Email l.a.kelley@imperial.ac.uk Description Q9VPU1 Date Tue Jan 22 11:34:19 GMT 2013 Unique Job ID 1e0757b109763eb9

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 c2fo0A_ 100.0 36 PDB header:transferase Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase abl1 (1b isoform); PDBTitle: organization of the sh3-sh2 unit in active and inactive forms of the2 c-abl tyrosine kinase 2 c1k9aB_ 100.0 41 PDB header:transferase Chain: B: PDB Molecule:carboxyl-terminal src kinase; PDBTitle: crystal structure analysis of full-length carboxyl-terminal2 src kinase at 2.5 a resolution 3 c1y57A_ 100.0 37 PDB header:transferase Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase src; PDBTitle: structure of unphosphorylated c-src in complex with an inhibitor 4 c1oplA_ 100.0 37 PDB header:transferase Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase; PDBTitle: structural basis for the auto-inhibition of c-abl tyrosine2 kinase 5 c2h8hA_ 100.0 38 PDB header:transferase Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase src; PDBTitle: src kinase in complex with a quinazoline inhibitor 6 c2ablA_ 100.0 36 PDB header:transferase Chain: A: PDB Molecule:abl tyrosine kinase; PDBTitle: sh3-sh2 domain fragment of human bcr-abl tyrosine kinase 7 c2c0iA_ 100.0 36 PDB header:transferase Chain: A: PDB Molecule:tyrosine-protein kinase hck; PDBTitle: src family kinase hck with bound inhibitor a-420983 8 c1x27F_ 100.0 36 PDB header:signaling protein Chain: F: PDB Molecule:proto-oncogene tyrosine-protein kinase lck; PDBTitle: crystal structure of lck sh2-sh3 with sh2 binding site of2 p130cas 9 c3nhnA_ 100.0 36 PDB header:transferase Chain: A: PDB Molecule:tyrosine-protein kinase hck; PDBTitle: crystal structure of the src-family kinase hck sh3-sh2-linker2 regulatory region 10 c1g83A_ 100.0 38 PDB header:transferase Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase fyn; PDBTitle: crystal structure of fyn sh3-sh2 11 c2b3oA_ 100.0 27 PDB header:hydrolase Chain: A: PDB Molecule:tyrosine-protein phosphatase, non-receptor type PDBTitle: crystal structure of human tyrosine phosphatase shp-1 12 c3ps5A_ 100.0 29 PDB header:hydrolase, signaling protein Chain: A: PDB Molecule:tyrosine-protein phosphatase non-receptor type 6; PDBTitle: crystal structure of the full-length human protein tyrosine2 phosphatase shp-1 13 c2shpA_ 100.0 23 PDB header:tyrosine phosphatase Chain: A: PDB Molecule:shp-2; PDBTitle: tyrosine phosphatase shp-2 14 c2ci8A_ 100.0 60 PDB header:translation Chain: A: PDB Molecule:cytoplasmic protein nck1; PDBTitle: sh2 domain of human nck1 adaptor protein - uncomplexed 15 c2eo6A_ 100.0 28 PDB header:signaling protein Chain: A: PDB Molecule:b-cell linker protein; PDBTitle: solution structure of the sh2 domain from mouse b-cell2 linker protein blnk 16 d2shpa2 100.0 30 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 17 c2eo3A_ 100.0 35 PDB header:signaling protein Chain: A: PDB Molecule:crk-like protein; PDBTitle: solution structure of the sh2 domain from human crk-like2 protein 18 c2lqnA_ 100.0 28 PDB header:signaling protein Chain: A: PDB Molecule:crk-like protein; PDBTitle: solution structure of crkl 19 c1x6cA_ 100.0 29 PDB header:signaling protein Chain: A: PDB Molecule:tyrosine-protein phosphatase, non-receptor type PDBTitle: solution structures of the sh2 domain of human protein-2 tyrosine phosphatase shp-1 20 c1griA_ 100.0 23 PDB header:signal transduction adaptor Chain: A: PDB Molecule:growth factor bound protein 2; PDBTitle: grb2 21 c3hizB_ not modelled 100.0 29 PDB header:transferase/oncoprotein Chain: B: PDB Molecule:phosphatidylinositol 3-kinase regulatory subunit PDBTitle: crystal structure of p110alpha h1047r mutant in complex with2 nish2 of p85alpha 22 c2crhA_ not modelled 100.0 21 PDB header:signaling protein Chain: A: PDB Molecule:vav proto-oncogene; PDBTitle: solution structure of the sh2 domain of human proto-2 oncogene protein vav1 23 d3c7ia1 not modelled 100.0 33 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 24 c2gsbA_ not modelled 100.0 29 PDB header:signaling protein Chain: A: PDB Molecule:ras gtpase-activating protein 1; PDBTitle: solution structure of the second sh2 domain of human ras2 gtpase-activating protein 1 25 d2oq1a1 not modelled 100.0 27 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 26 d1a81a1 not modelled 100.0 23 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 27 c2dlyA_ not modelled 100.0 29 PDB header:transferase Chain: A: PDB Molecule:fyn-related kinase; PDBTitle: solution structure of the sh2 domain of murine fyn-related2 kinase 28 c2dlzA_ not modelled 100.0 25 PDB header:signaling protein Chain: A: PDB Molecule:protein vav-2; PDBTitle: solution structure of the sh2 domain of human protein vav-2 29 d1mila_ not modelled 100.0 24 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 30 d1fhsa_ not modelled 100.0 32 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 31 c2oq1A_ not modelled 100.0 27 PDB header:transferase Chain: A: PDB Molecule:tyrosine-protein kinase zap-70; PDBTitle: tandem sh2 domains of zap-70 with 19-mer zeta1 peptide 32 c2hdxB_ not modelled 100.0 26 PDB header:signaling protein Chain: B: PDB Molecule:sh2-b ph domain containing signaling mediator 1 PDBTitle: crystal structure of the src homology-2 domain of sh2-b in2 complex with jak2 ptyr813 phosphopeptide 33 c3gqiB_ not modelled 100.0 31 PDB header:transferase/transferase inhibitor Chain: B: PDB Molecule:phospholipase c-gamma-1; PDBTitle: crystal structure of activated receptor tyrosine kinase in complex2 with substrates 34 d1a81e1 not modelled 99.9 23 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 35 c2y3aB_ not modelled 99.9 31 PDB header:transferase Chain: B: PDB Molecule:phosphatidylinositol 3-kinase regulatory subunit beta; PDBTitle: crystal structure of p110beta in complex with icsh2 of p85beta and2 the drug gdc-0941 36 c2eobA_ not modelled 99.9 28 PDB header:hydrolase Chain: A: PDB Molecule:1-phosphatidylinositol-4,5-bisphosphate PDBTitle: solution structure of the second sh2 domain from rat plc2 gamma-2 37 d1rjaa_ not modelled 99.9 27 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 38 c2el8A_ not modelled 99.9 22 PDB header:signaling protein Chain: A: PDB Molecule:signal-transducing adaptor protein 2; PDBTitle: solution structure of the human stap2 sh2 domain 39 c2kk6A_ not modelled 99.9 33 PDB header:transferase Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase fer; PDBTitle: solution structure of sh2 domain of proto-oncogene tyrosine-2 protein kinase fer from homo sapiens, northeast structural3 genomics consortium (nesg) target hr3461d 40 c1ka6A_ not modelled 99.9 26 PDB header:immune system Chain: A: PDB Molecule:sh2 domain protein 1a; PDBTitle: sap/sh2d1a bound to peptide n-py 41 d1ayaa_ not modelled 99.9 29 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 42 d2izva2 not modelled 99.9 22 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 43 d2oq1a2 not modelled 99.9 29 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 44 d1d4ta_ not modelled 99.9 28 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 45 c2ozoA_ not modelled 99.9 27 PDB header:transferase Chain: A: PDB Molecule:tyrosine-protein kinase zap-70; PDBTitle: autoinhibited intact human zap-70 46 d2eyva1 not modelled 99.9 31 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 47 c1ng2A_ not modelled 99.9 20 PDB header:oxidoreductase activator Chain: A: PDB Molecule:neutrophil cytosolic factor 1; PDBTitle: structure of autoinhibited p47phox 48 c2vifA_ not modelled 99.9 29 PDB header:signaling protein Chain: A: PDB Molecule:suppressor of cytokine signalling 6; PDBTitle: crystal structure of socs6 sh2 domain in complex with a c-kit2 phosphopeptide 49 d1a81e2 not modelled 99.9 29 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 50 d1a81a2 not modelled 99.9 32 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 51 d1nrva_ not modelled 99.9 29 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 52 c4fl2A_ not modelled 99.9 24 PDB header:transferase Chain: A: PDB Molecule:tyrosine-protein kinase syk; PDBTitle: structural and biophysical characterization of the syk activation2 switch 53 c2ysxA_ not modelled 99.9 29 PDB header:signaling protein Chain: A: PDB Molecule:signaling inositol polyphosphate phosphatase PDBTitle: solution structure of the human ship sh2 domain 54 d1jwoa_ not modelled 99.9 29 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 55 d1pica_ not modelled 99.9 26 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 56 d1csya_ not modelled 99.9 27 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 57 d1r1qa_ not modelled 99.9 32 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 58 d1opka2 not modelled 99.9 34 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 59 d1blja_ not modelled 99.9 27 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 60 d1jyra_ not modelled 99.9 36 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 61 d2shpa3 not modelled 99.9 29 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 62 d2fcia1 not modelled 99.9 31 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 63 c2dcrA_ not modelled 99.9 32 PDB header:transferase Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase fes/fps; PDBTitle: fully automated solution structure determination of the fes2 sh2 domain 64 d1k9aa2 not modelled 99.9 31 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 65 c2lctA_ not modelled 99.9 24 PDB header:signaling protein Chain: A: PDB Molecule:proto-oncogene vav; PDBTitle: solution structure of the vav1 sh2 domain complexed with a syk-derived2 doubly phosphorylated peptide 66 c2hmhA_ not modelled 99.9 25 PDB header:cytokine regulator Chain: A: PDB Molecule:suppressor of cytokine signaling 3; PDBTitle: crystal structure of socs3 in complex with gp130(ptyr757)2 phosphopeptide. 67 d1fu6a_ not modelled 99.9 29 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 68 c1ov3A_ not modelled 99.9 24 PDB header:oxidoreductase activator Chain: A: PDB Molecule:neutrophil cytosol factor 1; PDBTitle: structure of the p22phox-p47phox complex 69 c2c9wA_ not modelled 99.9 28 PDB header:transcription regulation Chain: A: PDB Molecule:suppressor of cytokine signaling 2; PDBTitle: crystal structure of socs-2 in complex with elongin-b and2 elongin-c at 1.9a resolution 70 c2izvA_ not modelled 99.9 22 PDB header:transcription Chain: A: PDB Molecule:suppressor of cytokine signaling 4; PDBTitle: crystal structure of socs-4 in complex with elongin-b and2 elongin-c at 2.55a resolution 71 c2ge9A_ not modelled 99.9 27 PDB header:transferase Chain: A: PDB Molecule:tyrosine-protein kinase btk; PDBTitle: solution structures of the sh2 domain of bruton's tyrosine2 kinase 72 c2augB_ not modelled 99.9 27 PDB header:signaling protein Chain: B: PDB Molecule:growth factor receptor-bound protein 14; PDBTitle: crystal structure of the grb14 sh2 domain 73 d1lkka_ not modelled 99.9 29 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 74 d1qcfa2 not modelled 99.9 33 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 75 d1i3za_ not modelled 99.9 29 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 76 d1o48a_ not modelled 99.9 32 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 77 d2qmsa1 not modelled 99.9 27 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 78 c1a81E_ not modelled 99.9 29 PDB header:complex (transferase/peptide) Chain: E: PDB Molecule:syk kinase; PDBTitle: crystal structure of the tandem sh2 domain of the syk kinase bound to2 a dually tyrosine-phosphorylated itam 79 d1qada_ not modelled 99.9 29 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 80 d1f2fa_ not modelled 99.9 33 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 81 c2knoA_ not modelled 99.9 29 PDB header:hydrolase Chain: A: PDB Molecule:tensin-like c1 domain-containing phosphatase; PDBTitle: nmr solution structure of sh2 domain of the human tensin like c12 domain containing phosphatase (tenc1) 82 c2eyzA_ not modelled 99.9 14 PDB header:signaling protein Chain: A: PDB Molecule:v-crk sarcoma virus ct10 oncogene homolog PDBTitle: ct10-regulated kinase isoform ii 83 d1bkla_ not modelled 99.9 32 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 84 d1g83a2 not modelled 99.9 34 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 85 d1luia_ not modelled 99.9 29 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 86 c2cr4A_ not modelled 99.9 20 PDB header:signaling protein Chain: A: PDB Molecule:sh3 domain-binding protein 2; PDBTitle: solution structure of the sh2 domain of human sh3bp2 protein 87 d1rpya_ not modelled 99.9 25 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 88 c1rqqC_ not modelled 99.9 25 PDB header:transferase/signaling protein Chain: C: PDB Molecule:adaptor protein aps; PDBTitle: crystal structure of the insulin receptor kinase in complex2 with the sh2 domain of aps 89 d2cs0a1 not modelled 99.9 30 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 90 c2ekxA_ not modelled 99.9 32 PDB header:signaling protein Chain: A: PDB Molecule:cytoplasmic tyrosine-protein kinase bmx; PDBTitle: solution structure of the human bmx sh2 domain 91 c3mazA_ not modelled 99.9 18 PDB header:signaling protein Chain: A: PDB Molecule:signal-transducing adaptor protein 1; PDBTitle: crystal structure of the human brdg1/stap-1 sh2 domain in complex with2 the ntal ptyr136 peptide 92 d1xa6a2 not modelled 99.9 22 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 93 d2c9wa2 not modelled 99.9 26 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 94 c2l3sA_ 99.9 20 PDB header:structural protein Chain: A: PDB Molecule:autoinhibited crk protein; PDBTitle: structure of the autoinhibited crk 95 d1cwea_ not modelled 99.9 31 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 96 c2dvjA_ not modelled 99.9 29 PDB header:signaling protein Chain: A: PDB Molecule:v-crk sarcoma virus ct10 oncogene homolog, PDBTitle: phosphorylated crk-ii 97 c2dm0A_ not modelled 99.9 22 PDB header:transferase Chain: A: PDB Molecule:tyrosine-protein kinase txk; PDBTitle: solution structure of the sh2 domain of human tyrosine-2 protein kinase txk 98 c2eyyA_ not modelled 99.9 29 PDB header:signaling protein Chain: A: PDB Molecule:v-crk sarcoma virus ct10 oncogene homolog PDBTitle: ct10-regulated kinase isoform i 99 c3qwyA_ not modelled 99.9 20 PDB header:signaling protein Chain: A: PDB Molecule:cell death abnormality protein 2; PDBTitle: ced-2 100 c3qwxX_ not modelled 99.9 20 PDB header:signaling protein Chain: X: PDB Molecule:cell death abnormality protein 2; PDBTitle: ced-2 1-174 101 c3gxxB_ not modelled 99.9 21 PDB header:transcription Chain: B: PDB Molecule:transcription elongation factor spt6; PDBTitle: structure of the sh2 domain of the candida glabrata2 transcription elongation factor spt6, crystal form b 102 c2dx0B_ not modelled 99.8 33 PDB header:hydrolase Chain: B: PDB Molecule:phospholipase c, gamma 2; PDBTitle: crystal structure of the n-terminal sh2 domain of mouse2 phospholipase c-gamma 2 103 c3or8A_ not modelled 99.8 24 PDB header:transcription Chain: A: PDB Molecule:transcription elongation factor spt6; PDBTitle: a tandem sh2 domain in transcription elongation factor spt6 104 c2xp1A_ not modelled 99.8 18 PDB header:transcription Chain: A: PDB Molecule:spt6; PDBTitle: structure of the tandem sh2 domains from antonospora locustae2 transcription elongation factor spt6 105 c1xa6A_ not modelled 99.8 27 PDB header:signaling protein Chain: A: PDB Molecule:beta2-chimaerin; PDBTitle: crystal structure of the human beta2-chimaerin 106 c2yt6A_ not modelled 99.8 33 PDB header:cell cycle Chain: A: PDB Molecule:adult male urinary bladder cdna, riken full- PDBTitle: solution structure of the sh3_1 domain of yamaguchi sarcoma2 viral (v-yes) oncogene homolog 1 107 d1uura3 not modelled 99.8 22 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 108 c1mv3A_ not modelled 99.8 13 PDB header:endocytosis/exocytosis Chain: A: PDB Molecule:myc box dependent interacting protein 1; PDBTitle: nmr structure of the tumor suppressor bin1: alternative2 splicing in melanoma and interaction with c-myc 109 d1udla_ not modelled 99.7 31 Fold:SH3-like barrel Superfamily:SH3-domain Family:SH3-domain 110 d1bf5a3 not modelled 99.7 17 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 111 c1wx6A_ not modelled 99.7 37 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:cytoplasmic protein nck2; PDBTitle: solution structure of the sh3 domain of the human2 cytoplasmic protein nck2 112 d1ng2a2 not modelled 99.6 16 Fold:SH3-like barrel Superfamily:SH3-domain Family:SH3-domain 113 d1u5sa1 not modelled 99.6 47 Fold:SH3-like barrel Superfamily:SH3-domain Family:SH3-domain 114 c2jxbA_ not modelled 99.6 27 PDB header:signaling protein complex Chain: A: PDB Molecule:t-cell surface glycoprotein cd3 epsilon chain, PDBTitle: structure of cd3epsilon-nck2 first sh3 domain complex 115 c2dlpA_ not modelled 99.6 26 PDB header:structural protein Chain: A: PDB Molecule:kiaa1783 protein; PDBTitle: solution structure of the sh3 domain of human kiaa17832 protein 116 d1wiea_ not modelled 99.6 23 Fold:SH3-like barrel Superfamily:SH3-domain Family:SH3-domain 117 c1u3oA_ not modelled 99.6 30 PDB header:signaling protein Chain: A: PDB Molecule:huntingtin-associated protein-interacting PDBTitle: solution structure of rat kalirin n-terminal sh3 domain 118 c2e5kA_ not modelled 99.6 19 PDB header:protein binding Chain: A: PDB Molecule:suppressor of t-cell receptor signaling 1; PDBTitle: solution structure of sh3 domain in suppressor of t-cell2 receptor signaling 1 119 c1x2qA_ not modelled 99.6 27 PDB header:signaling protein Chain: A: PDB Molecule:signal transducing adapter molecule 2; PDBTitle: solution structure of the sh3 domain of the signal2 transducing adaptor molecule 2 120 c2dybA_ not modelled 99.6 21 PDB header:oxidoreductase Chain: A: PDB Molecule:neutrophil cytosol factor 4; PDBTitle: the crystal structure of human p40(phox)