Alignment of TRAD_HUMAN_whole with 1ak1-0

Alignment of TRAD_HUMAN_whole with 1ak1-0

PSSM Score Key
-10																			10

Bad																			Good

TRAD_H_PSS	Predicted Secondary Structure for your Sequence
TRAD_H_Seq	Your Sequence
1ak1-0_Seq	Library Sequence
1ak1-0_SS	Known Secondary Structure of the Library Sequence (Assigned by STRIDE)
CORE	A measure of the burial and number of contacts made by a residue. (9 very buried/making many contacts, 0 not buried/making few contacts

TRAD_H_PSS

.

.

.

.

.

.

.

.

C

C

C

C

C

C

C

H

H

H

H

E

E

E

E

E

E

E

E

E

C

H

H

H

H

H

H

H

H

C

C

C

C

C

C

H

H

H

H

H

H

H

TRAD_H_Seq

.

.

.

.

.

.

.

.

M

A

A

G

Q

N

G

H

E

E

W

V

G

S

A

Y

L

F

V

E

S

S

L

D

K

V

V

L

S

D

A

Y

A

H

P

Q

Q

K

V

A

V

Y

-------

M

A

-

G

-

-

-

+

E

E

-

+

-

+

-

-

-

-

-

+

-

-

-

P

-

+

+

-

-

-

-

1ak1-0_Seq

R

K

K

M

G

L

L

V

M

A

Y

G

T

P

Y

K

E

E

D

I

.

.

.

.

.

.

.

.

.

.

E

R

Y

Y

T

H

I

R

R

G

R

K

P

E

P

E

M

L

Q

D

1ak1-0_SS

C

E

E

E

E

E

E

E

E

E

C

C

C

C

C

C

H

H

H

H

.

.

.

.

.

.

.

.

.

.

H

H

H

H

H

H

H

H

C

C

C

C

C

C

H

H

H

H

H

H

CORE

0

0

0

3

5

9

6

6

2

2

0

0

0

0

0

0

0

0

0

0

.

.

.

.

.

.

.

.

.

.

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

TRAD_H_PSS

H

H

H

H

H

H

H

H

C

C

C

C

C

C

.

.

.

.

.

.

.

.

.

.

C

H

H

H

H

H

H

H

H

C

C

C

C

E

E

E

E

E

E

H

H

H

C

C

C

H

TRAD_H_Seq

R

A

L

Q

A

A

L

A

E

S

G

G

S

P

.

.

.

.

.

.

.

.

.

.

D

V

L

Q

M

L

K

I

H

R

S

D

P

Q

L

I

V

Q

L

R

F

C

G

R

Q

P

-------

-

-

-

+

-

+

-

G

+

S

P

-

-

Q

-

L

-

+

-

-

-

-

+

-

-

+

-

-

-

P

1ak1-0_Seq

L

K

D

R

Y

E

A

I

.

G

G

I

S

P

L

A

Q

I

T

E

Q

Q

A

H

N

L

E

Q

H

L

N

E

I

Q

D

E

I

T

F

K

A

Y

I

G

L

K

H

I

E

P

1ak1-0_SS

H

H

H

H

H

H

H

H

.

C

C

H

H

H

H

H

H

H

H

H

H

H

H

H

H

H

H

H

H

H

H

H

H

C

C

C

E

E

E

E

E

E

E

E

E

C

C

C

C

C

CORE

0

0

0

0

0

0

0

0

.

0

0

0

0

0

0

0

0

0

1

0

0

0

4

0

0

8

1

0

0

5

0

0

1

0

0

0

1

0

6

0

6

1

2

2

1

0

0

0

0

0

TRAD_H_PSS

.

.

H

H

H

H

H

H

H

H

H

H

C

C

C

.

.

.

.

.

.

.

.

.

.

.

.

.

.

C

H

H

H

H

H

H

H

H

H

H

H

C

C

C

C

C

C

E

E

E

TRAD_H_Seq

.

.

C

G

R

F

L

R

A

Y

R

E

G

X

X

.

.

.

.

.

.

.

.

.

.

.

.

.

.

X

X

X

X

X

X

X

X

X

X

X

X

X

X

H

S

V

P

L

Q

L

-------

-

-

-

-

-

-

-

+

+

G

-

-

L

+

1ak1-0_Seq

F

I

E

D

A

V

A

E

M

H

K

D

G

I

T

E

A

V

S

I

V

L

A

P

H

F

S

T

F

S

V

Q

S

Y

N

K

R

A

K

E

E

A

E

K

L

G

G

L

T

I

1ak1-0_SS

E

H

H

H

H

H

H

H

H

H

H

H

C

C

C

E

E

E

E

E

E

C

C

C

C

C

C

C

C

C

H

H

H

H

H

H

H

H

H

H

H

H

H

H

H

C

C

C

E

E

CORE

0

2

0

0

2

6

0

0

5

0

0

0

0

3

0

0

6

9

3

8

0

4

0

1

0

0

0

0

0

0

0

0

0

0

0

0

0

7

0

0

0

5

0

0

1

0

0

4

0

7

TRAD_H_PSS

E

E

C

C

C

H

H

H

H

H

H

H

C

C

C

C

H

H

H

H

H

H

H

H

H

C

C

C

C

C

H

H

H

H

H

H

H

H

H

H

E

E

E

E

E

E

E

C

C

C

TRAD_H_Seq

E

L

R

A

G

A

E

R

L

D

A

L

L

A

D

E

E

R

C

L

S

C

I

L

A

Q

Q

P

X

X

X

X

X

X

X

X

X

X

X

X

X

X

X

X

N

L

K

C

G

S

-------

+

+

-

-

D

E

+

-

-

+

+

+

+

-

-

-

+

-

+

-

-

1ak1-0_Seq

T

S

.

.

.

.

.

.

V

E

S

.

W

Y

D

E

P

K

F

V

T

Y

.

W

V

D

R

V

K

E

T

Y

A

S

M

P

E

D

E

R

E

N

A

M

L

I

V

S

A

H

1ak1-0_SS

E

E

.

.

.

.

.

.

C

C

C

.

C

C

C

C

H

H

H

H

H

H

.

H

H

H

H

H

H

H

H

H

H

H

C

C

H

H

H

H

H

H

E

E

E

E

E

E

E

E

CORE

1

0

.

.

.

.

.

.

4

0

0

.

1

0

0

0

0

0

1

1

0

0

.

1

1

0

0

4

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

1

5

3

6

1

2

0

TRAD_H_PSS

C

C

C

C

C

C

C

C

C

C

C

C

C

H

H

H

H

H

H

H

H

H

H

H

H

H

H

H

H

H

H

H

H

H

E

E

E

E

E

C

C

C

C

C

C

C

C

C

C

C

TRAD_H_Seq

G

A

R

G

G

D

G

E

V

A

S

A

P

L

Q

X

X

X

X

X

X

X

X

X

X

X

X

X

X

X

X

X

A

Q

T

F

L

F

Q

G

Q

P

V

V

N

R

P

L

S

L

-------

+

-

-

-

-

-

-

E

-

-

P

-

+

-

+

-

+

Q

-

+

-

-

-

P

-

-

-

1ak1-0_Seq

S

L

P

E

K

I

K

E

.

F

G

D

P

Y

P

D

Q

L

H

E

S

A

K

L

I

A

E

G

A

G

V

S

E

Y

A

V

G

W

Q

S

E

G

N

T

P

D

P

W

L

G

1ak1-0_SS

C

C

E

H

H

H

H

H

.

H

C

C

H

H

H

H

H

H

H

H

H

H

H

H

H

H

H

H

H

C

C

C

C

E

E

E

E

E

E

C

C

C

C

C

C

C

C

E

C

C

CORE

0

0

0

0

0

0

0

0

.

0

0

0

0

0

0

0

0

4

0

0

1

3

0

0

6

2

0

0

1

0

2

0

0

1

3

2

2

0

0

0

0

0

0

0

0

0

0

0

1

0

TRAD_H_PSS

C

H

H

H

H

H

H

H

H

C

C

H

H

H

H

H

H

H

H

H

H

H

H

C

C

C

.

.

.

.

C

C

C

C

C

C

C

C

C

H

H

H

H

C

C

C

C

C

H

H

TRAD_H_Seq

K

D

Q

Q

T

F

A

R

S

V

G

L

K

W

R

K

V

G

R

S

L

Q

R

G

C

R

.

.

.

.

A

L

R

D

P

A

L

D

S

L

A

Y

E

Y

E

R

E

G

L

Y

-------

-

D

-

Q

-

-

-

R

+

-

-

Q

+

G

-

+

-

-

-

-

-

D

-

L

-

-

-

Y

+

-

+

-

-

+

1ak1-0_Seq

P

D

V

Q

D

L

T

R

D

.

.

.

.

.

.

.

.

.

L

F

E

Q

K

G

Y

Q

A

F

V

Y

V

P

V

G

F

V

A

D

H

L

E

V

L

Y

D

N

D

Y

E

C

1ak1-0_SS

C

E

H

H

H

H

H

H

H

.

.

.

.

.

.

.

.

.

H

H

H

H

H

C

C

C

E

E

E

E

E

C

C

C

C

C

C

C

C

H

H

H

H

H

C

C

C

H

H

H

CORE

0

0

2

0

0

2

1

0

0

.

.

.

.

.

.

.

.

.

2

0

0

0

0

0

0

0

0

2

2

0

5

0

4

0

0

2

0

0

0

0

0

0

0

0

0

0

0

0

0

0

TRAD_H_PSS

H

H

H

H

H

H

H

H

H

H

H

H

H

C

C

C

C

C

H

H

H

H

H

H

H

H

H

H

H

H

H

H

H

H

H

H

H

H

H

H

C

C

C

C

C

C

C

C

C

C

TRAD_H_Seq

E

Q

A

F

Q

L

L

R

R

F

V

Q

A

E

G

R

R

A

T

L

Q

R

L

V

E

A

L

E

E

N

E

L

T

S

L

A

E

D

L

L

G

L

T

D

P

N

G

G

L

A

-------

+

-

+

+

-

-

+

+

-

-

+

R

-

+

+

+

-

+

-

+

-

-

L

+

+

-

+

-

L

G

-

1ak1-0_Seq

K

V

V

.

.

.

T

D

D

I

G

A

S

Y

Y

R

P

E

M

P

.

.

N

A

K

P

E

F

I

D

A

L

A

T

V

V

L

K

K

L

G

.

.

.

.

.

.

.

.

R

1ak1-0_SS

H

H

H

.

.

.

H

H

H

H

C

C

E

E

E

C

C

C

C

C

.

.

C

C

C

H

H

H

H

H

H

H

H

H

H

H

H

H

H

H

C

.

.

.

.

.

.

.

.

C

CORE

0

0

0

.

.

.

1

0

0

0

0

1

0

0

0

0

1

0

0

0

.

.

0

0

0

0

0

1

1

0

0

4

4

0

2

9

2

0

0

3

0

.

.

.

.

.

.

.

.

0