Phyre Home Retrieve Phyre Job Id
Emaill.a.kelley@imperial.ac.uk
DescriptionO45498
DateSat Apr 13 13:01:14 BST 2013
Unique Job IDd626f8bd288f10a0

Summary 

Top model
Image coloured by rainbow N → C terminus
Model dimensions (Å):X:36.452 Y:50.179 Z:47.425
Model (left) based on template c2c9wA_
Top template information
PDB header:transcription regulation
Chain: A: PDB Molecule:suppressor of cytokine signaling 2;
PDBTitle: crystal structure of socs-2 in complex with elongin-b and2 elongin-c at 1.9a resolution
Confidence and coverage
Confidence:100.0% Coverage: 74%
143 residues ( 74% of your sequence) have been modelled with 100.0% confidence by the single highest scoring template.
3D viewing
Interactive 3D view in Jmol

Sequence analysis 

Secondary structure and disorder prediction 

   1........10.........20.........30.........40.........50.........60
Sequence  MPSNKVICSDLYDCDWYWGDLDWKWAERLLLLCPIGYFLIRDSRSETHLFTVSYHFQDRV
Secondary structure 
SS confidence 
Disorder  ?????????
?
??
Disorder confidence 
 
   .........70.........80.........90.........100.........110.........120
Sequence  YHSRLSLEDSRRNLGSRQPYVSRDYWNLVEIIERSLEQSLTGQQEMLHYRRGHEAEAARV
Secondary structure 
SS confidence 
Disorder 
??
????????
Disorder confidence 
 
   .........130.........140.........150.........160.........170.........180
Sequence  NLTRPLTKRELLPSLQYLCRFTLKTSQQKPPTPKTAPLPPTILKYLSDSKWIIPDLKKCE
Secondary structure 
SS confidence 
Disorder 
??
??????
?
Disorder confidence 
 
   .........190..
Sequence  EQLKLRFCVINN
Secondary structure 
SS confidence 
Disorder 
???
Disorder confidence 
 

Confidence Key
High(9)                    Low (0)
?Disordered ( 18%)
Alpha helix ( 35%)
Beta strand ( 18%)

Domain analysis 

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

RankAligned region

PDB 2c9w chain A

3D model

Region: 8 - 173
Aligned: 143
Modelled: 148
Confidence: 100.0%
Identity: 29%
PDB header:transcription regulation
Chain: A: PDB Molecule:suppressor of cytokine signaling 2;
PDBTitle: crystal structure of socs-2 in complex with elongin-b and2 elongin-c at 1.9a resolution

Phyre2

PDB 2izv chain A

3D model

Region: 8 - 174
Aligned: 150
Modelled: 153
Confidence: 100.0%
Identity: 25%
PDB header:transcription
Chain: A: PDB Molecule:suppressor of cytokine signaling 4;
PDBTitle: crystal structure of socs-4 in complex with elongin-b and2 elongin-c at 2.55a resolution

Phyre2

PDB 2vif chain A

3D model

Region: 6 - 131
Aligned: 123
Modelled: 126
Confidence: 100.0%
Identity: 26%
PDB header:signaling protein
Chain: A: PDB Molecule:suppressor of cytokine signalling 6;
PDBTitle: crystal structure of socs6 sh2 domain in complex with a c-kit2 phosphopeptide

Phyre2

PDB 3hiz chain B

3D model

Region: 11 - 132
Aligned: 102
Modelled: 107
Confidence: 100.0%
Identity: 25%
PDB header:transferase/oncoprotein
Chain: B: PDB Molecule:phosphatidylinositol 3-kinase regulatory subunit
PDBTitle: crystal structure of p110alpha h1047r mutant in complex with2 nish2 of p85alpha

Phyre2

PDB 2hmh chain A

3D model

Region: 5 - 129
Aligned: 113
Modelled: 125
Confidence: 99.9%
Identity: 22%
PDB header:cytokine regulator
Chain: A: PDB Molecule:suppressor of cytokine signaling 3;
PDBTitle: crystal structure of socs3 in complex with gp130(ptyr757)2 phosphopeptide.

Phyre2

PDB 2izv chain A domain 2

3D model

Region: 6 - 129
Aligned: 109
Modelled: 110
Confidence: 99.9%
Identity: 28%
Fold: SH2-like
Superfamily: SH2 domain
Family: SH2 domain

Phyre2

PDB 2c9w chain A domain 2

3D model

Region: 8 - 100
Aligned: 93
Modelled: 93
Confidence: 99.9%
Identity: 27%
Fold: SH2-like
Superfamily: SH2 domain
Family: SH2 domain

Phyre2

PDB 2eo6 chain A

3D model

Region: 2 - 134
Aligned: 126
Modelled: 133
Confidence: 99.9%
Identity: 22%
PDB header:signaling protein
Chain: A: PDB Molecule:b-cell linker protein;
PDBTitle: solution structure of the sh2 domain from mouse b-cell2 linker protein blnk

Phyre2

PDB 2crh chain A

3D model

Region: 8 - 133
Aligned: 110
Modelled: 115
Confidence: 99.9%
Identity: 23%
PDB header:signaling protein
Chain: A: PDB Molecule:vav proto-oncogene;
PDBTitle: solution structure of the sh2 domain of human proto-2 oncogene protein vav1

Phyre2

PDB 2y3a chain B

3D model

Region: 9 - 128
Aligned: 104
Modelled: 107
Confidence: 99.9%
Identity: 25%
PDB header:transferase
Chain: B: PDB Molecule:phosphatidylinositol 3-kinase regulatory subunit beta;
PDBTitle: crystal structure of p110beta in complex with icsh2 of p85beta and2 the drug gdc-0941

Phyre2

PDB 2dlz chain A

3D model

Region: 10 - 131
Aligned: 106
Modelled: 122
Confidence: 99.9%
Identity: 24%
PDB header:signaling protein
Chain: A: PDB Molecule:protein vav-2;
PDBTitle: solution structure of the sh2 domain of human protein vav-2

Phyre2

PDB 1ka6 chain A

3D model

Region: 11 - 131
Aligned: 105
Modelled: 105
Confidence: 99.9%
Identity: 22%
PDB header:immune system
Chain: A: PDB Molecule:sh2 domain protein 1a;
PDBTitle: sap/sh2d1a bound to peptide n-py

Phyre2

PDB 2oq1 chain A domain 1

3D model

Region: 11 - 148
Aligned: 118
Modelled: 122
Confidence: 99.9%
Identity: 18%
Fold: SH2-like
Superfamily: SH2 domain
Family: SH2 domain

Phyre2

PDB 1r1q chain A

3D model

Region: 10 - 109
Aligned: 95
Modelled: 100
Confidence: 99.9%
Identity: 23%
Fold: SH2-like
Superfamily: SH2 domain
Family: SH2 domain

Phyre2

PDB 1jwo chain A

3D model

Region: 11 - 128
Aligned: 97
Modelled: 102
Confidence: 99.9%
Identity: 26%
Fold: SH2-like
Superfamily: SH2 domain
Family: SH2 domain

Phyre2

PDB 1fu6 chain A

3D model

Region: 10 - 129
Aligned: 104
Modelled: 120
Confidence: 99.9%
Identity: 25%
Fold: SH2-like
Superfamily: SH2 domain
Family: SH2 domain

Phyre2

PDB 2lct chain A

3D model

Region: 8 - 128
Aligned: 105
Modelled: 116
Confidence: 99.9%
Identity: 23%
PDB header:signaling protein
Chain: A: PDB Molecule:proto-oncogene vav;
PDBTitle: solution structure of the vav1 sh2 domain complexed with a syk-derived2 doubly phosphorylated peptide

Phyre2

PDB 1pic chain A

3D model

Region: 8 - 130
Aligned: 107
Modelled: 123
Confidence: 99.9%
Identity: 23%
Fold: SH2-like
Superfamily: SH2 domain
Family: SH2 domain

Phyre2

PDB 1d4t chain A

3D model

Region: 11 - 128
Aligned: 102
Modelled: 102
Confidence: 99.9%
Identity: 23%
Fold: SH2-like
Superfamily: SH2 domain
Family: SH2 domain

Phyre2

PDB 2shp chain A domain 2

3D model

Region: 12 - 132
Aligned: 106
Modelled: 116
Confidence: 99.9%
Identity: 25%
Fold: SH2-like
Superfamily: SH2 domain
Family: SH2 domain

Phyre2
1
c2c9wA_
2
c2izvA_
3
c2vifA_
4
c3hizB_
5
c2hmhA_
6
d2izva2
7
d2c9wa2
8
c2eo6A_
9
c2crhA_
10
c2y3aB_
11
c2dlzA_
12
c1ka6A_
13
d2oq1a1
14
d1r1qa_
15
d1jwoa_
16
d1fu6a_
17
c2lctA_
18
d1pica_
19
d1d4ta_
20
d2shpa2
21
22
23
24
25
26
27
28
29
30
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Detailed template information 

#
Template Alignment Coverage3D Model Confidence
% i.d. Template Information
1c2c9wA_
100.0 29 PDB header:transcription regulation
Chain: A: PDB Molecule:suppressor of cytokine signaling 2;
PDBTitle: crystal structure of socs-2 in complex with elongin-b and2 elongin-c at 1.9a resolution
2c2izvA_
100.0 25 PDB header:transcription
Chain: A: PDB Molecule:suppressor of cytokine signaling 4;
PDBTitle: crystal structure of socs-4 in complex with elongin-b and2 elongin-c at 2.55a resolution
3c2vifA_
100.0 26 PDB header:signaling protein
Chain: A: PDB Molecule:suppressor of cytokine signalling 6;
PDBTitle: crystal structure of socs6 sh2 domain in complex with a c-kit2 phosphopeptide
4c3hizB_
100.0 25 PDB header:transferase/oncoprotein
Chain: B: PDB Molecule:phosphatidylinositol 3-kinase regulatory subunit
PDBTitle: crystal structure of p110alpha h1047r mutant in complex with2 nish2 of p85alpha
5c2hmhA_
99.9 22 PDB header:cytokine regulator
Chain: A: PDB Molecule:suppressor of cytokine signaling 3;
PDBTitle: crystal structure of socs3 in complex with gp130(ptyr757)2 phosphopeptide.
6d2izva2
99.9 28 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
7d2c9wa2
99.9 27 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
8c2eo6A_
99.9 22 PDB header:signaling protein
Chain: A: PDB Molecule:b-cell linker protein;
PDBTitle: solution structure of the sh2 domain from mouse b-cell2 linker protein blnk
9c2crhA_
99.9 23 PDB header:signaling protein
Chain: A: PDB Molecule:vav proto-oncogene;
PDBTitle: solution structure of the sh2 domain of human proto-2 oncogene protein vav1
10c2y3aB_
99.9 25 PDB header:transferase
Chain: B: PDB Molecule:phosphatidylinositol 3-kinase regulatory subunit beta;
PDBTitle: crystal structure of p110beta in complex with icsh2 of p85beta and2 the drug gdc-0941
11c2dlzA_
99.9 24 PDB header:signaling protein
Chain: A: PDB Molecule:protein vav-2;
PDBTitle: solution structure of the sh2 domain of human protein vav-2
12c1ka6A_
99.9 22 PDB header:immune system
Chain: A: PDB Molecule:sh2 domain protein 1a;
PDBTitle: sap/sh2d1a bound to peptide n-py
13d2oq1a1
99.9 18 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
14d1r1qa_
99.9 23 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
15d1jwoa_
99.9 26 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
16d1fu6a_
99.9 25 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
17c2lctA_
99.9 23 PDB header:signaling protein
Chain: A: PDB Molecule:proto-oncogene vav;
PDBTitle: solution structure of the vav1 sh2 domain complexed with a syk-derived2 doubly phosphorylated peptide
18d1pica_
99.9 23 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
19d1d4ta_
99.9 23 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
20d2shpa2
99.9 25 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
21c2ci8A_
not modelled 99.9 28 PDB header:translation
Chain: A: PDB Molecule:cytoplasmic protein nck1;
PDBTitle: sh2 domain of human nck1 adaptor protein - uncomplexed
22c2eo3A_
not modelled 99.9 21 PDB header:signaling protein
Chain: A: PDB Molecule:crk-like protein;
PDBTitle: solution structure of the sh2 domain from human crk-like2 protein
23c2oq1A_
not modelled 99.9 17 PDB header:transferase
Chain: A: PDB Molecule:tyrosine-protein kinase zap-70;
PDBTitle: tandem sh2 domains of zap-70 with 19-mer zeta1 peptide
24d1opka2
not modelled 99.9 27 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
25d3c7ia1
not modelled 99.9 20 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
26c2fo0A_
not modelled 99.9 26 PDB header:transferase
Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase abl1 (1b isoform);
PDBTitle: organization of the sh3-sh2 unit in active and inactive forms of the2 c-abl tyrosine kinase
27d1k9aa2
not modelled 99.9 23 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
28c2lqnA_
not modelled 99.9 21 PDB header:signaling protein
Chain: A: PDB Molecule:crk-like protein;
PDBTitle: solution structure of crkl
29d1ayaa_
not modelled 99.9 27 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
30d1a81e1
not modelled 99.9 16 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
31c2ysxA_
not modelled 99.9 24 PDB header:signaling protein
Chain: A: PDB Molecule:signaling inositol polyphosphate phosphatase
PDBTitle: solution structure of the human ship sh2 domain
32d2eyva1
not modelled 99.9 26 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
33c2dlyA_
not modelled 99.9 27 PDB header:transferase
Chain: A: PDB Molecule:fyn-related kinase;
PDBTitle: solution structure of the sh2 domain of murine fyn-related2 kinase
34c2kk6A_
not modelled 99.9 22 PDB header:transferase
Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase fer;
PDBTitle: solution structure of sh2 domain of proto-oncogene tyrosine-2 protein kinase fer from homo sapiens, northeast structural3 genomics consortium (nesg) target hr3461d
35c2hdxB_
not modelled 99.9 24 PDB header:signaling protein
Chain: B: PDB Molecule:sh2-b ph domain containing signaling mediator 1
PDBTitle: crystal structure of the src homology-2 domain of sh2-b in2 complex with jak2 ptyr813 phosphopeptide
36d1qada_
not modelled 99.9 24 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
37d1mila_
not modelled 99.9 21 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
38c1k9aB_
not modelled 99.9 23 PDB header:transferase
Chain: B: PDB Molecule:carboxyl-terminal src kinase;
PDBTitle: crystal structure analysis of full-length carboxyl-terminal2 src kinase at 2.5 a resolution
39c2augB_
not modelled 99.9 19 PDB header:signaling protein
Chain: B: PDB Molecule:growth factor receptor-bound protein 14;
PDBTitle: crystal structure of the grb14 sh2 domain
40d1a81a1
not modelled 99.9 15 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
41d1i3za_
not modelled 99.9 29 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
42d1fhsa_
not modelled 99.9 20 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
43c2gsbA_
not modelled 99.9 15 PDB header:signaling protein
Chain: A: PDB Molecule:ras gtpase-activating protein 1;
PDBTitle: solution structure of the second sh2 domain of human ras2 gtpase-activating protein 1
44d1a81e2
not modelled 99.9 19 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
45c2eobA_
not modelled 99.9 28 PDB header:hydrolase
Chain: A: PDB Molecule:1-phosphatidylinositol-4,5-bisphosphate
PDBTitle: solution structure of the second sh2 domain from rat plc2 gamma-2
46d1nrva_
not modelled 99.9 16 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
47c2ablA_
not modelled 99.9 28 PDB header:transferase
Chain: A: PDB Molecule:abl tyrosine kinase;
PDBTitle: sh3-sh2 domain fragment of human bcr-abl tyrosine kinase
48d1rjaa_
not modelled 99.9 26 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
49c1x6cA_
not modelled 99.9 27 PDB header:signaling protein
Chain: A: PDB Molecule:tyrosine-protein phosphatase, non-receptor type
PDBTitle: solution structures of the sh2 domain of human protein-2 tyrosine phosphatase shp-1
50c2el8A_
not modelled 99.9 15 PDB header:signaling protein
Chain: A: PDB Molecule:signal-transducing adaptor protein 2;
PDBTitle: solution structure of the human stap2 sh2 domain
51d1jyra_
not modelled 99.9 23 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
52c2shpA_
not modelled 99.9 25 PDB header:tyrosine phosphatase
Chain: A: PDB Molecule:shp-2;
PDBTitle: tyrosine phosphatase shp-2
53c2b3oA_
not modelled 99.9 30 PDB header:hydrolase
Chain: A: PDB Molecule:tyrosine-protein phosphatase, non-receptor type
PDBTitle: crystal structure of human tyrosine phosphatase shp-1
54d2oq1a2
not modelled 99.9 21 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
55c2ozoA_
not modelled 99.9 18 PDB header:transferase
Chain: A: PDB Molecule:tyrosine-protein kinase zap-70;
PDBTitle: autoinhibited intact human zap-70
56c1oplA_
not modelled 99.9 23 PDB header:transferase
Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase;
PDBTitle: structural basis for the auto-inhibition of c-abl tyrosine2 kinase
57d2shpa3
not modelled 99.9 27 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
58d1luia_
not modelled 99.9 23 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
59c3ps5A_
not modelled 99.9 25 PDB header:hydrolase, signaling protein
Chain: A: PDB Molecule:tyrosine-protein phosphatase non-receptor type 6;
PDBTitle: crystal structure of the full-length human protein tyrosine2 phosphatase shp-1
60d1g83a2
not modelled 99.9 28 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
61d1blja_
not modelled 99.9 25 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
62c3mazA_
not modelled 99.9 13 PDB header:signaling protein
Chain: A: PDB Molecule:signal-transducing adaptor protein 1;
PDBTitle: crystal structure of the human brdg1/stap-1 sh2 domain in complex with2 the ntal ptyr136 peptide
63c2ge9A_
not modelled 99.9 23 PDB header:transferase
Chain: A: PDB Molecule:tyrosine-protein kinase btk;
PDBTitle: solution structures of the sh2 domain of bruton's tyrosine2 kinase
64c2dcrA_
not modelled 99.9 24 PDB header:transferase
Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase fes/fps;
PDBTitle: fully automated solution structure determination of the fes2 sh2 domain
65d1lkka_
not modelled 99.9 29 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
66d2cs0a1
not modelled 99.9 28 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
67c4fl2A_
not modelled 99.9 17 PDB header:transferase
Chain: A: PDB Molecule:tyrosine-protein kinase syk;
PDBTitle: structural and biophysical characterization of the syk activation2 switch
68c2ekxA_
not modelled 99.9 26 PDB header:signaling protein
Chain: A: PDB Molecule:cytoplasmic tyrosine-protein kinase bmx;
PDBTitle: solution structure of the human bmx sh2 domain
69d1rpya_
not modelled 99.9 25 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
70d1csya_
not modelled 99.9 18 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
71c1y57A_
not modelled 99.9 20 PDB header:transferase
Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase src;
PDBTitle: structure of unphosphorylated c-src in complex with an inhibitor
72c1rqqC_
not modelled 99.9 27 PDB header:transferase/signaling protein
Chain: C: PDB Molecule:adaptor protein aps;
PDBTitle: crystal structure of the insulin receptor kinase in complex2 with the sh2 domain of aps
73d1a81a2
not modelled 99.9 17 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
74c2knoA_
not modelled 99.9 22 PDB header:hydrolase
Chain: A: PDB Molecule:tensin-like c1 domain-containing phosphatase;
PDBTitle: nmr solution structure of sh2 domain of the human tensin like c12 domain containing phosphatase (tenc1)
75d2qmsa1
not modelled 99.9 20 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
76d1o48a_
not modelled 99.9 23 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
77d1xa6a2
not modelled 99.9 17 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
78c1a81E_
not modelled 99.8 18 PDB header:complex (transferase/peptide)
Chain: E: PDB Molecule:syk kinase;
PDBTitle: crystal structure of the tandem sh2 domain of the syk kinase bound to2 a dually tyrosine-phosphorylated itam
79d1bkla_
not modelled 99.8 21 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
80c3nhnA_
not modelled 99.8 28 PDB header:transferase
Chain: A: PDB Molecule:tyrosine-protein kinase hck;
PDBTitle: crystal structure of the src-family kinase hck sh3-sh2-linker2 regulatory region
81c2h8hA_
not modelled 99.8 21 PDB header:transferase
Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase src;
PDBTitle: src kinase in complex with a quinazoline inhibitor
82d1qcfa2
not modelled 99.8 24 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
83d2fcia1
not modelled 99.8 26 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
84d1f2fa_
not modelled 99.8 24 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
85c1x27F_
not modelled 99.8 25 PDB header:signaling protein
Chain: F: PDB Molecule:proto-oncogene tyrosine-protein kinase lck;
PDBTitle: crystal structure of lck sh2-sh3 with sh2 binding site of2 p130cas
86c3gqiB_
not modelled 99.8 21 PDB header:transferase/transferase inhibitor
Chain: B: PDB Molecule:phospholipase c-gamma-1;
PDBTitle: crystal structure of activated receptor tyrosine kinase in complex2 with substrates
87c2c0iA_
not modelled 99.8 24 PDB header:transferase
Chain: A: PDB Molecule:tyrosine-protein kinase hck;
PDBTitle: src family kinase hck with bound inhibitor a-420983
88d1cwea_
not modelled 99.8 31 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
89c2dm0A_
not modelled 99.8 20 PDB header:transferase
Chain: A: PDB Molecule:tyrosine-protein kinase txk;
PDBTitle: solution structure of the sh2 domain of human tyrosine-2 protein kinase txk
90c1g83A_
not modelled 99.8 29 PDB header:transferase
Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase fyn;
PDBTitle: crystal structure of fyn sh3-sh2
91c2eyyA_
not modelled 99.8 19 PDB header:signaling protein
Chain: A: PDB Molecule:v-crk sarcoma virus ct10 oncogene homolog
PDBTitle: ct10-regulated kinase isoform i
92c2eyzA_
not modelled 99.8 24 PDB header:signaling protein
Chain: A: PDB Molecule:v-crk sarcoma virus ct10 oncogene homolog
PDBTitle: ct10-regulated kinase isoform ii
93c2dvjA_
not modelled 99.8 22 PDB header:signaling protein
Chain: A: PDB Molecule:v-crk sarcoma virus ct10 oncogene homolog,
PDBTitle: phosphorylated crk-ii
94c3gxxB_
not modelled 99.8 20 PDB header:transcription
Chain: B: PDB Molecule:transcription elongation factor spt6;
PDBTitle: structure of the sh2 domain of the candida glabrata2 transcription elongation factor spt6, crystal form b
95c2cr4A_
not modelled 99.8 20 PDB header:signaling protein
Chain: A: PDB Molecule:sh3 domain-binding protein 2;
PDBTitle: solution structure of the sh2 domain of human sh3bp2 protein
96c3qwyA_
not modelled 99.7 19 PDB header:signaling protein
Chain: A: PDB Molecule:cell death abnormality protein 2;
PDBTitle: ced-2
97c3qwxX_
not modelled 99.7 19 PDB header:signaling protein
Chain: X: PDB Molecule:cell death abnormality protein 2;
PDBTitle: ced-2 1-174
98c3or8A_
not modelled 99.7 23 PDB header:transcription
Chain: A: PDB Molecule:transcription elongation factor spt6;
PDBTitle: a tandem sh2 domain in transcription elongation factor spt6
99c2dx0B_
not modelled 99.7 28 PDB header:hydrolase
Chain: B: PDB Molecule:phospholipase c, gamma 2;
PDBTitle: crystal structure of the n-terminal sh2 domain of mouse2 phospholipase c-gamma 2
100d1uura3
not modelled 99.6 20 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
101c2xp1A_
not modelled 99.6 15 PDB header:transcription
Chain: A: PDB Molecule:spt6;
PDBTitle: structure of the tandem sh2 domains from antonospora locustae2 transcription elongation factor spt6
102c1xa6A_
not modelled 99.6 19 PDB header:signaling protein
Chain: A: PDB Molecule:beta2-chimaerin;
PDBTitle: crystal structure of the human beta2-chimaerin
103d2c9wa1
not modelled 99.5 36 Fold:SOCS box-like
Superfamily:SOCS box-like
Family:SOCS box-like
104d1bf5a3
not modelled 99.5 14 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
105d1bg1a3
not modelled 99.3 17 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
106d2izva1
not modelled 99.2 23 Fold:SOCS box-like
Superfamily:SOCS box-like
Family:SOCS box-like
107c3cblA_
not modelled 99.0 26 PDB header:transferase
Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase fes/fps;
PDBTitle: crystal structure of human feline sarcoma viral oncogene homologue (v-2 fes) in complex with staurosporine and a consensus peptide
108c1uusA_
not modelled 98.5 18 PDB header:signal transduction
Chain: A: PDB Molecule:stat protein;
PDBTitle: structure of an activated dictyostelium stat in its2 dna-unbound form
109c1yvlB_
not modelled 98.3 20 PDB header:signaling protein
Chain: B: PDB Molecule:signal transducer and activator of transcription
PDBTitle: structure of unphosphorylated stat1
110c1y1uA_
not modelled 98.3 27 PDB header:signaling protein
Chain: A: PDB Molecule:signal transducer and activator of transcription 5a;
PDBTitle: structure of unphosphorylated stat5a
111c2cblA_
not modelled 98.2 17 PDB header:complex (proto-oncogene/peptide)
Chain: A: PDB Molecule:proto-oncogene cbl;
PDBTitle: n-terminal domain of cbl in complex with its binding site2 on zap-70
112c3bunB_
not modelled 98.2 17 PDB header:ligase/signaling protein
Chain: B: PDB Molecule:e3 ubiquitin-protein ligase cbl;
PDBTitle: crystal structure of c-cbl-tkb domain complexed with its2 binding motif in sprouty4
113c1bf5A_
not modelled 98.2 22 PDB header:gene regulation/dna
Chain: A: PDB Molecule:signal transducer and activator of transcription
PDBTitle: tyrosine phosphorylated stat-1/dna complex
114c1bg1A_
not modelled 98.0 26 PDB header:transcription/dna
Chain: A: PDB Molecule:protein (transcription factor stat3b);
PDBTitle: transcription factor stat3b/dna complex
115c3cwgA_
not modelled 97.2 31 PDB header:transcription
Chain: A: PDB Molecule:signal transducer and activator of transcription
PDBTitle: unphosphorylated mouse stat3 core fragment
116c1fbvA_
not modelled 92.6 19 PDB header:ligase
Chain: A: PDB Molecule:signal transduction protein cbl;
PDBTitle: structure of a cbl-ubch7 complex: ring domain function in2 ubiquitin-protein ligases
117d3buxb3
not modelled 87.6 19 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
118c3op0B_
not modelled 81.3 19 PDB header:signaling protein/signaling protein regu
Chain: B: PDB Molecule:signal transduction protein cbl-c;
PDBTitle: crystal structure of cbl-c (cbl-3) tkb domain in complex with egfr2 py1069 peptide
119c2jz3A_
not modelled 80.8 40 PDB header:transcription inhibitor/transcription
Chain: A: PDB Molecule:suppressor of cytokine signaling 3;
PDBTitle: socs box elonginbc ternary complex
120c1griA_
not modelled 72.7 20 PDB header:signal transduction adaptor
Chain: A: PDB Molecule:growth factor bound protein 2;
PDBTitle: grb2

Binding site prediction 

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