Postdoctoral research associate in Mike Sternberg's group at Imperial College London since July 2002.
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Contact address:
Keiran Fleming
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[ how to get to Imperial College: nearest underground station is South Kensington, here's a link to a streetmap
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I studied Biochemistry as an undergraduate at Imperial College London. I was interested at the time in protein three dimensional structure determination, so studied for a PhD in biomolecular NMR, also at Imperial College London, in Dr. Steve Matthews's lab. I became increasingly involved in the computational aspects of NMR, and began to look towards structural bioinformatics as a possible next step. I now work on the e-Protein project, described below.
e-Protein
The e-Protein project involves development of the 3D-GENOMICS database, which contains protein structural annotations for 93 sequenced genomes. The initial 3D-GENOMICS database was developed by Arne Mueller as part of his PhD project. Working in collaboration with individuals based at UCL and at the EBI, our aim is to "To provide a fully automated distributed pipeline for large-scale structural and functional annotation of all major proteomes via the use of cutting-edge computer GRID technologies." More information can be found on the e-Protein website.
Publications:
Solution structure and RNA interactions of the RNA recognition motif from eukaryotic translation initiation factor 4B.Fleming K, Ghuman J, Yuan X, Simpson P, Szendroi A, Matthews S (2003) Biochemistry 42(30):8966-75.
The solution structure of PapGII from uropathogenic Escherichia coli and its recognition of glycolipid receptors.Sung MA, Fleming K, Chen HA, Matthews S (2001) EMBO Rep. 2(7):621-7.
Cellulose crystallites. Fleming K, Gray, DG, Matthews S (2001) Chemistry 7(9):1831-5.
Cellulose crystallites: A new and robust liquid crystalline medium for the measurement of residual dipolar couplings. Fleming K, Gray DG, Matthews S (2000) J Am Chem Soc. 122(21):5224-5.
Structure of the cell-adhesion fragment of intimin from enteropathogenic Escherichia coli. Kelly G, Prasannan S, Daniell S, Fleming K, Frankel G, Dougan G, Connerton I, Matthews S (1999) Nat Struct Biol. 6(4):313-8.