Alignment of TRAD_HUMAN_whole with 1aoa-0

Alignment of TRAD_HUMAN_whole with 1aoa-0

PSSM Score Key
-10																			10

Bad																			Good

TRAD_H_PSS	Predicted Secondary Structure for your Sequence
TRAD_H_Seq	Your Sequence
1aoa-0_Seq	Library Sequence
1aoa-0_SS	Known Secondary Structure of the Library Sequence (Assigned by STRIDE)
CORE	A measure of the burial and number of contacts made by a residue. (9 very buried/making many contacts, 0 not buried/making few contacts

TRAD_H_PSS		C	C	C	C	C	C	C	H	H	H		H	E	E	E	E	E	E	E	E	E		C	H	H	H	H	H	H	H	H	C		C	C	C	C	C	H	H	H	H	H		H	H	H	H	H	H	H	H	H	H
TRAD_H_Seq		M	A	A	G	Q	N	G	H	E	E		W	V	G	S	A	Y	L	F	V	E		S	S	L	D	K	V	V	L	S	D		A	Y	A	H	P	Q	Q	K	V	A		V	Y	R	A	L	Q	A	A	L	A
-------							-			E	E																															K	+	A		-	-		-	+		-	A	L	+
1aoa-0_Seq		.	.	.	.	.	Y	S	E	E	E		.	.	.	.	.	.	.	.	.	.		.	.	.	.	.	.	.	.	.	.		.	.	.	.	.	.	.	K	Y	A		F	V	N	W	I	N	K	A	L	E
1aoa-0_SS		.	.	.	.	.	C	C	H	H	H		.	.	.	.	.	.	.	.	.	.		.	.	.	.	.	.	.	.	.	.		.	.	.	.	.	.	.	H	H	H		H	H	H	H	H	H	H	H	H	C
CORE		.	.	.	.	.	0	0	0	0	0		.	.	.	.	.	.	.	.	.	.		.	.	.	.	.	.	.	.	.	.		.	.	.	.	.	.	.	0	0	2		3	1	0	0	6	0	0	1	3	0

TRAD_H_PSS

C

C

C

C

C

C

C

H

H

.

.

.

.

.

.

.

H

H

H

H

H

H

C

C

C

.

.

.

.

.

.

.

.

.

.

.

C

E

E

E

E

E

E

H

H

H

C

C

C

H

TRAD_H_Seq

E

S

G

G

S

P

D

V

L

.

.

.

.

.

.

.

Q

M

L

K

I

H

R

S

D

.

.

.

.

.

.

.

.

.

.

.

P

Q

L

I

V

Q

L

R

F

C

G

R

Q

P

-------

-

-

-

-

+

V

+

+

+

K

-

-

+

-

P

-

I

-

+

R

-

-

+

+

1aoa-0_Seq

N

D

P

D

C

R

H

V

I

P

M

N

P

N

T

D

D

L

F

K

A

V

G

D

G

I

V

L

C

K

M

I

N

L

S

V

P

D

T

I

D

E

.

R

A

I

N

K

K

K

1aoa-0_SS

C

C

C

C

C

C

C

C

C

C

C

C

C

C

C

H

H

H

H

H

H

H

C

C

C

H

H

H

H

H

H

H

H

H

H

C

C

C

C

C

C

H

.

H

H

C

C

C

C

C

CORE

0

0

0

0

2

0

0

1

3

0

2

0

0

0

0

0

0

5

1

0

1

8

0

0

1

1

5

9

2

0

3

6

0

1

2

1

0

0

2

3

0

0

.

0

0

2

0

0

0

0

TRAD_H_PSS

H

H

H

H

H

H

H

H

H

H

C

C

C

C

H

H

H

H

H

H

H

H

H

H

H

C

C

C

C

C

C

E

E

E

E

E

C

C

C

H

H

H

H

H

H

H

C

C

C

C

TRAD_H_Seq

C

G

R

F

L

R

A

Y

R

E

G

X

X

X

X

X

X

X

X

X

X

X

X

X

X

X

X

H

S

V

P

L

Q

L

E

L

R

A

G

A

E

R

L

D

A

L

L

A

D

E

-------

-

-

-

F

-

+

-

-

-

H

-

V

-

-

G

A

E

+

L

-

A

-

1aoa-0_Seq

L

T

P

F

I

I

Q

E

N

L

.

.

.

.

.

N

L

A

L

N

S

A

S

A

I

G

C

H

V

V

N

.

.

.

.

.

.

I

G

A

E

D

L

R

A

.

.

.

.

G

1aoa-0_SS

C

C

H

H

H

H

H

H

H

H

.

.

.

.

.

H

H

H

H

H

H

H

H

H

H

C

C

C

C

C

C

.

.

.

.

.

.

C

C

H

H

H

H

H

H

.

.

.

.

C

CORE

0

0

0

0

0

0

0

0

0

4

.

.

.

.

.

0

2

6

5

0

2

8

0

0

4

0

4

0

3

0

0

.

.

.

.

.

.

4

0

3

0

0

9

0

0

.

.

.

.

1

TRAD_H_PSS

H

H

H

H

H

H

H

H

H

C

C

C

C

C

H

H

H

H

H

H

H

H

H

H

E

E

E

E

E

E

E

C

C

C

C

C

C

C

C

C

C

C

C

C

C

C

C

H

H

H

TRAD_H_Seq

E

R

C

L

S

C

I

L

A

Q

Q

P

X

X

X

X

X

X

X

X

X

X

X

X

X

X

X

X

N

L

K

C

G

S

G

A

R

G

G

D

G

E

V

A

S

A

P

L

Q

X

-------

+

-

L

+

L

+

L

+

-

-

-

-

L

1aoa-0_Seq

K

P

H

L

.

.

V

L

G

.

.

.

.

.

L

L

W

Q

I

I

K

I

G

L

F

A

D

I

E

L

S

.

.

.

.

.

.

.

.

.

.

R

N

E

A

L

T

L

E

E

1aoa-0_SS

C

H

H

H

.

.

H

H

H

.

.

.

.

.

H

H

H

H

H

H

H

H

H

H

H

H

H

H

H

C

C

.

.

.

.

.

.

.

.

.

.

C

C

C

C

C

C

H

H

H

CORE

0

0

0

0

.

.

5

2

0

.

.

.

.

.

8

6

0

0

7

3

0

2

0

2

0

0

0

1

0

0

0

.

.

.

.

.

.

.

.

.

.

0

0

0

0

0

0

0

0

0

TRAD_H_PSS

H

H

H

H

H

H

H

H

H

H

H

H

H

H

H

H

H

H

E

E

E

E

E

C

C

C

C

C

C

C

C

C

C

C

C

H

H

H

H

H

H

H

H

C

C

H

H

H

H

H

TRAD_H_Seq

X

X

X

X

X

X

X

X

X

X

X

X

X

X

X

X

A

Q

T

F

L

F

Q

G

Q

P

V

V

N

R

P

L

S

L

K

D

Q

Q

T

F

A

R

S

V

G

L

K

W

R

K

-------

-

-

-

-

-

-

Q

-

+

-

N

-

-

-

+

K

D

-

+

+

+

-

1aoa-0_Seq

L

M

K

L

S

P

E

E

L

L

L

R

W

A

N

F

H

L

E

.

N

S

G

W

Q

K

I

N

N

F

S

A

D

I

K

D

S

K

A

Y

F

H

.

.

.

.

.

.

.

.

1aoa-0_SS

H

H

H

C

C

H

H

H

H

H

H

H

H

H

H

H

H

H

H

.

H

C

C

C

C

C

C

C

C

C

C

C

C

C

C

C

C

H

H

H

H

H

.

.

.

.

.

.

.

.

CORE

0

0

0

0

0

0

0

0

0

2

1

0

0

2

0

0

0

1

0

.

0

0

0

0

0

0

2

0

0

2

0

0

0

3

0

0

2

0

2

1

1

0

.

.

.

.

.

.

.

.

TRAD_H_PSS

H

H

H

H

H

H

H

C

C

C

C

C

C

C

C

C

C

C

C

H

H

H

H

C

C

C

C

C

H

H

H

H

H

H

H

H

H

H

H

H

H

H

H

C

C

C

C

.

C

H

TRAD_H_Seq

V

G

R

S

L

Q

R

G

C

R

A

L

R

D

P

A

L

D

S

L

A

Y

E

Y

E

R

E

G

L

Y

E

Q

A

F

Q

L

L

R

R

F

V

Q

A

E

G

R

R

.

A

T

-------

-

+

-

-

-

-

-

-

-

P

+

+

D

-

-

-

-

-

-

+

-

+

A

-

+

L

-

-

-

-

-

R

+

-

T

1aoa-0_Seq

L

L

N

Q

I

A

P

K

G

Q

K

E

G

E

P

R

I

D

I

N

M

S

G

F

N

E

T

D

D

L

K

R

A

E

S

M

L

Q

Q

A

D

K

L

G

C

R

Q

F

V

T

1aoa-0_SS

H

H

H

H

H

C

C

C

C

C

C

C

C

C

C

C

C

C

C

C

C

C

C

C

C

C

C

C

H

H

H

H

H

H

H

H

H

H

H

H

H

H

H

C

C

C

C

C

C

C

CORE

2

3

0

0

0

2

0

0

0

0

0

0

0

0

0

0

1

0

2

0

0

0

0

0

0

0

0

0

0

0

0

0

3

0

0

3

2

0

0

3

0

0

2

0

1

0

0

3

3

0

TRAD_H_PSS

H

H

H

H

H

H

H

H

H

H

H

H

H

H

H

H

H

H

H

H

H

C

C

C

C

C

C

C

C

C

C

TRAD_H_Seq

L

Q

R

L

V

E

A

L

E

E

N

E

L

T

S

L

A

E

D

L

L

G

L

T

D

P

N

G

G

L

A

-------

-

+

-

+

V

+

+

-

+

-

L

-

+

A

L

1aoa-0_Seq

P

A

D

V

V

S

G

N

P

K

L

N

L

A

F

V

A

.

N

L

F

N

.

.

.

.

.

.

.

.

.

1aoa-0_SS

H

H

H

H

H

H

C

C

H

H

H

H

H

H

H

H

H

.

H

H

H

C

.

.

.

.

.

.

.

.

.

CORE

0

0

0

5

0

0

0

0

0

0

2

0

1

2

3

2

2

.

0

2

0

0

.

.

.

.

.

.

.

.

.