Alignment of TRAD_HUMAN_whole with 1wer-0

Alignment of TRAD_HUMAN_whole with 1wer-0

PSSM Score Key
-10																			10

Bad																			Good

TRAD_H_PSS	Predicted Secondary Structure for your Sequence
TRAD_H_Seq	Your Sequence
1wer-0_Seq	Library Sequence
1wer-0_SS	Known Secondary Structure of the Library Sequence (Assigned by STRIDE)
CORE	A measure of the burial and number of contacts made by a residue. (9 very buried/making many contacts, 0 not buried/making few contacts

TRAD_H_PSS

C

C

C

C

C

C

C

H

H

H

H

E

E

E

E

E

E

E

E

E

C

H

H

H

H

H

H

H

H

C

C

C

C

C

C

H

H

H

H

H

H

H

H

H

H

H

H

H

H

H

TRAD_H_Seq

M

A

A

G

Q

N

G

H

E

E

W

V

G

S

A

Y

L

F

V

E

S

S

L

D

K

V

V

L

S

D

A

Y

A

H

P

Q

Q

K

V

A

V

Y

R

A

L

Q

A

A

L

A

-------

M

-

-

E

E

+

-

-

-

-

L

+

-

L

-

V

V

+

-

+

+

-

+

Q

-

-

-

+

-

+

L

-

-

-

+

-

1wer-0_Seq

M

.

.

.

.

.

P

E

E

E

Y

S

E

F

K

E

L

I

L

Q

K

E

L

.

H

V

V

Y

A

L

S

H

V

C

G

Q

D

R

T

L

L

A

S

I

L

L

R

I

F

L

1wer-0_SS

C

.

.

.

.

.

C

H

H

H

H

H

H

H

H

H

H

H

H

C

C

C

C

.

H

H

H

H

H

H

H

H

H

C

C

C

H

H

H

H

H

H

H

H

H

H

H

H

H

H

CORE

0

.

.

.

.

.

0

0

0

0

0

0

0

3

0

0

2

8

2

0

0

0

3

.

0

4

8

0

2

6

2

0

1

1

0

0

0

0

0

0

5

3

0

2

9

3

0

4

4

0

TRAD_H_PSS

C

C

C

C

C

C

C

H

H

H

.

.

.

H

H

H

H

H

C

C

C

.

C

E

E

E

E

E

E

H

H

H

C

C

C

H

H

H

H

H

H

H

H

H

H

H

C

C

C

C

TRAD_H_Seq

E

S

G

G

S

P

D

V

L

Q

.

.

.

M

L

K

I

H

R

S

D

.

P

Q

L

I

V

Q

L

R

F

C

G

R

Q

P

C

G

R

F

L

R

A

Y

R

E

G

X

X

X

-------

-

-

+

-

-

-

+

L

-

+

I

-

+

D

+

+

+

+

-

-

-

-

-

-

+

-

-

-

-

+

+

+

A

+

-

-

-

1wer-0_Seq

H

E

K

L

E

S

L

L

L

C

T

L

N

D

R

E

I

S

M

E

D

E

A

T

T

L

F

R

A

T

T

L

A

S

T

L

M

E

Q

Y

M

K

A

T

A

T

Q

F

V

H

1wer-0_SS

H

H

C

H

H

H

H

H

H

H

H

H

H

H

H

H

H

H

H

C

C

C

H

H

H

C

C

C

C

C

C

H

H

H

H

H

H

H

H

H

H

H

H

H

H

H

H

H

H

H

CORE

0

0

0

1

0

0

1

6

2

0

0

5

0

0

0

0

3

0

0

0

0

0

0

0

0

2

2

0

0

0

0

6

2

0

0

6

2

0

0

0

1

0

0

0

3

0

0

5

3

0

TRAD_H_PSS

H

H

H

H

H

H

H

H

H

H

H

C

C

C

.

.

.

C

C

.

C

E

E

E

E

E

C

C

C

H

H

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

TRAD_H_Seq

X

X

X

X

X

X

X

X

X

X

X

X

X

H

.

.

.

S

V

.

P

L

Q

L

E

L

R

A

G

A

E

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

-------

+

+

P

-

L

E

-

-

-

-

+

1wer-0_Seq

H

A

L

K

D

S

I

L

K

I

M

E

S

K

Q

S

C

E

L

S

P

S

K

L

E

K

N

E

D

V

N

T

N

L

T

H

L

L

N

I

L

S

E

L

V

E

K

I

F

M

1wer-0_SS

H

H

H

H

H

H

H

H

H

H

H

H

C

C

C

C

C

C

C

C

H

H

H

C

C

C

C

C

C

H

H

H

H

H

H

H

H

H

H

H

H

H

H

H

H

H

H

H

H

H

CORE

0

2

7

0

0

1

3

1

0

3

1

0

0

0

0

0

2

0

4

0

0

0

0

0

0

0

0

0

0

0

0

0

0

2

0

0

6

2

0

2

6

0

0

6

3

0

0

7

2

0

TRAD_H_PSS

.

.

.

H

H

H

H

H

C

C

C

C

H

H

H

H

H

H

H

H

H

.

C

C

C

C

C

H

H

H

H

H

H

H

H

H

H

E

E

E

E

E

E

E

C

C

C

C

C

C

TRAD_H_Seq

.

.

.

R

L

D

A

L

L

A

D

E

E

R

C

L

S

C

I

L

A

.

Q

Q

P

X

X

X

X

X

X

X

X

X

X

X

X

X

X

X

X

N

L

K

C

G

S

G

A

R

-------

+

L

-

-

L

-

+

-

-

+

C

L

-

+

-

+

+

+

-

P

L

-

C

-

-

-

-

1wer-0_Seq

A

S

E

I

L

P

P

T

L

R

Y

I

Y

G

C

L

Q

K

S

V

Q

H

K

W

P

T

N

T

T

M

R

T

R

V

V

S

G

F

V

F

L

R

L

I

C

P

A

I

L

N

1wer-0_SS

C

H

H

H

C

C

H

H

H

H

H

H

H

H

H

H

H

H

H

H

H

H

H

C

C

C

C

C

H

H

H

H

H

H

H

H

H

H

H

H

C

C

C

H

H

H

H

H

H

C

CORE

2

1

0

1

4

0

0

0

1

0

0

1

1

0

0

3

0

0

0

2

0

0

0

0

0

0

0

0

0

1

0

0

0

3

1

1

0

2

6

5

0

0

4

7

3

0

5

7

0

0

TRAD_H_PSS

C

C

C

C

C

C

C

C

C

C

H

H

H

H

H

H

H

H

H

H

H

H

H

H

H

H

H

H

H

H

H

E

E

E

E

E

C

C

C

C

C

C

C

C

C

C

C

C

H

H

TRAD_H_Seq

G

G

D

G

E

V

A

S

A

P

L

Q

X

X

X

X

X

X

X

X

X

X

X

X

X

X

X

X

X

A

Q

T

F

L

F

Q

G

Q

P

V

V

N

R

P

L

S

L

K

D

Q

-------

-

-

-

-

+

-

S

-

-

-

A

-

+

-

-

+

P

-

-

-

1wer-0_Seq

P

R

M

F

N

I

I

S

D

S

P

S

P

I

A

A

R

T

L

I

L

V

A

K

S

V

Q

N

L

A

N

.

.

.

.

L

V

E

F

G

A

K

E

P

.

Y

M

E

G

V

1wer-0_SS

C

C

C

C

C

C

C

C

C

C

C

C

H

H

H

H

H

H

H

H

H

H

H

H

H

H

H

H

H

H

H

.

.

.

.

C

C

C

C

C

C

C

C

H

.

H

H

H

H

H

CORE

1

0

0

1

0

4

0

0

0

0

0

0

0

0

1

0

0

1

3

0

3

7

3

0

5

9

0

0

2

2

0

.

.

.

.

0

0

0

2

0

0

0

0

0

.

0

3

0

0

6

TRAD_H_PSS

H

H

H

H

H

H

C

C

H

H

H

H

H

H

H

H

H

H

H

H

C

C

C

C

C

C

C

C

C

C

C

C

H

H

H

H

C

C

C

C

C

H

H

H

H

H

H

H

H

H

TRAD_H_Seq

Q

T

F

A

R

S

V

G

L

K

W

R

K

V

G

R

S

L

Q

R

G

C

R

A

L

R

D

P

A

L

D

S

L

A

Y

E

Y

E

R

E

G

L

Y

E

Q

A

F

Q

L

L

-------

F

-

+

S

-

-

-

+

+

-

-

-

L

-

-

+

-

+

-

-

-

-

-

+

-

-

-

-

-

-

L

E

-

-

-

+

1wer-0_Seq

N

P

F

I

K

S

N

K

H

R

M

I

M

F

L

D

E

L

G

N

V

P

E

L

P

D

T

T

E

H

S

R

T

D

L

S

R

D

L

A

A

L

H

E

I

C

V

A

H

S

1wer-0_SS

H

H

H

H

H

H

H

H

H

H

H

H

H

H

H

H

H

H

C

C

C

C

C

C

C

C

C

C

C

C

C

C

C

C

H

H

H

H

H

H

H

H

H

H

H

H

H

H

H

H

CORE

0

0

2

1

0

0

0

0

0

0

2

0

0

4

3

0

0

3

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

1

0

0

0

3

0

0

7

0

0

3

3

0

0

0

0

TRAD_H_PSS

H

H

H

H

H

H

C

C

C

C

C

H

H

H

H

H

H

H

H

H

H

H

H

H

H

H

H

H

H

H

H

H

H

C

C

C

C

C

C

C

C

C

C

TRAD_H_Seq

R

R

F

V

Q

A

E

G

R

R

A

T

L

Q

R

L

V

E

A

L

E

E

N

E

L

T

S

L

A

E

D

L

L

G

L

T

D

P

N

G

G

L

A

-------

-

-

+

-

-

R

-

-

Q

-

L

-

+

-

L

+

+

-

-

-

-

-

T

1wer-0_Seq

D

E

L

R

T

L

S

N

E

R

G

A

Q

Q

H

V

L

K

K

L

L

.

A

I

T

E

L

L

Q

Q

K

Q

N

Q

Y

T

.

.

.

.

.

.

.

1wer-0_SS

H

H

H

H

H

H

H

H

C

C

C

H

H

H

H

H

H

H

H

H

H

.

H

H

H

H

H

H

H

H

H

H

H

C

C

C

.

.

.

.

.

.

.

CORE

0

0

4

0

0

1

0

0

0

0

0

0

0

0

0

1

2

0

0

3

1

.

0

1

1

0

0

0

0

0

0

0

0

0

0

0

.

.

.

.

.

.

.