Supersites within superfolds

Binding site similarity in the absence of homology

Rossmann-like

• SCOP FOLD AB.13 Flavodoxin-like
• superfamily Catalase, C-terminal domain
• superfamily CheY-like
• superfamily Succinyl-CoA synthetase domains
• superfamily Flavoproteins
• superfamily Cobalamin vitamin B12 -binding domain
• superfamily Ornithine decarboxylase N-terminal "wing" domain
• superfamily Cutinase
• superfamily Esterase
• superfamily Formate glycerate dehydrogenases, substrate-binding domain
• SCOP FOLD AB.14 Ferredoxin reductase-like, C-terminal NADP-linked domain
• superfamily Ferredoxin reductase-like, C-terminal NADP-linked domain
• SCOP FOLD AB.15 ATP pyrophoshatases
• superfamily Class I aminoacyl-tRNA synthetases RS , catalytic domain
• superfamily N-type ATP pyrophosphatases
• SCOP FOLD AB.16 N-terminal domain of DNA photolyase
• superfamily N-terminal domain of DNA photolyase
• SCOP FOLD AB.17 A nucleotide-binding domain
• superfamily A nucleotide-binding domain
• SCOP FOLD AB.18 NAD P -binding Rossmann-fold domains
• superfamily NAD P -binding Rossmann-fold domains
• SCOP FOLD AB.19 Biotin carboxylase N-terminal domain-like
• superfamily Biotin carboxylase N-terminal domain-like
• SCOP FOLD AB.20 Pyruvate oxidase and decarboxylase, middle domain
• superfamily Pyruvate oxidase and decarboxylase, middle domain
• SCOP FOLD AB.21 N-carbamoylsarcosine amidohydrolase
• superfamily N-carbamoylsarcosine amidohydrolase
• SCOP FOLD AB.22 Glucosamine 6-phosphate deaminase
• superfamily Glucosamine 6-phosphate deaminase
• SCOP FOLD AB.24 P-loop containing nucleotide triphosphate hydrolases
• superfamily P-loop containing nucleotide triphosphate hydrolases
• SCOP FOLD AB.25 CheB methylesterase domain C-terminal residues 152-349
• superfamily CheB methylesterase domain C-terminal residues 152-349
• SCOP FOLD AB.28 Phosphotyrosine protein phosphatases I
• superfamily Phosphotyrosine protein phosphatases I
• SCOP FOLD AB.31 Transketolase, C-terminal domain
• superfamily Transketolase, C-terminal domain
• SCOP FOLD AB.32 Pyruvate kinase, C-terminal domain
• superfamily Pyruvate kinase, C-terminal domain
• SCOP FOLD AB.33 Leucine aminopeptidase, N-terminal domain
• superfamily Leucine aminopeptidase, N-terminal domain
• SCOP FOLD AB.35 Restriction endonucleases
• superfamily Restriction endonucleases
• SCOP FOLD AB.36 gamma,delta resolvase, large fragment
• superfamily gamma,delta resolvase, large fragment
• SCOP FOLD AB.37 The IIA domain of mannose transporter, IIA-Man
• superfamily The IIA domain of mannose transporter, IIA-Man
• SCOP FOLD AB.38 Ribonuclease H-like motif
• superfamily actin-like ATPase domain
• superfamily Creatinase, N-terminal domain
• superfamily Ribonuclease H-like
• superfamily Ada DNA repair protein, the middle domain
• SCOP FOLD AB.40 Phosphoglycerate mutase-like
• superfamily Phosphoglycerate mutase-like
• SCOP FOLD AB.42 Integrin A or I domain
• superfamily Integrin A or I domain
• SCOP FOLD AB.43 Glycinamide ribonucleotide transformylase
• superfamily Glycinamide ribonucleotide transformylase
• SCOP FOLD AB.44 S-adenosyl-L-methionine-dependent methyltransferases
• superfamily S-adenosyl-L-methionine-dependent methyltransferases
• SCOP FOLD AB.45 PLP-dependent transferases
• superfamily PLP-dependent transferases
• SCOP FOLD AB.49 Purine nucleoside hydrolase
• superfamily Purine nucleoside hydrolase
• SCOP FOLD AB.61 Phosphoglycerate kinase
• superfamily Phosphoglycerate kinase
• SCOP FOLD AB.62 Nitrogenase iron-molybdenum protein, alpha and beta chains
• superfamily Nitrogenase iron-molybdenum protein, alpha and beta chains
• SCOP FOLD AB.63 beta-Glucosyltransferase + glycogen phosphorylase
• superfamily beta-Glucosyltransferase + glycogen phosphorylase
• SCOP FOLD AB.64 Glutaminase Asparaginase
• superfamily Glutaminase Asparaginase
• SCOP FOLD AB.65 Phosphofructokinase
• superfamily Phosphofructokinase
• SCOP FOLD AB.67 Periplasmic binding protein-like I
• superfamily Periplasmic binding protein-like I
• SCOP FOLD Mult.11 type I DNA topoisomerase
• superfamily type I DNA topoisomerase
• SCOP FOLD Mult.12 type II DNA topoisomerase
• superfamily type II DNA topoisomerase
• SCOP FOLD Mult.17 L-2-Haloacid dehalogenase
• superfamily L-2-Haloacid dehalogenase
• SCOP FOLD Mult.7 Sugar phosphatases
• superfamily Sugar phosphatases

Beta-alpha_barrel

• SCOP FOLD AB.1 beta alpha TIM -barrel
• superfamily Glycosyltransferases
• superfamily Metal-dependent hydrolases
• superfamily Aldolases
• superfamily NAD P -linked oxidoreductase
• superfamily Enolase + muconate-lactonizing enzyme, C-terminal domain
• superfamily FMN-linked oxidoreductases
• superfamily Tryptophan biosynthesis enzymes
• superfamily Phosphoenolpyruvate pyruvate domain
• superfamily RuBisCo, C-terminal domain
• superfamily Triosephosphate isomerase TIM
• superfamily Xylose isomerase
• superfamily Bacterial luciferase-like
• superfamily Phosphatidylinositol-specific phospholipase C PI-PLC
• superfamily Methylmalonyl-CoA mutase, N-terminal CoA-binding domain
• superfamily Alanine racemase, N-terminal domain
• SCOP FOLD AB.2 Cellulases
• superfamily Cellulases

Beta_propeller

• SCOP FOLD B.42 4-bladed beta-propeller
• superfamily Hemopexin-like domain
• SCOP FOLD B.43 6-bladed beta-propeller
• superfamily Sialidases
• SCOP FOLD B.44 7-bladed beta-propeller
• superfamily Galactose oxidase, central domain
• superfamily Methylamine dehydrogenase, H-chain
• superfamily Trp-Asp repeat WD-repeat
• SCOP FOLD B.45 8-bladed beta-propeller
• superfamily Methanol dehydrogenase, heavy chain

• SCOP FOLD Small.34 Rubredoxin-like
• superfamily Methionyl-tRNA synthetase MetRS , Zn-domain
• superfamily A transcriptional factor domain
• superfamily Rubredoxin
• superfamily Aspartate carbamoyltransferase, Regulatory-chain, C-terminal

• SCOP FOLD A.4 DNA-binding 3-helical bundle
• superfamily Homeodomain-like
• superfamily Ada DNA repair protein, C-terminal domain
• superfamily Winged DNA-binding domain

• SCOP FOLD A+B.47 SH2-like
• superfamily SH2 domain
• SCOP FOLD A+B.55 Class II aaRS and biotin synthetases
• superfamily Class II aaRS and biotin synthetases

Ferredoxin-like

• SCOP FOLD A+B.12 FAD-linked reductases, C-terminal domain
• superfamily FAD-linked reductases, C-terminal domain
• SCOP FOLD A+B.24 Ribosomal protein L7 12, C-terminal fragment
• superfamily Ribosomal protein L7 12, C-terminal fragment
• SCOP FOLD A+B.27 KH-domain
• superfamily KH-domain
• SCOP FOLD A+B.28 GMP synthetase, the C-terminal, dimerisation domain
• superfamily GMP synthetase, the C-terminal, dimerisation domain
• SCOP FOLD A+B.31 Ferredoxin-like
• superfamily 4Fe-4S ferredoxins
• superfamily Aspartate carbamoyltransferase, Regulatory-chain, N-terminal
• superfamily Protease propeptides
• superfamily Muconalactone isomerase
• superfamily Signal transducing protein P2 product of glnB
• superfamily Nucleoside diphosphate kinases
• superfamily RNA-binding domain
• superfamily viral DNA-binding domain
• superfamily RuBisCO, large subunit, small N-terminal domain
• superfamily Acylphosphatase
• superfamily Ribosomal protein S6
• superfamily Elongation factor G EF-G , domain V
• superfamily Translational regulator protein regA
• superfamily Phosphoglycerate dehydrogenase, regulatory C-terminal
• superfamily Probable ACP-binding domain of malonyl-CoA ACP transacylase
• superfamily CheY-binding domain of CheA
• SCOP FOLD A+B.36 DCoH-like
• superfamily Pterin-4a-carbinolamine dehydratase PCD dimerization
• superfamily C-terminal domain of arginine repressor
• SCOP FOLD A+B.37 Chorismate mutase
• superfamily Chorismate mutase
• SCOP FOLD A+B.38 Tautomerase MIF
• superfamily Tautomerase MIF
• SCOP FOLD A+B.46 Metzincin-like
• superfamily Metzincins, catalytic N-terminal domain
• superfamily Bacterial chitobiase, Domain 2
• SCOP FOLD A+B.48 Histidine-containing phosphocarrier proteins HPr
• superfamily Histidine-containing phosphocarrier proteins HPr
• SCOP FOLD A+B.68 Creatinase methionine aminopeptidase
• superfamily Creatinase methionine aminopeptidase
• SCOP FOLD A+B.69 TBP-like
• superfamily TATA-box binding protein-like
• superfamily Phosphoglucomutase, the C-terminal domain
• SCOP FOLD A+B.73 Phenol hydroxylase P2 protein
• superfamily Phenol hydroxylase P2 protein
• SCOP FOLD A+B.78 Uridine diphospho-N-Acetylenolpyruvylglucosamine reductase, MurB,
• superfamily Uridine diphospho-N-Acetylenolpyruvylglucosamine reductase,
• SCOP FOLD Mult.10 Glutamine synthetase
• superfamily Glutamine synthetase
• SCOP FOLD Mult.12 type II DNA topoisomerase
• superfamily type II DNA topoisomerase
• SCOP FOLD Mult.5 Thymidine phosphorylase
• superfamily Thymidine phosphorylase
• SCOP FOLD Mult.8 DNA RNA polymerases
• superfamily DNA RNA polymerases
• SCOP FOLD Mult.9 Nucleotidyltransferases
• superfamily Nucleotidyltransferases

Double stranded beta helix

• SCOP FOLD B.54 Double-stranded beta-helix
• superfamily Seed storage 7S proteins
• superfamily cAMP-binding domain
• superfamily Trp RNA-binding attenuation protein TRAP

Four helix bundle

• SCOP FOLD A.20 Four-helical up-and-down bundle
• superfamily Apolipoprotein
• superfamily Aspartate receptor, ligand-binding domain
• superfamily Cytochromes
• superfamily Hemerythrin
• superfamily Viral coat proteins
• superfamily Acyl-CoA dehydrogenase flavoprotein , C-terminal domain

• SCOP FOLD Small.3 Knottins Small inhibitors, toxins, lectins
• superfamily Plant lectins antimicrobial peptides
• superfamily Plant inhibitors of proteinases
• superfamily Kalata B1
• superfamily Gurmarin, a sweet taste-suppressing polypeptide
• superfamily omega-Conotoxin-like
• superfamily Scorpion toxin-like
• superfamily Cellulose-binding domain
• superfamily Pro colipase
• superfamily Bromelain inhibitor VI cysteine protease inhibitor
• superfamily Bowman-Birk inhibitor
• superfamily Elafin-like

• SCOP FOLD AB.38 Ribonuclease H-like motif
• superfamily actin-like ATPase domain
• superfamily Creatinase, N-terminal domain
• superfamily Ribonuclease H-like
• superfamily Ada DNA repair protein, the middle domain

Beta grasp

• SCOP FOLD A+B.11 beta-Grasp
• superfamily Immunoglobulin-binding domains
• superfamily Ubiquitin
• superfamily c-Raf1, Ras-binding domain
• superfamily 2Fe-2S ferredoxin
• superfamily Superantigen toxins, C-terminal domain
• superfamily Translation initiation factor IF3, N-terminal domain

• SCOP FOLD B.10 Colipase binding domain-like
• superfamily Lipoxigenase, N-terminal domain
• superfamily Colipase-binding domain
• SCOP FOLD B.27 Reductase elongation factor common domain
• superfamily Ferredoxin reductase-like, FAD-linked N-terminal domain
• superfamily Translation factors
• SCOP FOLD B.28 Elongation factor Tu EF-Tu , the C-terminal domain
• superfamily Elongation factor Tu EF-Tu , the C-terminal domain
• SCOP FOLD B.38 Pyruvate kinase beta-barrel domain
• superfamily Pyruvate kinase beta-barrel domain

• SCOP FOLD AB.5 The swivelling beta beta alpha domain
• superfamily Phosphohistidine domain
• superfamily Aconitase, C-terminal domain
• superfamily the apical domain of GroEL

Ig-like

• SCOP FOLD B.1 Immunoglobulin-like beta-sandwich
• superfamily Immunoglobulin
• superfamily Fibronectin type III
• superfamily beta-Galactosidase, domains 2 and 4
• superfamily Transglutaminase
• superfamily Cadherin
• superfamily Actinoxantin-like
• superfamily Cu,Zn superoxide dismutase
• superfamily PapD-like
• superfamily Purple acid phosphatase, N-terminal domain
• SCOP FOLD B.2 Common fold of diphtheria toxin transcription factors cytochrome f
• superfamily Diphtheria toxin, C-terminal domain
• superfamily a carbohydrate-binding domain
• superfamily Transcription factors p53 and NF-kappa B
• superfamily Cytochrome f, large domain
• SCOP FOLD B.3 Prealbumin-like
• superfamily Starch-binding domain
• superfamily Transthyretin synonym: prealbumin
• superfamily Protocatechuate-3,4-dioxygenase, alpha and beta chains
• SCOP FOLD B.4 alpha-Amylase inhibitor
• superfamily alpha-Amylase inhibitor
• SCOP FOLD B.5 Cupredoxins
• superfamily Cupredoxins
• SCOP FOLD B.6 C2 domain-like
• superfamily C2 domain Calcium lipid-binding domain, CaLB
• superfamily PapD, C-domain

• SCOP FOLD A.31 EF Hand-like
• superfamily EF-hand
• superfamily Cloroperoxidase

• SCOP FOLD B.55 Barrel-sandwich hybrid
• superfamily Single hybrid motif
• superfamily Rudiment single hybrid motif
• superfamily Duplicated hybrid motif

• SCOP FOLD A+B.57 Profilin-like
• superfamily Profilin actin-binding protein
• superfamily Photoactive yellow protein

• SCOP FOLD B.11 Glycosyl-asparaginase
• superfamily Glycosyl-asparaginase
• SCOP FOLD B.13 Galactose-binding domain-like
• superfamily Galactose-binding domain-like
• SCOP FOLD B.14 Segmented RNA-genome viruses' proteins
• superfamily Segmented RNA-genome viruses' proteins
• SCOP FOLD B.15 Adenovirus type 5 fiber protein, knob domain
• superfamily Adenovirus type 5 fiber protein, knob domain
• SCOP FOLD B.16 Tumor necrosis factor
• superfamily Tumor necrosis factor
• SCOP FOLD B.18 ConA-like lectins glucanases
• superfamily ConA-like lectins glucanases
• SCOP FOLD B.19 Supersandwich
• superfamily beta-Galactosidase, domain 5
• superfamily Copper amine oxidase, domain 4 catalytic
• SCOP FOLD B.55 Barrel-sandwich hybrid
• superfamily Single hybrid motif
• superfamily Rudiment single hybrid motif
• superfamily Duplicated hybrid motif
• SCOP FOLD B.8 Viral coat and capsid proteins
• superfamily Viral coat and capsid proteins

• SCOP FOLD B.26 beta-Trefoil
• superfamily Cytokine
• superfamily Plant cytotoxin B-chain lectin
• superfamily Kunitz STI inhibitors
• superfamily Histidine-rich actin-binding protein hisactophilin

• SCOP FOLD B.24 OB-fold
• superfamily Bacterial pathogens
• superfamily An anticodon-binding domain
• superfamily Inorganic pyrophosphatase
• superfamily Cold shock DNA-binding domain
• superfamily Bacteriophage ssDNA-binding proteins
• superfamily Ribosomal S17 protein

• SCOP FOLD B.20 SH3-like barrel
• superfamily the C-terminal domain of biotin, diphtheria toxin and LexA
• superfamily SH3-domain
• superfamily Myosin S1 fragment, N-terminal domain
• superfamily Photosystem I accessory protein E PSAE
• superfamily DNA-binding domain of HIV-1 integrase

Cystatin-like

• SCOP FOLD A+B.13 Cystatin-like
• superfamily Cystatin monellin
• superfamily Copper amine oxidase, domains 2 and 3
• superfamily NTF2-like
• superfamily Uracil-DNA glycosylase inhibitor protein

• SCOP FOLD B.39 Lipocalins
• superfamily Lipocalins
• SCOP FOLD B.40 Streptavidin-like
• superfamily Avidin streptavidin
• superfamily Metalloprotease inhibitor
• SCOP FOLD Mult.4 Heme-linked catalases
• superfamily Heme-linked catalases

• SCOP FOLD B.19 Supersandwich
• superfamily beta-Galactosidase, domain 5
• superfamily Copper amine oxidase, domain 4 catalytic

• SCOP FOLD A.15 ATP syntase F1-ATPase , gamma subunit
• superfamily ATP syntase F1-ATPase , gamma subunit

• SCOP FOLD A+B.26 dsRBD + PDA domains
• superfamily dsRNA-binding domain-like
• superfamily Porphobilinogen deaminase PDA , C-terminal domain

• SCOP FOLD A+B.46 Metzincin-like
• superfamily Metzincins, catalytic N-terminal domain
• superfamily Bacterial chitobiase, Domain 2

• SCOP FOLD A.1 Globin-like
• superfamily Globin-like
• SCOP FOLD Memb.1 Toxins membrane translocation domains
• superfamily Colicin

• SCOP FOLD B.52 Single-stranded right-handed beta-helix
• superfamily Pectate lyase
• superfamily P22 tailspike protein

• SCOP FOLD A+B.33 IF3-like
• superfamily Translation initiation factor IF3
• superfamily 5-enol-pyruvyl-3-phosphate synthase

• SCOP FOLD B.49 beta-Prism I
• superfamily Vitelline membrane outer protein-I VMO-I
• superfamily delta-Endotoxin insectocide , middle domain