Alignment of thymidine_kinase with 2at2A0

Alignment of thymidine_kinase with 2at2A0

PSSM Score Key
-10																			10

Bad																			Good

thymid_PSS	Predicted Secondary Structure for your Sequence
thymid_Seq	Your Sequence
2at2A0_Seq	Library Sequence
2at2A0_SS	Known Secondary Structure of the Library Sequence (Assigned by STRIDE)
CORE	A measure of the burial and number of contacts made by a residue. (9 very buried/making many contacts, 0 not buried/making few contacts

thymid_PSS

C

C

C

C

C

C

C

C

C

C

C

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

C

C

C

C

C

C

C

E

E

E

E

E

E

E

E

E

C

C

C

C

H

H

thymid_Seq

M

S

C

I

N

L

P

T

V

L

P

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

G

S

P

S

K

T

R

G

Q

I

Q

V

I

L

G

P

M

F

S

G

K

S

-------

M

-

-

+

-

-

-

-

-

L

-

+

-

+

G

+

+

-

-

-

-

F

-

-

2at2A0_Seq

M

K

H

L

T

T

M

S

E

L

S

T

E

E

I

K

D

L

L

Q

T

A

Q

E

L

K

S

G

K

T

D

N

Q

L

T

G

K

.

.

F

A

A

N

L

F

F

E

P

.

.

2at2A0_SS

C

C

C

C

C

C

C

C

C

C

C

H

H

H

H

H

H

H

H

H

H

H

H

H

H

H

H

C

C

C

C

C

C

C

C

C

C

.

.

E

E

E

E

E

E

C

C

C

.

.

CORE

3

0

0

8

0

0

1

0

0

5

0

0

0

0

3

0

0

7

1

0

0

3

0

0

1

0

0

0

0

0

0

0

0

2

0

0

0

.

.

0

2

1

0

0

0

0

0

0

.

.

thymid_PSS

H

H

H

H

H

H

H

H

H

H

H

H

C

C

C

E

E

E

E

E

E

E

C

C

C

C

C

C

C

C

C

E

E

E

E

C

C

C

C

C

C

C

C

C

C

C

C

H

H

H

thymid_Seq

T

E

L

M

R

R

V

R

R

F

Q

I

A

Q

Y

K

C

L

V

I

K

Y

A

K

D

T

R

Y

S

S

S

F

C

T

H

D

R

N

T

M

E

A

L

P

A

C

L

L

R

D

-------

-

-

R

-

-

-

-

F

+

+

A

-

+

K

-

+

-

-

-

D

-

+

-

-

+

-

-

-

-

-

L

+

D

2at2A0_Seq

.

.

S

T

R

T

R

F

S

F

E

V

A

E

K

K

.

.

.

.

.

.

.

.

.

.

.

L

G

M

N

V

L

N

L

D

G

T

S

T

S

V

Q

K

G

E

T

L

Y

D

2at2A0_SS

.

.

C

H

H

H

H

H

H

H

H

H

C

C

C

C

.

.

.

.

.

.

.

.

.

.

.

C

C

E

E

E

E

E

E

C

C

C

C

C

C

C

C

C

C

C

C

C

C

C

CORE

.

.

0

0

0

0

0

0

0

3

0

0

0

1

0

0

.

.

.

.

.

.

.

.

.

.

.

2

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

thymid_PSS

H

H

H

H

H

C

C

E

E

E

E

E

E

E

C

C

.

.

.

C

C

C

C

H

H

H

H

H

H

H

H

H

H

H

C

C

C

E

E

E

E

E

C

C

C

C

C

H

H

H

thymid_Seq

V

A

Q

E

A

L

G

V

A

V

I

G

I

D

E

G

.

.

.

Q

F

F

P

D

I

M

E

F

C

E

A

M

A

N

A

G

K

T

V

I

V

A

A

L

D

G

T

F

Q

R

-------

+

+

-

-

-

+

I

G

D

-

-

-

+

-

-

E

E

+

-

-

-

+

+

-

+

+

-

A

D

G

+

Q

2at2A0_Seq

T

I

R

T

L

E

S

.

.

.

I

G

V

D

V

C

V

I

R

H

S

E

D

E

Y

Y

E

.

.

E

L

V

S

Q

V

N

I

P

I

L

N

A

G

.

D

G

C

G

Q

.

2at2A0_SS

H

H

H

H

H

H

C

.

.

.

C

C

C

C

C

C

C

C

C

C

C

C

C

C

H

H

H

.

.

H

H

H

C

C

C

C

C

C

C

C

C

C

C

.

C

C

C

C

C

.

CORE

0

0

0

0

0

0

0

.

.

.

0

0

0

0

2

3

0

0

0

0

0

0

0

0

0

0

0

.

.

0

0

0

0

0

0

0

0

0

0

8

0

0

0

.

0

0

0

0

0

.

thymid_PSS		C	C	C	C	C	H	H	H	H	H		H	H	.	.	.	.	.	.	.	.		.	.	.	.	.	.	.	.	.	.		.	.	.	.	.	.	.	.	.	H		H	H	H	H	H	C	C	H	H	H
thymid_Seq		K	P	F	G	A	I	L	N	L	V		P	L	.	.	.	.	.	.	.	.		.	.	.	.	.	.	.	.	.	.		.	.	.	.	.	.	.	.	.	A		E	S	V	V	K	L	T	A	V	C
-------		-	P	-	-	+		L		L	-		-	+																														A		E	-	-	-	+	L	-	A	+
2at2A0_Seq		H	P	T	Q	S	L	L	D	L	M		T	I	Y	E	E	F	N	T	F	K		G	L	T	V	S	I	H	G	D	I		K	H	S	R	V	A	R	S	N	A		E	V	L	T	R	L	G	A	R	V
2at2A0_SS		C	H	H	H	H	H	H	H	H	H		H	H	H	H	H	C	C	C	C	C		C	C	C	E	E	E	E	C	C	C		C	C	C	H	H	H	H	H	H	H		H	H	H	H	H	H	C	C	C	C
CORE		0	2	5	0	1	8	1	0	2	3		0	9	0	0	0	3	0	0	0	0		0	5	0	9	3	4	0	0	0	0		0	0	0	0	0	2	0	0	1	4		0	1	7	1	0	0	0	1	0	6

thymid_PSS

H

H

H

C

.

.

.

.

.

.

.

.

.

.

.

.

C

C

C

C

E

E

E

E

E

C

C

C

C

E

E

E

E

.

.

.

.

.

.

.

.

.

.

E

C

C

C

C

C

C

thymid_Seq

M

E

C

F

.

.

.

.

.

.

.

.

.

.

.

.

R

E

A

A

Y

T

K

R

L

G

T

E

K

E

V

E

V

.

.

.

.

.

.

.

.

.

.

I

G

G

A

D

K

Y

-------

-

+

-

+

-

-

-

-

+

-

-

-

-

V

-

+

-

-

+

+

Y

2at2A0_Seq

L

F

S

G

P

S

E

W

Q

D

E

E

N

T

F

G

T

Y

V

S

M

D

E

A

V

E

S

S

D

V

V

M

L

L

R

I

Q

N

E

R

H

Q

S

A

V

S

Q

E

G

Y

2at2A0_SS

C

C

C

C

C

C

C

C

C

C

C

C

C

C

C

C

C

C

C

C

C

C

C

C

C

C

C

C

C

E

E

E

E

C

C

C

C

C

C

C

C

C

C

C

C

C

C

C

C

C

CORE

1

2

1

0

0

0

0

0

0

0

1

0

0

2

1

0

0

0

3

0

0

0

0

1

3

0

0

3

0

8

2

6

4

2

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

thymid_PSS

H

H

.

.

.

.

.

.

.

.

.

.

H

H

H

H

H

C

C

C

C

C

C

C

C

C

C

C

C

C

C

C

C

C

C

C

C

C

C

C

C

C

H

H

H

H

H

H

H

.

thymid_Seq

H

S

.

.

.

.

.

.

.

.

.

.

V

C

R

L

C

Y

F

K

K

A

S

G

Q

P

A

G

P

D

N

K

E

N

C

P

V

P

G

K

P

G

E

A

V

A

A

R

K

.

-------

+

-

-

-

+

-

-

-

-

-

-

-

-

+

-

-

-

-

-

-

-

-

-

-

-

V

-

+

+

-

-

-

-

-

-

-

K

2at2A0_Seq

L

N

K

Y

G

L

T

V

E

R

A

E

R

M

K

R

H

A

I

I

M

H

P

A

P

V

N

R

G

V

E

I

D

D

S

L

V

E

S

E

K

S

R

I

F

K

Q

M

K

N

2at2A0_SS

H

H

H

C

C

C

C

C

C

C

C

C

C

C

C

C

C

C

E

E

C

C

C

C

C

C

C

C

C

C

C

C

C

C

C

H

H

H

C

C

C

E

H

H

H

H

H

H

H

H

CORE

0

0

0

0

0

0

0

2

0

0

0

0

0

0

0

0

0

0

4

4

4

0

1

0

0

0

0

0

0

0

0

3

0

0

0

2

2

0

0

0

0

1

0

3

0

0

0

0

0

0

thymid_PSS

.

H

C

C

C

H

H

H

H

C

C

.

.

.

.

C

C

C

C

thymid_Seq

.

L

F

A

P

Q

Q

I

L

Q

C

.

.

.

.

S

P

A

N

-------

+

F

+

-

-

-

+

+

Q

C

-

-

2at2A0_Seq

G

V

F

I

R

M

A

V

I

Q

C

A

L

Q

T

N

V

K

R

2at2A0_SS

H

H

H

H

H

H

H

H

H

H

H

H

C

C

C

C

C

C

C

CORE

1

0

0

4

0

0

2

9

4

0

2

1

1

0

0

0

0

0

0