Found 257 pleiotropic proteins (16.0 %) and 1345 non-pleiotropic proteins (84.0 %).
1602 items found (page 30 of 33)
| Gene | UniProt | Protein Type | Disease |
|---|---|---|---|
| TFR2 | Q9UP52 | non-pleiotropic | Hemochromatosis 3 (HFE3) [MIM:604250] |
| TGFB2 | P61812 | non-pleiotropic | Loeys-Dietz syndrome 4 (LDS4) [MIM:614816] |
| TGFB3 | P10600 | non-pleiotropic | Rienhoff syndrome (RNHF) [MIM:615582] |
| TGFBR1 | P36897 | pleiotropic | Loeys-Dietz syndrome 1 (LDS1) [MIM:609192] Multiple self-healing squamous epithelioma (MSSE) [MIM:132800] |
| TGFBR2 | P37173 | pleiotropic | Hereditary non-polyposis colorectal cancer 6 (HNPCC6) [MIM:614331] Esophageal cancer (ESCR) [MIM:133239] Loeys-Dietz syndrome 2 (LDS2) [MIM:610168] |
| TGIF1 | Q15583 | non-pleiotropic | Holoprosencephaly 4 (HPE4) [MIM:142946] |
| TGM1 | P22735 | non-pleiotropic | Ichthyosis, congenital, autosomal recessive 1 (ARCI1) [MIM:242300] |
| TGM5 | O43548 | non-pleiotropic | Peeling skin syndrome, acral type (APSS) [MIM:609796] |
| TGM6 | O95932 | non-pleiotropic | Spinocerebellar ataxia 35 (SCA35) [MIM:613908] |
| TH | P07101 | non-pleiotropic | Segawa syndrome autosomal recessive (ARSEGS) [MIM:605407] |
| THAP1 | Q9NVV9 | non-pleiotropic | Dystonia 6, torsion (DYT6) [MIM:602629] |
| THBD | P07204 | pleiotropic | Hemolytic uremic syndrome atypical 6 (AHUS6) [MIM:612926] Thrombophilia due to thrombomodulin defect (THPH12) [MIM:614486] |
| THOC6 | Q86W42 | non-pleiotropic | Beaulieu-Boycott-Innes syndrome (BBIS) [MIM:613680] |
| THRB | P10828 | pleiotropic | Generalized thyroid hormone resistance (GTHR) [MIM:188570] Selective pituitary thyroid hormone resistance (PRTH) [MIM:145650] |
| TIA1 | P31483 | non-pleiotropic | Welander distal myopathy (WDM) [MIM:604454] |
| TICAM1 | Q8IUC6 | non-pleiotropic | Herpes simplex encephalitis 4 (HSE4) [MIM:614850] |
| TIMP3 | P35625 | non-pleiotropic | Sorsby fundus dystrophy (SFD) [MIM:136900] |
| TJP2 | Q9UDY2 | non-pleiotropic | Familial hypercholanemia (FHCA) [MIM:607748] |
| TK2 | O00142 | non-pleiotropic | Mitochondrial DNA depletion syndrome 2 (MTDPS2) [MIM:609560] |
| TLL1 | O43897 | non-pleiotropic | Atrial septal defect 6 (ASD6) [MIM:613087] |
| TLR3 | O15455 | non-pleiotropic | Herpes simplex encephalitis 2 (HSE2) [MIM:613002] |
| TMEM138 | Q9NPI0 | non-pleiotropic | Joubert syndrome 16 (JBTS16) [MIM:614465] |
| TMEM165 | Q9HC07 | non-pleiotropic | Congenital disorder of glycosylation 2K (CDG2K) [MIM:614727] |
| TMEM43 | Q9BTV4 | pleiotropic | Arrhythmogenic right ventricular dysplasia, familial, 5 (ARVD5) [MIM:604400] Emery-Dreifuss muscular dystrophy 7, autosomal dominant (EDMD7) [MIM:614302] |
| TMEM5 | Q9Y2B1 | non-pleiotropic | Muscular dystrophy-dystroglycanopathy congenital with brain and eye anomalies A10 (MDDGA10) [MIM:615041] |
| TMEM67 | Q5HYA8 | pleiotropic | Meckel syndrome 3 (MKS3) [MIM:607361] COACH syndrome (COACHS) [MIM:216360] Joubert syndrome 6 (JBTS6) [MIM:610688] Nephronophthisis 11 (NPHP11) [MIM:613550] |
| TMEM70 | Q9BUB7 | non-pleiotropic | Mitochondrial complex V deficiency, nuclear 2 (MC5DN2) [MIM:614052] |
| TMIE | Q8NEW7 | non-pleiotropic | Deafness, autosomal recessive, 6 (DFNB6) [MIM:600971] |
| TMPO | P42166 | non-pleiotropic | Cardiomyopathy, dilated 1T (CMD1T) [MIM:613740] |
| TMPRSS6 | Q8IU80 | non-pleiotropic | Iron-refractory iron deficiency anemia (IRIDA) [MIM:206200] |
| TNC | P24821 | non-pleiotropic | Deafness, autosomal dominant, 56 (DFNA56) [MIM:615629] |
| TNFRSF4 | P43489 | non-pleiotropic | Immunodeficiency 16 (IMD16) [MIM:615593] |
| TNFSF11 | O14788 | non-pleiotropic | Osteopetrosis, autosomal recessive 2 (OPTB2) [MIM:259710] |
| TNNI2 | P48788 | non-pleiotropic | Arthrogryposis, distal, 2B (DA2B) [MIM:601680] |
| TNNT3 | P45378 | non-pleiotropic | Arthrogryposis, distal, 2B (DA2B) [MIM:601680] |
| TOR1A | O14656 | non-pleiotropic | Dystonia 1, torsion, autosomal dominant (DYT1) [MIM:128100] |
| TP63 | Q9H3D4 | pleiotropic | Split-hand/foot malformation 4 (SHFM4) [MIM:605289] Ectrodactyly, ectodermal dysplasia, and cleft lip/palate syndrome 3 (EEC3) [MIM:604292] Ectodermal dysplasia, Rapp-Hodgkin type (EDRH) [MIM:129400] Acro-dermato-ungual-lacrimal-tooth syndrome (ADULT syndrome) [MIM:103285] Ankyloblepharon-ectodermal defects-cleft lip/palate (AEC) [MIM:106260] Non-syndromic orofacial cleft 8 (OFC8) [MIM:129400] |
| TPI1 | P60174 | non-pleiotropic | Triosephosphate isomerase deficiency (TPID) [MIM:615512] |
| TPK1 | Q9H3S4 | non-pleiotropic | Thiamine metabolism dysfunction syndrome 5, episodic encephalopathy type (THMD5) [MIM:614458] |
| TPM2 | P07951 | pleiotropic | Nemaline myopathy 4 (NEM4) [MIM:609285] Arthrogryposis, distal, 1A (DA1A) [MIM:108120] Arthrogryposis, distal, 2B (DA2B) [MIM:601680] Cap myopathy 2 (CAPM2) [MIM:609285] |
| TPMT | P51580 | non-pleiotropic | Thiopurine S-methyltransferase deficiency (TPMT deficiency) [MIM:610460] |
| TPO | P07202 | non-pleiotropic | Thyroid dyshormonogenesis 2A (TDH2A) [MIM:274500] |
| TPP1 | O14773 | pleiotropic | Ceroid lipofuscinosis, neuronal, 2 (CLN2) [MIM:204500] Spinocerebellar ataxia, autosomal recessive, 7 (SCAR7) [MIM:609270] |
| TRAF3 | Q13114 | non-pleiotropic | Herpes simplex encephalitis 3 (HSE3) [MIM:614849] |
| TRAPPC11 | Q7Z392 | non-pleiotropic | Limb-girdle muscular dystrophy 2S (LGMD2S) [MIM:615356] |
| TRAPPC2 | P0DI81 | non-pleiotropic | Spondyloepiphyseal dysplasia tarda (SEDT) [MIM:313400] |
| TRDN | Q13061 | non-pleiotropic | Ventricular tachycardia, catecholaminergic polymorphic, 5, with or without muscle weakness (CPVT5) [MIM:615441] |
| TREM2 | Q9NZC2 | non-pleiotropic | Polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL) [MIM:221770] |
| TREX1 | Q9NSU2 | pleiotropic | Aicardi-Goutieres syndrome 1 (AGS1) [MIM:225750] Systemic lupus erythematosus (SLE) [MIM:152700] Chilblain lupus 1 (CHBL1) [MIM:610448] |
| TRIM2 | Q9C040 | non-pleiotropic | Charcot-Marie-Tooth disease 2R (CMT2R) [MIM:615490] |