Phyre Home Retrieve Phyre Job Id
Emaill.a.kelley@imperial.ac.uk
DescriptionQ967F3
DateSat Apr 13 13:12:35 BST 2013
Unique Job ID801295d60fd67ab0

Summary 

Top model
Image coloured by rainbow N → C terminus
Model dimensions (Å):X:55.941 Y:40.203 Z:43.342
Model (left) based on template c2knoA_
Top template information
PDB header:hydrolase
Chain: A: PDB Molecule:tensin-like c1 domain-containing phosphatase;
PDBTitle: nmr solution structure of sh2 domain of the human tensin like c12 domain containing phosphatase (tenc1)
Confidence and coverage
Confidence: 99.9% Coverage: 18%
111 residues ( 18% of your sequence) have been modelled with 99.9% confidence by the single highest scoring template.
Additional confident templates have been detected (see Domain analysis) which cover other regions of your sequence.
306 residues ( 49%) could be modelled at >90% confidence using multiple-templates.
You may wish to try resubmitting your sequence in "intensive" mode to model more of your sequence.
Warning: 52% of your sequence is predicted disordered. Disordered regions cannot be meaningfully predicted.
3D viewing
Interactive 3D view in Jmol

Sequence analysis 

Secondary structure and disorder prediction 

   1........10.........20.........30.........40.........50.........60
Sequence  MYSRLKSSLLNHFQKGANSSSNPSYNGLTKEEKKRLRHSLAECQLNDVYDPDSAHSSYQH
Secondary structure 
SS confidence 
Disorder  ???
???????????????
????????
Disorder confidence 
 
   .........70.........80.........90.........100.........110.........120
Sequence  SVSFVTTKPSSRHHQQTIDTSGHAPLAPQEVYLDETSSNSASTFYSDLLASSFSSAGGNS
Secondary structure 
SS confidence 
Disorder 
???????????????
?
?
?
??????????
Disorder confidence 
 
   .........130.........140.........150.........160.........170.........180
Sequence  SFTCDYEDTNETSFIMSSGLPALSWNVQYIGSFPISGSYVDNLGRRIDSFQPTTSGGMQS
Secondary structure 
SS confidence 
Disorder 
??
?????
?????
?????
?
Disorder confidence 
 
   .........190.........200.........210.........220.........230.........240
Sequence  VELSISVLGVKICCEKTVLMSHSLRRVTDISARPDTQNIGYVATEPVGRTYRRLCHVFHC
Secondary structure 
SS confidence 
Disorder 
?
????
Disorder confidence 
 
   .........250.........260.........270.........280.........290.........300
Sequence  QSLKEAEEIENVLRNANQSQVLAAKQPKSAVSTSSMHPTNTASTMTEKRSASTVFLNRFL
Secondary structure 
SS confidence 
Disorder 
???????????????????????????????????????
Disorder confidence 
 
   .........310.........320.........330.........340.........350.........360
Sequence  GKKGSQTVDESGQCKRKRRPVSAVFSSAIHRLSSSTSSVNPKRMSTIEPQAPTREQLLQL
Secondary structure 
SS confidence 
Disorder  ????????????????????????????????????????????????????????????
Disorder confidence 
 
   .........370.........380.........390.........400.........410.........420
Sequence  QNQMRCAASSPVPEEPRPTDLCAASTTTSTSSVASSSSSNGSSSSTDTSPVPPAPQTALV
Secondary structure 
SS confidence 
Disorder  ????????????????????????????????????????????????????????
Disorder confidence 
 
   .........430.........440.........450.........460.........470.........480
Sequence  YDEKLGEWIYPIDQALMTQLDNCSYFVGQPTKDSMVYNLNTQPEGAFVIRYSESKSKCLA
Secondary structure 
SS confidence 
Disorder 
???
??????
??
??
Disorder confidence 
 
   .........490.........500.........510.........520.........530.........540
Sequence  LSMRVPCSHNPSGISHYLIIRNEQGFRLKLSATKKPFPTLQMMLTHHSVLESHLPCTLHF
Secondary structure 
SS confidence 
Disorder 
?????
??
?
Disorder confidence 
 
   .........550.........560.........570.........580.........590.........600
Sequence  VQWQKTNFKQLAAMSTVERPLRTFNRHSTALTKIDENRNVTATSTPYRPSGRCGGGIDDF
Secondary structure 
SS confidence 
Disorder  ????????????????????????
??????
???????
?????????
??
????
Disorder confidence 
 
   .........610.........620........
Sequence  TTPKNRRTRNEINAMRRSHFFDDRQIVL
Secondary structure 
SS confidence 
Disorder 
?
???????????????
???
??
Disorder confidence 
 

Confidence Key
High(9)                    Low (0)
?Disordered ( 52%)
Alpha helix ( 21%)
Beta strand ( 17%)

Domain analysis 

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

RankAligned region

PDB 2kno chain A

3D model

Region: 426 - 540
Aligned: 111
Modelled: 115
Confidence: 99.9%
Identity: 22%
PDB header:hydrolase
Chain: A: PDB Molecule:tensin-like c1 domain-containing phosphatase;
PDBTitle: nmr solution structure of sh2 domain of the human tensin like c12 domain containing phosphatase (tenc1)

Phyre2

PDB 1wj1 chain A

3D model

Region: 114 - 273
Aligned: 152
Modelled: 160
Confidence: 99.9%
Identity: 16%
Fold: PH domain-like barrel
Superfamily: PH domain-like
Family: Phosphotyrosine-binding domain (PTB)

Phyre2

PDB 1oy2 chain A

3D model

Region: 143 - 266
Aligned: 120
Modelled: 121
Confidence: 99.8%
Identity: 20%
Fold: PH domain-like barrel
Superfamily: PH domain-like
Family: Phosphotyrosine-binding domain (PTB)

Phyre2

PDB 1lkk chain A

3D model

Region: 440 - 539
Aligned: 98
Modelled: 100
Confidence: 99.8%
Identity: 24%
Fold: SH2-like
Superfamily: SH2 domain
Family: SH2 domain

Phyre2

PDB 3so6 chain A

3D model

Region: 140 - 270
Aligned: 129
Modelled: 131
Confidence: 99.8%
Identity: 16%
PDB header:protein binding/protein transport
Chain: A: PDB Molecule:ldl receptor adaptor protein;
PDBTitle: crystal structure of the ldl receptor tail in complex with autosomal2 recessive hypercholesterolemia ptb domain

Phyre2

PDB 1g83 chain A domain 2

3D model

Region: 438 - 540
Aligned: 101
Modelled: 101
Confidence: 99.8%
Identity: 25%
Fold: SH2-like
Superfamily: SH2 domain
Family: SH2 domain

Phyre2

PDB 1cwe chain A

3D model

Region: 443 - 538
Aligned: 94
Modelled: 96
Confidence: 99.8%
Identity: 26%
Fold: SH2-like
Superfamily: SH2 domain
Family: SH2 domain

Phyre2

PDB 1opk chain A domain 2

3D model

Region: 440 - 540
Aligned: 94
Modelled: 101
Confidence: 99.8%
Identity: 29%
Fold: SH2-like
Superfamily: SH2 domain
Family: SH2 domain

Phyre2

PDB 2c9w chain A

3D model

Region: 436 - 538
Aligned: 96
Modelled: 103
Confidence: 99.8%
Identity: 22%
PDB header:transcription regulation
Chain: A: PDB Molecule:suppressor of cytokine signaling 2;
PDBTitle: crystal structure of socs-2 in complex with elongin-b and2 elongin-c at 1.9a resolution

Phyre2

PDB 2oq1 chain A domain 1

3D model

Region: 444 - 538
Aligned: 88
Modelled: 93
Confidence: 99.8%
Identity: 22%
Fold: SH2-like
Superfamily: SH2 domain
Family: SH2 domain

Phyre2

PDB 2lct chain A

3D model

Region: 437 - 540
Aligned: 96
Modelled: 104
Confidence: 99.8%
Identity: 22%
PDB header:signaling protein
Chain: A: PDB Molecule:proto-oncogene vav;
PDBTitle: solution structure of the vav1 sh2 domain complexed with a syk-derived2 doubly phosphorylated peptide

Phyre2

PDB 2oq1 chain A

3D model

Region: 438 - 538
Aligned: 94
Modelled: 99
Confidence: 99.8%
Identity: 20%
PDB header:transferase
Chain: A: PDB Molecule:tyrosine-protein kinase zap-70;
PDBTitle: tandem sh2 domains of zap-70 with 19-mer zeta1 peptide

Phyre2

PDB 2dly chain A

3D model

Region: 438 - 538
Aligned: 94
Modelled: 101
Confidence: 99.8%
Identity: 29%
PDB header:transferase
Chain: A: PDB Molecule:fyn-related kinase;
PDBTitle: solution structure of the sh2 domain of murine fyn-related2 kinase

Phyre2

PDB 1ddm chain A

3D model

Region: 142 - 263
Aligned: 119
Modelled: 122
Confidence: 99.8%
Identity: 16%
Fold: PH domain-like barrel
Superfamily: PH domain-like
Family: Phosphotyrosine-binding domain (PTB)

Phyre2

PDB 1lui chain A

3D model

Region: 438 - 540
Aligned: 102
Modelled: 103
Confidence: 99.8%
Identity: 20%
Fold: SH2-like
Superfamily: SH2 domain
Family: SH2 domain

Phyre2

PDB 2vif chain A

3D model

Region: 434 - 528
Aligned: 90
Modelled: 95
Confidence: 99.8%
Identity: 19%
PDB header:signaling protein
Chain: A: PDB Molecule:suppressor of cytokine signalling 6;
PDBTitle: crystal structure of socs6 sh2 domain in complex with a c-kit2 phosphopeptide

Phyre2

PDB 1a81 chain A domain 1

3D model

Region: 441 - 540
Aligned: 93
Modelled: 98
Confidence: 99.8%
Identity: 23%
Fold: SH2-like
Superfamily: SH2 domain
Family: SH2 domain

Phyre2

PDB 2y3a chain B

3D model

Region: 434 - 540
Aligned: 99
Modelled: 107
Confidence: 99.8%
Identity: 26%
PDB header:transferase
Chain: B: PDB Molecule:phosphatidylinositol 3-kinase regulatory subunit beta;
PDBTitle: crystal structure of p110beta in complex with icsh2 of p85beta and2 the drug gdc-0941

Phyre2

PDB 2ekx chain A

3D model

Region: 438 - 540
Aligned: 100
Modelled: 103
Confidence: 99.8%
Identity: 21%
PDB header:signaling protein
Chain: A: PDB Molecule:cytoplasmic tyrosine-protein kinase bmx;
PDBTitle: solution structure of the human bmx sh2 domain

Phyre2

PDB 2qms chain A domain 1

3D model

Region: 435 - 540
Aligned: 101
Modelled: 106
Confidence: 99.8%
Identity: 22%
Fold: SH2-like
Superfamily: SH2 domain
Family: SH2 domain

Phyre2

PDB 2m38 chain A

3D model

Region: 144 - 261
Aligned: 116
Modelled: 116
Confidence: 99.8%
Identity: 22%
PDB header:peptide binding protein
Chain: A: PDB Molecule:ankyrin repeat and sterile alpha motif domain-containing
PDBTitle: ptb domain of aida1

Phyre2

PDB 2dyq chain A

3D model

Region: 145 - 266
Aligned: 117
Modelled: 110
Confidence: 99.8%
Identity: 18%
PDB header:protein binding
Chain: A: PDB Molecule:amyloid beta a4 precursor protein-binding family b member
PDBTitle: crystal structure of the c-terminal phophotyrosine interaction domain2 of human apbb3

Phyre2

PDB 3ps5 chain A

3D model

Region: 421 - 579
Aligned: 143
Modelled: 143
Confidence: 99.5%
Identity: 13%
PDB header:hydrolase, signaling protein
Chain: A: PDB Molecule:tyrosine-protein phosphatase non-receptor type 6;
PDBTitle: crystal structure of the full-length human protein tyrosine2 phosphatase shp-1

Phyre2
1
c2knoA_
2
d1wj1a_
3
d1oy2a_
4
d1lkka_
5
c3so6A_
6
d1g83a2
7
d1cwea_
8
d1opka2
9
c2c9wA_
10
d2oq1a1
11
c2lctA_
12
c2oq1A_
13
c2dlyA_
14
d1ddma_
15
d1luia_
16
c2vifA_
17
d1a81a1
18
c2y3aB_
19
c2ekxA_
20
d2qmsa1
21
22
23
24
25
c2m38A_
26
27
28
c2dyqA_
29
30
31
32
33
34
35
36
37
38
39
40
41
42
43
44
45
46
47
48
49
50
51
52
53
54
55
56
57
58
59
60
61
62
63
64
65
66
67
68
69
70
71
72
73
74
75
76
77
78
79
80
81
82
83
84
85
86
87
88
89
90
91
92
93
94
95
96
97
98
99
100
101
102
103
104
105
106
c3ps5A_
107
108
109
110
111
112
113
114
115
116
117
118
119
120
121
122
123
124
125
126
127
128
129
130
131
132
133
134
135
136
137
138
139
140
141



Detailed template information 

#
Template Alignment Coverage3D Model Confidence
% i.d. Template Information
1c2knoA_
99.9 22 PDB header:hydrolase
Chain: A: PDB Molecule:tensin-like c1 domain-containing phosphatase;
PDBTitle: nmr solution structure of sh2 domain of the human tensin like c12 domain containing phosphatase (tenc1)
2d1wj1a_
99.9 16 Fold:PH domain-like barrel
Superfamily:PH domain-like
Family:Phosphotyrosine-binding domain (PTB)
3d1oy2a_
99.8 20 Fold:PH domain-like barrel
Superfamily:PH domain-like
Family:Phosphotyrosine-binding domain (PTB)
4d1lkka_
99.8 24 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
5c3so6A_
99.8 16 PDB header:protein binding/protein transport
Chain: A: PDB Molecule:ldl receptor adaptor protein;
PDBTitle: crystal structure of the ldl receptor tail in complex with autosomal2 recessive hypercholesterolemia ptb domain
6d1g83a2
99.8 25 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
7d1cwea_
99.8 26 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
8d1opka2
99.8 29 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
9c2c9wA_
99.8 22 PDB header:transcription regulation
Chain: A: PDB Molecule:suppressor of cytokine signaling 2;
PDBTitle: crystal structure of socs-2 in complex with elongin-b and2 elongin-c at 1.9a resolution
10d2oq1a1
99.8 22 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
11c2lctA_
99.8 22 PDB header:signaling protein
Chain: A: PDB Molecule:proto-oncogene vav;
PDBTitle: solution structure of the vav1 sh2 domain complexed with a syk-derived2 doubly phosphorylated peptide
12c2oq1A_
99.8 20 PDB header:transferase
Chain: A: PDB Molecule:tyrosine-protein kinase zap-70;
PDBTitle: tandem sh2 domains of zap-70 with 19-mer zeta1 peptide
13c2dlyA_
99.8 29 PDB header:transferase
Chain: A: PDB Molecule:fyn-related kinase;
PDBTitle: solution structure of the sh2 domain of murine fyn-related2 kinase
14d1ddma_
99.8 16 Fold:PH domain-like barrel
Superfamily:PH domain-like
Family:Phosphotyrosine-binding domain (PTB)
15d1luia_
99.8 20 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
16c2vifA_
99.8 19 PDB header:signaling protein
Chain: A: PDB Molecule:suppressor of cytokine signalling 6;
PDBTitle: crystal structure of socs6 sh2 domain in complex with a c-kit2 phosphopeptide
17d1a81a1
99.8 23 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
18c2y3aB_
99.8 26 PDB header:transferase
Chain: B: PDB Molecule:phosphatidylinositol 3-kinase regulatory subunit beta;
PDBTitle: crystal structure of p110beta in complex with icsh2 of p85beta and2 the drug gdc-0941
19c2ekxA_
99.8 21 PDB header:signaling protein
Chain: A: PDB Molecule:cytoplasmic tyrosine-protein kinase bmx;
PDBTitle: solution structure of the human bmx sh2 domain
20d2qmsa1
99.8 22 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
21d1o48a_
not modelled 99.8 22 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
22d2oq1a2
not modelled 99.8 20 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
23c1ka6A_
not modelled 99.8 17 PDB header:immune system
Chain: A: PDB Molecule:sh2 domain protein 1a;
PDBTitle: sap/sh2d1a bound to peptide n-py
24d1blja_
not modelled 99.8 26 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
25c2m38A_
99.8 22 PDB header:peptide binding protein
Chain: A: PDB Molecule:ankyrin repeat and sterile alpha motif domain-containing
PDBTitle: ptb domain of aida1
26d1qcfa2
not modelled 99.8 23 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
27d1a81e1
not modelled 99.8 23 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
28c2dyqA_
99.8 18 PDB header:protein binding
Chain: A: PDB Molecule:amyloid beta a4 precursor protein-binding family b member
PDBTitle: crystal structure of the c-terminal phophotyrosine interaction domain2 of human apbb3
29d1bkla_
not modelled 99.8 23 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
30d1f2fa_
not modelled 99.8 23 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
31d1a81a2
not modelled 99.8 20 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
32d1aqca_
not modelled 99.7 21 Fold:PH domain-like barrel
Superfamily:PH domain-like
Family:Phosphotyrosine-binding domain (PTB)
33d2eyva1
not modelled 99.7 28 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
34c3dxeC_
not modelled 99.7 17 PDB header:protein binding
Chain: C: PDB Molecule:amyloid beta a4 protein-binding family b member
PDBTitle: crystal structure of the intracellular domain of human app2 (t668a mutant) in complex with fe65-ptb2
35c3sv1C_
not modelled 99.7 22 PDB header:protein binding
Chain: C: PDB Molecule:amyloid beta a4 precursor protein-binding family a member
PDBTitle: crystal structure of app peptide bound rat mint2 parm
36c2ge9A_
not modelled 99.7 24 PDB header:transferase
Chain: A: PDB Molecule:tyrosine-protein kinase btk;
PDBTitle: solution structures of the sh2 domain of bruton's tyrosine2 kinase
37d1d4ta_
not modelled 99.7 17 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
38d1jwoa_
not modelled 99.7 20 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
39c2augB_
not modelled 99.7 24 PDB header:signaling protein
Chain: B: PDB Molecule:growth factor receptor-bound protein 14;
PDBTitle: crystal structure of the grb14 sh2 domain
40c4fl2A_
not modelled 99.7 23 PDB header:transferase
Chain: A: PDB Molecule:tyrosine-protein kinase syk;
PDBTitle: structural and biophysical characterization of the syk activation2 switch
41d1nrva_
not modelled 99.7 21 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
42c2ysxA_
not modelled 99.7 25 PDB header:signaling protein
Chain: A: PDB Molecule:signaling inositol polyphosphate phosphatase
PDBTitle: solution structure of the human ship sh2 domain
43d1k9aa2
not modelled 99.7 19 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
44c2gsbA_
not modelled 99.7 15 PDB header:signaling protein
Chain: A: PDB Molecule:ras gtpase-activating protein 1;
PDBTitle: solution structure of the second sh2 domain of human ras2 gtpase-activating protein 1
45d1csya_
not modelled 99.7 22 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
46d1i3za_
not modelled 99.7 27 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
47d1a81e2
not modelled 99.7 22 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
48d2izva2
not modelled 99.7 21 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
49d1p3ra_
not modelled 99.7 17 Fold:PH domain-like barrel
Superfamily:PH domain-like
Family:Phosphotyrosine-binding domain (PTB)
50c2izvA_
not modelled 99.7 22 PDB header:transcription
Chain: A: PDB Molecule:suppressor of cytokine signaling 4;
PDBTitle: crystal structure of socs-4 in complex with elongin-b and2 elongin-c at 2.55a resolution
51c2ablA_
not modelled 99.7 29 PDB header:transferase
Chain: A: PDB Molecule:abl tyrosine kinase;
PDBTitle: sh3-sh2 domain fragment of human bcr-abl tyrosine kinase
52c2elaB_
not modelled 99.7 16 PDB header:cell cycle
Chain: B: PDB Molecule:adapter protein containing ph domain, ptb domain
PDBTitle: crystal structure of the ptb domain of human appl1
53c2crhA_
not modelled 99.7 21 PDB header:signaling protein
Chain: A: PDB Molecule:vav proto-oncogene;
PDBTitle: solution structure of the sh2 domain of human proto-2 oncogene protein vav1
54c2eo3A_
not modelled 99.7 23 PDB header:signaling protein
Chain: A: PDB Molecule:crk-like protein;
PDBTitle: solution structure of the sh2 domain from human crk-like2 protein
55d1rjaa_
not modelled 99.7 28 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
56d2c9wa2
not modelled 99.7 23 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
57c2dlzA_
not modelled 99.7 16 PDB header:signaling protein
Chain: A: PDB Molecule:protein vav-2;
PDBTitle: solution structure of the sh2 domain of human protein vav-2
58c2hmhA_
not modelled 99.7 22 PDB header:cytokine regulator
Chain: A: PDB Molecule:suppressor of cytokine signaling 3;
PDBTitle: crystal structure of socs3 in complex with gp130(ptyr757)2 phosphopeptide.
59c2eo6A_
not modelled 99.7 16 PDB header:signaling protein
Chain: A: PDB Molecule:b-cell linker protein;
PDBTitle: solution structure of the sh2 domain from mouse b-cell2 linker protein blnk
60c2hdxB_
not modelled 99.7 21 PDB header:signaling protein
Chain: B: PDB Molecule:sh2-b ph domain containing signaling mediator 1
PDBTitle: crystal structure of the src homology-2 domain of sh2-b in2 complex with jak2 ptyr813 phosphopeptide
61d1pica_
not modelled 99.7 23 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
62d1r1qa_
not modelled 99.7 17 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
63c1a81E_
not modelled 99.7 23 PDB header:complex (transferase/peptide)
Chain: E: PDB Molecule:syk kinase;
PDBTitle: crystal structure of the tandem sh2 domain of the syk kinase bound to2 a dually tyrosine-phosphorylated itam
64c1x27F_
not modelled 99.7 23 PDB header:signaling protein
Chain: F: PDB Molecule:proto-oncogene tyrosine-protein kinase lck;
PDBTitle: crystal structure of lck sh2-sh3 with sh2 binding site of2 p130cas
65c2yszA_
not modelled 99.7 23 PDB header:protein binding
Chain: A: PDB Molecule:amyloid beta a4 precursor protein-binding family
PDBTitle: solution structure of the chimera of the c-terminal pid2 domain of fe65l and the c-terminal tail peptide of app
66c3hizB_
not modelled 99.7 14 PDB header:transferase/oncoprotein
Chain: B: PDB Molecule:phosphatidylinositol 3-kinase regulatory subunit
PDBTitle: crystal structure of p110alpha h1047r mutant in complex with2 nish2 of p85alpha
67c2ozoA_
not modelled 99.7 20 PDB header:transferase
Chain: A: PDB Molecule:tyrosine-protein kinase zap-70;
PDBTitle: autoinhibited intact human zap-70
68c2fo0A_
not modelled 99.7 28 PDB header:transferase
Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase abl1 (1b isoform);
PDBTitle: organization of the sh3-sh2 unit in active and inactive forms of the2 c-abl tyrosine kinase
69c3suzA_
not modelled 99.7 22 PDB header:protein binding
Chain: A: PDB Molecule:amyloid beta a4 precursor protein-binding family a member
PDBTitle: crystal structure of rat mint2 ppc
70d1ntva_
not modelled 99.7 19 Fold:PH domain-like barrel
Superfamily:PH domain-like
Family:Phosphotyrosine-binding domain (PTB)
71c2eobA_
not modelled 99.7 19 PDB header:hydrolase
Chain: A: PDB Molecule:1-phosphatidylinositol-4,5-bisphosphate
PDBTitle: solution structure of the second sh2 domain from rat plc2 gamma-2
72c1g83A_
not modelled 99.7 25 PDB header:transferase
Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase fyn;
PDBTitle: crystal structure of fyn sh3-sh2
73c3nhnA_
not modelled 99.7 24 PDB header:transferase
Chain: A: PDB Molecule:tyrosine-protein kinase hck;
PDBTitle: crystal structure of the src-family kinase hck sh3-sh2-linker2 regulatory region
74c2el8A_
not modelled 99.7 13 PDB header:signaling protein
Chain: A: PDB Molecule:signal-transducing adaptor protein 2;
PDBTitle: solution structure of the human stap2 sh2 domain
75c1y57A_
not modelled 99.7 22 PDB header:transferase
Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase src;
PDBTitle: structure of unphosphorylated c-src in complex with an inhibitor
76c2h8hA_
not modelled 99.7 21 PDB header:transferase
Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase src;
PDBTitle: src kinase in complex with a quinazoline inhibitor
77d2shpa2
not modelled 99.7 23 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
78d2cs0a1
not modelled 99.7 25 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
79d3c7ia1
not modelled 99.7 23 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
80c2lqnA_
not modelled 99.7 23 PDB header:signaling protein
Chain: A: PDB Molecule:crk-like protein;
PDBTitle: solution structure of crkl
81d1ayaa_
not modelled 99.6 22 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
82d1fhsa_
not modelled 99.6 23 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
83d1mila_
not modelled 99.6 19 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
84d2shpa3
not modelled 99.6 20 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
85c2shpA_
not modelled 99.6 21 PDB header:tyrosine phosphatase
Chain: A: PDB Molecule:shp-2;
PDBTitle: tyrosine phosphatase shp-2
86d1qada_
not modelled 99.6 24 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
87c2dm0A_
not modelled 99.6 22 PDB header:transferase
Chain: A: PDB Molecule:tyrosine-protein kinase txk;
PDBTitle: solution structure of the sh2 domain of human tyrosine-2 protein kinase txk
88c2ci8A_
not modelled 99.6 22 PDB header:translation
Chain: A: PDB Molecule:cytoplasmic protein nck1;
PDBTitle: sh2 domain of human nck1 adaptor protein - uncomplexed
89c3gqiB_
not modelled 99.6 19 PDB header:transferase/transferase inhibitor
Chain: B: PDB Molecule:phospholipase c-gamma-1;
PDBTitle: crystal structure of activated receptor tyrosine kinase in complex2 with substrates
90c1k9aB_
not modelled 99.6 20 PDB header:transferase
Chain: B: PDB Molecule:carboxyl-terminal src kinase;
PDBTitle: crystal structure analysis of full-length carboxyl-terminal2 src kinase at 2.5 a resolution
91c2kk6A_
not modelled 99.6 19 PDB header:transferase
Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase fer;
PDBTitle: solution structure of sh2 domain of proto-oncogene tyrosine-2 protein kinase fer from homo sapiens, northeast structural3 genomics consortium (nesg) target hr3461d
92c1x6cA_
not modelled 99.6 14 PDB header:signaling protein
Chain: A: PDB Molecule:tyrosine-protein phosphatase, non-receptor type
PDBTitle: solution structures of the sh2 domain of human protein-2 tyrosine phosphatase shp-1
93d2fcia1
not modelled 99.6 19 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
94d1rpya_
not modelled 99.6 19 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
95d1jyra_
not modelled 99.6 25 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
96c1oplA_
not modelled 99.6 30 PDB header:transferase
Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase;
PDBTitle: structural basis for the auto-inhibition of c-abl tyrosine2 kinase
97d1fu6a_
not modelled 99.6 15 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
98c3mazA_
not modelled 99.6 17 PDB header:signaling protein
Chain: A: PDB Molecule:signal-transducing adaptor protein 1;
PDBTitle: crystal structure of the human brdg1/stap-1 sh2 domain in complex with2 the ntal ptyr136 peptide
99c2c0iA_
not modelled 99.6 24 PDB header:transferase
Chain: A: PDB Molecule:tyrosine-protein kinase hck;
PDBTitle: src family kinase hck with bound inhibitor a-420983
100c2dcrA_
not modelled 99.6 19 PDB header:transferase
Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase fes/fps;
PDBTitle: fully automated solution structure determination of the fes2 sh2 domain
101c1rqqC_
not modelled 99.6 23 PDB header:transferase/signaling protein
Chain: C: PDB Molecule:adaptor protein aps;
PDBTitle: crystal structure of the insulin receptor kinase in complex2 with the sh2 domain of aps
102c2yt1A_
not modelled 99.5 23 PDB header:protein binding
Chain: A: PDB Molecule:amyloid beta a4 protein and amyloid beta a4
PDBTitle: solution structure of the chimera of the c-terminal tail2 peptide of app and the c-terminal pid domain of fe65l
103c2b3oA_
not modelled 99.5 14 PDB header:hydrolase
Chain: A: PDB Molecule:tyrosine-protein phosphatase, non-receptor type
PDBTitle: crystal structure of human tyrosine phosphatase shp-1
104c3gxxB_
not modelled 99.5 19 PDB header:transcription
Chain: B: PDB Molecule:transcription elongation factor spt6;
PDBTitle: structure of the sh2 domain of the candida glabrata2 transcription elongation factor spt6, crystal form b
105d1wgua_
not modelled 99.5 24 Fold:PH domain-like barrel
Superfamily:PH domain-like
Family:Phosphotyrosine-binding domain (PTB)
106c3ps5A_
99.5 13 PDB header:hydrolase, signaling protein
Chain: A: PDB Molecule:tyrosine-protein phosphatase non-receptor type 6;
PDBTitle: crystal structure of the full-length human protein tyrosine2 phosphatase shp-1
107d2cy5a1
not modelled 99.5 21 Fold:PH domain-like barrel
Superfamily:PH domain-like
Family:Phosphotyrosine-binding domain (PTB)
108d2dkqa1
not modelled 99.5 21 Fold:PH domain-like barrel
Superfamily:PH domain-like
Family:Phosphotyrosine-binding domain (PTB)
109c3d8dA_
not modelled 99.4 17 PDB header:protein binding
Chain: A: PDB Molecule:amyloid beta a4 precursor protein-binding family b member
PDBTitle: crystal structure of the human fe65-ptb1 domain
110d1wvha1
not modelled 99.4 21 Fold:PH domain-like barrel
Superfamily:PH domain-like
Family:Phosphotyrosine-binding domain (PTB)
111c2eyzA_
not modelled 99.4 23 PDB header:signaling protein
Chain: A: PDB Molecule:v-crk sarcoma virus ct10 oncogene homolog
PDBTitle: ct10-regulated kinase isoform ii
112d1xa6a2
not modelled 99.4 23 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
113c2dvjA_
not modelled 99.4 24 PDB header:signaling protein
Chain: A: PDB Molecule:v-crk sarcoma virus ct10 oncogene homolog,
PDBTitle: phosphorylated crk-ii
114c3qwxX_
not modelled 99.4 21 PDB header:signaling protein
Chain: X: PDB Molecule:cell death abnormality protein 2;
PDBTitle: ced-2 1-174
115c3qwyA_
not modelled 99.4 21 PDB header:signaling protein
Chain: A: PDB Molecule:cell death abnormality protein 2;
PDBTitle: ced-2
116c2eyyA_
not modelled 99.4 25 PDB header:signaling protein
Chain: A: PDB Molecule:v-crk sarcoma virus ct10 oncogene homolog
PDBTitle: ct10-regulated kinase isoform i
117c3or8A_
not modelled 99.2 21 PDB header:transcription
Chain: A: PDB Molecule:transcription elongation factor spt6;
PDBTitle: a tandem sh2 domain in transcription elongation factor spt6
118d1uura3
not modelled 99.2 24 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
119c2cr4A_
not modelled 99.2 26 PDB header:signaling protein
Chain: A: PDB Molecule:sh3 domain-binding protein 2;
PDBTitle: solution structure of the sh2 domain of human sh3bp2 protein
120c2xp1A_
not modelled 99.1 19 PDB header:transcription
Chain: A: PDB Molecule:spt6;
PDBTitle: structure of the tandem sh2 domains from antonospora locustae2 transcription elongation factor spt6

Binding site prediction 

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Transmembrane helix prediction 

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