Email l.a.kelley@imperial.ac.uk Description Q9VXH3 Date Wed Feb 13 11:23:55 GMT 2013 Unique Job ID 2eb76761bdeaa822

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 c3ohmB_ 100.0 38 PDB header:signaling protein / hydrolase Chain: B: PDB Molecule:1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase PDBTitle: crystal structure of activated g alpha q bound to its effector2 phospholipase c beta 3 2 c3qr0A_ 100.0 35 PDB header:hydrolase Chain: A: PDB Molecule:phospholipase c-beta (plc-beta); PDBTitle: crystal structure of s. officinalis plc21 3 c2fjuB_ 100.0 36 PDB header:signaling protein,apoptosis/hydrolase Chain: B: PDB Molecule:1-phosphatidylinositol-4,5-bisphosphate PDBTitle: activated rac1 bound to its effector phospholipase c beta 2 4 c1djyB_ 100.0 45 PDB header:lipid degradation Chain: B: PDB Molecule:phosphoinositide-specific phospholipase c, PDBTitle: phosphoinositide-specific phospholipase c-delta1 from rat2 complexed with inositol-2,4,5-trisphosphate 5 d2zkmx4 100.0 59 Fold:TIM beta/alpha-barrel Superfamily:PLC-like phosphodiesterases Family:Mammalian PLC 6 d1qasa3 100.0 65 Fold:TIM beta/alpha-barrel Superfamily:PLC-like phosphodiesterases Family:Mammalian PLC 7 c2lqnA_ 100.0 19 PDB header:signaling protein Chain: A: PDB Molecule:crk-like protein; PDBTitle: solution structure of crkl 8 c2eyzA_ 100.0 18 PDB header:signaling protein Chain: A: PDB Molecule:v-crk sarcoma virus ct10 oncogene homolog PDBTitle: ct10-regulated kinase isoform ii 9 c3gqiB_ 100.0 48 PDB header:transferase/transferase inhibitor Chain: B: PDB Molecule:phospholipase c-gamma-1; PDBTitle: crystal structure of activated receptor tyrosine kinase in complex2 with substrates 10 d2zkmx2 100.0 26 Fold:C2 domain-like Superfamily:C2 domain (Calcium/lipid-binding domain, CaLB) Family:PLC-like (P variant) 11 c2shpA_ 100.0 31 PDB header:tyrosine phosphatase Chain: A: PDB Molecule:shp-2; PDBTitle: tyrosine phosphatase shp-2 12 c2b3oA_ 100.0 30 PDB header:hydrolase Chain: A: PDB Molecule:tyrosine-protein phosphatase, non-receptor type PDBTitle: crystal structure of human tyrosine phosphatase shp-1 13 c3ps5A_ 100.0 30 PDB header:hydrolase, signaling protein Chain: A: PDB Molecule:tyrosine-protein phosphatase non-receptor type 6; PDBTitle: crystal structure of the full-length human protein tyrosine2 phosphatase shp-1 14 d1qasa2 100.0 32 Fold:C2 domain-like Superfamily:C2 domain (Calcium/lipid-binding domain, CaLB) Family:PLC-like (P variant) 15 c2eyyA_ 99.9 28 PDB header:signaling protein Chain: A: PDB Molecule:v-crk sarcoma virus ct10 oncogene homolog PDBTitle: ct10-regulated kinase isoform i 16 c2oq1A_ 99.9 26 PDB header:transferase Chain: A: PDB Molecule:tyrosine-protein kinase zap-70; PDBTitle: tandem sh2 domains of zap-70 with 19-mer zeta1 peptide 17 c2dvjA_ 99.9 29 PDB header:signaling protein Chain: A: PDB Molecule:v-crk sarcoma virus ct10 oncogene homolog, PDBTitle: phosphorylated crk-ii 18 c4fl2A_ 99.9 25 PDB header:transferase Chain: A: PDB Molecule:tyrosine-protein kinase syk; PDBTitle: structural and biophysical characterization of the syk activation2 switch 19 c3qwyA_ 99.9 26 PDB header:signaling protein Chain: A: PDB Molecule:cell death abnormality protein 2; PDBTitle: ced-2 20 c2ozoA_ 99.9 25 PDB header:transferase Chain: A: PDB Molecule:tyrosine-protein kinase zap-70; PDBTitle: autoinhibited intact human zap-70 21 c3qwxX_ not modelled 99.9 26 PDB header:signaling protein Chain: X: PDB Molecule:cell death abnormality protein 2; PDBTitle: ced-2 1-174 22 d2zkmx3 not modelled 99.9 20 Fold:PH domain-like barrel Superfamily:PH domain-like Family:Pleckstrin-homology domain (PH domain) 23 c1a81E_ not modelled 99.9 25 PDB header:complex (transferase/peptide) Chain: E: PDB Molecule:syk kinase; PDBTitle: crystal structure of the tandem sh2 domain of the syk kinase bound to2 a dually tyrosine-phosphorylated itam 24 d1djxb1 not modelled 99.8 21 Fold:EF Hand-like Superfamily:EF-hand Family:EF-hand modules in multidomain proteins 25 d2zkmx1 not modelled 99.8 16 Fold:EF Hand-like Superfamily:EF-hand Family:EF-hand modules in multidomain proteins 26 c3h4wA_ not modelled 99.8 23 PDB header:hydrolase Chain: A: PDB Molecule:phosphatidylinositol-specific phospholipase c1; PDBTitle: structure of a ca+2 dependent phosphatidylinositol-specific2 phospholipase c (pi-plc) enzyme from streptomyces antibioticus 27 d1qasa1 not modelled 99.7 21 Fold:EF Hand-like Superfamily:EF-hand Family:EF-hand modules in multidomain proteins 28 d1maia_ not modelled 99.7 19 Fold:PH domain-like barrel Superfamily:PH domain-like Family:Pleckstrin-homology domain (PH domain) 29 c2vszA_ not modelled 99.6 18 PDB header:apoptosis Chain: A: PDB Molecule:engulfment and cell motility protein 1; PDBTitle: crystal structure of the elmo1 ph domain 30 c2fjlA_ not modelled 99.6 35 PDB header:hydrolase Chain: A: PDB Molecule:1-phosphatidylinositol-4,5-bisphosphate PDBTitle: solution structure of the split ph domain in phospholipase2 c-gamma1 31 c2xp1A_ not modelled 99.5 15 PDB header:transcription Chain: A: PDB Molecule:spt6; PDBTitle: structure of the tandem sh2 domains from antonospora locustae2 transcription elongation factor spt6 32 c2hdxB_ not modelled 99.5 28 PDB header:signaling protein Chain: B: PDB Molecule:sh2-b ph domain containing signaling mediator 1 PDBTitle: crystal structure of the src homology-2 domain of sh2-b in2 complex with jak2 ptyr813 phosphopeptide 33 c3or8A_ not modelled 99.5 16 PDB header:transcription Chain: A: PDB Molecule:transcription elongation factor spt6; PDBTitle: a tandem sh2 domain in transcription elongation factor spt6 34 c2gsbA_ not modelled 99.5 32 PDB header:signaling protein Chain: A: PDB Molecule:ras gtpase-activating protein 1; PDBTitle: solution structure of the second sh2 domain of human ras2 gtpase-activating protein 1 35 c2y3aB_ not modelled 99.5 26 PDB header:transferase Chain: B: PDB Molecule:phosphatidylinositol 3-kinase regulatory subunit beta; PDBTitle: crystal structure of p110beta in complex with icsh2 of p85beta and2 the drug gdc-0941 36 c2dx0B_ not modelled 99.5 54 PDB header:hydrolase Chain: B: PDB Molecule:phospholipase c, gamma 2; PDBTitle: crystal structure of the n-terminal sh2 domain of mouse2 phospholipase c-gamma 2 37 c1griA_ not modelled 99.5 30 PDB header:signal transduction adaptor Chain: A: PDB Molecule:growth factor bound protein 2; PDBTitle: grb2 38 c3hizB_ not modelled 99.4 29 PDB header:transferase/oncoprotein Chain: B: PDB Molecule:phosphatidylinositol 3-kinase regulatory subunit PDBTitle: crystal structure of p110alpha h1047r mutant in complex with2 nish2 of p85alpha 39 d3c7ia1 not modelled 99.4 35 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 40 d1gmia_ not modelled 99.4 18 Fold:C2 domain-like Superfamily:C2 domain (Calcium/lipid-binding domain, CaLB) Family:PLC-like (P variant) 41 c2fo0A_ not modelled 99.4 19 PDB header:transferase Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase abl1 (1b isoform); PDBTitle: organization of the sh3-sh2 unit in active and inactive forms of the2 c-abl tyrosine kinase 42 d2oq1a1 not modelled 99.4 24 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 43 d2oq1a2 not modelled 99.4 30 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 44 d2eyva1 not modelled 99.4 38 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 45 c2q3xA_ not modelled 99.4 16 PDB header:transport protein Chain: A: PDB Molecule:regulating synaptic membrane exocytosis protein 1; PDBTitle: the rim1alpha c2b domain 46 c2dlzA_ not modelled 99.4 28 PDB header:signaling protein Chain: A: PDB Molecule:protein vav-2; PDBTitle: solution structure of the sh2 domain of human protein vav-2 47 d2qmsa1 not modelled 99.4 25 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 48 d1fhsa_ not modelled 99.4 33 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 49 c2eo3A_ not modelled 99.4 32 PDB header:signaling protein Chain: A: PDB Molecule:crk-like protein; PDBTitle: solution structure of the sh2 domain from human crk-like2 protein 50 d1csya_ not modelled 99.4 26 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 51 d2shpa2 not modelled 99.4 32 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 52 d1a81e2 not modelled 99.4 27 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 53 d2izva2 not modelled 99.4 25 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 54 c3m7fB_ not modelled 99.4 24 PDB header:signaling protein/ligase Chain: B: PDB Molecule:e3 ubiquitin-protein ligase nedd4; PDBTitle: crystal structure of the nedd4 c2/grb10 sh2 complex 55 d1a81a1 not modelled 99.4 25 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 56 d2nq3a1 not modelled 99.4 18 Fold:C2 domain-like Superfamily:C2 domain (Calcium/lipid-binding domain, CaLB) Family:PLC-like (P variant) 57 c2nq3A_ not modelled 99.4 18 PDB header:ligase Chain: A: PDB Molecule:itchy homolog e3 ubiquitin protein ligase; PDBTitle: crystal structure of the c2 domain of human itchy homolog2 e3 ubiquitin protein ligase 58 d1nrva_ not modelled 99.4 24 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 59 d1a81a2 not modelled 99.4 26 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 60 d2r83a1 not modelled 99.4 21 Fold:C2 domain-like Superfamily:C2 domain (Calcium/lipid-binding domain, CaLB) Family:Synaptotagmin-like (S variant) 61 c2crhA_ not modelled 99.4 25 PDB header:signaling protein Chain: A: PDB Molecule:vav proto-oncogene; PDBTitle: solution structure of the sh2 domain of human proto-2 oncogene protein vav1 62 c1oplA_ not modelled 99.4 20 PDB header:transferase Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase; PDBTitle: structural basis for the auto-inhibition of c-abl tyrosine2 kinase 63 d1rjaa_ not modelled 99.4 30 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 64 d1a81e1 not modelled 99.4 25 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 65 c2l3sA_ not modelled 99.4 11 PDB header:structural protein Chain: A: PDB Molecule:autoinhibited crk protein; PDBTitle: structure of the autoinhibited crk 66 c2dlyA_ not modelled 99.4 31 PDB header:transferase Chain: A: PDB Molecule:fyn-related kinase; PDBTitle: solution structure of the sh2 domain of murine fyn-related2 kinase 67 c2augB_ not modelled 99.4 27 PDB header:signaling protein Chain: B: PDB Molecule:growth factor receptor-bound protein 14; PDBTitle: crystal structure of the grb14 sh2 domain 68 c3l9bA_ not modelled 99.4 14 PDB header:membrane protein Chain: A: PDB Molecule:otoferlin; PDBTitle: crystal structure of rat otoferlin c2a 69 c2dmhA_ not modelled 99.3 23 PDB header:lipid binding protein Chain: A: PDB Molecule:myoferlin; PDBTitle: solution structure of the first c2 domain of human myoferlin 70 c3kwtA_ not modelled 99.3 22 PDB header:metal binding protein Chain: A: PDB Molecule:munc13-1; PDBTitle: munc13-1 c2b-domain, calcium-free 71 c2ci8A_ not modelled 99.3 24 PDB header:translation Chain: A: PDB Molecule:cytoplasmic protein nck1; PDBTitle: sh2 domain of human nck1 adaptor protein - uncomplexed 72 c2eo6A_ not modelled 99.3 26 PDB header:signaling protein Chain: A: PDB Molecule:b-cell linker protein; PDBTitle: solution structure of the sh2 domain from mouse b-cell2 linker protein blnk 73 d1blja_ not modelled 99.3 28 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 74 c2chdA_ not modelled 99.3 24 PDB header:protein transport Chain: A: PDB Molecule:rabphilin-3a; PDBTitle: crystal structure of the c2a domain of rabphilin-3a 75 d1pica_ not modelled 99.3 28 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 76 c3a98B_ not modelled 99.3 18 PDB header:signaling protein Chain: B: PDB Molecule:engulfment and cell motility protein 1; PDBTitle: crystal structure of the complex of the interacting regions of dock22 and elmo1 77 d1rlwa_ not modelled 99.3 17 Fold:C2 domain-like Superfamily:C2 domain (Calcium/lipid-binding domain, CaLB) Family:PLC-like (P variant) 78 d2cs0a1 not modelled 99.3 29 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 79 c1y57A_ not modelled 99.3 29 PDB header:transferase Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase src; PDBTitle: structure of unphosphorylated c-src in complex with an inhibitor 80 c2cr4A_ not modelled 99.3 23 PDB header:signaling protein Chain: A: PDB Molecule:sh3 domain-binding protein 2; PDBTitle: solution structure of the sh2 domain of human sh3bp2 protein 81 c2kk6A_ not modelled 99.3 34 PDB header:transferase Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase fer; PDBTitle: solution structure of sh2 domain of proto-oncogene tyrosine-2 protein kinase fer from homo sapiens, northeast structural3 genomics consortium (nesg) target hr3461d 82 d1qcfa2 not modelled 99.3 25 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 83 d1opka2 not modelled 99.3 30 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 84 d1jyra_ not modelled 99.3 36 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 85 c1ka6A_ not modelled 99.3 23 PDB header:immune system Chain: A: PDB Molecule:sh2 domain protein 1a; PDBTitle: sap/sh2d1a bound to peptide n-py 86 d1rpya_ not modelled 99.3 26 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 87 d2fcia1 not modelled 99.3 30 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 88 c3nsjA_ not modelled 99.3 18 PDB header:immune system Chain: A: PDB Molecule:perforin-1; PDBTitle: the x-ray crystal structure of lymphocyte perforin 89 c2dcrA_ not modelled 99.3 30 PDB header:transferase Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase fes/fps; PDBTitle: fully automated solution structure determination of the fes2 sh2 domain 90 d2shpa3 not modelled 99.3 34 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 91 c2ysxA_ not modelled 99.3 31 PDB header:signaling protein Chain: A: PDB Molecule:signaling inositol polyphosphate phosphatase PDBTitle: solution structure of the human ship sh2 domain 92 c3fbkB_ not modelled 99.3 13 PDB header:signaling protein Chain: B: PDB Molecule:regulator of g-protein signaling 3; PDBTitle: crystal structure of the c2 domain of the human regulator2 of g-protein signaling 3 isoform 6 (rgp3), northeast3 structural genomics consortium target hr5550a 93 d1ayaa_ not modelled 99.2 34 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 94 c2lctA_ not modelled 99.2 25 PDB header:signaling protein Chain: A: PDB Molecule:proto-oncogene vav; PDBTitle: solution structure of the vav1 sh2 domain complexed with a syk-derived2 doubly phosphorylated peptide 95 d1r1qa_ not modelled 99.2 28 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 96 c1x6cA_ not modelled 99.2 26 PDB header:signaling protein Chain: A: PDB Molecule:tyrosine-protein phosphatase, non-receptor type PDBTitle: solution structures of the sh2 domain of human protein-2 tyrosine phosphatase shp-1 97 c1x27F_ not modelled 99.2 25 PDB header:signaling protein Chain: F: PDB Molecule:proto-oncogene tyrosine-protein kinase lck; PDBTitle: crystal structure of lck sh2-sh3 with sh2 binding site of2 p130cas 98 d1bkla_ not modelled 99.2 32 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 99 c2ablA_ not modelled 99.2 31 PDB header:transferase Chain: A: PDB Molecule:abl tyrosine kinase; PDBTitle: sh3-sh2 domain fragment of human bcr-abl tyrosine kinase 100 d1dsya_ not modelled 99.2 20 Fold:C2 domain-like Superfamily:C2 domain (Calcium/lipid-binding domain, CaLB) Family:Synaptotagmin-like (S variant) 101 c1mv3A_ not modelled 99.2 12 PDB header:endocytosis/exocytosis Chain: A: PDB Molecule:myc box dependent interacting protein 1; PDBTitle: nmr structure of the tumor suppressor bin1: alternative2 splicing in melanoma and interaction with c-myc 102 d1d4ta_ not modelled 99.2 24 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 103 c2nsqA_ not modelled 99.2 23 PDB header:ligase Chain: A: PDB Molecule:e3 ubiquitin-protein ligase nedd4-like protein; PDBTitle: crystal structure of the c2 domain of the human e3 ubiquitin-protein2 ligase nedd4-like protein 104 c2fk9A_ not modelled 99.2 19 PDB header:transferase Chain: A: PDB Molecule:protein kinase c, eta type; PDBTitle: human protein kinase c, eta 105 c2z0uB_ not modelled 99.2 20 PDB header:lipid binding protein Chain: B: PDB Molecule:ww domain-containing protein 1; PDBTitle: crystal structure of c2 domain of kibra protein 106 c1rqqC_ not modelled 99.2 29 PDB header:transferase/signaling protein Chain: C: PDB Molecule:adaptor protein aps; PDBTitle: crystal structure of the insulin receptor kinase in complex2 with the sh2 domain of aps 107 d1xa6a2 not modelled 99.2 29 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 108 d1f2fa_ not modelled 99.2 32 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 109 d1lkka_ not modelled 99.2 26 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 110 d1a25a_ not modelled 99.2 17 Fold:C2 domain-like Superfamily:C2 domain (Calcium/lipid-binding domain, CaLB) Family:Synaptotagmin-like (S variant) 111 c3jzyA_ not modelled 99.2 20 PDB header:endocytosis Chain: A: PDB Molecule:intersectin 2; PDBTitle: crystal structure of human intersectin 2 c2 domain 112 c1k9aB_ not modelled 99.2 30 PDB header:transferase Chain: B: PDB Molecule:carboxyl-terminal src kinase; PDBTitle: crystal structure analysis of full-length carboxyl-terminal2 src kinase at 2.5 a resolution 113 c2h8hA_ not modelled 99.2 29 PDB header:transferase Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase src; PDBTitle: src kinase in complex with a quinazoline inhibitor 114 c2ge9A_ not modelled 99.2 30 PDB header:transferase Chain: A: PDB Molecule:tyrosine-protein kinase btk; PDBTitle: solution structures of the sh2 domain of bruton's tyrosine2 kinase 115 d1i3za_ not modelled 99.2 26 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 116 c3nhnA_ not modelled 99.2 25 PDB header:transferase Chain: A: PDB Molecule:tyrosine-protein kinase hck; PDBTitle: crystal structure of the src-family kinase hck sh3-sh2-linker2 regulatory region 117 c2c0iA_ not modelled 99.2 25 PDB header:transferase Chain: A: PDB Molecule:tyrosine-protein kinase hck; PDBTitle: src family kinase hck with bound inhibitor a-420983 118 c2el8A_ not modelled 99.2 21 PDB header:signaling protein Chain: A: PDB Molecule:signal-transducing adaptor protein 2; PDBTitle: solution structure of the human stap2 sh2 domain 119 c2hmhA_ not modelled 99.2 17 PDB header:cytokine regulator Chain: A: PDB Molecule:suppressor of cytokine signaling 3; PDBTitle: crystal structure of socs3 in complex with gp130(ptyr757)2 phosphopeptide. 120 d1k9aa2 not modelled 99.2 33 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain