HHsearch 1.5 NAME c4n8pA_ FAM FILE c4n8pA_ COM /bmm/www/servers/phyre2/HH/hhmake -i c4n8pA_.a3m DATE Sat Nov 2 08:28:18 2013 LENG 119 match states, 119 columns in multiple alignment FILT 18 out of 22 sequences passed filter (-id 90 -cov 0 -qid 0 -qsc -20.00 -diff 100) NEFF 3.8 EVD 0.4164 -0.8992 SEQ >ss_dssp CCSCCCCCEECCSCCCCCTTSCEEEEEEECCSSCCSEEEEEEEEEETTEEEEEEEEEEECCCCCCCCEEEEEEETTEEEEEEESCCGGGCSEEEEEEEEE SCCSCCCCCCCCCCCCCCC >sa_dssp EEEEEECECDCDEEDEDDEEBDBDCCADBECEDEBECBDAAACBDDEEEEDECBCCDCEDEEEEEECECDBECDECCADACBCDCEEEBEEEBDBDBDCC EDCEEDEEEEEEEEEEEEE >ss_pred CCCCCEEEECCCEEEEEEECCEEEEEEECCCCCCCEEEEEEEEECCCCEEEEEEEEECCCCCCCCCEEEEEEECCCEEEEEEECCCCCCCEEEEEEEEEE CCCCHHEECCCCEEEEEEC >ss_conf 9888506711772999983574999941478997216999999826760124776420355434411347882398179999725542111799988750 6982121138823999989 >Consensus xxxxxaxxvtqpxvvvaxxxGxaslxCxyxxxxxxxExrxsLlKgxxxxxxevcxxsxnxxnxxxxxxCxgxxsxnsVxfxLxgLxxxxtdiYxCxiexm yPPPYxxxxxngTxiyVxE >c4n8pA_ YGGPPALQVTQPRVVLASMKGVASLACEYEFTGKAKEIRVTLIRQTGNEFHEVCASSFTTEYEPFDIECHVQPSENNVTLTLMGLKATDTGLYVCRVELM YPPPYYMGLGNGTQIYVVE >UniRef50_A8E5W7(20-135:210) Cd28 protein n=2 Tax=Xenopus RepID=A8E5W7_XENTR E=2e-17 s/c=0.78 id=36% cov=92% -------ETQQQVVLVAVKQIEITFPSNFKDN---KESRVSLLRGVKKSIT-VCSGSFNSSYQSFESNayqsirCIGIPTENKITFHLSGLTENHTDIYF FRKEDMYPPPYTCYQDNGTVIHVKE >UniRef50_UPI000194CAA2(13-137:222) PREDICTED: CD28 antigen n=1 Tax=Taeniopygia guttata RepID=UPI000194CAA2 E=5e-32 s/c=1.10 id=34% cov=97% ----PTADVTENKILVAQHpllivaNQTATLVCNYTYNGTGKEFRASLQKGTDSSV-EVCVISWNTTKISSNsnkgFNCQGSYDKDKVIFNLWNMNTNQT DIYFCKIEVMYPPPYvYNEKSNGTVIHVKE >UniRef50_A6PZH9(35-146:212) Inducible T-cell co-stimulator protein n=3 Tax=Neognathae RepID=A6PZH9_CHICK E=1e-25 s/c=1.04 id=24% cov=92% ------LQVSDPQGIVEFENGNFKLI--FQNPKNVNEFSMTLLKG--RERKAICALHMNNKKAVPESNvtyCQAEHSDTSTTFILTNLDRKHIDTYTCCL ESLLPPPYIHCHLKETYLYIQD >UniRef50_A1L4S5(1-99:177) Cytotoxic T-lymphocyte protein 4 (Fragment) n=4 Tax=Clupeocephala RepID=A1L4S5_DANRE E=1e-21 s/c=1.05 id=32% cov=80% -----------------------SMHCSFRSKLRPEEVQVSVYKALHG--HERICSAYVNLSEPYfatdgPVRCRGNINFGGVDLIIAGLRGEDTDVYRC EIEILFPPPYLRALGNGTVVYIQE >UniRef50_B5XE43(36-132:234) T-cell-specific surface glycoprotein CD28 n=7 Tax=Salmoninae RepID=B5XE43_SALSA E=5e-19 s/c=0.98 id=24% cov=77% -------------VVHVSVNGTASVRCPNLTGKDQEEMRFHLYLGLVEVGNHTHDNAHNHNSTETVSPVgeglglRVNKQDHTVSFVLSGMTTERAGVYT CEGHPMYPPP--------------- >UniRef50_A1L4S4(34-137:222) Costimulatory receptor CD28 n=3 Tax=Takifugu rubripes RepID=A1L4S4_TAKRU E=2e-08 s/c=0.58 id=28% cov=69% --------------------GNVNVPCP---NSSAEDIKFSLFKDGECVHHHTQISGATTPNQNTSTNPVGVeyPSANSPNFTITGVNASSHGIYTCEVT EMFPPP--------------- >UniRef50_UPI000155BE52(173-283:318) PREDICTED: similar to ICOS protein, partial n=1 Tax=Ornithorhynchus anatinus RepID=UPI000155BE52 E=2e-24 s/c=1.02 id=25% cov=86% --------------MMAFHNGVVKVTC--HYPRSARDFTMQLLKGTMRQ--KVCELIRDKdiTNTTTQKEliyCQPDLSNDSVIFTLSNLDIRHADYYFC SLEVSFPPPYQNCTPDEAYLYVYE >UniRef50_Q9Y6W8(30-132:199) Inducible T-cell costimulator n=6 Tax=Catarrhini RepID=ICOS_HUMAN E=1e-20 s/c=0.97 id=24% cov=81% --------------------GGVQILCKY--PDIVQQFKMQLLKG-GQILCDLTKTkgSGNTVSIKSLKFCHSQLSNNSVSFFLYNLDHSHANYYFCNLS IFDPPPFKVTLTGG-YLHIYE >UniRef50_UPI000175F21A(32-139:225) PREDICTED: similar to CD28-like protein n=2 Tax=Danio rerio RepID=UPI000175F21A E=8e-12 s/c=0.66 id=29% cov=50% ----------------------------------------------------------TNTNKEFPAEFSVDL-DNSSSFILTVVTVNMTALYTCEASIS YPPPFkYVDHKPQTIVFV-- # NULL 3706 5728 4211 4064 4839 3729 4763 4308 4069 3323 5509 4640 4464 4937 4285 4423 3815 3783 6325 4665 HMM A C D E F G H I K L M N P Q R S T V W Y M->M M->I M->D I->M I->I D->M D->D Neff Neff_I Neff_D 0 * * 0 * 0 * * * * Y 1 * * * * * * * * * * * * * * * * * * * 0 1 0 * * * * * * 1000 0 0 G 2 * * * * * 0 * * * * * * * * * * * * * * 2 0 * * * * * * 1000 0 0 G 3 * * * * * 0 * * * * * * * * * * * * * * 3 0 * * * * * * 1000 0 0 P 4 * * * * * * * * * * * * 0 * * * * * * * 4 0 * * * * * * 1000 0 0 P 5 * * * * * * * * * * * * 0 * * * * * * * 5 0 * * * * * * 1897 0 0 A 6 481 * * * * * * * * * * * * * * 2698 2950 * * * 6 0 * * * * * * 2499 0 0 L 7 2404 * * * * * * 2170 * 1360 2328 * * * * * * * * * 7 0 * * * * * * 2930 0 0 Q 8 * * 2624 2334 * * 3434 * * * * * * 1191 3199 * * * * * 8 0 * * * * * * 3092 0 0 V 9 * * * * * * * * * * * * * * * * 3247 161 * * 9 0 * * * * * * 3139 0 0 T 10 3545 * * * * * * * 3628 * * * * 3247 * 2752 787 * * * 10 0 * * * * * * 3139 0 0 Q 11 * * 2752 2819 * 3466 * * * * * * * 691 * * * * * * 11 0 * * * * * * 3139 0 0 P 12 * * * * * * * * * * * 2106 594 3247 * * * * * * 12 0 * * * * * * 3139 0 0 R 13 2619 * * * * * * * 2106 * * * 3628 2752 3684 3500 * 3247 * 3265 13 0 * * * * * * 3139 0 0 V 14 * * * * * 2909 * 1882 * 3802 * * * * 3482 * * 1203 * * 14 0 * * * * * * 3404 0 0 V 15 * * * * * * * 3210 * 1611 3288 * * * * * * 1113 * * 15 0 * * * * * * 3589 0 0 L 16 * * * * * * 3184 * * 1887 3288 * * * * * * 951 * * 16 239 3825 3611 2585 263 * * 3589 1000 0 A 17 544 * * 3083 * * * * * * * * * * * * * 2350 * * 17 0 * * * * 0 * 3479 0 1000 S 18 3825 * * * 2249 * * * * * * 3982 * 3187 * 1326 3954 3601 * * 18 83 4153 * 2585 263 * * 3589 1000 0 M 19 4153 * * 3210 * * 2072 * 3601 * 3976 3954 * * 3982 2800 * 3184 * 3825 19 80 4221 * 2585 263 * * 3589 1000 0 K 20 * * 3825 * * * 3756 * 3976 * * 1015 * 2779 2723 * * * * * 20 0 * * * * * * 3589 0 0 G 21 * * * 4200 * 463 * 3807 * * * 4144 * 4460 4422 * * * * * 21 0 * * * * * * 4047 0 0 V 22 4144 * * 2846 * 3453 * 3980 * * * 2583 * * * * 2381 1782 * * 22 81 * 4200 * * * * 4047 0 0 A 23 1145 * * * 3568 * * 3694 * * * * * * * * * 1373 * * 23 0 * * * * 0 * 4017 0 1000 S 24 * * * 4118 * * * * 2844 * * 2437 * 3541 * 1407 2684 * * * 24 0 * * * * * * 4200 0 0 L 25 * * * * 2439 * * 3541 * 1248 3760 * * * * * * 2089 * * 25 0 * * * * * * 4200 0 0 A 26 4378 * * * 4118 * 3760 3727 * 3541 * * 2264 * 3460 4235 3972 2040 * * 26 113 * 3727 * * * * 4200 0 0 C 27 * 111 * * * * * * * * * * * * * 3753 * * * * 27 110 * 3768 * * * 0 4043 0 1000 E 28 * * * 2437 * * * * 2544 * * 1759 2345 * * 2721 * * * * 28 143 * 3401 * * 1000 1000 3938 0 1492 Y 29 * * * * 1928 * * * * * * 3401 * * * * * * * 638 29 170 * 3171 * * 1017 983 3803 0 1610 E 30 3998 * * 4110 * * 2596 4078 2866 3333 * * * 3334 3598 2902 3280 * * * 30 0 * * * * * 0 3731 0 1703 F 31 * * 3664 * 4110 * 2983 * * * * 3334 3882 * * 2784 3333 * * 1620 31 0 * * * * 0 * 3731 0 1703 T 32 * * * * * 3460 * 4364 3760 * * 1555 1828 * * 4080 3242 * * * 32 103 * 3864 * * * * 4200 0 0 G 33 * * 3490 * * 1380 3975 * 2501 2896 * * * * 3900 3552 * * * * 33 0 * * * * * 0 4098 0 1000 K 34 * * 3384 * 4123 * * 3490 3140 * * 2341 * * 2841 2252 3359 * * * 34 0 * * * * * 0 4098 0 1000 A 35 1650 * * * * 3359 * * * * * 3997 3700 3384 4115 4123 3975 2558 * * 35 93 3997 * 1000 1000 0 * 4098 1000 1000 K 36 * * 4080 1724 * * * * 1987 * * 3727 * 3541 3098 * 3215 * * * 36 0 * * * * * * 4200 0 0 E 37 * * 2794 377 * * * * * * * * * 3541 * * * * * * 37 0 * * * * * * 4200 0 0 I 38 * * * * 1264 * * 2498 * 4118 3460 * * * * 3864 * 2400 * * 38 0 * * * * * * 4200 0 0 R 39 * * * * * * * * 2588 * * * * 3760 688 3727 3972 * * * 39 0 * * * * * * 4200 0 0 V 40 2387 * * * 2545 * * 4118 * * 2151 * * * * * * 1495 * * 40 0 * * * * * * 4200 0 0 T 41 * * * * * * 3460 * * * * * * 2741 * 1272 1534 * * * 41 0 * * * * * * 4200 0 0 L 42 * * * * * * * * * 303 * * * * * * * 2400 * * 42 0 * * * * * * 4200 0 0 I 43 * * * * 3636 * 3367 4378 * 1126 * * * 3407 * * * * * 2170 43 0 * * * * * * 4200 0 0 R 44 * * * * * * * * 692 3460 * * * * 1786 * * * * * 44 0 * * * * * * 4200 0 0 Q 45 3760 * 3636 * * 659 * * * * * * * 2236 * * * * * * 45 254 * 2631 * * * * 4200 0 0 T 46 3988 * * * * 3373 * * * 1955 3897 * * * * * 1404 2862 * * 46 0 * * * * 1000 1000 3826 0 1573 G 47 * * 1915 3525 * 2330 3652 * 3753 * 3768 3974 * * * * * 3367 * 4026 47 0 * * * * 0 * 4043 0 1000 N 48 * 3636 3215 3460 * 2928 * * 3864 * * 4378 * 3541 2844 2013 * * * * 48 111 * 3760 * * * * 4200 0 0 E 49 2666 * * 2320 * * * 3453 4259 * * * * 2353 * 3097 * 2426 * * 49 101 * 3891 * * * 0 4047 0 1000 F 50 * * * * 3196 3257 3410 3756 * 3286 3881 * * 3779 3469 * * 1813 * * 50 355 * 2197 * * 970 1031 3970 0 1728 H 51 * 3060 * 3682 * * 1931 * 3240 * * 3098 * * * * 1656 * * * 51 152 * 3321 * * 0 * 3890 0 2020 E 52 3628 * 3490 781 * * 2465 * 3900 * * * * * * * * * * * 52 93 3997 * 1000 1000 0 * 4098 1000 1000 V 53 * * * * * * * 3011 * 3541 * * * * 3760 * 2168 1018 * * 53 0 * * * * * * 4200 0 0 C 54 * 580 * * * * 3460 3760 * * * * * 3636 * * 3541 * * * 54 0 * * * * * * 4200 0 0 A 55 1797 3760 3460 3972 4513 * * 3636 3541 * * * * * * 3061 4118 3378 * * 55 76 4289 * 1585 585 * * 4200 1000 0 S 56 4145 * * * * 3864 * 3525 * 2844 * 2816 * * * 1697 2786 4235 * * 56 130 3541 * 1000 1000 * * 4200 1000 0 S 57 2602 * * * * 3636 3727 3972 * * * * * * * 1526 2606 4289 * 4235 57 0 * * * * * * 4200 0 0 F 58 3636 * * * 2099 2847 3460 * * * 3727 * * * 3972 4289 * * 3525 2483 58 0 * * * * * * 4200 0 0 T 59 * * 4031 * * * 4378 * * * 4179 1195 * * * * 1624 3749 * * 59 137 3467 * 2188 357 * * 4262 1339 0 T 60 * * * 4099 * * 2783 * 4031 * 4179 2141 * 3361 * 3982 1773 * * * 60 91 4031 * 1000 1000 * * 4262 1000 0 E 61 * * * 2817 * 4179 * * 2942 3749 * 2783 3713 * * 3258 2827 2928 * * 61 0 * * * * * * 4262 0 0 Y 62 * * * * 4425 * * * 3156 * * 1196 * * * 2028 * * * 2646 62 0 * * * * * * 4262 0 0 E 63 3800 * * 2500 * * * 3028 3541 * * * * 2841 * 2852 1917 * * * 63 0 * * * * * * 4262 0 0 P 64 4140 * * 2967 * * * * 2928 4179 4425 3089 2559 * * 3270 4031 2942 * * 64 0 * * * * * * 4262 0 0 F 65 * * * * 1982 4099 * * 4601 * * * 3800 * * 2551 1597 * * 3749 65 200 2948 * 2041 402 * * 4262 1558 0 D 66 * * 3287 2504 4099 4344 * * * 3605 * 3498 3137 3085 * 3025 * 3497 * * 66 134 3498 * 1563 596 * * 4262 1319 0 I 67 4668 * * * 2483 * * 4405 2802 4099 * * * * * 1842 3713 2493 * * 67 87 4099 * 1585 585 * * 4262 1000 0 E 68 * * * 1994 2831 * * 4179 * * * 1357 3497 * 3749 * * * * * 68 514 1739 * 2238 344 * * 4262 2645 0 C 69 * 332 * * 3958 * * * * * * * 3869 * * * * 3786 * * 69 109 3786 * 2585 263 * * 4036 1000 0 H 70 * * 4433 * * * 2329 4046 * 4181 * * * 2595 2138 3062 4104 3869 * * 70 0 * * * * * * 4036 0 0 V 71 3826 * * * * 904 * * * * * * 4244 * * 4097 * 2128 * 4181 71 0 * * * * * * 4036 0 0 Q 72 * * 3094 3826 * * 4181 2716 4433 * * 2859 * 2748 * 3473 3139 3869 * * 72 102 3869 * 1000 1000 * * 4036 1000 0 P 73 * * * * 3265 * 3138 3936 3786 1629 * * 2179 * * 4104 * * * 4565 73 96 * 3958 * * * * 4036 0 0 S 74 * * 3625 * * 4351 * * * * * 2440 * 3455 4129 1079 3964 * * * 74 0 * * * * 0 * 4258 0 1000 E 75 3869 * 2270 2261 3936 4104 * * 3551 * * 2234 4432 * 4386 * * * * * 75 0 * * * * * * 4036 0 0 N 76 * * 2857 4433 * 3163 3786 * * * * 1130 * * * 4175 3069 * * * 76 0 * * * * * * 4036 0 0 N 77 * * * * * 3936 * * 2379 * * 3443 * 4104 4175 1266 3045 * * * 77 0 * * * * * * 4036 0 0 V 78 * * * * * * * 4046 * * 4362 * 3869 * * 3958 3826 541 * * 78 0 * * * * * * 4036 0 0 T 79 * * 3936 * * * * 2857 * * * 2131 * * * 1997 1653 * * * 79 0 * * * * * * 4036 0 0 L 80 * * * * 550 * * * * 1657 * * * * * * * * * * 80 0 * * * * * * 4036 0 0 T 81 * * * * 3139 * 3195 2321 * * * 3551 * * * * 1423 3786 * 4433 81 0 * * * * * * 4036 0 0 L 82 * * * * * * * 1768 * 501 * * * * * * * * * * 82 0 * * * * * * 4036 0 0 M 83 3936 * * * * * * * * * 4502 4181 * 2646 * 2107 1994 * 2900 4097 83 0 * * * * * * 4036 0 0 G 84 * * 4362 * * 947 * * * * * 1441 * * * * * 3958 * * 84 0 * * * * * * 4036 0 0 L 85 * * * * * * * * * 612 2664 * 4181 * * * * 2913 * * 85 0 * * * * * * 4036 0 0 K 86 * * 2078 * * * * * 4502 4362 * 3176 * 4386 2151 4538 2341 * * 4433 86 0 * * * * * * 4036 0 0 A 87 1658 * * 4046 * 3163 4097 4244 * * * * * * 3826 4181 3123 2650 * * 87 0 * * * * * * 4036 0 0 T 88 * * * 2859 * * * * 3826 * 4104 1489 * * 4244 2152 4502 4175 * * 88 0 * * * * * * 4036 0 0 D 89 * * 1657 * * * 2045 * * * 3958 * * 2087 3786 3869 * * * * 89 0 * * * * * * 4036 0 0 T 90 2444 * * * * 4181 3869 3826 * * * * * * * * 684 * * * 90 0 * * * * * * 4036 0 0 G 91 3958 * 1072 * * 1530 * * * * * 4097 * * * 4181 * * * * 91 0 * * * * * * 4036 0 0 L 92 * * * * * * * 1693 * 1661 * * * * * * 3826 2859 * 2588 92 0 * * * * * * 4036 0 0 Y 93 * * * * * * * * * * * * * * * * * * * 0 93 0 * * * * * * 4036 0 0 V 94 * * * * 1297 * * 4104 * 4175 * * * * 3163 * 1858 3443 * * 94 0 * * * * * * 4036 0 0 C 95 * 90 * * 4046 * * * * * * * * * * * * * * * 95 0 * * * * * * 4036 0 0 R 96 4432 3826 * 1886 * * * * 1550 * * 4097 * * 3256 3213 * * * * 96 0 * * * * * * 4036 0 0 V 97 3958 * * * * 3786 * 1776 4046 2078 4386 * * * * * * 2145 * * 97 0 * * * * * * 4036 0 0 E 98 * * * 554 * * 3786 * * * * * * * * 2491 3869 * * * 98 0 * * * * * * 4036 0 0 L 99 4538 * 4046 3869 * * * 2040 * 2666 * * 3786 * 4386 3826 * 2081 * * 99 0 * * * * * * 4036 0 0 M 100 * * * * 3139 * * * * 2457 768 * * * * 3094 * * * * 100 0 * * * * * * 4036 0 0 Y 101 * * 3139 * 2423 * * * * 3826 * * * * * * * * * 668 101 0 * * * * * * 4036 0 0 P 102 * * * * * * * * * * * * 0 * * * * * * * 102 0 * * * * * * 4036 0 0 P 103 * * * * * * * * * * * * 0 * * * * * * * 103 0 * * * * * * 4036 0 0 P 104 * * * * * * * * * * * * 0 * * * * * * * 104 0 * * * * * * 4036 0 0 Y 105 * * * * 2091 * * * * * * * * * * * * * * 386 105 301 2407 * 0 * * * 3782 1812 0 Y 106 * * * * 3177 * * 3662 3849 2467 * * * 2829 * * 3845 * * 1515 106 72 4353 * 0 * * * 3782 1000 0 M 107 * 3845 * 3792 * * 2938 * * 4024 3312 2232 * * 2923 * * 2179 * * 107 0 * * * * * * 3782 0 0 G 108 3761 2761 3425 2793 * 2572 * * * * * 3269 * * 3792 * 2971 * * 3845 108 76 4280 * 0 * * * 3782 1000 0 L 109 * * * * 4104 * 2539 4024 2011 2384 4100 3792 * 3845 * * 3867 * * * 109 0 * * * * * * 3782 0 0 G 110 * * 3845 * * 1505 * * 3425 2725 * * 3867 * * 2352 3849 * * * 110 0 * * * * * * 3782 0 0 N 111 * * 3867 * * 3849 * * 3662 * * 695 3425 * * 3792 * * * * 111 0 * * * * * * 3782 0 0 G 112 * * * 2761 * 397 * * * * * * * 3425 * * * * * * 112 104 * 3849 * * * * 3782 0 0 T 113 3689 * * * * 3502 * * * * * * * * * * 261 * * * 113 0 * * * * 0 * 3710 0 1000 Q 114 * * * * * * * 2370 * 4104 * * * 2181 * * * 2067 * 1790 114 0 * * * * * * 3782 0 0 I 115 * * * * * * * 1206 * 1324 * * * * * * * 2584 * * 115 0 * * * * * * 3782 0 0 Y 116 * * * * 3425 * 1297 * * * * * * * * * * * * 1000 116 0 * * * * * * 3782 0 0 V 117 * * * * * * * 1504 * * * * * * * * * 627 * * 117 0 * * * * * * 3782 0 0 V 118 * * * * * * * 2433 2069 * * * * 2490 4343 * 3833 4157 * 2165 118 0 * * * * * * 3752 0 0 E 119 * * 2057 397 * * * * * * * * * * * * * * * * 119 0 * * 0 * * * 3625 0 0 //