Email l.a.kelley@imperial.ac.uk Description Q961S1 Date Wed Feb 13 11:30:56 GMT 2013 Unique Job ID 044af2714b9ff5d5

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 c1xa6A_ 100.0 46 PDB header:signaling protein Chain: A: PDB Molecule:beta2-chimaerin; PDBTitle: crystal structure of the human beta2-chimaerin 2 d1xa6a1 100.0 46 Fold:GTPase activation domain, GAP Superfamily:GTPase activation domain, GAP Family:BCR-homology GTPase activation domain (BH-domain) 3 c3byiA_ 100.0 28 PDB header:signaling protein Chain: A: PDB Molecule:rho gtpase activating protein 15; PDBTitle: crystal structure of human rho gtpase activating protein 15 (arhgap15) 4 c3kuqA_ 100.0 25 PDB header:hydrolase activator Chain: A: PDB Molecule:rho gtpase-activating protein 7; PDBTitle: crystal structure of the dlc1 rhogap domain 5 c3iugA_ 100.0 31 PDB header:splicing Chain: A: PDB Molecule:rho/cdc42/rac gtpase-activating protein rics; PDBTitle: crystal structure of the rhogap domain of rics 6 c2ee5A_ 100.0 30 PDB header:hydrolase Chain: A: PDB Molecule:rho gtpase activating protein 5 variant; PDBTitle: solution structure of the n-teruminus extended rhogap2 domain from human rho gtpase activating protein 5 variant 7 c3fk2B_ 100.0 32 PDB header:signaling protein, hydrolase activator Chain: B: PDB Molecule:glucocorticoid receptor dna-binding factor 1; PDBTitle: crystal structure of the rhogap domain of human2 glucocorticoid receptor dna-binding factor 1 8 c3qisA_ 100.0 20 PDB header:hydrolase/protein binding Chain: A: PDB Molecule:inositol polyphosphate 5-phosphatase ocrl-1; PDBTitle: recognition of the f&h motif by the lowe syndrome protein ocrl 9 d1tx4a_ 100.0 24 Fold:GTPase activation domain, GAP Superfamily:GTPase activation domain, GAP Family:BCR-homology GTPase activation domain (BH-domain) 10 c2ngrB_ 100.0 22 PDB header:hydrolase Chain: B: PDB Molecule:protein (gtpase activating protein (rhg)); PDBTitle: transition state complex for gtp hydrolysis by cdc42:2 comparisons of the high resolution structures for cdc423 bound to the active and catalytically compromised forms of4 the cdc42-gap. 11 c3msxB_ 100.0 24 PDB header:protein binding Chain: B: PDB Molecule:rho gtpase-activating protein 20; PDBTitle: crystal structure of rhoa.gdp.mgf3 in complex with gap domain of2 arhgap20 12 c2ovjA_ 100.0 32 PDB header:signaling protein Chain: A: PDB Molecule:rac gtpase-activating protein 1; PDBTitle: the crystal structure of the human rac gtpase activating protein 12 (racgap1) mgcracgap. 13 c2qv2A_ 100.0 23 PDB header:hydrolase Chain: A: PDB Molecule:inositol polyphosphate 5-phosphatase ocrl-1; PDBTitle: a role of the lowe syndrome protein ocrl in early steps of2 the endocytic pathway 14 d1f7ca_ 100.0 28 Fold:GTPase activation domain, GAP Superfamily:GTPase activation domain, GAP Family:BCR-homology GTPase activation domain (BH-domain) 15 c1f7cA_ 100.0 28 PDB header:signaling protein Chain: A: PDB Molecule:rhogap protein; PDBTitle: crystal structure of the bh domain from graf, the gtpase2 regulator associated with focal adhesion kinase 16 d1pbwa_ 99.9 25 Fold:GTPase activation domain, GAP Superfamily:GTPase activation domain, GAP Family:BCR-homology GTPase activation domain (BH-domain) 17 c1pbwB_ 99.9 24 PDB header:phosphotransferase Chain: B: PDB Molecule:phosphatidylinositol 3-kinase; PDBTitle: structure of bcr-homology (bh) domain 18 c3eapD_ 99.9 23 PDB header:hydrolase activator Chain: D: PDB Molecule:rho gtpase-activating protein 11a; PDBTitle: crystal structure of the rhogap domain of arhgap11a 19 d1xa6a2 99.9 38 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 20 c2xs6A_ 99.9 26 PDB header:transferase Chain: A: PDB Molecule:phosphatidylinositol 3-kinase regulatory subunit beta; PDBTitle: crystal structure of the rhogap domain of human pik3r2 21 c3hizB_ not modelled 99.5 27 PDB header:transferase/oncoprotein Chain: B: PDB Molecule:phosphatidylinositol 3-kinase regulatory subunit PDBTitle: crystal structure of p110alpha h1047r mutant in complex with2 nish2 of p85alpha 22 c2eo6A_ not modelled 99.4 26 PDB header:signaling protein Chain: A: PDB Molecule:b-cell linker protein; PDBTitle: solution structure of the sh2 domain from mouse b-cell2 linker protein blnk 23 c2c9wA_ not modelled 99.4 26 PDB header:transcription regulation Chain: A: PDB Molecule:suppressor of cytokine signaling 2; PDBTitle: crystal structure of socs-2 in complex with elongin-b and2 elongin-c at 1.9a resolution 24 c2oq1A_ not modelled 99.4 26 PDB header:transferase Chain: A: PDB Molecule:tyrosine-protein kinase zap-70; PDBTitle: tandem sh2 domains of zap-70 with 19-mer zeta1 peptide 25 c2y3aB_ not modelled 99.4 23 PDB header:transferase Chain: B: PDB Molecule:phosphatidylinositol 3-kinase regulatory subunit beta; PDBTitle: crystal structure of p110beta in complex with icsh2 of p85beta and2 the drug gdc-0941 26 d2oq1a1 not modelled 99.3 26 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 27 c2ozoA_ not modelled 99.3 25 PDB header:transferase Chain: A: PDB Molecule:tyrosine-protein kinase zap-70; PDBTitle: autoinhibited intact human zap-70 28 c2shpA_ not modelled 99.3 31 PDB header:tyrosine phosphatase Chain: A: PDB Molecule:shp-2; PDBTitle: tyrosine phosphatase shp-2 29 c2fo0A_ not modelled 99.3 34 PDB header:transferase Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase abl1 (1b isoform); PDBTitle: organization of the sh3-sh2 unit in active and inactive forms of the2 c-abl tyrosine kinase 30 c2lqnA_ not modelled 99.3 29 PDB header:signaling protein Chain: A: PDB Molecule:crk-like protein; PDBTitle: solution structure of crkl 31 c4fl2A_ not modelled 99.3 24 PDB header:transferase Chain: A: PDB Molecule:tyrosine-protein kinase syk; PDBTitle: structural and biophysical characterization of the syk activation2 switch 32 c2vifA_ not modelled 99.3 27 PDB header:signaling protein Chain: A: PDB Molecule:suppressor of cytokine signalling 6; PDBTitle: crystal structure of socs6 sh2 domain in complex with a c-kit2 phosphopeptide 33 c2crhA_ not modelled 99.3 24 PDB header:signaling protein Chain: A: PDB Molecule:vav proto-oncogene; PDBTitle: solution structure of the sh2 domain of human proto-2 oncogene protein vav1 34 d2eyva1 not modelled 99.3 35 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 35 d1fhsa_ not modelled 99.3 24 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 36 d1a81a1 not modelled 99.3 24 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 37 d1r1qa_ not modelled 99.3 21 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 38 d2izva2 not modelled 99.3 21 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 39 c2izvA_ not modelled 99.3 21 PDB header:transcription Chain: A: PDB Molecule:suppressor of cytokine signaling 4; PDBTitle: crystal structure of socs-4 in complex with elongin-b and2 elongin-c at 2.55a resolution 40 d1k9aa2 not modelled 99.3 25 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 41 d1a81e1 not modelled 99.3 24 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 42 c3gqiB_ not modelled 99.3 32 PDB header:transferase/transferase inhibitor Chain: B: PDB Molecule:phospholipase c-gamma-1; PDBTitle: crystal structure of activated receptor tyrosine kinase in complex2 with substrates 43 c2dlzA_ not modelled 99.3 21 PDB header:signaling protein Chain: A: PDB Molecule:protein vav-2; PDBTitle: solution structure of the sh2 domain of human protein vav-2 44 c1oplA_ not modelled 99.3 34 PDB header:transferase Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase; PDBTitle: structural basis for the auto-inhibition of c-abl tyrosine2 kinase 45 c2gsbA_ not modelled 99.3 20 PDB header:signaling protein Chain: A: PDB Molecule:ras gtpase-activating protein 1; PDBTitle: solution structure of the second sh2 domain of human ras2 gtpase-activating protein 1 46 d2c9wa2 not modelled 99.2 26 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 47 c2dlyA_ not modelled 99.2 21 PDB header:transferase Chain: A: PDB Molecule:fyn-related kinase; PDBTitle: solution structure of the sh2 domain of murine fyn-related2 kinase 48 c2b3oA_ not modelled 99.2 25 PDB header:hydrolase Chain: A: PDB Molecule:tyrosine-protein phosphatase, non-receptor type PDBTitle: crystal structure of human tyrosine phosphatase shp-1 49 c3ps5A_ not modelled 99.2 25 PDB header:hydrolase, signaling protein Chain: A: PDB Molecule:tyrosine-protein phosphatase non-receptor type 6; PDBTitle: crystal structure of the full-length human protein tyrosine2 phosphatase shp-1 50 d1rjaa_ not modelled 99.2 22 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 51 c2eo3A_ not modelled 99.2 29 PDB header:signaling protein Chain: A: PDB Molecule:crk-like protein; PDBTitle: solution structure of the sh2 domain from human crk-like2 protein 52 c2hmhA_ not modelled 99.2 19 PDB header:cytokine regulator Chain: A: PDB Molecule:suppressor of cytokine signaling 3; PDBTitle: crystal structure of socs3 in complex with gp130(ptyr757)2 phosphopeptide. 53 c1k9aB_ not modelled 99.2 25 PDB header:transferase Chain: B: PDB Molecule:carboxyl-terminal src kinase; PDBTitle: crystal structure analysis of full-length carboxyl-terminal2 src kinase at 2.5 a resolution 54 d1jwoa_ not modelled 99.2 32 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 55 d2cs0a1 not modelled 99.2 23 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 56 c3pfqA_ not modelled 99.2 37 PDB header:transferase Chain: A: PDB Molecule:protein kinase c beta type; PDBTitle: crystal structure and allosteric activation of protein kinase c beta2 ii 57 c2hdxB_ not modelled 99.2 28 PDB header:signaling protein Chain: B: PDB Molecule:sh2-b ph domain containing signaling mediator 1 PDBTitle: crystal structure of the src homology-2 domain of sh2-b in2 complex with jak2 ptyr813 phosphopeptide 58 d2oq1a2 not modelled 99.2 32 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 59 d1nrva_ not modelled 99.2 18 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 60 d1ayaa_ not modelled 99.2 32 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 61 d1a81e2 not modelled 99.2 27 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 62 c2ysxA_ not modelled 99.2 22 PDB header:signaling protein Chain: A: PDB Molecule:signaling inositol polyphosphate phosphatase PDBTitle: solution structure of the human ship sh2 domain 63 d3c7ia1 not modelled 99.2 24 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 64 c2eobA_ not modelled 99.2 22 PDB header:hydrolase Chain: A: PDB Molecule:1-phosphatidylinositol-4,5-bisphosphate PDBTitle: solution structure of the second sh2 domain from rat plc2 gamma-2 65 c1ka6A_ not modelled 99.2 22 PDB header:immune system Chain: A: PDB Molecule:sh2 domain protein 1a; PDBTitle: sap/sh2d1a bound to peptide n-py 66 c2ci8A_ not modelled 99.2 24 PDB header:translation Chain: A: PDB Molecule:cytoplasmic protein nck1; PDBTitle: sh2 domain of human nck1 adaptor protein - uncomplexed 67 d1a81a2 not modelled 99.2 25 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 68 c2lctA_ not modelled 99.2 29 PDB header:signaling protein Chain: A: PDB Molecule:proto-oncogene vav; PDBTitle: solution structure of the vav1 sh2 domain complexed with a syk-derived2 doubly phosphorylated peptide 69 d1csya_ not modelled 99.2 27 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 70 d1xa6a3 not modelled 99.2 63 Fold:Cysteine-rich domain Superfamily:Cysteine-rich domain Family:Protein kinase cysteine-rich domain (cys2, phorbol-binding domain) 71 d1rpya_ not modelled 99.2 27 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 72 c2el8A_ not modelled 99.2 18 PDB header:signaling protein Chain: A: PDB Molecule:signal-transducing adaptor protein 2; PDBTitle: solution structure of the human stap2 sh2 domain 73 d2shpa2 not modelled 99.2 31 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 74 c1rqqC_ not modelled 99.2 27 PDB header:transferase/signaling protein Chain: C: PDB Molecule:adaptor protein aps; PDBTitle: crystal structure of the insulin receptor kinase in complex2 with the sh2 domain of aps 75 d1opka2 not modelled 99.2 34 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 76 c2ablA_ not modelled 99.2 34 PDB header:transferase Chain: A: PDB Molecule:abl tyrosine kinase; PDBTitle: sh3-sh2 domain fragment of human bcr-abl tyrosine kinase 77 c1a81E_ not modelled 99.2 23 PDB header:complex (transferase/peptide) Chain: E: PDB Molecule:syk kinase; PDBTitle: crystal structure of the tandem sh2 domain of the syk kinase bound to2 a dually tyrosine-phosphorylated itam 78 d1jyra_ not modelled 99.2 24 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 79 c2augB_ not modelled 99.2 21 PDB header:signaling protein Chain: B: PDB Molecule:growth factor receptor-bound protein 14; PDBTitle: crystal structure of the grb14 sh2 domain 80 d1i3za_ not modelled 99.2 24 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 81 d2shpa3 not modelled 99.2 31 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 82 c1x6cA_ not modelled 99.1 33 PDB header:signaling protein Chain: A: PDB Molecule:tyrosine-protein phosphatase, non-receptor type PDBTitle: solution structures of the sh2 domain of human protein-2 tyrosine phosphatase shp-1 83 d1d4ta_ not modelled 99.1 22 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 84 d1lkka_ not modelled 99.1 28 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 85 d1cwea_ not modelled 99.1 23 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 86 d1pica_ not modelled 99.1 25 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 87 d1blja_ not modelled 99.1 26 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 88 d1qcfa2 not modelled 99.1 22 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 89 d1f2fa_ not modelled 99.1 28 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 90 c1y57A_ not modelled 99.1 32 PDB header:transferase Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase src; PDBTitle: structure of unphosphorylated c-src in complex with an inhibitor 91 c2knoA_ not modelled 99.1 22 PDB header:hydrolase Chain: A: PDB Molecule:tensin-like c1 domain-containing phosphatase; PDBTitle: nmr solution structure of sh2 domain of the human tensin like c12 domain containing phosphatase (tenc1) 92 c2eyzA_ not modelled 99.1 36 PDB header:signaling protein Chain: A: PDB Molecule:v-crk sarcoma virus ct10 oncogene homolog PDBTitle: ct10-regulated kinase isoform ii 93 d2qmsa1 not modelled 99.1 25 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 94 c1x27F_ not modelled 99.1 22 PDB header:signaling protein Chain: F: PDB Molecule:proto-oncogene tyrosine-protein kinase lck; PDBTitle: crystal structure of lck sh2-sh3 with sh2 binding site of2 p130cas 95 c2dvjA_ not modelled 99.1 33 PDB header:signaling protein Chain: A: PDB Molecule:v-crk sarcoma virus ct10 oncogene homolog, PDBTitle: phosphorylated crk-ii 96 c4b6dA_ not modelled 99.0 29 PDB header:signaling protein Chain: A: PDB Molecule:rac gtpase-activating protein 1; PDBTitle: structure of the atypical c1 domain of mgcracgap 97 d1qada_ not modelled 99.0 26 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 98 c2h8hA_ not modelled 99.0 32 PDB header:transferase Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase src; PDBTitle: src kinase in complex with a quinazoline inhibitor 99 d1mila_ not modelled 99.0 33 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 100 d1luia_ not modelled 99.0 25 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 101 c2kk6A_ not modelled 99.0 28 PDB header:transferase Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase fer; PDBTitle: solution structure of sh2 domain of proto-oncogene tyrosine-2 protein kinase fer from homo sapiens, northeast structural3 genomics consortium (nesg) target hr3461d 102 c2e73A_ not modelled 99.0 32 PDB header:transferase Chain: A: PDB Molecule:protein kinase c gamma type; PDBTitle: solution structure of the phorbol esters/diacylglycerol2 binding domain of protein kinase c gamma 103 c3gxxB_ not modelled 99.0 16 PDB header:transcription Chain: B: PDB Molecule:transcription elongation factor spt6; PDBTitle: structure of the sh2 domain of the candida glabrata2 transcription elongation factor spt6, crystal form b 104 c2eliA_ not modelled 99.0 30 PDB header:transferase Chain: A: PDB Molecule:protein kinase c alpha type; PDBTitle: solution structure of the second phorbol2 esters/diacylglycerol binding domain of human protein3 kinase c alpha type 105 d1bkla_ not modelled 99.0 29 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 106 c2dcrA_ not modelled 99.0 23 PDB header:transferase Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase fes/fps; PDBTitle: fully automated solution structure determination of the fes2 sh2 domain 107 d1g83a2 not modelled 99.0 32 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 108 d1fu6a_ not modelled 99.0 27 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 109 c3nhnA_ not modelled 99.0 23 PDB header:transferase Chain: A: PDB Molecule:tyrosine-protein kinase hck; PDBTitle: crystal structure of the src-family kinase hck sh3-sh2-linker2 regulatory region 110 c3mazA_ not modelled 99.0 17 PDB header:signaling protein Chain: A: PDB Molecule:signal-transducing adaptor protein 1; PDBTitle: crystal structure of the human brdg1/stap-1 sh2 domain in complex with2 the ntal ptyr136 peptide 111 c2c0iA_ not modelled 99.0 29 PDB header:transferase Chain: A: PDB Molecule:tyrosine-protein kinase hck; PDBTitle: src family kinase hck with bound inhibitor a-420983 112 c2rowA_ not modelled 99.0 21 PDB header:transferase Chain: A: PDB Molecule:rho-associated protein kinase 2; PDBTitle: the c1 domain of rock ii 113 d1tbna_ not modelled 99.0 31 Fold:Cysteine-rich domain Superfamily:Cysteine-rich domain Family:Protein kinase cysteine-rich domain (cys2, phorbol-binding domain) 114 d2fcia1 not modelled 99.0 23 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 115 c2ennA_ not modelled 99.0 26 PDB header:transferase Chain: A: PDB Molecule:protein kinase c theta type; PDBTitle: solution structure of the first c1 domain from human2 protein kinase c theta 116 c2ge9A_ not modelled 99.0 24 PDB header:transferase Chain: A: PDB Molecule:tyrosine-protein kinase btk; PDBTitle: solution structures of the sh2 domain of bruton's tyrosine2 kinase 117 c2eyyA_ not modelled 99.0 33 PDB header:signaling protein Chain: A: PDB Molecule:v-crk sarcoma virus ct10 oncogene homolog PDBTitle: ct10-regulated kinase isoform i 118 d1o48a_ not modelled 99.0 29 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 119 c2db6A_ not modelled 99.0 30 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:sh3 and cysteine rich domain 3; PDBTitle: solution structure of rsgi ruh-051, a c1 domain of stac32 from human cdna 120 c2enzA_ not modelled 98.9 38 PDB header:transferase Chain: A: PDB Molecule:protein kinase c theta type; PDBTitle: solution structure of the second c1 domain from human2 protein kinase c theta