Phyre Home Retrieve Phyre Job Id
Emaill.a.kelley@imperial.ac.uk
DescriptionG5EC24
DateFri May 3 21:06:01 BST 2013
Unique Job ID84e226cc6a76541a

Summary 

Top model
Image coloured by rainbow N → C terminus
Model dimensions (Å):X:58.211 Y:88.744 Z:60.242
Model (left) based on template c3ps5A_
Top template information
PDB header:hydrolase, signaling protein
Chain: A: PDB Molecule:tyrosine-protein phosphatase non-receptor type 6;
PDBTitle: crystal structure of the full-length human protein tyrosine2 phosphatase shp-1
Confidence and coverage
Confidence:100.0% Coverage: 75%
500 residues ( 75% of your sequence) have been modelled with 100.0% confidence by the single highest scoring template.
Additional confident templates have been detected (see Domain analysis) which cover other regions of your sequence.
590 residues ( 88%) could be modelled at >90% confidence using multiple-templates.
You may wish to try resubmitting your sequence in "intensive" mode to model more of your sequence.
3D viewing
Interactive 3D view in Jmol

Sequence analysis 

Secondary structure and disorder prediction 

   1........10.........20.........30.........40.........50.........60
Sequence  MPRLALRQYNFYYRVNGEKAEELLKEYGEDGDFLLRYSESNPQNFSISVRVAEDKILHIK
Secondary structure 
SS confidence 
Disorder  ??????????????
?
?
??
??????????
?
Disorder confidence 
 
   .........70.........80.........90.........100.........110.........120
Sequence  VTKYESDMLSIFEDERTTPNQFGSITELAEFYMEFPEKLREKNGLFLELKKPVYVPYHLE
Secondary structure 
SS confidence 
Disorder 
?
?????
Disorder confidence 
 
   .........130.........140.........150.........160.........170.........180
Sequence  ACAEEQRRTQLYRWWHGNLPASSANKLLQTEKNGTYLLRASQHIPGALVISAKTEGQVVH
Secondary structure 
SS confidence 
Disorder  ????
?
?????
Disorder confidence 
 
   .........190.........200.........210.........220.........230.........240
Sequence  LTIYQDPSTGRFNIDGDRTKFQSAWLLIDSYSKNPIVEKGEASRVLYLEEPLFNTFIEAD
Secondary structure 
SS confidence 
Disorder 
????
??????
????
???
?
?
?
Disorder confidence 
 
   .........250.........260.........270.........280.........290.........300
Sequence  LFVDRFEIIRRPINPRESMEKTGISEEFDRLSQEALPAEQYLSKREGRRPVNAEKNRYKN
Secondary structure 
SS confidence 
Disorder  ?
???????
???????
?
Disorder confidence 
 
   .........310.........320.........330.........340.........350.........360
Sequence  IVPFDHTRVILTDRPNTPGSDYINASYVRFENSQRTKNVTFACEKSFIATQGCLETTISD
Secondary structure 
SS confidence 
Disorder 
??????
??????????
Disorder confidence 
 
   .........370.........380.........390.........400.........410.........420
Sequence  FWSMVWQENSRVIVMPTMENERKEKCARYWPAEVNKPEVHGDISLTCTIERKVQRAVSDE
Secondary structure 
SS confidence 
Disorder 
???
?
??
Disorder confidence 
 
   .........430.........440.........450.........460.........470.........480
Sequence  VKAELEQEKTNRIAKGLVPEAELNGDGISYILRTLVMKKGKDTREIRQLQYLTWPDHGCP
Secondary structure 
SS confidence 
Disorder 
?
????????????????????
Disorder confidence 
 
   .........490.........500.........510.........520.........530.........540
Sequence  LHPYAVLNFLEDVDREYDYFNAQPIAASLPQGPIVVHCSAGIGRTGTVLVLDALLNQVKK
Secondary structure 
SS confidence 
Disorder 
???????????
Disorder confidence 
 
   .........550.........560.........570.........580.........590.........600
Sequence  VGLLCPMDVYKMVKYVRTYRSGLVQTEQQYQFLYKALAFYLKNNNPYPVKSFIDGDTDAF
Secondary structure 
SS confidence 
Disorder 
?
?
??
?
??
???
Disorder confidence 
 
   .........610.........620.........630.........640.........650.........660
Sequence  DFPRRLRPTPNASRPSSARQVTSSRPSSSASSRTSHSRPRTGPQAEPIFERSTSSTSSSS
Secondary structure 
SS confidence 
Disorder  ????????????????????????????????????????????????????????????
Disorder confidence 
 
   ........
Sequence  TLLKSTKK
Secondary structure 
SS confidence 
Disorder  ????????
Disorder confidence 
 

Confidence Key
High(9)                    Low (0)
?Disordered ( 32%)
Alpha helix ( 25%)
Beta strand ( 19%)

Domain analysis 

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

RankAligned region

PDB 3ps5 chain A

3D model

Region: 10 - 583
Aligned: 500
Modelled: 529
Confidence: 100.0%
Identity: 41%
PDB header:hydrolase, signaling protein
Chain: A: PDB Molecule:tyrosine-protein phosphatase non-receptor type 6;
PDBTitle: crystal structure of the full-length human protein tyrosine2 phosphatase shp-1

Phyre2

PDB 2b3o chain A

3D model

Region: 10 - 583
Aligned: 483
Modelled: 515
Confidence: 100.0%
Identity: 42%
PDB header:hydrolase
Chain: A: PDB Molecule:tyrosine-protein phosphatase, non-receptor type
PDBTitle: crystal structure of human tyrosine phosphatase shp-1

Phyre2

PDB 2shp chain A

3D model

Region: 8 - 583
Aligned: 478
Modelled: 540
Confidence: 100.0%
Identity: 44%
PDB header:tyrosine phosphatase
Chain: A: PDB Molecule:shp-2;
PDBTitle: tyrosine phosphatase shp-2

Phyre2

PDB 1ygu chain A

3D model

Region: 229 - 665
Aligned: 366
Modelled: 392
Confidence: 100.0%
Identity: 28%
PDB header:hydrolase
Chain: A: PDB Molecule:leukocyte common antigen;
PDBTitle: crystal structure of the tandem phosphatase domains of rptp2 cd45 with a ptyr peptide

Phyre2

PDB 2nlk chain A

3D model

Region: 236 - 586
Aligned: 280
Modelled: 315
Confidence: 100.0%
Identity: 42%
PDB header:hydrolase
Chain: A: PDB Molecule:protein tyrosine phosphatase, receptor type, g variant
PDBTitle: crystal structure of d1 and d2 catalytic domains of human protein2 tyrosine phosphatase gamma (d1+d2 ptprg)

Phyre2

PDB 3sr9 chain A

3D model

Region: 237 - 665
Aligned: 355
Modelled: 382
Confidence: 100.0%
Identity: 32%
PDB header:hydrolase
Chain: A: PDB Molecule:receptor-type tyrosine-protein phosphatase s;
PDBTitle: crystal structure of mouse ptpsigma

Phyre2

PDB 1lar chain B

3D model

Region: 234 - 584
Aligned: 284
Modelled: 317
Confidence: 100.0%
Identity: 37%
PDB header:hydrolase
Chain: B: PDB Molecule:protein (lar);
PDBTitle: crystal structure of the tandem phosphatase domains of rptp2 lar

Phyre2

PDB 1wch chain A

3D model

Region: 224 - 583
Aligned: 288
Modelled: 309
Confidence: 100.0%
Identity: 36%
Fold: (Phosphotyrosine protein) phosphatases II
Superfamily: (Phosphotyrosine protein) phosphatases II
Family: Higher-molecular-weight phosphotyrosine protein phosphatases

Phyre2

PDB 1jln chain A

3D model

Region: 234 - 589
Aligned: 280
Modelled: 310
Confidence: 100.0%
Identity: 39%
Fold: (Phosphotyrosine protein) phosphatases II
Superfamily: (Phosphotyrosine protein) phosphatases II
Family: Higher-molecular-weight phosphotyrosine protein phosphatases

Phyre2

PDB 2jjd chain A

3D model

Region: 246 - 665
Aligned: 330
Modelled: 352
Confidence: 100.0%
Identity: 33%
PDB header:hydrolase
Chain: A: PDB Molecule:receptor-type tyrosine-protein phosphatase epsilon;
PDBTitle: protein tyrosine phosphatase, receptor type, e isoform

Phyre2

PDB 3s3f chain A

3D model

Region: 232 - 584
Aligned: 284
Modelled: 308
Confidence: 100.0%
Identity: 37%
PDB header:hydrolase/hydrolase inhibitor
Chain: A: PDB Molecule:tyrosine-protein phosphatase 10d;
PDBTitle: crystal structure of the catalytic domain of ptp10d from drosophila2 melanogaster with a small molecule inhibitor vanadate

Phyre2

PDB 2nz6 chain A

3D model

Region: 234 - 589
Aligned: 273
Modelled: 322
Confidence: 100.0%
Identity: 34%
PDB header:hydrolase
Chain: A: PDB Molecule:receptor-type tyrosine-protein phosphatase eta;
PDBTitle: crystal structure of the ptprj inactivating mutant c1239s

Phyre2

PDB 2pa5 chain A

3D model

Region: 226 - 585
Aligned: 287
Modelled: 323
Confidence: 100.0%
Identity: 36%
PDB header:hydrolase
Chain: A: PDB Molecule:tyrosine-protein phosphatase non-receptor type 9;
PDBTitle: crystal structure of human protein tyrosine phosphatase ptpn9

Phyre2

PDB 1lar chain A domain 1

3D model

Region: 239 - 586
Aligned: 277
Modelled: 314
Confidence: 100.0%
Identity: 41%
Fold: (Phosphotyrosine protein) phosphatases II
Superfamily: (Phosphotyrosine protein) phosphatases II
Family: Higher-molecular-weight phosphotyrosine protein phosphatases

Phyre2

PDB 3i36 chain A

3D model

Region: 234 - 584
Aligned: 282
Modelled: 305
Confidence: 100.0%
Identity: 36%
PDB header:hydrolase
Chain: A: PDB Molecule:vascular protein tyrosine phosphatase 1;
PDBTitle: crystal structure of rat protein tyrosine phosphatase eta catalytic2 domain

Phyre2

PDB 2bzl chain A

3D model

Region: 245 - 584
Aligned: 278
Modelled: 306
Confidence: 100.0%
Identity: 34%
PDB header:hydrolase
Chain: A: PDB Molecule:tyrosine-protein phosphatase, non-receptor type
PDBTitle: crystal structure of the human protein tyrosine phosphatase2 n14 at 1.65 a resolution

Phyre2

PDB 2shp chain A domain 1

3D model

Region: 235 - 583
Aligned: 274
Modelled: 315
Confidence: 100.0%
Identity: 48%
Fold: (Phosphotyrosine protein) phosphatases II
Superfamily: (Phosphotyrosine protein) phosphatases II
Family: Higher-molecular-weight phosphotyrosine protein phosphatases

Phyre2

PDB 2qdm chain A

3D model

Region: 259 - 586
Aligned: 258
Modelled: 291
Confidence: 100.0%
Identity: 36%
PDB header:hydrolase
Chain: A: PDB Molecule:tyrosine-protein phosphatase non-receptor type 7;
PDBTitle: crystal structure of the heptp catalytic domain c270s/d236a/q314a2 mutant

Phyre2

PDB 2oc3 chain A

3D model

Region: 264 - 581
Aligned: 264
Modelled: 285
Confidence: 100.0%
Identity: 39%
PDB header:hydrolase
Chain: A: PDB Molecule:tyrosine-protein phosphatase non-receptor type
PDBTitle: crystal structure of the catalytic domain of human protein2 tyrosine phosphatase non-receptor type 18

Phyre2

PDB 2c7s chain A

3D model

Region: 236 - 586
Aligned: 277
Modelled: 302
Confidence: 100.0%
Identity: 40%
PDB header:hydrolase
Chain: A: PDB Molecule:receptor-type tyrosine-protein phosphatase kappa;
PDBTitle: crystal structure of human protein tyrosine phosphatase2 kappa at 1.95a resolution

Phyre2
1
c3ps5A_
2
c2b3oA_
3
c2shpA_
4
c1yguA_
5
c2nlkA_
6
c3sr9A_
7
c1larB_
8
d1wcha_
9
d1jlna_
10
c2jjdA_
11
c3s3fA_
12
c2nz6A_
13
c2pa5A_
14
d1lara1
15
c3i36A_
16
c2bzlA_
17
d2shpa1
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c2qdmA_
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c2oc3A_
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c2c7sA_
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Detailed template information 

#
Template Alignment Coverage3D Model Confidence
% i.d. Template Information
1c3ps5A_
100.0 41 PDB header:hydrolase, signaling protein
Chain: A: PDB Molecule:tyrosine-protein phosphatase non-receptor type 6;
PDBTitle: crystal structure of the full-length human protein tyrosine2 phosphatase shp-1
2c2b3oA_
100.0 42 PDB header:hydrolase
Chain: A: PDB Molecule:tyrosine-protein phosphatase, non-receptor type
PDBTitle: crystal structure of human tyrosine phosphatase shp-1
3c2shpA_
100.0 44 PDB header:tyrosine phosphatase
Chain: A: PDB Molecule:shp-2;
PDBTitle: tyrosine phosphatase shp-2
4c1yguA_
100.0 28 PDB header:hydrolase
Chain: A: PDB Molecule:leukocyte common antigen;
PDBTitle: crystal structure of the tandem phosphatase domains of rptp2 cd45 with a ptyr peptide
5c2nlkA_
100.0 42 PDB header:hydrolase
Chain: A: PDB Molecule:protein tyrosine phosphatase, receptor type, g variant
PDBTitle: crystal structure of d1 and d2 catalytic domains of human protein2 tyrosine phosphatase gamma (d1+d2 ptprg)
6c3sr9A_
100.0 32 PDB header:hydrolase
Chain: A: PDB Molecule:receptor-type tyrosine-protein phosphatase s;
PDBTitle: crystal structure of mouse ptpsigma
7c1larB_
100.0 37 PDB header:hydrolase
Chain: B: PDB Molecule:protein (lar);
PDBTitle: crystal structure of the tandem phosphatase domains of rptp2 lar
8d1wcha_
100.0 36 Fold:(Phosphotyrosine protein) phosphatases II
Superfamily:(Phosphotyrosine protein) phosphatases II
Family:Higher-molecular-weight phosphotyrosine protein phosphatases
9d1jlna_
100.0 39 Fold:(Phosphotyrosine protein) phosphatases II
Superfamily:(Phosphotyrosine protein) phosphatases II
Family:Higher-molecular-weight phosphotyrosine protein phosphatases
10c2jjdA_
100.0 33 PDB header:hydrolase
Chain: A: PDB Molecule:receptor-type tyrosine-protein phosphatase epsilon;
PDBTitle: protein tyrosine phosphatase, receptor type, e isoform
11c3s3fA_
100.0 37 PDB header:hydrolase/hydrolase inhibitor
Chain: A: PDB Molecule:tyrosine-protein phosphatase 10d;
PDBTitle: crystal structure of the catalytic domain of ptp10d from drosophila2 melanogaster with a small molecule inhibitor vanadate
12c2nz6A_
100.0 34 PDB header:hydrolase
Chain: A: PDB Molecule:receptor-type tyrosine-protein phosphatase eta;
PDBTitle: crystal structure of the ptprj inactivating mutant c1239s
13c2pa5A_
100.0 36 PDB header:hydrolase
Chain: A: PDB Molecule:tyrosine-protein phosphatase non-receptor type 9;
PDBTitle: crystal structure of human protein tyrosine phosphatase ptpn9
14d1lara1
100.0 41 Fold:(Phosphotyrosine protein) phosphatases II
Superfamily:(Phosphotyrosine protein) phosphatases II
Family:Higher-molecular-weight phosphotyrosine protein phosphatases
15c3i36A_
100.0 36 PDB header:hydrolase
Chain: A: PDB Molecule:vascular protein tyrosine phosphatase 1;
PDBTitle: crystal structure of rat protein tyrosine phosphatase eta catalytic2 domain
16c2bzlA_
100.0 34 PDB header:hydrolase
Chain: A: PDB Molecule:tyrosine-protein phosphatase, non-receptor type
PDBTitle: crystal structure of the human protein tyrosine phosphatase2 n14 at 1.65 a resolution
17d2shpa1
100.0 48 Fold:(Phosphotyrosine protein) phosphatases II
Superfamily:(Phosphotyrosine protein) phosphatases II
Family:Higher-molecular-weight phosphotyrosine protein phosphatases
18c2qdmA_
100.0 36 PDB header:hydrolase
Chain: A: PDB Molecule:tyrosine-protein phosphatase non-receptor type 7;
PDBTitle: crystal structure of the heptp catalytic domain c270s/d236a/q314a2 mutant
19c2oc3A_
100.0 39 PDB header:hydrolase
Chain: A: PDB Molecule:tyrosine-protein phosphatase non-receptor type
PDBTitle: crystal structure of the catalytic domain of human protein2 tyrosine phosphatase non-receptor type 18
20c2c7sA_
100.0 40 PDB header:hydrolase
Chain: A: PDB Molecule:receptor-type tyrosine-protein phosphatase kappa;
PDBTitle: crystal structure of human protein tyrosine phosphatase2 kappa at 1.95a resolution
21d1fpra_
not modelled 100.0 47 Fold:(Phosphotyrosine protein) phosphatases II
Superfamily:(Phosphotyrosine protein) phosphatases II
Family:Higher-molecular-weight phosphotyrosine protein phosphatases
22c2qcjB_
not modelled 100.0 38 PDB header:hydrolase
Chain: B: PDB Molecule:tyrosine-protein phosphatase non-receptor type
PDBTitle: native structure of lyp
23c2hy3A_
not modelled 100.0 41 PDB header:hydrolase
Chain: A: PDB Molecule:receptor-type tyrosine-protein phosphatase gamma;
PDBTitle: crystal structure of the human tyrosine receptor phosphate gamma in2 complex with vanadate
24d2f71a1
not modelled 100.0 38 Fold:(Phosphotyrosine protein) phosphatases II
Superfamily:(Phosphotyrosine protein) phosphatases II
Family:Higher-molecular-weight phosphotyrosine protein phosphatases
25d1rpma_
not modelled 100.0 39 Fold:(Phosphotyrosine protein) phosphatases II
Superfamily:(Phosphotyrosine protein) phosphatases II
Family:Higher-molecular-weight phosphotyrosine protein phosphatases
26d1yfoa_
not modelled 100.0 39 Fold:(Phosphotyrosine protein) phosphatases II
Superfamily:(Phosphotyrosine protein) phosphatases II
Family:Higher-molecular-weight phosphotyrosine protein phosphatases
27c2vexA_
not modelled 100.0 38 PDB header:hydrolase
Chain: A: PDB Molecule:tyrosine-protein phosphatase non-receptor type 1;
PDBTitle: crystal strucutre of protein tyrosine phosphatase 1b in2 complex with an isothiazolidinone-containing inhibitor
28d1larb1
not modelled 100.0 44 Fold:(Phosphotyrosine protein) phosphatases II
Superfamily:(Phosphotyrosine protein) phosphatases II
Family:Higher-molecular-weight phosphotyrosine protein phosphatases
29c2h04A_
not modelled 100.0 39 PDB header:hydrolase
Chain: A: PDB Molecule:protein tyrosine phosphatase, receptor type, b,;
PDBTitle: structural studies of protein tyrosine phosphatase beta2 catalytic domain in complex with inhibitors
30c2qepA_
not modelled 100.0 33 PDB header:hydrolase
Chain: A: PDB Molecule:receptor-type tyrosine-protein phosphatase n2;
PDBTitle: crystal structure of the d1 domain of ptprn2 (ia2beta)
31c2g59B_
not modelled 100.0 34 PDB header:hydrolase
Chain: B: PDB Molecule:receptor-type tyrosine-protein phosphatase o;
PDBTitle: crystal structure of the catalytic domain of protein2 tyrosine phosphatase from homo sapiens
32c2bijA_
not modelled 100.0 38 PDB header:hydrolase
Chain: A: PDB Molecule:tyrosine-protein phosphatase, non-receptor type 5;
PDBTitle: crystal structure of the human protein tyrosine phosphatase2 ptpn5 (step, striatum enriched enriched phosphatase)
33d1l8ka_
not modelled 100.0 35 Fold:(Phosphotyrosine protein) phosphatases II
Superfamily:(Phosphotyrosine protein) phosphatases II
Family:Higher-molecular-weight phosphotyrosine protein phosphatases
34c1l8kA_
not modelled 100.0 35 PDB header:hydrolase
Chain: A: PDB Molecule:t-cell protein-tyrosine phosphatase;
PDBTitle: t cell protein-tyrosine phosphatase structure
35c2b49A_
not modelled 100.0 36 PDB header:hydrolase
Chain: A: PDB Molecule:protein tyrosine phosphatase, non-receptor type 3;
PDBTitle: crystal structure of the catalytic domain of protein tyrosine2 phosphatase, non-receptor type 3
36c2i75A_
not modelled 100.0 35 PDB header:hydrolase
Chain: A: PDB Molecule:tyrosine-protein phosphatase non-receptor type 4;
PDBTitle: crystal structure of human protein tyrosine phosphatase n4 (ptpn4)
37d1lara2
not modelled 100.0 41 Fold:(Phosphotyrosine protein) phosphatases II
Superfamily:(Phosphotyrosine protein) phosphatases II
Family:Higher-molecular-weight phosphotyrosine protein phosphatases
38c1g4wR_
not modelled 100.0 16 PDB header:signaling protein
Chain: R: PDB Molecule:protein tyrosine phosphatase sptp;
PDBTitle: crystal structure of the salmonella tyrosine phosphatase2 and gtpase activating protein sptp
39c3m4uB_
not modelled 100.0 29 PDB header:hydrolase
Chain: B: PDB Molecule:tyrosine specific protein phosphatase, putative;
PDBTitle: crystal structure of trypanosoma brucei protein tyrosine phosphatase2 tbptp1
40c3jrlA_
not modelled 100.0 50 PDB header:hydrolase
Chain: A: PDB Molecule:oncogenic tyrosine phosphatase shp2;
PDBTitle: crystal structure of the oncogenic tyrosine phosphatase shp2 complexed2 with a salicylic acid-based small molecule inhibitor
41c4az1B_
not modelled 100.0 30 PDB header:hydrolase
Chain: B: PDB Molecule:tyrosine specific protein phosphatase;
PDBTitle: crystal structure of the trypanosoma cruzi protein tyrosine2 phosphatase tcptp1, a potential therapeutic target for chagas'3 disease
42d1p15a_
not modelled 100.0 41 Fold:(Phosphotyrosine protein) phosphatases II
Superfamily:(Phosphotyrosine protein) phosphatases II
Family:Higher-molecular-weight phosphotyrosine protein phosphatases
43d1lyva_
not modelled 100.0 19 Fold:(Phosphotyrosine protein) phosphatases II
Superfamily:(Phosphotyrosine protein) phosphatases II
Family:Higher-molecular-weight phosphotyrosine protein phosphatases
44d1g4us2
not modelled 100.0 19 Fold:(Phosphotyrosine protein) phosphatases II
Superfamily:(Phosphotyrosine protein) phosphatases II
Family:Higher-molecular-weight phosphotyrosine protein phosphatases
45c2oq1A_
not modelled 100.0 30 PDB header:transferase
Chain: A: PDB Molecule:tyrosine-protein kinase zap-70;
PDBTitle: tandem sh2 domains of zap-70 with 19-mer zeta1 peptide
46c2ozoA_
not modelled 100.0 29 PDB header:transferase
Chain: A: PDB Molecule:tyrosine-protein kinase zap-70;
PDBTitle: autoinhibited intact human zap-70
47c4fl2A_
not modelled 100.0 29 PDB header:transferase
Chain: A: PDB Molecule:tyrosine-protein kinase syk;
PDBTitle: structural and biophysical characterization of the syk activation2 switch
48c3gqiB_
not modelled 100.0 28 PDB header:transferase/transferase inhibitor
Chain: B: PDB Molecule:phospholipase c-gamma-1;
PDBTitle: crystal structure of activated receptor tyrosine kinase in complex2 with substrates
49c1a81E_
not modelled 100.0 23 PDB header:complex (transferase/peptide)
Chain: E: PDB Molecule:syk kinase;
PDBTitle: crystal structure of the tandem sh2 domain of the syk kinase bound to2 a dually tyrosine-phosphorylated itam
50c3or8A_
not modelled 100.0 14 PDB header:transcription
Chain: A: PDB Molecule:transcription elongation factor spt6;
PDBTitle: a tandem sh2 domain in transcription elongation factor spt6
51d1v3aa_
not modelled 100.0 26 Fold:(Phosphotyrosine protein) phosphatases II
Superfamily:(Phosphotyrosine protein) phosphatases II
Family:Dual specificity phosphatase-like
52d1rxda_
not modelled 100.0 28 Fold:(Phosphotyrosine protein) phosphatases II
Superfamily:(Phosphotyrosine protein) phosphatases II
Family:Dual specificity phosphatase-like
53c2xp1A_
not modelled 100.0 17 PDB header:transcription
Chain: A: PDB Molecule:spt6;
PDBTitle: structure of the tandem sh2 domains from antonospora locustae2 transcription elongation factor spt6
54c3s4oB_
not modelled 99.9 24 PDB header:structural genomics, unknown function
Chain: B: PDB Molecule:protein tyrosine phosphatase-like protein;
PDBTitle: protein tyrosine phosphatase (putative) from leishmania major
55c3rz2B_
not modelled 99.9 26 PDB header:hydrolase
Chain: B: PDB Molecule:protein tyrosine phosphatase type iva 1;
PDBTitle: crystal of prl-1 complexed with peptide
56d2oq1a1
not modelled 99.9 30 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
57c2y3aB_
not modelled 99.9 22 PDB header:transferase
Chain: B: PDB Molecule:phosphatidylinositol 3-kinase regulatory subunit beta;
PDBTitle: crystal structure of p110beta in complex with icsh2 of p85beta and2 the drug gdc-0941
58d2shpa2
not modelled 99.9 30 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
59d1pica_
not modelled 99.9 24 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
60d1a81a1
not modelled 99.9 25 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
61c1x6cA_
not modelled 99.9 28 PDB header:signaling protein
Chain: A: PDB Molecule:tyrosine-protein phosphatase, non-receptor type
PDBTitle: solution structures of the sh2 domain of human protein-2 tyrosine phosphatase shp-1
62c3hizB_
not modelled 99.9 19 PDB header:transferase/oncoprotein
Chain: B: PDB Molecule:phosphatidylinositol 3-kinase regulatory subunit
PDBTitle: crystal structure of p110alpha h1047r mutant in complex with2 nish2 of p85alpha
63d1a81e1
not modelled 99.9 26 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
64c2hdxB_
not modelled 99.9 25 PDB header:signaling protein
Chain: B: PDB Molecule:sh2-b ph domain containing signaling mediator 1
PDBTitle: crystal structure of the src homology-2 domain of sh2-b in2 complex with jak2 ptyr813 phosphopeptide
65d2oq1a2
not modelled 99.9 26 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
66c2ysxA_
not modelled 99.9 26 PDB header:signaling protein
Chain: A: PDB Molecule:signaling inositol polyphosphate phosphatase
PDBTitle: solution structure of the human ship sh2 domain
67d1qada_
not modelled 99.9 25 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
68d3c7ia1
not modelled 99.9 24 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
69c2fo0A_
not modelled 99.9 27 PDB header:transferase
Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase abl1 (1b isoform);
PDBTitle: organization of the sh3-sh2 unit in active and inactive forms of the2 c-abl tyrosine kinase
70c2lqnA_
not modelled 99.9 24 PDB header:signaling protein
Chain: A: PDB Molecule:crk-like protein;
PDBTitle: solution structure of crkl
71c2eo6A_
not modelled 99.9 21 PDB header:signaling protein
Chain: A: PDB Molecule:b-cell linker protein;
PDBTitle: solution structure of the sh2 domain from mouse b-cell2 linker protein blnk
72c2crhA_
not modelled 99.9 21 PDB header:signaling protein
Chain: A: PDB Molecule:vav proto-oncogene;
PDBTitle: solution structure of the sh2 domain of human proto-2 oncogene protein vav1
73d1fhsa_
not modelled 99.9 22 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
74c1ka6A_
not modelled 99.9 25 PDB header:immune system
Chain: A: PDB Molecule:sh2 domain protein 1a;
PDBTitle: sap/sh2d1a bound to peptide n-py
75c2ci8A_
not modelled 99.9 28 PDB header:translation
Chain: A: PDB Molecule:cytoplasmic protein nck1;
PDBTitle: sh2 domain of human nck1 adaptor protein - uncomplexed
76d1ayaa_
not modelled 99.9 29 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
77c2eobA_
not modelled 99.9 25 PDB header:hydrolase
Chain: A: PDB Molecule:1-phosphatidylinositol-4,5-bisphosphate
PDBTitle: solution structure of the second sh2 domain from rat plc2 gamma-2
78d1a81a2
not modelled 99.9 26 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
79d1a81e2
not modelled 99.9 28 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
80c2dlyA_
not modelled 99.9 24 PDB header:transferase
Chain: A: PDB Molecule:fyn-related kinase;
PDBTitle: solution structure of the sh2 domain of murine fyn-related2 kinase
81d2izva2
not modelled 99.9 18 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
82c2dlzA_
not modelled 99.9 25 PDB header:signaling protein
Chain: A: PDB Molecule:protein vav-2;
PDBTitle: solution structure of the sh2 domain of human protein vav-2
83d1d4ta_
not modelled 99.9 25 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
84c2gsbA_
not modelled 99.9 24 PDB header:signaling protein
Chain: A: PDB Molecule:ras gtpase-activating protein 1;
PDBTitle: solution structure of the second sh2 domain of human ras2 gtpase-activating protein 1
85c1oplA_
not modelled 99.9 27 PDB header:transferase
Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase;
PDBTitle: structural basis for the auto-inhibition of c-abl tyrosine2 kinase
86c2ablA_
not modelled 99.9 26 PDB header:transferase
Chain: A: PDB Molecule:abl tyrosine kinase;
PDBTitle: sh3-sh2 domain fragment of human bcr-abl tyrosine kinase
87d2shpa3
not modelled 99.9 39 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
88d2qmsa1
not modelled 99.9 22 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
89c2lctA_
not modelled 99.9 22 PDB header:signaling protein
Chain: A: PDB Molecule:proto-oncogene vav;
PDBTitle: solution structure of the vav1 sh2 domain complexed with a syk-derived2 doubly phosphorylated peptide
90d1blja_
not modelled 99.9 25 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
91d1nrva_
not modelled 99.9 27 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
92c2ge9A_
not modelled 99.9 23 PDB header:transferase
Chain: A: PDB Molecule:tyrosine-protein kinase btk;
PDBTitle: solution structures of the sh2 domain of bruton's tyrosine2 kinase
93d1r1qa_
not modelled 99.9 29 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
94d1rjaa_
not modelled 99.9 26 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
95c1k9aB_
not modelled 99.9 25 PDB header:transferase
Chain: B: PDB Molecule:carboxyl-terminal src kinase;
PDBTitle: crystal structure analysis of full-length carboxyl-terminal2 src kinase at 2.5 a resolution
96d1xa6a2
not modelled 99.9 25 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
97d1lkka_
not modelled 99.9 23 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
98c2augB_
not modelled 99.8 25 PDB header:signaling protein
Chain: B: PDB Molecule:growth factor receptor-bound protein 14;
PDBTitle: crystal structure of the grb14 sh2 domain
99c2eo3A_
not modelled 99.8 25 PDB header:signaling protein
Chain: A: PDB Molecule:crk-like protein;
PDBTitle: solution structure of the sh2 domain from human crk-like2 protein
100d1i3za_
not modelled 99.8 22 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
101d1ohea2
not modelled 99.8 26 Fold:(Phosphotyrosine protein) phosphatases II
Superfamily:(Phosphotyrosine protein) phosphatases II
Family:Dual specificity phosphatase-like
102d1k9aa2
not modelled 99.8 27 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
103d1opka2
not modelled 99.8 28 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
104d1bkla_
not modelled 99.8 25 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
105d1jyra_
not modelled 99.8 25 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
106d1jwoa_
not modelled 99.8 27 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
107c1y57A_
not modelled 99.8 23 PDB header:transferase
Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase src;
PDBTitle: structure of unphosphorylated c-src in complex with an inhibitor
108d2eyva1
not modelled 99.8 30 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
109c2hmhA_
not modelled 99.8 22 PDB header:cytokine regulator
Chain: A: PDB Molecule:suppressor of cytokine signaling 3;
PDBTitle: crystal structure of socs3 in complex with gp130(ptyr757)2 phosphopeptide.
110d1mila_
not modelled 99.8 31 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
111d1csya_
not modelled 99.8 27 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
112c3nhnA_
not modelled 99.8 21 PDB header:transferase
Chain: A: PDB Molecule:tyrosine-protein kinase hck;
PDBTitle: crystal structure of the src-family kinase hck sh3-sh2-linker2 regulatory region
113d1qcfa2
not modelled 99.8 27 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
114c2vifA_
not modelled 99.8 21 PDB header:signaling protein
Chain: A: PDB Molecule:suppressor of cytokine signalling 6;
PDBTitle: crystal structure of socs6 sh2 domain in complex with a c-kit2 phosphopeptide
115d1luia_
not modelled 99.8 26 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
116c2el8A_
not modelled 99.8 24 PDB header:signaling protein
Chain: A: PDB Molecule:signal-transducing adaptor protein 2;
PDBTitle: solution structure of the human stap2 sh2 domain
117c2knoA_
not modelled 99.8 18 PDB header:hydrolase
Chain: A: PDB Molecule:tensin-like c1 domain-containing phosphatase;
PDBTitle: nmr solution structure of sh2 domain of the human tensin like c12 domain containing phosphatase (tenc1)
118d1g83a2
not modelled 99.8 29 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
119c2c9wA_
not modelled 99.8 32 PDB header:transcription regulation
Chain: A: PDB Molecule:suppressor of cytokine signaling 2;
PDBTitle: crystal structure of socs-2 in complex with elongin-b and2 elongin-c at 1.9a resolution
120d1f2fa_
not modelled 99.8 25 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain

Binding site prediction 

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