Alignment of TRAD_HUMAN_whole with 1toh-0

Alignment of TRAD_HUMAN_whole with 1toh-0

PSSM Score Key
-10																			10

Bad																			Good

TRAD_H_PSS	Predicted Secondary Structure for your Sequence
TRAD_H_Seq	Your Sequence
1toh-0_Seq	Library Sequence
1toh-0_SS	Known Secondary Structure of the Library Sequence (Assigned by STRIDE)
CORE	A measure of the burial and number of contacts made by a residue. (9 very buried/making many contacts, 0 not buried/making few contacts

TRAD_H_PSS

C

C

C

C

C

C

C

H

H

H

H

E

E

E

E

E

E

E

E

E

C

H

H

H

H

H

H

H

H

C

C

C

C

C

C

H

H

H

H

H

H

H

H

H

.

.

.

.

.

H

TRAD_H_Seq

M

A

A

G

Q

N

G

H

E

E

W

V

G

S

A

Y

L

F

V

E

S

S

L

D

K

V

V

L

S

D

A

Y

A

H

P

Q

Q

K

V

A

V

Y

R

A

.

.

.

.

.

L

-------

-

-

-

-

-

-

+

-

L

D

K

-

D

+

-

H

P

-

-

+

-

V

Y

R

+

-

1toh-0_Seq

K

V

P

W

F

P

R

K

V

S

.

.

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.

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E

L

D

K

.

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.

C

D

L

.

D

H

P

G

F

S

D

Q

V

Y

R

Q

R

R

K

L

I

A

1toh-0_SS

C

C

C

C

C

C

C

E

H

H

.

.

.

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.

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.

H

H

H

H

.

.

.

C

C

C

.

C

C

C

C

C

C

C

H

H

H

H

H

H

H

H

H

H

H

CORE

0

0

0

0

3

1

0

0

1

0

.

.

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.

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.

.

.

.

.

.

0

2

0

0

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.

.

0

0

0

.

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

TRAD_H_PSS

H

H

H

H

H

C

C

C

C

C

C

.

.

.

.

.

.

.

.

.

C

H

H

H

H

H

H

H

H

C

C

C

C

E

E

E

E

E

E

H

H

H

C

C

C

H

H

H

H

H

TRAD_H_Seq

Q

A

A

L

A

E

S

G

G

S

P

.

.

.

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.

.

.

D

V

L

Q

M

L

K

I

H

R

S

D

P

Q

L

I

V

Q

L

R

F

C

G

R

Q

P

C

G

R

F

-------

-

A

+

-

-

G

P

+

+

-

-

-

-

-

+

+

-

G

-

-

+

-

+

-

1toh-0_Seq

E

I

A

F

Q

Y

K

H

G

E

P

I

P

H

V

E

Y

T

A

E

E

I

A

T

W

K

E

V

Y

V

.

.

.

.

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.

T

L

K

G

L

Y

A

T

.

H

A

1toh-0_SS

H

H

H

H

H

C

C

C

C

C

C

C

C

C

C

C

C

C

H

H

H

H

H

H

H

H

H

H

H

H

.

.

.

.

.

.

.

.

.

H

H

H

H

H

H

H

H

.

H

E

CORE

0

1

0

0

0

0

0

0

0

0

0

5

0

0

0

0

0

0

0

0

0

0

0

0

1

0

0

0

0

0

.

.

.

.

.

.

.

.

.

0

1

0

0

1

1

0

0

.

0

1

TRAD_H_PSS

H

H

H

H

H

H

C

C

C

C

H

H

H

H

H

H

H

H

H

H

H

C

C

C

C

C

C

E

E

E

E

E

C

C

C

H

H

H

H

H

H

H

C

C

C

C

H

H

H

H

TRAD_H_Seq

L

R

A

Y

R

E

G

X

X

X

X

X

X

X

X

X

X

X

X

X

X

X

X

H

S

V

P

L

Q

L

E

L

R

A

G

A

E

R

L

D

A

L

L

A

D

E

E

R

C

L

-------

-

R

-

+

+

E

-

S

+

P

-

-

E

-

-

L

+

+

-

1toh-0_Seq

C

R

E

H

L

E

.

.

.

.

G

F

Q

L

L

E

R

Y

C

G

Y

R

E

D

S

I

P

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.

Q

L

E

D

V

S

R

F

L

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K

E

R

T

1toh-0_SS

C

H

H

H

H

H

.

.

.

.

H

H

H

H

H

H

H

H

H

C

C

E

C

C

E

C

C

.

.

.

.

.

.

.

C

H

H

H

H

H

H

H

H

.

.

.

H

H

H

H

CORE

1

0

0

0

0

0

.

.

.

.

0

1

0

0

3

0

0

0

1

0

2

0

0

0

0

3

2

.

.

.

.

.

.

.

0

6

0

0

7

3

0

1

5

.

.

.

0

0

0

0

TRAD_H_PSS

H

H

H

H

H

C

C

C

C

C

H

H

H

H

H

H

H

H

H

H

E

E

E

E

E

E

E

C

C

C

C

C

C

C

C

C

C

C

C

C

C

C

C

H

H

H

H

H

H

H

TRAD_H_Seq

S

C

I

L

A

Q

Q

P

X

X

X

X

X

X

X

X

X

X

X

X

X

X

X

X

N

L

K

C

G

S

G

A

R

G

G

D

G

E

V

A

S

A

P

L

Q

X

X

X

X

X

-------

-

-

L

-

-

-

-

C

-

-

-

R

-

-

-

-

S

-

-

-

1toh-0_Seq

G

F

Q

L

R

P

V

A

G

L

L

S

A

R

D

F

L

A

S

L

A

F

R

V

.

F

Q

C

T

Q

Y

I

R

H

A

S

S

P

M

H

S

P

E

P

D

C

C

H

E

L

1toh-0_SS

C

C

E

E

E

E

C

C

C

C

C

C

H

H

H

H

H

H

H

H

H

C

C

E

.

E

E

E

C

C

C

C

C

C

C

C

C

C

C

C

C

C

C

C

C

H

H

H

H

H

CORE

0

2

0

9

0

2

0

0

0

0

0

0

1

0

0

0

4

3

1

2

5

2

0

1

.

3

0

4

0

0

0

2

0

0

0

0

0

0

0

0

0

0

0

0

0

1

1

0

0

7

TRAD_H_PSS

H

H

H

H

H

H

H

H

H

H

H

H

H

H

E

E

E

E

E

C

C

C

C

C

C

C

C

C

C

C

C

H

H

H

H

H

H

H

H

C

C

H

H

H

.

.

.

.

.

.

TRAD_H_Seq

X

X

X

X

X

X

X

X

X

X

X

X

A

Q

T

F

L

F

Q

G

Q

P

V

V

N

R

P

L

S

L

K

D

Q

Q

T

F

A

R

S

V

G

L

K

W

.

.

.

.

.

.

-------

A

Q

F

Q

-

+

-

-

-

-

L

-

-

D

-

-

-

-

S

+

-

W

1toh-0_Seq

L

G

H

V

P

M

L

A

D

R

T

F

A

Q

.

.

.

F

S

.

Q

D

I

G

L

A

S

L

G

A

S

D

E

E

I

E

K

L

S

T

.

V

Y

W

F

T

V

E

F

G

1toh-0_SS

H

H

H

H

H

H

H

H

C

H

H

H

H

H

.

.

.

H

H

.

H

H

H

H

H

H

H

C

C

C

C

H

H

H

H

H

H

H

H

H

.

H

H

H

H

C

C

C

C

C

CORE

2

1

0

6

0

2

3

2

0

0

0

1

1

0

.

.

.

2

2

.

0

0

5

2

3

2

2

4

1

1

0

0

0

0

2

0

0

4

1

0

.

5

1

0

0

2

3

0

1

3

TRAD_H_PSS		.	.	.	.	.	.	.	.	.	.		.	.	.	.	.	.	.	.	.	H		H	H	H	H	H	H	H	H	C	C		.	.	.	.	.	.	.	.	C	C		C	C	C	C	C	C	C	C	H	H
TRAD_H_Seq		.	.	.	.	.	.	.	.	.	.		.	.	.	.	.	.	.	.	.	R		K	V	G	R	S	L	Q	R	G	C		.	.	.	.	.	.	.	.	R	A		L	R	D	P	A	L	D	S	L	A
-------																						-				-	-	S	L		-	-	+											A		-	-		P	-	+	D
1toh-0_Seq		L	C	K	Q	N	G	E	L	K	A		Y	G	A	G	L	L	S	S	Y	G		E	L	L	H	S	L	S	E	E	P		E	V	R	A	F	D	P	D	T	A		A	V	Q	P	Y	Q	D	Q	.	.
1toh-0_SS		E	E	E	E	C	C	E	E	E	E		C	C	H	H	H	H	H	C	H	H		H	H	H	H	H	H	C	C	C	C		E	E	E	E	C	C	H	H	H	H		H	H	C	C	C	C	C	C	.	.
CORE		7	1	0	0	0	0	0	3	0	9		1	0	0	0	7	4	0	0	0	0		0	5	0	0	5	2	0	0	0	0		0	3	0	0	3	0	1	0	0	3		2	0	0	0	0	0	0	0	.	.

TRAD_H_PSS

H

H

C

C

C

.

.

.

.

.

C

C

H

H

H

H

H

H

H

H

H

H

H

H

H

H

H

C

C

C

.

.

.

.

.

.

.

.

.

C

C

H

H

H

H

H

.

H

H

H

TRAD_H_Seq

Y

E

Y

E

R

.

.

.

.

.

E

G

L

Y

E

Q

A

F

Q

L

L

R

R

F

V

Q

A

E

G

R

.

.

.

.

.

.

.

.

.

R

A

T

L

Q

R

L

.

V

E

A

-------

+

Y

+

-

E

+

+

A

-

+

-

L

R

+

-

R

-

-

+

+

-

L

-

-

1toh-0_Seq

.

T

Y

Q

P

V

Y

F

V

S

E

S

.

F

N

D

A

K

D

K

L

R

N

Y

A

S

R

I

Q

R

P

F

S

V

K

F

D

P

Y

T

L

A

I

D

V

L

D

S

P

H

1toh-0_SS

.

C

C

C

C

E

E

E

E

E

C

C

.

H

H

H

H

H

H

H

H

H

H

H

H

H

H

C

C

C

C

C

E

E

E

E

E

C

C

C

C

E

E

E

E

E

C

C

H

H

CORE

.

0

0

0

0

0

1

1

3

1

0

0

.

1

0

0

2

0

0

0

4

0

0

1

0

0

0

1

0

0

0

1

0

4

0

2

0

0

0

0

1

0

5

0

2

0

0

0

0

0

TRAD_H_PSS

H

H

H

H

H

H

H

H

H

H

H

H

H

H

C

C

C

C

C

C

C

C

C

C

TRAD_H_Seq

L

E

E

N

E

L

T

S

L

A

E

D

L

L

G

L

T

D

P

N

G

G

L

A

-------

-

-

+

+

-

L

-

+

+

-

+

+

L

-

-

L

+

+

-

-

+

-

+

1toh-0_Seq

T

I

Q

R

S

L

E

G

V

Q

D

E

L

H

T

L

A

H

A

L

S

A

I

S

1toh-0_SS

H

H

H

H

H

H

H

H

H

H

H

H

H

H

H

H

H

H

H

H

H

H

H

C

CORE

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0