Phyre 2 Results for Q9U2T9

Email	l.a.kelley@imperial.ac.uk
Description	Q9U2T9
Date	Fri May 3 21:47:53 BST 2013
Unique Job ID	a42f66bda372091e

Summary

Top model

Image coloured by rainbow N → C terminus

Model dimensions (Å):

X:36.288 Y:40.825 Z:34.547

Model (left) based on template c2khnA_

Top template information

PDB header:signaling protein
Chain: A: PDB Molecule:intersectin-1;
PDBTitle: nmr solution structure of the eh 1 domain from human2 intersectin-1 protein. northeast structural genomics3 consortium target hr3646e.

Confidence and coverage

Confidence:

100.0%

Coverage:

100 residues ( 9% of your sequence) have been modelled with 100.0% confidence by the single highest scoring template.

Additional confident templates have been detected (see Domain analysis) which cover other regions of your sequence.

323 residues ( 30%) could be modelled at >90% confidence using multiple-templates.

You may wish to try resubmitting your sequence in "intensive" mode to model more of your sequence.

3D viewing

Interactive 3D view in Jmol

Sequence analysis

Secondary structure and disorder prediction

1 . . . . . . . . 10 . . . . . . . . . 20 . . . . . . . . . 30 . . . . . . . . . 40 . . . . . . . . . 50 . . . . . . . . . 60

Sequence M T N P W E V S D A E Y Q K N F A M F G Q L T G G Q P F M D A V T A R N A L M R S N L P T Q V L S Q I W A L S D L D K D

Secondary structure

SS confidence

Disorder ? ? ? ? ? ? ?
? ? ? ? ? ?
? ? ?
? ?

Disorder confidence

. . . . . . . . . 70 . . . . . . . . . 80 . . . . . . . . . 90 . . . . . . . . . 100 . . . . . . . . . 110 . . . . . . . . . 120

Sequence G R L D I R E Y S I A M R L A L N C L A G I P I P P Q L P P S L L V V P A R N A P P T W P G S R H G S V D Y S Q T L P P

Secondary structure

SS confidence

Disorder ? ?
?
?
? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 130 . . . . . . . . . 140 . . . . . . . . . 150 . . . . . . . . . 160 . . . . . . . . . 170 . . . . . . . . . 180

Sequence A I D R R M S Q S Y I P S A P V S I A G T P S S R H N S I S A G S P L N N D R N V F E G R Q L E N W A I P H H N K L K Y

Secondary structure

SS confidence

Disorder ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 190 . . . . . . . . . 200 . . . . . . . . . 210 . . . . . . . . . 220 . . . . . . . . . 230 . . . . . . . . . 240

Sequence S Q L F N A L D K E R L G S L S S Q V G R S A L G L S G L P T N V L A H I W F L S D V N K D G K L S V D E Y A I S Q Y M

Secondary structure

SS confidence

Disorder
?
? ?

Disorder confidence

. . . . . . . . . 250 . . . . . . . . . 260 . . . . . . . . . 270 . . . . . . . . . 280 . . . . . . . . . 290 . . . . . . . . . 300

Sequence I E M F K S G F A L P K I T P L E L V R M C G I S S R S A N N T P E L E P G A E P P Q K S P A P K T F E D K R Q D N L S

Secondary structure

SS confidence

Disorder
? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 310 . . . . . . . . . 320 . . . . . . . . . 330 . . . . . . . . . 340 . . . . . . . . . 350 . . . . . . . . . 360

Sequence K G Q A E L E R R R R V L E E E E Q R R R A E V E K K E R E E E A K K N R E R Q E K E R Q A E V E R Q A E L E R Q R I I

Secondary structure

SS confidence

Disorder ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?
? ? ?

Disorder confidence

. . . . . . . . . 370 . . . . . . . . . 380 . . . . . . . . . 390 . . . . . . . . . 400 . . . . . . . . . 410 . . . . . . . . . 420

Sequence E A Q R E E E E K K R R L E M E R R R E E D E K M R K V Q M E K A K V K Q M Q N Q K Q Q E N E R L A Q R Q Q R E K T L Q

Secondary structure

SS confidence

Disorder

Disorder confidence

. . . . . . . . . 430 . . . . . . . . . 440 . . . . . . . . . 450 . . . . . . . . . 460 . . . . . . . . . 470 . . . . . . . . . 480

Sequence F Q L Q A L D E K V I D V E V D I G K A K E A V A E V T G F I E R M R S T R D E K V A R I K E L Q E T N Q K T A I E S Q

Secondary structure

SS confidence

Disorder

Disorder confidence

. . . . . . . . . 490 . . . . . . . . . 500 . . . . . . . . . 510 . . . . . . . . . 520 . . . . . . . . . 530 . . . . . . . . . 540

Sequence E L G H Q L L Q K Q S A H K E T T Q R K S E L E A L R R K R D A I R K A I E D A A L E L S T E K E K S Y N Q T E I L K T

Secondary structure

SS confidence

Disorder
?

Disorder confidence

. . . . . . . . . 550 . . . . . . . . . 560 . . . . . . . . . 570 . . . . . . . . . 580 . . . . . . . . . 590 . . . . . . . . . 600

Sequence N K E K Y K T D V Y S K L V A K R E E Y R N S F E L L V H A Q T H A R S K I G E F E A K S A P A S A A P A P A P A P A P

Secondary structure

SS confidence

Disorder
? ? ? ? ?
? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 610 . . . . . . . . . 620 . . . . . . . . . 630 . . . . . . . . . 640 . . . . . . . . . 650 . . . . . . . . . 660

Sequence T T T N G F P A N F N D A F G E F D K T D A S Q R F D A D F G A T S T A D P F A Q I A Q A P A H S K G A V D Q S A F N I

Secondary structure

SS confidence

Disorder ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 670 . . . . . . . . . 680 . . . . . . . . . 690 . . . . . . . . . 700 . . . . . . . . . 710 . . . . . . . . . 720

Sequence H D T Y K C R A L F A F E A R S E D E L S F E P G D V I I V F Q S H A A E P G W R A G Q L R E K V G W F P E A F V E A I

Secondary structure

SS confidence

Disorder ? ?
?
? ? ?
?
?
? ?
?
? ?

Disorder confidence

. . . . . . . . . 730 . . . . . . . . . 740 . . . . . . . . . 750 . . . . . . . . . 760 . . . . . . . . . 770 . . . . . . . . . 780

Sequence A A V P T P G G D P P I Q N M P P N M T P S S S V D Q I G V K A A R K A E I A A A M G L T E G G A P P A S S A P A A A A

Secondary structure

SS confidence

Disorder ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 790 . . . . . . . . . 800 . . . . . . . . . 810 . . . . . . . . . 820 . . . . . . . . . 830 . . . . . . . . . 840

Sequence V I S Q C I A Q F Q W R A R N E E D L S F A K G D T I E V L E K Q E M K W K G R N P A G E I G W F P K S Y V K E V G A T

Secondary structure

SS confidence

Disorder ?
? ? ? ? ? ?
?
? ?
? ? ?
? ? ? ?

Disorder confidence

. . . . . . . . . 850 . . . . . . . . . 860 . . . . . . . . . 870 . . . . . . . . . 880 . . . . . . . . . 890 . . . . . . . . . 900

Sequence T S T T T P I V S P S K A S A G A P G A A A G A Q Y D V V P S D V T L Q A S E T A P Q Q Q L Y T V I Y D F E A V E T T D

Secondary structure

SS confidence

Disorder ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?
? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 910 . . . . . . . . . 920 . . . . . . . . . 930 . . . . . . . . . 940 . . . . . . . . . 950 . . . . . . . . . 960

Sequence L A L H V G D T I L V L E K N D E W W K G R C N G R E G I F P A N Y V E I S V Q Q A G D P T P P T Q A P T P A A P P T V

Secondary structure

SS confidence

Disorder ? ? ? ? ? ? ?
?
? ?
? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 970 . . . . . . . . . 980 . . . . . . . . . 990 . . . . . . . . . 1000 . . . . . . . . . 1010 . . . . . . . . . 1020

Sequence L C E A K V V V D F V A S A P N Q L G I K V G E I V K I R E K S A A G W W E G E L I R N G K P I A G W F P G E Y V K V L

Secondary structure

SS confidence

Disorder ? ? ? ?
?
?
? ?
? ? ? ? ? ? ? ?
?
? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?
? ? ?

Disorder confidence

. . . . . . . . . 1030 . . . . . . . . . 1040 . . . . . . . . . 1050 . . . . . . . . . 1060 . . . . . . . . . 1070 . . . . . . . . . 1080

Sequence E E A A S P A T R A T A V Y D Y E A S Q P D E L G F K T G D V I I V T D K S E A E W W S G H R E Q D P S K S G L F P S N

Secondary structure

SS confidence

Disorder ? ? ? ? ? ? ? ? ?
?
? ? ? ? ?

Disorder confidence

. . . . .

Sequence Y V Q Q Q

Secondary structure

SS confidence

Disorder
? ? ? ?

Disorder confidence

Confidence Key
High(9) Low (0)

? Disordered ( 48%)

Alpha helix ( 38%)

Beta strand ( 10%)

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank	Aligned region

PDB 2khn chain A

Region: 2 - 101
Aligned: 100
Modelled: 100
Confidence: 100.0%
Identity: 37%
PDB header:signaling protein
Chain: A: PDB Molecule:intersectin-1;
PDBTitle: nmr solution structure of the eh 1 domain from human2 intersectin-1 protein. northeast structural genomics3 consortium target hr3646e.

Phyre2

PDB 1gri chain A

Region: 887 - 1083
Aligned: 190
Modelled: 197
Confidence: 100.0%
Identity: 25%
PDB header:signal transduction adaptor
Chain: A: PDB Molecule:growth factor bound protein 2;
PDBTitle: grb2

Phyre2

PDB 2jq6 chain A

Region: 1 - 99
Aligned: 98
Modelled: 99
Confidence: 99.9%
Identity: 32%
PDB header:metal binding protein
Chain: A: PDB Molecule:eh domain-containing protein 1;
PDBTitle: structure of eh-domain of ehd1

Phyre2

PDB 3fia chain A

Region: 2 - 93
Aligned: 92
Modelled: 92
Confidence: 99.9%
Identity: 38%
PDB header:protein binding
Chain: A: PDB Molecule:intersectin-1;
PDBTitle: crystal structure of the eh 1 domain from human intersectin-2 1 protein. northeast structural genomics consortium target3 hr3646e.

Phyre2

PDB 2lqn chain A

Region: 861 - 1084
Aligned: 190
Modelled: 193
Confidence: 99.9%
Identity: 20%
PDB header:signaling protein
Chain: A: PDB Molecule:crk-like protein;
PDBTitle: solution structure of crkl

Phyre2

PDB 2kfh chain A

Region: 2 - 99
Aligned: 97
Modelled: 98
Confidence: 99.9%
Identity: 32%
PDB header:protein binding
Chain: A: PDB Molecule:eh domain-containing protein 1;
PDBTitle: structure of the c-terminal domain of ehd1 with fnyestgpftak

Phyre2

PDB 2jxc chain A domain 1

Region: 4 - 98
Aligned: 95
Modelled: 95
Confidence: 99.9%
Identity: 36%
Fold: EF Hand-like
Superfamily: EF-hand
Family: Eps15 homology domain (EH domain)

Phyre2

PDB 2eyz chain A

Region: 867 - 1084
Aligned: 175
Modelled: 178
Confidence: 99.9%
Identity: 19%
PDB header:signaling protein
Chain: A: PDB Molecule:v-crk sarcoma virus ct10 oncogene homolog
PDBTitle: ct10-regulated kinase isoform ii

Phyre2

PDB 2l3s chain A

Region: 885 - 1085
Aligned: 158
Modelled: 161
Confidence: 99.9%
Identity: 22%
PDB header:structural protein
Chain: A: PDB Molecule:autoinhibited crk protein;
PDBTitle: structure of the autoinhibited crk

Phyre2

PDB 2qpt chain A

Region: 2 - 100
Aligned: 98
Modelled: 99
Confidence: 99.9%
Identity: 31%
PDB header:endocytosis
Chain: A: PDB Molecule:eh domain-containing protein-2;
PDBTitle: crystal structure of an ehd atpase involved in membrane remodelling

Phyre2

PDB 1ov3 chain A

Region: 957 - 1084
Aligned: 121
Modelled: 128
Confidence: 99.9%
Identity: 26%
PDB header:oxidoreductase activator
Chain: A: PDB Molecule:neutrophil cytosol factor 1;
PDBTitle: structure of the p22phox-p47phox complex

Phyre2

PDB 1iq3 chain A

Region: 2 - 95
Aligned: 94
Modelled: 94
Confidence: 99.9%
Identity: 32%
Fold: EF Hand-like
Superfamily: EF-hand
Family: Eps15 homology domain (EH domain)

Phyre2

PDB 1ng2 chain A

Region: 960 - 1083
Aligned: 117
Modelled: 124
Confidence: 99.9%
Identity: 27%
PDB header:oxidoreductase activator
Chain: A: PDB Molecule:neutrophil cytosolic factor 1;
PDBTitle: structure of autoinhibited p47phox

Phyre2

PDB 2kgr chain A

Region: 5 - 100
Aligned: 96
Modelled: 96
Confidence: 99.9%
Identity: 34%
PDB header:protein binding
Chain: A: PDB Molecule:intersectin-1;
PDBTitle: solution structure of protein itsn1 from homo sapiens.2 northeast structural genomics consortium target hr5524a

Phyre2

PDB 1fi6 chain A

Region: 5 - 94
Aligned: 90
Modelled: 90
Confidence: 99.9%
Identity: 33%
Fold: EF Hand-like
Superfamily: EF-hand
Family: Eps15 homology domain (EH domain)

Phyre2

PDB 1c07 chain A

Region: 4 - 96
Aligned: 93
Modelled: 93
Confidence: 99.8%
Identity: 28%
Fold: EF Hand-like
Superfamily: EF-hand
Family: Eps15 homology domain (EH domain)

Phyre2

PDB 1mv3 chain A

Region: 843 - 1084
Aligned: 198
Modelled: 198
Confidence: 99.8%
Identity: 20%
PDB header:endocytosis/exocytosis
Chain: A: PDB Molecule:myc box dependent interacting protein 1;
PDBTitle: nmr structure of the tumor suppressor bin1: alternative2 splicing in melanoma and interaction with c-myc

Phyre2

PDB 1qjt chain A

Region: 9 - 97
Aligned: 89
Modelled: 89
Confidence: 99.7%
Identity: 25%
Fold: EF Hand-like
Superfamily: EF-hand
Family: Eps15 homology domain (EH domain)

Phyre2

PDB 2dx1 chain A

Region: 1029 - 1083
Aligned: 52
Modelled: 55
Confidence: 99.7%
Identity: 42%
PDB header:signaling protein
Chain: A: PDB Molecule:rho guanine nucleotide exchange factor 4;
PDBTitle: crystal structure of rhogef protein asef

Phyre2

PDB 1udl chain A

Region: 999 - 1083
Aligned: 80
Modelled: 85
Confidence: 99.7%
Identity: 43%
Fold: SH3-like barrel
Superfamily: SH3-domain
Family: SH3-domain

Phyre2

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