Job Description Q24145 Confidence 98.79% Date Tue Jan 22 11:35:34 GMT 2013 Rank 386 Aligned Residues 218 % Identity 36% Template c1a81E_ PDB info PDB header:complex (transferase/peptide) Chain: E: PDB Molecule:syk kinase; PDBTitle: crystal structure of the tandem sh2 domain of the syk kinase bound to2 a dually tyrosine-phosphorylated itam Resolution 3.00 Å

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		4	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.		.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60	.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.
Predicted Secondary structure																								.
Query SS confidence																								.
Query Sequence		D	S	D	P	M	K	W	Y	H	G	N	L	S	R	E	A	A	D	E	L	L	K	.	Q	G	Y	E	D	G	T	F	L	V	R	E	S	S	T	A	A	G	D	F	V	L	S	L	L	C	Q	G	E	V	C	H	Y	Q	V	R	R	H	G	G	E	D	A	F	F	S	I	D	D	K	V	Q	T	K	I	L	H
Query Conservation																								.
Alig confidence																								.																																														.	.	.	.	.
Template Conservation																																																																						.	.	.	.	.
Template Sequence		S	A	N	H	L	P	F	F	F	G	N	I	T	R	E	E	A	E	D	Y	L	V	Q	G	G	M	S	D	G	L	Y	L	L	R	Q	S	R	N	Y	L	G	G	F	A	L	S	V	A	H	G	R	K	A	H	H	Y	T	I	E	R	E	L	N	G	T	Y	A	I	.	.	.	.	.	A	G	G	R	T	H	A
Template Known Secondary structure			G	G	G		T	T			S	S												T	T	T			T	T								S	S	S	T	T									S	S	S										T	T	T					.	.	.	.	.	T	T	S			B	S
Template Predicted Secondary structure																																																																						.	.	.	.	.
Template SS confidence
		9	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60	.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.						.	.	.	80	.	.	.
		83	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120	.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.
Predicted Secondary structure
Query SS confidence
Query Sequence		G	L	D	T	L	V	D	Y	Y	Q	Q	A	A	N	G	L	P	T	K	L	T	V	P	L	I	R	D	L	P	P	H	N	T	R	S	H	G	V	T	N	L	L	H	R	A	T	S	K	N	E	S	K	V	V	F	E	L	L	K	C	G	Y	R	N	F	D	A	K	N	Q	D	G	Q	T	A	L	H	L	A	A
Query Conservation
Alig confidence																																							.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.
Template Conservation																																							.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.
Template Sequence		S	P	A	D	L	C	H	Y	H	S	Q	E	S	D	G	L	V	C	L	L	K	K	P	F	N	R	P	Q	G	V	Q	P	K	T	P	Q	L	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.
Template Known Secondary structure		S									T	T			T	T	S	S	S				S	B					T	T									.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.
Template Predicted Secondary structure																																							.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.
Template SS confidence
		84	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
		163	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180	.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240	.	.
Predicted Secondary structure
Query SS confidence
Query Sequence		L	H	S	D	E	D	I	L	K	H	L	L	N	A	K	V	Q	V	N	S	S	D	S	F	G	C	Q	P	L	H	Y	A	A	R	S	K	P	A	S	F	I	R	T	L	I	S	A	Q	A	N	V	Q	G	R	N	I	D	N	G	Y	V	P	L	H	E	A	A	K	H	G	N	L	E	A	V	Q	E	L	L	L
Query Conservation
Template Conservation		.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.
Template Sequence		.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.
Template Known Secondary structure		.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.
Template Predicted Secondary structure		.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.
Template SS confidence
		243	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300	.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.
Predicted Secondary structure
Query SS confidence
Query Sequence		A	E	A	P	P	L	P	R	T	S	S	G	E	F	P	F	D	L	A	K	E	A	G	Q	T	A	V	E	E	F	L	L	N	Y	K	L	P	P	A	N	T	T	R	D	Q	W	Y	H	G	T	L	T	R	E	E	A	V	A	I	L	K	K	H	A	K	E	L	L	A	K	Q	P	E	V	D	T	S	G	C	F
Query Conservation
Alig confidence		.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.																														.	.	.	.	.	.	.	.	.	.
Template Conservation		.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.																														.	.	.	.	.	.	.	.	.	.
Template Sequence		.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	E	K	L	I	A	T	T	A	H	E	K	M	P	W	F	H	G	K	I	S	R	E	E	S	E	Q	I	V	L	.	.	.	.	.	.	.	.	.	.	I	G	S	K	T	N	G	K	F
Template Known Secondary structure		.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.							T	S	G	G	G		T	T																.	.	.	.	.	.	.	.	.	.	S	S				T	T
Template Predicted Secondary structure		.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.																														.	.	.	.	.	.	.	.	.	.
Template SS confidence
																																		155	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180	.	.	.											.	.	.	.	.	.	190	.	.
		323	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360	.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.
Predicted Secondary structure
Query SS confidence
Query Sequence		L	V	R	Y	S	E	S	P	A	A	S	G	L	V	L	T	L	L	C	D	Q	V	V	K	N	F	R	I	S	Q	A	D	L	Y	Q	N	G	N	K	V	Q	S	G	G	S	K	F	L	Y	I	D	D	G	P	Y	W	P	S	V	E	H	L	I	A	H	F	M	R	F	S	Y	G	L	P	V	S	L	K	Y	P
Query Conservation
Alig confidence												.	.																	.	.	.	.	.	.	.	.	.	.	.	.
Template Conservation												.	.																	.	.	.	.	.	.	.	.	.	.	.	.
Template Sequence		L	I	R	A	R	D	N	N	G	S	.	.	Y	A	L	C	L	L	H	E	G	K	V	L	H	Y	R	I	.	.	.	.	.	.	.	.	.	.	.	.	D	K	D	K	T	G	K	L	S	I	P	E	G	K	K	F	D	T	L	W	Q	L	V	E	H	Y	S	Y	K	A	D	G	L	L	R	V	L	T	V	P
Template Known Secondary structure							S	S	S	S		.	.								T	T								.	.	.	.	.	.	.	.	.	.	.	.				T	T	S					T	T	S			B	S										T	T			T	T	S	S	S				S	B
Template Predicted Secondary structure												.	.																	.	.	.	.	.	.	.	.	.	.	.	.
Template SS confidence
		193	.	.	.	.	.	.	200	.	.			.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.													.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240	.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.
		403	.	.
Predicted Secondary structure
Query SS confidence
Query Sequence		V	P	P
Query Conservation
Alig confidence
Template Conservation
Template Sequence		C	Q	K
Template Known Secondary structure
Template Predicted Secondary structure
Template SS confidence
		259	260	.

No model constructed - rank, confidence too low

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Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
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