLLCQGEVCHYQVRRHGGEDAFFSIDDKVQTKILH
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Template Sequence  SANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAHHYTIEREL. . NGTYAIAGGRT. . . HA
Template Known Secondary structure 

TT
TTB
BS

TT

TT
TTSSS
TT
T..TS
TT


...BS
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   910.........20.........30.........40.........50.........60.........70 .........80. ..
 
   83......90.........100.........110.........120.........130.........140.........150.........160..
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Query Sequence  GLDTLVDYYQQAANGLPTKLTVPLIRDLPPHNTRSHGVTNLLHRATSKNESKVVFELLKCGYRNFDAKNQDGQTALHLAA
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Template Sequence  SPADLCHYHSQESDGLVCLLKKPFNRPQGV. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Template Known Secondary structure  STTT

SSSSS






TTB..................................................
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   84.....90.........100.........110...
 
   163......170.........180.........190.........200.........210.........220.........230.........240..
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Query Sequence  LHSDEDILKHLLNAKVQVNSSDSFGCQPLHYAARSKPASFIRTLISAQANVQGRNIDNGYVPLHEAAKHGNLEAVQELLL
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Template Conservation  .................................................................               
Template Sequence  . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . QPKTGPFEDLKENLI
Template Known Secondary structure  .................................................................

B
S
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   114.....120........
 
   243......250.........260.........270.........280.........290.........300.........310.........320..
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Query Sequence  AEAPPLPRTSSGEFPFDLAKEAGQTAVEEFLLNYKLPPANTTRDQWYHGTLTREEAVAILKKHAKELLAKQPEVDTSGCF
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Template Sequence  REYVKQTWNLQGQALEQAIISQKPQ. . . . . . LEKLIATTAHEKMPWFHGKISREESEQIVL. . . . . . . . . . IGSKTNGKF
Template Known Secondary structure 


......TTS
GGGSTTB

S

..........SSS

TT
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   129130.........140.........150... ......160.........170.........180... ......190..
 
   323......330.........340.........350.........360.........370.........380.........390.........400..
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Query Sequence  LVRYSESPAASGLVLTLLCDQVVKNFRISQADLYQNGNKVQSGGSKFLYIDDGPYWPSVEHLIAHFMRFSYGLPVSLKYP
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Template Sequence  LIRARDNNGS. . YALCLLHEGKVLHYRI. . . . . . . . . . . . DKDKTGKLSIPEGKKFDTLWQLVEHYSYKADGLLRVLTVP
Template Known Secondary structure  TTT..TT............
TTS
STT


BSSTTB
TTSSS


SB
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   193......200.. .......210........ .220.........230.........240.........250........
 
   403......410.........420.........430.........440.........450.........460.........470.........480..
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Query Sequence  VPPQPKPEVPSFATIPRSNMKPKAASPATPPTPVSPHSHHQHPHVPALTITKKKQKENSSSMFNTLRLTSPKKALFDMNS
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Template Conservation                               ...................................................
Template Sequence  CQKIGTQREALPMDTEVYESPYADPEEIR. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Template Known Secondary structure 


S


TT

GGGSGGGS
GGGSTTS

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   259260.........270.........280.......
 
   483......490.........500.........510.........520.........530.........540.........550.........560..
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Query Sequence  LRKNKSKGKRSDSESSVSGSLAGTEQELQAAAPMLKSLSFSTEFSTFNADGVTGSGAAAAGEVYNVPRNNTPIEIDLPPI
Query Conservation                 
 
 
   
       

       
   
            
                      
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Template Sequence  . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
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   563......570.........580.........590.........600.........610.........620.........630.........640..
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Query Sequence  AQKTEAEVEYFTKSDVAIERERAGQWIGNGYQPTMDVLSLLDQQIKAPAVARLNSLGPNASTESEMASYLHRKCSGTPST
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Template Conservation  ................................................................................
Template Sequence  . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
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   643......650.........660.........670.........680.........690.........700... ......710.........
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Query Sequence  PSATEVEAAKLRFFIEPEKLVLDREIGHGEFGSVHSGWLLRKSGAGEESRLEVAIKMLSDE. . . HSNKQEFLREASVMMR
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Template Sequence  . . . . . . . . PKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKK. . . . . VVKTVAVKILKNEANDPALKDELLAEANVMQQ
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SSSB

GGGTTTT.....
SGGG
GGG
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   360.........370.........380.........390.... .....400.........410.........420......
 
   720.........730.........740.........750.........760.........770.........780.........790.........
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Query Sequence  LEHKCIVRLIGIAKGEMLMMVQELAPLGSMLQYILDHGHEITANAELKVWASQIACGMHYLESQHFVHRDLAARNILLTA
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Template Sequence  LDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRH. . VKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVT
Template Known Secondary structure 


TTB

SSS

TT
B
TT..S
TT


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SGGG
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   427..430.........440.........450.........460..... ....470.........480.........490.........500....
 
   800.........810.........820.........830.........840.........850.........860.........870.........
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Query Sequence  RHQAKISDFGMSRSLRPGSTEYQFTQGGRWPIRWYAPESFNLGIFSHASDVWSFGVTIWEMFSLGAPPYGEISNVDAIKL
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Template Sequence  QHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAM
Template Known Secondary structure  TT

TTTT

S
BTTB
GGGG





TTT

SSTT

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   505....510.........520.........530.........540.........550.........560.........570.........580....
 
   880.........890.........900.........910.........920...
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Query Sequence  VDSGERLPQPNLCPAYIYAVMQSCWKERPKDRPTFVYLTEFFAR
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Template Sequence  LEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRLRN
Template Known Secondary structure  TT





TT

T
SSTTTS

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   585....590.........600.........610.........620........
 
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Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
 
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Lawrence Kelley, Benjamin Jefferys 
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