Phyre Home Retrieve Phyre Job Id
Emaill.a.kelley@imperial.ac.uk
DescriptionG5EDP9
DateFri May 3 21:23:35 BST 2013
Unique Job IDe065cf77b31cdff4

Summary 

Top model
Image coloured by rainbow N → C terminus
Model dimensions (Å):X:51.865 Y:63.078 Z:60.057
Model (left) based on template c2oq1A_
Top template information
PDB header:transferase
Chain: A: PDB Molecule:tyrosine-protein kinase zap-70;
PDBTitle: tandem sh2 domains of zap-70 with 19-mer zeta1 peptide
Confidence and coverage
Confidence:100.0% Coverage: 48%
250 residues ( 48% of your sequence) have been modelled with 100.0% confidence by the single highest scoring template.
Additional confident templates have been detected (see Domain analysis) which cover other regions of your sequence.
372 residues ( 71%) could be modelled at >90% confidence using multiple-templates.
You may wish to try resubmitting your sequence in "intensive" mode to model more of your sequence.
3D viewing
Interactive 3D view in Jmol

Sequence analysis 

Secondary structure and disorder prediction 

   1........10.........20.........30.........40.........50.........60
Sequence  MSTTPGTPHGVTHSLMEQGWYWADADRSAVSKALSDQPDGSFIVRNASTPGDYTLSVKFA
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Disorder  ????????????????

















??
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   .........70.........80.........90.........100.........110.........120
Sequence  AQVKLLRIVVKDGKCGFNTDSLTHDSVVRLIEFHRNISLNIFNDALDVRLLYPVSVRRNS
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?????











????
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   .........130.........140.........150.........160.........170.........180
Sequence  QNGKPFFKKGQLQQRMILSAKNDHDWRERLEMENLRAVHLAFERGAKLYDSAHQEMERAE
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Disorder  ??????????????
?
???????
?




????







?
?







?

??
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   .........190.........200.........210.........220.........230.........240
Sequence  SLYHALNQSVRDNEIKLGKLNNLLEAETDVVTQIQGSQTTSEMLKGAFANNKTFVEESIR
Secondary structure 


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Disorder 

?
???


???








??

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?????????????????????



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   .........250.........260.........270.........280.........290.........300
Sequence  RINTELTSSKDKKKTLSGILDEIAMKRSNSKTRLCKLMELRSAVYDKMEPALCSRMAAML
Secondary structure 





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?
????????
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   .........310.........320.........330.........340.........350.........360
Sequence  DAGAEMINSEPTKVTQLLVDMELKWTPAQYLMCGTSKENAANALIHARYRIAQLDKAVGL
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Disorder  ?????????????







?
??
???

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   .........370.........380.........390.........400.........410.........420
Sequence  KREPQDGIFLIRGSSSHGDKLVLSVLHGERVSHCLIEQNEEGWGFEHSNVYLTTISDFVR
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   .........430.........440.........450.........460.........470.........480
Sequence  YYSHFSLETHADAIKTPLRTPAFDAVTSDTSKPLRNGPGQVFTALPISRKYMEKALLTDD
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Disorder 







???












???????????????????
?

??????
??????
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   .........490.........500.........510.........520..
Sequence  PTKPPESPEPRPDSWDSPSPDTPSSSDSRLVHPTTLPKSIPE
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Disorder  ??????????????????????????????????????????
Disorder confidence 









































 

Confidence Key
High(9)                    Low (0)
?Disordered ( 43%)
Alpha helix ( 39%)
Beta strand ( 12%)

Domain analysis 

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

RankAligned region

PDB 2oq1 chain A

3D model

Region: 14 - 444
Aligned: 250
Modelled: 261
Confidence: 100.0%
Identity: 20%
PDB header:transferase
Chain: A: PDB Molecule:tyrosine-protein kinase zap-70;
PDBTitle: tandem sh2 domains of zap-70 with 19-mer zeta1 peptide

Phyre2

PDB 4fl2 chain A

3D model

Region: 14 - 466
Aligned: 272
Modelled: 283
Confidence: 100.0%
Identity: 21%
PDB header:transferase
Chain: A: PDB Molecule:tyrosine-protein kinase syk;
PDBTitle: structural and biophysical characterization of the syk activation2 switch

Phyre2

PDB 2ozo chain A

3D model

Region: 12 - 469
Aligned: 277
Modelled: 288
Confidence: 100.0%
Identity: 21%
PDB header:transferase
Chain: A: PDB Molecule:tyrosine-protein kinase zap-70;
PDBTitle: autoinhibited intact human zap-70

Phyre2

PDB 2shp chain A

3D model

Region: 16 - 445
Aligned: 205
Modelled: 208
Confidence: 100.0%
Identity: 24%
PDB header:tyrosine phosphatase
Chain: A: PDB Molecule:shp-2;
PDBTitle: tyrosine phosphatase shp-2

Phyre2

PDB 2b3o chain A

3D model

Region: 20 - 444
Aligned: 200
Modelled: 203
Confidence: 100.0%
Identity: 29%
PDB header:hydrolase
Chain: A: PDB Molecule:tyrosine-protein phosphatase, non-receptor type
PDBTitle: crystal structure of human tyrosine phosphatase shp-1

Phyre2

PDB 1a81 chain E

3D model

Region: 14 - 445
Aligned: 217
Modelled: 228
Confidence: 100.0%
Identity: 24%
PDB header:complex (transferase/peptide)
Chain: E: PDB Molecule:syk kinase;
PDBTitle: crystal structure of the tandem sh2 domain of the syk kinase bound to2 a dually tyrosine-phosphorylated itam

Phyre2

PDB 3ps5 chain A

3D model

Region: 20 - 446
Aligned: 203
Modelled: 211
Confidence: 100.0%
Identity: 28%
PDB header:hydrolase, signaling protein
Chain: A: PDB Molecule:tyrosine-protein phosphatase non-receptor type 6;
PDBTitle: crystal structure of the full-length human protein tyrosine2 phosphatase shp-1

Phyre2

PDB 3gqi chain B

3D model

Region: 17 - 443
Aligned: 196
Modelled: 206
Confidence: 100.0%
Identity: 36%
PDB header:transferase/transferase inhibitor
Chain: B: PDB Molecule:phospholipase c-gamma-1;
PDBTitle: crystal structure of activated receptor tyrosine kinase in complex2 with substrates

Phyre2

PDB 3hiz chain B

3D model

Region: 14 - 277
Aligned: 219
Modelled: 229
Confidence: 100.0%
Identity: 27%
PDB header:transferase/oncoprotein
Chain: B: PDB Molecule:phosphatidylinositol 3-kinase regulatory subunit
PDBTitle: crystal structure of p110alpha h1047r mutant in complex with2 nish2 of p85alpha

Phyre2

PDB 2y3a chain B

3D model

Region: 10 - 117
Aligned: 108
Modelled: 108
Confidence: 100.0%
Identity: 29%
PDB header:transferase
Chain: B: PDB Molecule:phosphatidylinositol 3-kinase regulatory subunit beta;
PDBTitle: crystal structure of p110beta in complex with icsh2 of p85beta and2 the drug gdc-0941

Phyre2

PDB 2fo0 chain A

3D model

Region: 5 - 177
Aligned: 168
Modelled: 173
Confidence: 99.9%
Identity: 18%
PDB header:transferase
Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase abl1 (1b isoform);
PDBTitle: organization of the sh3-sh2 unit in active and inactive forms of the2 c-abl tyrosine kinase

Phyre2

PDB 2crh chain A

3D model

Region: 2 - 120
Aligned: 118
Modelled: 119
Confidence: 99.9%
Identity: 23%
PDB header:signaling protein
Chain: A: PDB Molecule:vav proto-oncogene;
PDBTitle: solution structure of the sh2 domain of human proto-2 oncogene protein vav1

Phyre2

PDB 1pic chain A

3D model

Region: 9 - 119
Aligned: 111
Modelled: 111
Confidence: 99.9%
Identity: 28%
Fold: SH2-like
Superfamily: SH2 domain
Family: SH2 domain

Phyre2

PDB 2eo6 chain A

3D model

Region: 2 - 123
Aligned: 122
Modelled: 122
Confidence: 99.9%
Identity: 25%
PDB header:signaling protein
Chain: A: PDB Molecule:b-cell linker protein;
PDBTitle: solution structure of the sh2 domain from mouse b-cell2 linker protein blnk

Phyre2

PDB 2oq1 chain A domain 1

3D model

Region: 14 - 184
Aligned: 124
Modelled: 129
Confidence: 99.9%
Identity: 19%
Fold: SH2-like
Superfamily: SH2 domain
Family: SH2 domain

Phyre2

PDB 2dly chain A

3D model

Region: 4 - 121
Aligned: 113
Modelled: 118
Confidence: 99.9%
Identity: 28%
PDB header:transferase
Chain: A: PDB Molecule:fyn-related kinase;
PDBTitle: solution structure of the sh2 domain of murine fyn-related2 kinase

Phyre2

PDB 2vif chain A

3D model

Region: 2 - 119
Aligned: 118
Modelled: 118
Confidence: 99.9%
Identity: 33%
PDB header:signaling protein
Chain: A: PDB Molecule:suppressor of cytokine signalling 6;
PDBTitle: crystal structure of socs6 sh2 domain in complex with a c-kit2 phosphopeptide

Phyre2

PDB 1opl chain A

3D model

Region: 5 - 177
Aligned: 168
Modelled: 173
Confidence: 99.9%
Identity: 18%
PDB header:transferase
Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase;
PDBTitle: structural basis for the auto-inhibition of c-abl tyrosine2 kinase

Phyre2

PDB 2dlz chain A

3D model

Region: 6 - 117
Aligned: 111
Modelled: 112
Confidence: 99.9%
Identity: 24%
PDB header:signaling protein
Chain: A: PDB Molecule:protein vav-2;
PDBTitle: solution structure of the sh2 domain of human protein vav-2

Phyre2

PDB 2lct chain A

3D model

Region: 10 - 115
Aligned: 105
Modelled: 106
Confidence: 99.9%
Identity: 26%
PDB header:signaling protein
Chain: A: PDB Molecule:proto-oncogene vav;
PDBTitle: solution structure of the vav1 sh2 domain complexed with a syk-derived2 doubly phosphorylated peptide

Phyre2

PDB 2dvj chain A

3D model

Region: 322 - 521
Aligned: 182
Modelled: 182
Confidence: 99.7%
Identity: 21%
PDB header:signaling protein
Chain: A: PDB Molecule:v-crk sarcoma virus ct10 oncogene homolog,
PDBTitle: phosphorylated crk-ii

Phyre2
1

c2oq1A_
2

c4fl2A_
3

c2ozoA_
4

c2shpA_
5

c2b3oA_
6

c1a81E_
7

c3ps5A_
8

c3gqiB_
9

c3hizB_
10

c2y3aB_
11

c2fo0A_
12

c2crhA_
13

d1pica_
14

c2eo6A_
15

d2oq1a1
16

c2dlyA_
17

c2vifA_
18

c1oplA_
19

c2dlzA_
20

c2lctA_
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c2dvjA_
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Detailed template information 

#
Template Alignment Coverage3D Model Confidence
% i.d. Template Information
1c2oq1A_



100.0 20 PDB header:transferase
Chain: A: PDB Molecule:tyrosine-protein kinase zap-70;
PDBTitle: tandem sh2 domains of zap-70 with 19-mer zeta1 peptide
2c4fl2A_



100.0 21 PDB header:transferase
Chain: A: PDB Molecule:tyrosine-protein kinase syk;
PDBTitle: structural and biophysical characterization of the syk activation2 switch
3c2ozoA_



100.0 21 PDB header:transferase
Chain: A: PDB Molecule:tyrosine-protein kinase zap-70;
PDBTitle: autoinhibited intact human zap-70
4c2shpA_



100.0 24 PDB header:tyrosine phosphatase
Chain: A: PDB Molecule:shp-2;
PDBTitle: tyrosine phosphatase shp-2
5c2b3oA_



100.0 29 PDB header:hydrolase
Chain: A: PDB Molecule:tyrosine-protein phosphatase, non-receptor type
PDBTitle: crystal structure of human tyrosine phosphatase shp-1
6c1a81E_



100.0 24 PDB header:complex (transferase/peptide)
Chain: E: PDB Molecule:syk kinase;
PDBTitle: crystal structure of the tandem sh2 domain of the syk kinase bound to2 a dually tyrosine-phosphorylated itam
7c3ps5A_



100.0 28 PDB header:hydrolase, signaling protein
Chain: A: PDB Molecule:tyrosine-protein phosphatase non-receptor type 6;
PDBTitle: crystal structure of the full-length human protein tyrosine2 phosphatase shp-1
8c3gqiB_



100.0 36 PDB header:transferase/transferase inhibitor
Chain: B: PDB Molecule:phospholipase c-gamma-1;
PDBTitle: crystal structure of activated receptor tyrosine kinase in complex2 with substrates
9c3hizB_



100.0 27 PDB header:transferase/oncoprotein
Chain: B: PDB Molecule:phosphatidylinositol 3-kinase regulatory subunit
PDBTitle: crystal structure of p110alpha h1047r mutant in complex with2 nish2 of p85alpha
10c2y3aB_



100.0 29 PDB header:transferase
Chain: B: PDB Molecule:phosphatidylinositol 3-kinase regulatory subunit beta;
PDBTitle: crystal structure of p110beta in complex with icsh2 of p85beta and2 the drug gdc-0941
11c2fo0A_



99.9 18 PDB header:transferase
Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase abl1 (1b isoform);
PDBTitle: organization of the sh3-sh2 unit in active and inactive forms of the2 c-abl tyrosine kinase
12c2crhA_



99.9 23 PDB header:signaling protein
Chain: A: PDB Molecule:vav proto-oncogene;
PDBTitle: solution structure of the sh2 domain of human proto-2 oncogene protein vav1
13d1pica_



99.9 28 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
14c2eo6A_



99.9 25 PDB header:signaling protein
Chain: A: PDB Molecule:b-cell linker protein;
PDBTitle: solution structure of the sh2 domain from mouse b-cell2 linker protein blnk
15d2oq1a1



99.9 19 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
16c2dlyA_



99.9 28 PDB header:transferase
Chain: A: PDB Molecule:fyn-related kinase;
PDBTitle: solution structure of the sh2 domain of murine fyn-related2 kinase
17c2vifA_



99.9 33 PDB header:signaling protein
Chain: A: PDB Molecule:suppressor of cytokine signalling 6;
PDBTitle: crystal structure of socs6 sh2 domain in complex with a c-kit2 phosphopeptide
18c1oplA_



99.9 18 PDB header:transferase
Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase;
PDBTitle: structural basis for the auto-inhibition of c-abl tyrosine2 kinase
19c2dlzA_



99.9 24 PDB header:signaling protein
Chain: A: PDB Molecule:protein vav-2;
PDBTitle: solution structure of the sh2 domain of human protein vav-2
20c2lctA_



99.9 26 PDB header:signaling protein
Chain: A: PDB Molecule:proto-oncogene vav;
PDBTitle: solution structure of the vav1 sh2 domain complexed with a syk-derived2 doubly phosphorylated peptide
21d1opka2



not modelled 99.9 27 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
22d1a81e2



not modelled 99.9 20 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
23d2oq1a2



not modelled 99.9 22 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
24d1a81a2



not modelled 99.9 19 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
25d1csya_



not modelled 99.9 19 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
26c2ablA_



not modelled 99.9 25 PDB header:transferase
Chain: A: PDB Molecule:abl tyrosine kinase;
PDBTitle: sh3-sh2 domain fragment of human bcr-abl tyrosine kinase
27c2hmhA_



not modelled 99.9 25 PDB header:cytokine regulator
Chain: A: PDB Molecule:suppressor of cytokine signaling 3;
PDBTitle: crystal structure of socs3 in complex with gp130(ptyr757)2 phosphopeptide.
28d1a81e1



not modelled 99.9 21 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
29d2shpa2



not modelled 99.9 19 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
30d2izva2



not modelled 99.9 20 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
31c2eo3A_



not modelled 99.9 28 PDB header:signaling protein
Chain: A: PDB Molecule:crk-like protein;
PDBTitle: solution structure of the sh2 domain from human crk-like2 protein
32c2ge9A_



not modelled 99.9 27 PDB header:transferase
Chain: A: PDB Molecule:tyrosine-protein kinase btk;
PDBTitle: solution structures of the sh2 domain of bruton's tyrosine2 kinase
33d1jwoa_



not modelled 99.9 25 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
34c2eobA_



not modelled 99.9 22 PDB header:hydrolase
Chain: A: PDB Molecule:1-phosphatidylinositol-4,5-bisphosphate
PDBTitle: solution structure of the second sh2 domain from rat plc2 gamma-2
35d1nrva_



not modelled 99.9 17 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
36d1lkka_



not modelled 99.9 30 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
37d1rjaa_



not modelled 99.9 24 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
38d1blja_



not modelled 99.9 23 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
39d1a81a1



not modelled 99.9 21 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
40c1y57A_



not modelled 99.9 19 PDB header:transferase
Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase src;
PDBTitle: structure of unphosphorylated c-src in complex with an inhibitor
41c2gsbA_



not modelled 99.9 19 PDB header:signaling protein
Chain: A: PDB Molecule:ras gtpase-activating protein 1;
PDBTitle: solution structure of the second sh2 domain of human ras2 gtpase-activating protein 1
42c1k9aB_



not modelled 99.9 18 PDB header:transferase
Chain: B: PDB Molecule:carboxyl-terminal src kinase;
PDBTitle: crystal structure analysis of full-length carboxyl-terminal2 src kinase at 2.5 a resolution
43d1qada_



not modelled 99.9 32 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
44c2c9wA_



not modelled 99.9 31 PDB header:transcription regulation
Chain: A: PDB Molecule:suppressor of cytokine signaling 2;
PDBTitle: crystal structure of socs-2 in complex with elongin-b and2 elongin-c at 1.9a resolution
45d1k9aa2



not modelled 99.9 27 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
46c2lqnA_



not modelled 99.9 24 PDB header:signaling protein
Chain: A: PDB Molecule:crk-like protein;
PDBTitle: solution structure of crkl
47c1ka6A_



not modelled 99.9 20 PDB header:immune system
Chain: A: PDB Molecule:sh2 domain protein 1a;
PDBTitle: sap/sh2d1a bound to peptide n-py
48d3c7ia1



not modelled 99.9 26 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
49d1ayaa_



not modelled 99.9 22 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
50c2ysxA_



not modelled 99.9 29 PDB header:signaling protein
Chain: A: PDB Molecule:signaling inositol polyphosphate phosphatase
PDBTitle: solution structure of the human ship sh2 domain
51c2c0iA_



not modelled 99.9 19 PDB header:transferase
Chain: A: PDB Molecule:tyrosine-protein kinase hck;
PDBTitle: src family kinase hck with bound inhibitor a-420983
52c2izvA_



not modelled 99.9 17 PDB header:transcription
Chain: A: PDB Molecule:suppressor of cytokine signaling 4;
PDBTitle: crystal structure of socs-4 in complex with elongin-b and2 elongin-c at 2.55a resolution
53d1o48a_



not modelled 99.9 31 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
54d1d4ta_



not modelled 99.9 21 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
55d1i3za_



not modelled 99.9 24 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
56c2hdxB_



not modelled 99.9 22 PDB header:signaling protein
Chain: B: PDB Molecule:sh2-b ph domain containing signaling mediator 1
PDBTitle: crystal structure of the src homology-2 domain of sh2-b in2 complex with jak2 ptyr813 phosphopeptide
57d1luia_



not modelled 99.9 34 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
58d1bkla_



not modelled 99.9 28 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
59d1fu6a_



not modelled 99.9 50 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
60c2ekxA_



not modelled 99.9 29 PDB header:signaling protein
Chain: A: PDB Molecule:cytoplasmic tyrosine-protein kinase bmx;
PDBTitle: solution structure of the human bmx sh2 domain
61d1qcfa2



not modelled 99.9 29 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
62c2kk6A_



not modelled 99.9 28 PDB header:transferase
Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase fer;
PDBTitle: solution structure of sh2 domain of proto-oncogene tyrosine-2 protein kinase fer from homo sapiens, northeast structural3 genomics consortium (nesg) target hr3461d
63c2augB_



not modelled 99.9 20 PDB header:signaling protein
Chain: B: PDB Molecule:growth factor receptor-bound protein 14;
PDBTitle: crystal structure of the grb14 sh2 domain
64d1g83a2



not modelled 99.9 26 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
65c2knoA_



not modelled 99.9 23 PDB header:hydrolase
Chain: A: PDB Molecule:tensin-like c1 domain-containing phosphatase;
PDBTitle: nmr solution structure of sh2 domain of the human tensin like c12 domain containing phosphatase (tenc1)
66c2h8hA_



not modelled 99.9 21 PDB header:transferase
Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase src;
PDBTitle: src kinase in complex with a quinazoline inhibitor
67d2qmsa1



not modelled 99.9 21 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
68c2xp1A_



not modelled 99.9 21 PDB header:transcription
Chain: A: PDB Molecule:spt6;
PDBTitle: structure of the tandem sh2 domains from antonospora locustae2 transcription elongation factor spt6
69c3or8A_



not modelled 99.9 21 PDB header:transcription
Chain: A: PDB Molecule:transcription elongation factor spt6;
PDBTitle: a tandem sh2 domain in transcription elongation factor spt6
70d2cs0a1



not modelled 99.9 23 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
71c2dm0A_



not modelled 99.9 28 PDB header:transferase
Chain: A: PDB Molecule:tyrosine-protein kinase txk;
PDBTitle: solution structure of the sh2 domain of human tyrosine-2 protein kinase txk
72c2dcrA_



not modelled 99.9 24 PDB header:transferase
Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase fes/fps;
PDBTitle: fully automated solution structure determination of the fes2 sh2 domain
73d1fhsa_



not modelled 99.9 24 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
74c3nhnA_



not modelled 99.9 27 PDB header:transferase
Chain: A: PDB Molecule:tyrosine-protein kinase hck;
PDBTitle: crystal structure of the src-family kinase hck sh3-sh2-linker2 regulatory region
75d1mila_



not modelled 99.9 30 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
76d1f2fa_



not modelled 99.9 27 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
77d2eyva1



not modelled 99.9 30 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
78c1x27F_



not modelled 99.9 27 PDB header:signaling protein
Chain: F: PDB Molecule:proto-oncogene tyrosine-protein kinase lck;
PDBTitle: crystal structure of lck sh2-sh3 with sh2 binding site of2 p130cas
79c1x6cA_



not modelled 99.9 23 PDB header:signaling protein
Chain: A: PDB Molecule:tyrosine-protein phosphatase, non-receptor type
PDBTitle: solution structures of the sh2 domain of human protein-2 tyrosine phosphatase shp-1
80d1r1qa_



not modelled 99.9 21 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
81c2ci8A_



not modelled 99.9 19 PDB header:translation
Chain: A: PDB Molecule:cytoplasmic protein nck1;
PDBTitle: sh2 domain of human nck1 adaptor protein - uncomplexed
82d2shpa3



not modelled 99.9 24 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
83d2c9wa2



not modelled 99.9 33 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
84d2fcia1



not modelled 99.9 25 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
85c3mazA_



not modelled 99.9 12 PDB header:signaling protein
Chain: A: PDB Molecule:signal-transducing adaptor protein 1;
PDBTitle: crystal structure of the human brdg1/stap-1 sh2 domain in complex with2 the ntal ptyr136 peptide
86d1cwea_



not modelled 99.8 28 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
87c2el8A_



not modelled 99.8 11 PDB header:signaling protein
Chain: A: PDB Molecule:signal-transducing adaptor protein 2;
PDBTitle: solution structure of the human stap2 sh2 domain
88d1xa6a2



not modelled 99.8 18 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
89c1g83A_



not modelled 99.8 25 PDB header:transferase
Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase fyn;
PDBTitle: crystal structure of fyn sh3-sh2
90d1jyra_



not modelled 99.8 26 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
91d1rpya_



not modelled 99.8 21 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
92c2eyzA_



not modelled 99.8 30 PDB header:signaling protein
Chain: A: PDB Molecule:v-crk sarcoma virus ct10 oncogene homolog
PDBTitle: ct10-regulated kinase isoform ii
93c2cr4A_



not modelled 99.8 19 PDB header:signaling protein
Chain: A: PDB Molecule:sh3 domain-binding protein 2;
PDBTitle: solution structure of the sh2 domain of human sh3bp2 protein
94c1rqqC_



not modelled 99.8 26 PDB header:transferase/signaling protein
Chain: C: PDB Molecule:adaptor protein aps;
PDBTitle: crystal structure of the insulin receptor kinase in complex2 with the sh2 domain of aps
95c2dx0B_



not modelled 99.8 34 PDB header:hydrolase
Chain: B: PDB Molecule:phospholipase c, gamma 2;
PDBTitle: crystal structure of the n-terminal sh2 domain of mouse2 phospholipase c-gamma 2
96c3gxxB_



not modelled 99.8 12 PDB header:transcription
Chain: B: PDB Molecule:transcription elongation factor spt6;
PDBTitle: structure of the sh2 domain of the candida glabrata2 transcription elongation factor spt6, crystal form b
97c2eyyA_



not modelled 99.8 28 PDB header:signaling protein
Chain: A: PDB Molecule:v-crk sarcoma virus ct10 oncogene homolog
PDBTitle: ct10-regulated kinase isoform i
98c3qwyA_



not modelled 99.7 23 PDB header:signaling protein
Chain: A: PDB Molecule:cell death abnormality protein 2;
PDBTitle: ced-2
99c3qwxX_



not modelled 99.7 22 PDB header:signaling protein
Chain: X: PDB Molecule:cell death abnormality protein 2;
PDBTitle: ced-2 1-174
100c2dvjA_



99.7 21 PDB header:signaling protein
Chain: A: PDB Molecule:v-crk sarcoma virus ct10 oncogene homolog,
PDBTitle: phosphorylated crk-ii
101d1uura3



not modelled 99.6 19 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
102c1xa6A_



not modelled 99.5 20 PDB header:signaling protein
Chain: A: PDB Molecule:beta2-chimaerin;
PDBTitle: crystal structure of the human beta2-chimaerin
103d1bf5a3



not modelled 99.5 15 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
104d1bg1a3



not modelled 99.3 16 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
105c3cblA_



not modelled 99.3 24 PDB header:transferase
Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase fes/fps;
PDBTitle: crystal structure of human feline sarcoma viral oncogene homologue (v-2 fes) in complex with staurosporine and a consensus peptide
106c1yvlB_



not modelled 97.8 16 PDB header:signaling protein
Chain: B: PDB Molecule:signal transducer and activator of transcription
PDBTitle: structure of unphosphorylated stat1
107c1uusA_



not modelled 97.8 23 PDB header:signal transduction
Chain: A: PDB Molecule:stat protein;
PDBTitle: structure of an activated dictyostelium stat in its2 dna-unbound form
108c1bg1A_



not modelled 97.6 18 PDB header:transcription/dna
Chain: A: PDB Molecule:protein (transcription factor stat3b);
PDBTitle: transcription factor stat3b/dna complex
109c1bf5A_



not modelled 97.5 17 PDB header:gene regulation/dna
Chain: A: PDB Molecule:signal transducer and activator of transcription
PDBTitle: tyrosine phosphorylated stat-1/dna complex
110c1y1uA_



not modelled 97.5 23 PDB header:signaling protein
Chain: A: PDB Molecule:signal transducer and activator of transcription 5a;
PDBTitle: structure of unphosphorylated stat5a
111c2cblA_



not modelled 96.6 25 PDB header:complex (proto-oncogene/peptide)
Chain: A: PDB Molecule:proto-oncogene cbl;
PDBTitle: n-terminal domain of cbl in complex with its binding site2 on zap-70
112c3bunB_



not modelled 96.6 25 PDB header:ligase/signaling protein
Chain: B: PDB Molecule:e3 ubiquitin-protein ligase cbl;
PDBTitle: crystal structure of c-cbl-tkb domain complexed with its2 binding motif in sprouty4
113c1griA_



not modelled 95.7 20 PDB header:signal transduction adaptor
Chain: A: PDB Molecule:growth factor bound protein 2;
PDBTitle: grb2
114c3cwgA_



not modelled 95.1 23 PDB header:transcription
Chain: A: PDB Molecule:signal transducer and activator of transcription
PDBTitle: unphosphorylated mouse stat3 core fragment
115c3lvrE_



not modelled 93.8 8 PDB header:protein transport
Chain: E: PDB Molecule:arf-gap with sh3 domain, ank repeat and ph domain-
PDBTitle: the crystal structure of asap3 in complex with arf6 in transition2 state soaked with calcium
116c3jueA_



not modelled 91.7 14 PDB header:protein transport/endocytosis
Chain: A: PDB Molecule:arfgap with coiled-coil, ank repeat and ph domain-
PDBTitle: crystal structure of arfgap and ank repeat domain of acap1
117c2b0oF_



not modelled 90.5 12 PDB header:metal binding protein
Chain: F: PDB Molecule:uplc1;
PDBTitle: crystal structure of uplc1 gap domain
118c3t9kA_



not modelled 88.1 14 PDB header:protein transport
Chain: A: PDB Molecule:arf-gap with coiled-coil, ank repeat and ph domain-
PDBTitle: crystal structure of acap1 c-portion mutant s554d fused with integrin2 beta1 peptide
119c1dcqA_



not modelled 86.4 8 PDB header:metal binding protein
Chain: A: PDB Molecule:pyk2-associated protein beta;
PDBTitle: crystal structure of the arf-gap domain and ankyrin repeats2 of papbeta.
120c3ui2A_



not modelled 85.7 3 PDB header:transport protein
Chain: A: PDB Molecule:signal recognition particle 43 kda protein, chloroplastic;
PDBTitle: crystal structure of the cpsrp54 tail bound to cpsrp43

Binding site prediction 

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