Phyre 2 Results for Q22070

Email	l.a.kelley@imperial.ac.uk
Description	Q22070
Date	Sat Apr 13 12:57:32 BST 2013
Unique Job ID	810548c15e619017

Summary

Top model

Image coloured by rainbow N → C terminus

Model dimensions (Å):

X:61.646 Y:94.080 Z:99.817

Model (left) based on template c3ohmB_

Top template information

PDB header:signaling protein / hydrolase
Chain: B: PDB Molecule:1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase
PDBTitle: crystal structure of activated g alpha q bound to its effector2 phospholipase c beta 3

Confidence and coverage

Confidence:

100.0%

Coverage:

52%

708 residues ( 52% of your sequence) have been modelled with 100.0% confidence by the single highest scoring template.

You may wish to submit your sequence to Phyrealarm. This will automatically scan your sequence every week for new potential templates as they appear in the Phyre2 library.

3D viewing

Interactive 3D view in Jmol

Sequence analysis

Secondary structure and disorder prediction

1 . . . . . . . . 10 . . . . . . . . . 20 . . . . . . . . . 30 . . . . . . . . . 40 . . . . . . . . . 50 . . . . . . . . . 60

Sequence M Q H G S L G P S S S S R K T T V T S T A G S V H L H H R S S N G F S T A S R A Q L N R H N E M D F G K M F A A M E K G

Secondary structure

SS confidence

Disorder ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 70 . . . . . . . . . 80 . . . . . . . . . 90 . . . . . . . . . 100 . . . . . . . . . 110 . . . . . . . . . 120

Sequence H K V C K I A V L K K W D P A Y K Q L T L D R Y S R Q I F L T K L E L S A V R N K P T I L D I R Q I R E V Q T L N Y K L

Secondary structure

SS confidence

Disorder
? ? ? ?
?
? ? ? ? ? ? ? ?
?

Disorder confidence

. . . . . . . . . 130 . . . . . . . . . 140 . . . . . . . . . 150 . . . . . . . . . 160 . . . . . . . . . 170 . . . . . . . . . 180

Sequence N T I K V D D K W K K D R E I V N F D S K A I L I I S Y G M G F A L S Y W I L L F E S E D A C K L W S Q G L H N L M M D

Secondary structure

SS confidence

Disorder ? ? ? ? ?
? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 190 . . . . . . . . . 200 . . . . . . . . . 210 . . . . . . . . . 220 . . . . . . . . . 230 . . . . . . . . . 240

Sequence T R D R D S S P H P L R I E R F L H K H F L S L M S P A N D A V A R K H M K P F V Q T S L Q F K V Q S D Q L Q Q V T E D

Secondary structure

SS confidence

Disorder
? ? ? ? ? ? ?
? ? ? ? ? ? ? ?
? ? ?

Disorder confidence

. . . . . . . . . 250 . . . . . . . . . 260 . . . . . . . . . 270 . . . . . . . . . 280 . . . . . . . . . 290 . . . . . . . . . 300

Sequence Q M N S D Q F S F A S R Q L I H V P E L F S S R F A D L A E K H E R K G L V V T F Q N F L R F L D G K Q F D E L A S N R

Secondary structure

SS confidence

Disorder
?
? ? ?

Disorder confidence

. . . . . . . . . 310 . . . . . . . . . 320 . . . . . . . . . 330 . . . . . . . . . 340 . . . . . . . . . 350 . . . . . . . . . 360

Sequence T R A L E F L N R Y F Q E D Q A Y F G D R N E P S M T V F E F C D F L F S R E N S L W D P T N E K V T H D M S R P L S H

Secondary structure

SS confidence

Disorder
? ? ? ? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 370 . . . . . . . . . 380 . . . . . . . . . 390 . . . . . . . . . 400 . . . . . . . . . 410 . . . . . . . . . 420

Sequence Y W I A S S H N T Y L T G D Q L R S E S S L D C Y A Q A L L M G C R C I E L D C W D G Q K K P G S A E F I D I V I Y H G

Secondary structure

SS confidence

Disorder
? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 430 . . . . . . . . . 440 . . . . . . . . . 450 . . . . . . . . . 460 . . . . . . . . . 470 . . . . . . . . . 480

Sequence Y T M T S K I L L R D V L H V I R H Y A F V T S E Y P V I L S I E D N C S V P A Q R L L A Q E L K D I L G D Y L L T Q P

Secondary structure

SS confidence

Disorder

Disorder confidence

. . . . . . . . . 490 . . . . . . . . . 500 . . . . . . . . . 510 . . . . . . . . . 520 . . . . . . . . . 530 . . . . . . . . . 540

Sequence A N R E E K Q L P S P A A L K K K I I V K H K K L P I E S E D L A A V V K T D E F Q D T E I I S R E C V K K G I L M V K

Secondary structure

SS confidence

Disorder
? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 550 . . . . . . . . . 560 . . . . . . . . . 570 . . . . . . . . . 580 . . . . . . . . . 590 . . . . . . . . . 600

Sequence N N N S H E W T S H V F I L F P D R L C Y L I Q T A D P E N P N D D T V S V S G D E E R E E E T P S G F G V K P E E M H

Secondary structure

SS confidence

Disorder
?
?
? ? ? ? ? ? ?
? ? ? ? ? ?
? ? ? ? ? ? ? ? ? ? ? ? ? ?
?
?
? ?
?
? ? ?

Disorder confidence

. . . . . . . . . 610 . . . . . . . . . 620 . . . . . . . . . 630 . . . . . . . . . 640 . . . . . . . . . 650 . . . . . . . . . 660

Sequence V T E E W F H G R C E R D E A K K R I L E H K E K G N G L F M I R D S N L F I G D F S L S I L H D G K V H H V R I R S K

Secondary structure

SS confidence

Disorder
?
?
?

Disorder confidence

. . . . . . . . . 670 . . . . . . . . . 680 . . . . . . . . . 690 . . . . . . . . . 700 . . . . . . . . . 710 . . . . . . . . . 720

Sequence I I D K E K K Y Y F M D N K V C D T L Y E L V S Y Y T R H Y L T T A H F K M V L T I P C P Q P Q P H L N Q P W F S A T A

Secondary structure

SS confidence

Disorder
?
? ? ? ?
? ? ? ?
?

Disorder confidence

. . . . . . . . . 730 . . . . . . . . . 740 . . . . . . . . . 750 . . . . . . . . . 760 . . . . . . . . . 770 . . . . . . . . . 780

Sequence D K E K A E E L L S L V P E D G A F L I R T S S T D S S V Y V L S L K V D G E F W H Y R L K R D G R I F V V N Q K V F E

Secondary structure

SS confidence

Disorder
? ?
? ?
?

Disorder confidence

. . . . . . . . . 790 . . . . . . . . . 800 . . . . . . . . . 810 . . . . . . . . . 820 . . . . . . . . . 830 . . . . . . . . . 840

Sequence N L N Q I V E F Y A N R E F V R G I S L R F P V N E K D I S H L T A E L A E A R T P G C Y M D L K D L D K E V Q A R A L

Secondary structure

SS confidence

Disorder
? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 850 . . . . . . . . . 860 . . . . . . . . . 870 . . . . . . . . . 880 . . . . . . . . . 890 . . . . . . . . . 900

Sequence R P Y R G T A D D E L S F P A N V I I T V L R K E E G L W R G R Y G S L T G W F P S A H V Q E I L P E K V S T S E T S N

Secondary structure

SS confidence

Disorder
?
? ?
? ? ? ? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 910 . . . . . . . . . 920 . . . . . . . . . 930 . . . . . . . . . 940 . . . . . . . . . 950 . . . . . . . . . 960

Sequence Y N T I E L A G T L I E R I H D A D R P N V I R I S Q S N Q H W M N K Q Y Y L L A A S S S E E A D G W Q N N L F E L T R

Secondary structure

SS confidence

Disorder ? ? ? ?
?
? ?
? ? ?
? ? ? ? ? ? ? ? ?
? ?
?
? ?
?
? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 970 . . . . . . . . . 980 . . . . . . . . . 990 . . . . . . . . . 1000 . . . . . . . . . 1010 . . . . . . . . . 1020

Sequence S V N T K M S I L R T K E K E K R I A A E L S N L V V Y C Q A V P F D P A H I Y N D A F Y E M C S F V E G K L D K L V E

Secondary structure

SS confidence

Disorder ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?
?
?
? ?
?

Disorder confidence

. . . . . . . . . 1030 . . . . . . . . . 1040 . . . . . . . . . 1050 . . . . . . . . . 1060 . . . . . . . . . 1070 . . . . . . . . . 1080

Sequence K G L L P F N S R K L S R V Y P N G S R I T S N N Y S P V P M W N A G C H M V A L N Y Q T G D K P M Q L N Q G K F L A N

Secondary structure

SS confidence

Disorder

Disorder confidence

. . . . . . . . . 1090 . . . . . . . . . 1100 . . . . . . . . . 1110 . . . . . . . . . 1120 . . . . . . . . . 1130 . . . . . . . . . 1140

Sequence G R C G Y L L K P D Y M L T D D F D P T N T E K F A T A Y P I R L N V Q V I G G R H L S R K D K N K G I C S P F V E I E

Secondary structure

SS confidence

Disorder ? ? ?
? ? ? ?
? ? ? ? ? ? ? ? ?
? ? ? ? ?

Disorder confidence

. . . . . . . . . 1150 . . . . . . . . . 1160 . . . . . . . . . 1170 . . . . . . . . . 1180 . . . . . . . . . 1190 . . . . . . . . . 1200

Sequence I I G M P C D T K V F Q T K T I A S N G L N P I W N Q T F T F E I Q C P E V A L I R F H V E D G D F V G P K T D P F I G

Secondary structure

SS confidence

Disorder
? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 1210 . . . . . . . . . 1220 . . . . . . . . . 1230 . . . . . . . . . 1240 . . . . . . . . . 1250 . . . . . . . . . 1260

Sequence Q A V F P V D S I R C G F R S V P L K N Q Y S E E L E L S S L L V D V Q M C S R E G T Q L I R S S S H F L Q A S R L A P

Secondary structure

SS confidence

Disorder
?
? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 1270 . . . . . . . . . 1280 . . . . . . . . . 1290 . . . . . . . . . 1300 . . . . . . . . . 1310 . . . . . . . . . 1320

Sequence V F A H R K I T N G D S I P R E M A P R L R T S A T D R S L D S P T N S E S R A T L L S G Q R G S Q D S M D S A A E T S

Secondary structure

SS confidence

Disorder
? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 1330 . . . . . . . . . 1340 . . . . . . . . . 1350

Sequence S I A S G T I S S R D G K K K Q N W L K K F S F G K S S K S

Secondary structure

SS confidence

Disorder ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?
? ? ? ? ? ? ? ? ?

Disorder confidence

Confidence Key
High(9) Low (0)

? Disordered ( 32%)

Alpha helix ( 26%)

Beta strand ( 18%)

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank	Aligned region

PDB 3ohm chain B

Region: 52 - 1265
Aligned: 708
Modelled: 744
Confidence: 100.0%
Identity: 37%
PDB header:signaling protein / hydrolase
Chain: B: PDB Molecule:1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase
PDBTitle: crystal structure of activated g alpha q bound to its effector2 phospholipase c beta 3

Phyre2

PDB 3qr0 chain A

Region: 52 - 1273
Aligned: 732
Modelled: 771
Confidence: 100.0%
Identity: 33%
PDB header:hydrolase
Chain: A: PDB Molecule:phospholipase c-beta (plc-beta);
PDBTitle: crystal structure of s. officinalis plc21

Phyre2

PDB 2fju chain B

Region: 52 - 1239
Aligned: 661
Modelled: 720
Confidence: 100.0%
Identity: 37%
PDB header:signaling protein,apoptosis/hydrolase
Chain: B: PDB Molecule:1-phosphatidylinositol-4,5-bisphosphate
PDBTitle: activated rac1 bound to its effector phospholipase c beta 2

Phyre2

PDB 1djy chain B

Region: 210 - 1239
Aligned: 545
Modelled: 565
Confidence: 100.0%
Identity: 46%
PDB header:lipid degradation
Chain: B: PDB Molecule:phosphoinositide-specific phospholipase c,
PDBTitle: phosphoinositide-specific phospholipase c-delta1 from rat2 complexed with inositol-2,4,5-trisphosphate

Phyre2

PDB 2zkm chain X domain 4

Region: 352 - 1095
Aligned: 287
Modelled: 294
Confidence: 100.0%
Identity: 54%
Fold: TIM beta/alpha-barrel
Superfamily: PLC-like phosphodiesterases
Family: Mammalian PLC

Phyre2

PDB 1qas chain A domain 3

Region: 355 - 1099
Aligned: 269
Modelled: 276
Confidence: 100.0%
Identity: 59%
Fold: TIM beta/alpha-barrel
Superfamily: PLC-like phosphodiesterases
Family: Mammalian PLC

Phyre2

PDB 3gqi chain B

Region: 600 - 818
Aligned: 218
Modelled: 219
Confidence: 100.0%
Identity: 32%
PDB header:transferase/transferase inhibitor
Chain: B: PDB Molecule:phospholipase c-gamma-1;
PDBTitle: crystal structure of activated receptor tyrosine kinase in complex2 with substrates

Phyre2

PDB 2b3o chain A

Region: 604 - 847
Aligned: 237
Modelled: 238
Confidence: 100.0%
Identity: 24%
PDB header:hydrolase
Chain: A: PDB Molecule:tyrosine-protein phosphatase, non-receptor type
PDBTitle: crystal structure of human tyrosine phosphatase shp-1

Phyre2

PDB 3ps5 chain A

Region: 604 - 809
Aligned: 199
Modelled: 204
Confidence: 100.0%
Identity: 29%
PDB header:hydrolase, signaling protein
Chain: A: PDB Molecule:tyrosine-protein phosphatase non-receptor type 6;
PDBTitle: crystal structure of the full-length human protein tyrosine2 phosphatase shp-1

Phyre2

PDB 2zkm chain X domain 2

Region: 1112 - 1239
Aligned: 117
Modelled: 128
Confidence: 100.0%
Identity: 27%
Fold: C2 domain-like
Superfamily: C2 domain (Calcium/lipid-binding domain, CaLB)
Family: PLC-like (P variant)

Phyre2

PDB 2shp chain A

Region: 602 - 807
Aligned: 199
Modelled: 204
Confidence: 100.0%
Identity: 29%
PDB header:tyrosine phosphatase
Chain: A: PDB Molecule:shp-2;
PDBTitle: tyrosine phosphatase shp-2

Phyre2

PDB 1qas chain A domain 2

Region: 1110 - 1239
Aligned: 124
Modelled: 130
Confidence: 100.0%
Identity: 38%
Fold: C2 domain-like
Superfamily: C2 domain (Calcium/lipid-binding domain, CaLB)
Family: PLC-like (P variant)

Phyre2

PDB 2lqn chain A

Region: 598 - 897
Aligned: 290
Modelled: 300
Confidence: 99.9%
Identity: 20%
PDB header:signaling protein
Chain: A: PDB Molecule:crk-like protein;
PDBTitle: solution structure of crkl

Phyre2

PDB 4fl2 chain A

Region: 605 - 843
Aligned: 231
Modelled: 239
Confidence: 99.9%
Identity: 27%
PDB header:transferase
Chain: A: PDB Molecule:tyrosine-protein kinase syk;
PDBTitle: structural and biophysical characterization of the syk activation2 switch

Phyre2

PDB 2oq1 chain A

Region: 605 - 805
Aligned: 193
Modelled: 201
Confidence: 99.9%
Identity: 30%
PDB header:transferase
Chain: A: PDB Molecule:tyrosine-protein kinase zap-70;
PDBTitle: tandem sh2 domains of zap-70 with 19-mer zeta1 peptide

Phyre2

PDB 2eyz chain A

Region: 598 - 896
Aligned: 277
Modelled: 284
Confidence: 99.9%
Identity: 17%
PDB header:signaling protein
Chain: A: PDB Molecule:v-crk sarcoma virus ct10 oncogene homolog
PDBTitle: ct10-regulated kinase isoform ii

Phyre2

PDB 2ozo chain A

Region: 595 - 805
Aligned: 201
Modelled: 211
Confidence: 99.9%
Identity: 28%
PDB header:transferase
Chain: A: PDB Molecule:tyrosine-protein kinase zap-70;
PDBTitle: autoinhibited intact human zap-70

Phyre2

PDB 1a81 chain E

Region: 605 - 806
Aligned: 197
Modelled: 202
Confidence: 99.9%
Identity: 26%
PDB header:complex (transferase/peptide)
Chain: E: PDB Molecule:syk kinase;
PDBTitle: crystal structure of the tandem sh2 domain of the syk kinase bound to2 a dually tyrosine-phosphorylated itam

Phyre2

PDB 2zkm chain X domain 1

Region: 193 - 351
Aligned: 127
Modelled: 158
Confidence: 99.8%
Identity: 17%
Fold: EF Hand-like
Superfamily: EF-hand
Family: EF-hand modules in multidomain proteins

Phyre2

PDB 1qas chain A domain 1

Region: 251 - 354
Aligned: 94
Modelled: 104
Confidence: 99.8%
Identity: 20%
Fold: EF Hand-like
Superfamily: EF-hand
Family: EF-hand modules in multidomain proteins

Phyre2

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	1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence	M	Q	H	G	S	L	G	P	S	S	S	S	R	K	T	T	V	T	S	T	A	G	S	V	H	L	H	H	R	S	S	N	G	F	S	T	A	S	R	A	Q	L	N	R	H	N	E	M	D	F	G	K	M	F	A	A	M	E	K	G
Secondary structure
SS confidence
Disorder	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence	H	K	V	C	K	I	A	V	L	K	K	W	D	P	A	Y	K	Q	L	T	L	D	R	Y	S	R	Q	I	F	L	T	K	L	E	L	S	A	V	R	N	K	P	T	I	L	D	I	R	Q	I	R	E	V	Q	T	L	N	Y	K	L
Secondary structure
SS confidence
Disorder								?	?	?	?			?																			?	?	?	?	?	?	?	?																				?
Disorder confidence

	.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence	N	T	I	K	V	D	D	K	W	K	K	D	R	E	I	V	N	F	D	S	K	A	I	L	I	I	S	Y	G	M	G	F	A	L	S	Y	W	I	L	L	F	E	S	E	D	A	C	K	L	W	S	Q	G	L	H	N	L	M	M	D
Secondary structure
SS confidence
Disorder	?	?	?	?	?					?	?	?	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence	T	R	D	R	D	S	S	P	H	P	L	R	I	E	R	F	L	H	K	H	F	L	S	L	M	S	P	A	N	D	A	V	A	R	K	H	M	K	P	F	V	Q	T	S	L	Q	F	K	V	Q	S	D	Q	L	Q	Q	V	T	E	D
Secondary structure
SS confidence
Disorder				?	?	?	?	?	?	?																?	?	?	?	?	?	?	?																									?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence	Q	M	N	S	D	Q	F	S	F	A	S	R	Q	L	I	H	V	P	E	L	F	S	S	R	F	A	D	L	A	E	K	H	E	R	K	G	L	V	V	T	F	Q	N	F	L	R	F	L	D	G	K	Q	F	D	E	L	A	S	N	R
Secondary structure
SS confidence
Disorder			?																																	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence	T	R	A	L	E	F	L	N	R	Y	F	Q	E	D	Q	A	Y	F	G	D	R	N	E	P	S	M	T	V	F	E	F	C	D	F	L	F	S	R	E	N	S	L	W	D	P	T	N	E	K	V	T	H	D	M	S	R	P	L	S	H
Secondary structure
SS confidence
Disorder															?	?	?	?	?	?	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence	Y	W	I	A	S	S	H	N	T	Y	L	T	G	D	Q	L	R	S	E	S	S	L	D	C	Y	A	Q	A	L	L	M	G	C	R	C	I	E	L	D	C	W	D	G	Q	K	K	P	G	S	A	E	F	I	D	I	V	I	Y	H	G
Secondary structure
SS confidence
Disorder																																														?	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480
Sequence	Y	T	M	T	S	K	I	L	L	R	D	V	L	H	V	I	R	H	Y	A	F	V	T	S	E	Y	P	V	I	L	S	I	E	D	N	C	S	V	P	A	Q	R	L	L	A	Q	E	L	K	D	I	L	G	D	Y	L	L	T	Q	P
Secondary structure
SS confidence
Disorder
Disorder confidence

	.	.	.	.	.	.	.	.	.	490	.	.	.	.	.	.	.	.	.	500	.	.	.	.	.	.	.	.	.	510	.	.	.	.	.	.	.	.	.	520	.	.	.	.	.	.	.	.	.	530	.	.	.	.	.	.	.	.	.	540
Sequence	A	N	R	E	E	K	Q	L	P	S	P	A	A	L	K	K	K	I	I	V	K	H	K	K	L	P	I	E	S	E	D	L	A	A	V	V	K	T	D	E	F	Q	D	T	E	I	I	S	R	E	C	V	K	K	G	I	L	M	V	K
Secondary structure
SS confidence
Disorder																								?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	550	.	.	.	.	.	.	.	.	.	560	.	.	.	.	.	.	.	.	.	570	.	.	.	.	.	.	.	.	.	580	.	.	.	.	.	.	.	.	.	590	.	.	.	.	.	.	.	.	.	600
Sequence	N	N	N	S	H	E	W	T	S	H	V	F	I	L	F	P	D	R	L	C	Y	L	I	Q	T	A	D	P	E	N	P	N	D	D	T	V	S	V	S	G	D	E	E	R	E	E	E	T	P	S	G	F	G	V	K	P	E	E	M	H
Secondary structure
SS confidence
Disorder		?												?		?	?	?	?	?	?	?		?	?	?	?	?	?		?	?	?	?	?	?	?	?	?	?	?	?	?	?		?			?			?	?		?		?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	610	.	.	.	.	.	.	.	.	.	620	.	.	.	.	.	.	.	.	.	630	.	.	.	.	.	.	.	.	.	640	.	.	.	.	.	.	.	.	.	650	.	.	.	.	.	.	.	.	.	660
Sequence	V	T	E	E	W	F	H	G	R	C	E	R	D	E	A	K	K	R	I	L	E	H	K	E	K	G	N	G	L	F	M	I	R	D	S	N	L	F	I	G	D	F	S	L	S	I	L	H	D	G	K	V	H	H	V	R	I	R	S	K
Secondary structure
SS confidence
Disorder																						?		?		?
Disorder confidence

	.	.	.	.	.	.	.	.	.	670	.	.	.	.	.	.	.	.	.	680	.	.	.	.	.	.	.	.	.	690	.	.	.	.	.	.	.	.	.	700	.	.	.	.	.	.	.	.	.	710	.	.	.	.	.	.	.	.	.	720
Sequence	I	I	D	K	E	K	K	Y	Y	F	M	D	N	K	V	C	D	T	L	Y	E	L	V	S	Y	Y	T	R	H	Y	L	T	T	A	H	F	K	M	V	L	T	I	P	C	P	Q	P	Q	P	H	L	N	Q	P	W	F	S	A	T	A
Secondary structure
SS confidence
Disorder																														?		?	?	?	?												?	?	?	?		?
Disorder confidence

	.	.	.	.	.	.	.	.	.	730	.	.	.	.	.	.	.	.	.	740	.	.	.	.	.	.	.	.	.	750	.	.	.	.	.	.	.	.	.	760	.	.	.	.	.	.	.	.	.	770	.	.	.	.	.	.	.	.	.	780
Sequence	D	K	E	K	A	E	E	L	L	S	L	V	P	E	D	G	A	F	L	I	R	T	S	S	T	D	S	S	V	Y	V	L	S	L	K	V	D	G	E	F	W	H	Y	R	L	K	R	D	G	R	I	F	V	V	N	Q	K	V	F	E
Secondary structure
SS confidence
Disorder										?	?		?	?													?
Disorder confidence

	.	.	.	.	.	.	.	.	.	790	.	.	.	.	.	.	.	.	.	800	.	.	.	.	.	.	.	.	.	810	.	.	.	.	.	.	.	.	.	820	.	.	.	.	.	.	.	.	.	830	.	.	.	.	.	.	.	.	.	840
Sequence	N	L	N	Q	I	V	E	F	Y	A	N	R	E	F	V	R	G	I	S	L	R	F	P	V	N	E	K	D	I	S	H	L	T	A	E	L	A	E	A	R	T	P	G	C	Y	M	D	L	K	D	L	D	K	E	V	Q	A	R	A	L
Secondary structure
SS confidence
Disorder																											?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	850	.	.	.	.	.	.	.	.	.	860	.	.	.	.	.	.	.	.	.	870	.	.	.	.	.	.	.	.	.	880	.	.	.	.	.	.	.	.	.	890	.	.	.	.	.	.	.	.	.	900
Sequence	R	P	Y	R	G	T	A	D	D	E	L	S	F	P	A	N	V	I	I	T	V	L	R	K	E	E	G	L	W	R	G	R	Y	G	S	L	T	G	W	F	P	S	A	H	V	Q	E	I	L	P	E	K	V	S	T	S	E	T	S	N
Secondary structure
SS confidence
Disorder					?																					?	?																							?	?	?	?	?	?	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	910	.	.	.	.	.	.	.	.	.	920	.	.	.	.	.	.	.	.	.	930	.	.	.	.	.	.	.	.	.	940	.	.	.	.	.	.	.	.	.	950	.	.	.	.	.	.	.	.	.	960
Sequence	Y	N	T	I	E	L	A	G	T	L	I	E	R	I	H	D	A	D	R	P	N	V	I	R	I	S	Q	S	N	Q	H	W	M	N	K	Q	Y	Y	L	L	A	A	S	S	S	E	E	A	D	G	W	Q	N	N	L	F	E	L	T	R
Secondary structure
SS confidence
Disorder	?	?	?	?		?				?	?			?	?	?													?	?	?	?	?	?	?	?	?		?	?			?		?	?		?					?	?	?	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	970	.	.	.	.	.	.	.	.	.	980	.	.	.	.	.	.	.	.	.	990	.	.	.	.	.	.	.	.	.	1000	.	.	.	.	.	.	.	.	.	1010	.	.	.	.	.	.	.	.	.	1020
Sequence	S	V	N	T	K	M	S	I	L	R	T	K	E	K	E	K	R	I	A	A	E	L	S	N	L	V	V	Y	C	Q	A	V	P	F	D	P	A	H	I	Y	N	D	A	F	Y	E	M	C	S	F	V	E	G	K	L	D	K	L	V	E
Secondary structure
SS confidence
Disorder	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?														?		?		?	?				?
Disorder confidence

	.	.	.	.	.	.	.	.	.	1030	.	.	.	.	.	.	.	.	.	1040	.	.	.	.	.	.	.	.	.	1050	.	.	.	.	.	.	.	.	.	1060	.	.	.	.	.	.	.	.	.	1070	.	.	.	.	.	.	.	.	.	1080
Sequence	K	G	L	L	P	F	N	S	R	K	L	S	R	V	Y	P	N	G	S	R	I	T	S	N	N	Y	S	P	V	P	M	W	N	A	G	C	H	M	V	A	L	N	Y	Q	T	G	D	K	P	M	Q	L	N	Q	G	K	F	L	A	N
Secondary structure
SS confidence
Disorder
Disorder confidence

	.	.	.	.	.	.	.	.	.	1090	.	.	.	.	.	.	.	.	.	1100	.	.	.	.	.	.	.	.	.	1110	.	.	.	.	.	.	.	.	.	1120	.	.	.	.	.	.	.	.	.	1130	.	.	.	.	.	.	.	.	.	1140
Sequence	G	R	C	G	Y	L	L	K	P	D	Y	M	L	T	D	D	F	D	P	T	N	T	E	K	F	A	T	A	Y	P	I	R	L	N	V	Q	V	I	G	G	R	H	L	S	R	K	D	K	N	K	G	I	C	S	P	F	V	E	I	E
Secondary structure
SS confidence
Disorder	?	?	?										?	?	?	?		?	?	?	?	?	?	?	?	?																				?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	1150	.	.	.	.	.	.	.	.	.	1160	.	.	.	.	.	.	.	.	.	1170	.	.	.	.	.	.	.	.	.	1180	.	.	.	.	.	.	.	.	.	1190	.	.	.	.	.	.	.	.	.	1200
Sequence	I	I	G	M	P	C	D	T	K	V	F	Q	T	K	T	I	A	S	N	G	L	N	P	I	W	N	Q	T	F	T	F	E	I	Q	C	P	E	V	A	L	I	R	F	H	V	E	D	G	D	F	V	G	P	K	T	D	P	F	I	G
Secondary structure
SS confidence
Disorder																																																	?	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	1210	.	.	.	.	.	.	.	.	.	1220	.	.	.	.	.	.	.	.	.	1230	.	.	.	.	.	.	.	.	.	1240	.	.	.	.	.	.	.	.	.	1250	.	.	.	.	.	.	.	.	.	1260
Sequence	Q	A	V	F	P	V	D	S	I	R	C	G	F	R	S	V	P	L	K	N	Q	Y	S	E	E	L	E	L	S	S	L	L	V	D	V	Q	M	C	S	R	E	G	T	Q	L	I	R	S	S	S	H	F	L	Q	A	S	R	L	A	P
Secondary structure
SS confidence
Disorder																							?																	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	1270	.	.	.	.	.	.	.	.	.	1280	.	.	.	.	.	.	.	.	.	1290	.	.	.	.	.	.	.	.	.	1300	.	.	.	.	.	.	.	.	.	1310	.	.	.	.	.	.	.	.	.	1320
Sequence	V	F	A	H	R	K	I	T	N	G	D	S	I	P	R	E	M	A	P	R	L	R	T	S	A	T	D	R	S	L	D	S	P	T	N	S	E	S	R	A	T	L	L	S	G	Q	R	G	S	Q	D	S	M	D	S	A	A	E	T	S
Secondary structure
SS confidence
Disorder				?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	1330	.	.	.	.	.	.	.	.	.	1340	.	.	.	.	.	.	.	.	.	1350
Sequence	S	I	A	S	G	T	I	S	S	R	D	G	K	K	K	Q	N	W	L	K	K	F	S	F	G	K	S	S	K	S
Secondary structure
SS confidence
Disorder	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?					?	?	?	?	?	?	?	?	?
Disorder confidence