Alignment of TRAD_HUMAN_whole with 1ah7-0

Alignment of TRAD_HUMAN_whole with 1ah7-0

PSSM Score Key
-10																			10

Bad																			Good

TRAD_H_PSS	Predicted Secondary Structure for your Sequence
TRAD_H_Seq	Your Sequence
1ah7-0_Seq	Library Sequence
1ah7-0_SS	Known Secondary Structure of the Library Sequence (Assigned by STRIDE)
CORE	A measure of the burial and number of contacts made by a residue. (9 very buried/making many contacts, 0 not buried/making few contacts

TRAD_H_PSS

C

C

C

C

C

C

C

H

H

H

H

E

E

E

E

E

E

E

E

E

C

H

H

H

H

H

H

H

H

C

C

C

C

C

C

H

H

H

H

H

H

.

.

.

.

H

H

H

H

H

TRAD_H_Seq

M

A

A

G

Q

N

G

H

E

E

W

V

G

S

A

Y

L

F

V

E

S

S

L

D

K

V

V

L

S

D

A

Y

A

H

P

Q

Q

K

V

A

V

.

.

.

.

Y

R

A

L

Q

-------

-

+

+

-

H

E

-

V

+

S

-

+

+

V

+

+

D

+

-

+

-

-

-

Q

V

A

+

-

-

L

+

1ah7-0_Seq

W

S

.

A

E

D

K

H

K

E

G

V

N

S

H

L

W

I

V

N

R

A

I

D

.

I

M

S

R

N

T

T

L

V

K

Q

D

R

V

A

Q

L

N

E

W

R

T

E

L

E

1ah7-0_SS

C

C

.

E

C

C

C

C

C

C

C

C

E

H

H

H

H

H

H

H

H

H

H

H

.

H

H

H

H

C

C

C

C

C

C

H

H

H

H

H

H

H

H

H

H

H

H

H

H

H

CORE

0

0

.

0

0

0

0

0

0

0

0

0

0

0

0

1

0

2

8

0

0

6

7

0

.

2

6

0

0

0

0

0

0

3

0

0

0

0

4

0

0

9

0

0

0

0

0

0

9

0

TRAD_H_PSS

.

.

H

H

H

H

C

C

C

C

C

C

C

H

H

H

H

H

H

H

H

C

C

C

C

.

.

.

.

.

.

.

E

E

E

E

E

E

H

H

H

C

C

C

H

H

H

H

H

H

TRAD_H_Seq

.

.

A

A

L

A

E

S

G

G

S

P

D

V

L

Q

M

L

K

I

H

R

S

D

P

.

.

.

.

.

.

.

Q

L

I

V

Q

L

R

F

C

G

R

Q

P

C

G

R

F

L

-------

-

-

A

+

-

-

-

-

-

-

-

-

H

-

-

D

P

-

-

-

Q

-

+

-

-

G

+

-

-

-

-

-

-

1ah7-0_Seq

N

G

I

Y

A

A

D

Y

E

N

P

Y

Y

D

N

S

T

F

A

S

H

F

Y

D

P

D

N

G

K

T

Y

I

P

F

A

K

Q

A

K

E

T

G

A

K

Y

F

K

L

A

G

1ah7-0_SS

H

H

H

H

H

H

C

C

C

C

C

C

C

H

H

H

C

C

H

H

H

C

C

E

C

C

C

C

E

C

C

C

C

C

C

C

C

H

H

H

H

H

H

H

H

H

H

H

H

H

CORE

0

1

4

0

1

1

0

0

0

0

0

0

0

0

0

0

0

0

1

0

0

0

1

0

0

0

0

0

0

0

0

0

0

0

0

0

0

3

0

0

0

1

2

0

0

2

0

0

2

0

TRAD_H_PSS

H

H

H

H

H

C

C

C

C

H

H

H

H

H

H

H

H

H

H

H

C

C

C

C

C

C

E

E

E

E

E

C

C

C

H

H

H

H

H

H

H

C

C

C

C

H

H

H

H

H

TRAD_H_Seq

R

A

Y

R

E

G

X

X

X

X

X

X

X

X

X

X

X

X

X

X

X

X

H

S

V

P

L

Q

L

E

L

R

A

G

A

E

R

L

D

A

L

L

A

D

E

E

R

C

L

S

-------

-

Y

+

+

+

H

-

-

-

+

-

-

-

-

-

1ah7-0_Seq

E

S

Y

K

N

K

D

.

.

.

M

K

Q

A

F

F

Y

L

G

L

S

L

H

.

.

.

.

.

.

.

.

.

.

.

.

.

.

Y

L

G

D

V

N

Q

P

M

H

A

A

N

1ah7-0_SS

H

H

H

H

H

C

C

.

.

.

H

H

H

H

H

H

H

H

H

H

H

H

H

.

.

.

.

.

.

.

.

.

.

.

.

.

.

H

H

H

H

H

H

C

H

H

H

H

C

C

CORE

0

0

0

0

0

0

0

.

.

.

0

0

0

0

4

0

0

5

2

1

1

8

0

.

.

.

.

.

.

.

.

.

.

.

.

.

.

0

4

0

0

4

0

0

1

2

0

2

0

0

TRAD_H_PSS

H

H

H

H

C

C

C

C

C

H

H

H

H

H

H

H

H

H

H

E

E

E

E

E

E

E

C

C

C

C

C

C

C

C

C

C

C

C

C

C

C

C

H

H

H

H

H

H

H

H

TRAD_H_Seq

C

I

L

A

Q

Q

P

X

X

X

X

X

X

X

X

X

X

X

X

X

X

X

X

N

L

K

C

G

S

G

A

R

G

G

D

G

E

V

A

S

A

P

L

Q

X

X

X

X

X

X

-------

-

-

-

P

N

-

K

-

-

D

G

-

+

+

-

-

-

-

1ah7-0_Seq

F

T

N

L

S

Y

P

Q

G

F

H

S

K

Y

E

N

F

V

D

T

I

K

D

N

Y

K

.

.

.

.

.

.

V

T

D

G

N

G

Y

W

N

W

K

G

T

N

P

E

E

W

1ah7-0_SS

C

C

C

C

C

C

C

C

C

H

H

H

H

H

H

H

H

H

H

H

H

H

H

H

C

C

.

.

.

.

.

.

C

C

C

C

C

C

C

C

C

C

C

C

C

C

H

H

H

H

CORE

1

0

0

0

0

0

0

0

0

3

0

0

0

1

0

0

0

1

0

0

0

0

0

0

0

0

.

.

.

.

.

.

0

0

0

0

0

1

0

1

0

0

0

0

0

0

1

0

0

1

TRAD_H_PSS		H	H	H	H	H	H	H	H	H	H		H	H	H	E	E	E	E	E	C	C		C	C	C	C	C	C	C	C	C	C		H	H	H	H	H	H	H	H	C	C		H	H	H	H	H	H	H	H	H	H
TRAD_H_Seq		X	X	X	X	X	X	X	X	X	X		X	A	Q	T	F	L	F	Q	G	Q		P	V	V	N	R	P	L	S	L	K		D	Q	Q	T	F	A	R	S	V	G		L	K	W	R	K	V	G	R	S	L
-------														-	-																																+		-	+		+		+
1ah7-0_Seq		I	H	G	A	A	V	V	A	K	Q		D	Y	S	G	.	.	.	.	.	.		.	.	.	.	.	.	.	.	.	.		.	.	.	.	.	.	.	.	.	.		I	V	N	D	N	T	K	D	W	.
1ah7-0_SS		H	H	H	H	H	H	H	H	H	H		H	H	H	H	.	.	.	.	.	.		.	.	.	.	.	.	.	.	.	.		.	.	.	.	.	.	.	.	.	.		C	C	C	H	H	H	H	H	H	.
CORE		4	0	0	4	3	0	0	1	0	0		0	0	0	0	.	.	.	.	.	.		.	.	.	.	.	.	.	.	.	.		.	.	.	.	.	.	.	.	.	.		3	2	0	0	0	1	0	0	0	.

TRAD_H_PSS

H

H

C

C

C

C

C

C

C

C

C

C

C

C

H

H

H

H

C

C

C

C

C

H

H

H

H

H

H

H

H

H

H

H

H

H

H

H

C

C

C

C

C

H

H

H

H

H

H

H

TRAD_H_Seq

Q

R

G

C

R

A

L

R

D

P

A

L

D

S

L

A

Y

E

Y

E

R

E

G

L

Y

E

Q

A

F

Q

L

L

R

R

F

V

Q

A

E

G

R

R

A

T

L

Q

R

L

V

E

-------

+

-

+

-

-

-

E

A

-

-

-

-

-

+

+

G

R

L

1ah7-0_Seq

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

F

V

K

A

A

V

S

.

Q

E

Y

A

D

K

W

R

A

E

V

T

P

M

T

G

.

.

.

.

.

K

R

L

M

D

1ah7-0_SS

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

H

H

H

H

H

C

C

.

H

H

H

H

H

H

H

H

H

H

H

H

H

H

H

H

.

.

.

.

.

H

H

H

H

H

CORE

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

0

0

0

0

0

0

0

.

0

0

0

0

0

0

0

0

0

0

3

0

0

1

1

0

.

.

.

.

.

0

0

1

0

0

TRAD_H_PSS

H

H

H

H

H

H

.

H

H

H

H

H

H

H

H

H

C

C

C

C

C

C

C

C

C

C

TRAD_H_Seq

A

L

E

E

N

E

.

L

T

S

L

A

E

D

L

L

G

L

T

D

P

N

G

G

L

A

-------

A

-

-

-

-

-

L

-

-

D

-

-

G

-

-

1ah7-0_Seq

A

Q

R

V

T

A

G

Y

I

Q

L

W

F

D

T

Y

G

.

.

.

.

.

.

.

D

R

1ah7-0_SS

H

H

H

H

H

H

H

H

H

H

H

H

H

H

H

H

H

.

.

.

.

.

.

.

C

C

CORE

1

0

0

3

5

6

0

2

9

0

1

1

3

0

0

0

0

.

.

.

.

.

.

.

0

0