Phyre 2 Results for Q62415

Email	l.a.kelley@imperial.ac.uk
Description	Q62415
Date	Tue Jul 30 13:16:45 BST 2013
Unique Job ID	eb04dc0bf7b652f9
Sequence	MMPMILTVFL ... Download FASTA

Summary

Top model

Image coloured by rainbow N → C terminus

Model dimensions (Å):

X:54.974 Y:37.076 Z:45.813

Model (left) based on template c1ycsB_

Top template information

PDB header:complex (anti-oncogene/ankyrin repeats)
Chain: B: PDB Molecule:53bp2;
PDBTitle: p53-53bp2 complex

Confidence and coverage

Confidence:

100.0%

Coverage:

18%

193 residues ( 18% of your sequence) have been modelled with 100.0% confidence by the single highest scoring template.

Additional confident templates have been detected (see Domain analysis) which cover other regions of your sequence.

276 residues ( 25%) could be modelled at >90% confidence using multiple-templates.

You may wish to try resubmitting your sequence in "intensive" mode to model more of your sequence.

Warning: 56% of your sequence is predicted disordered. Disordered regions cannot be meaningfully predicted.

3D viewing

Interactive 3D view in Jmol

For other options to view your downloaded structure offline see the FAQ

Sequence analysis

Secondary structure and disorder prediction

1 . . . . . . . . 10 . . . . . . . . . 20 . . . . . . . . . 30 . . . . . . . . . 40 . . . . . . . . . 50 . . . . . . . . . 60

Sequence M M P M I L T V F L S N N E Q I L T E V P I T P E T T C R D V V E F C K E P G E G G C H L A E V W R G S E R P I P Y D H

Secondary structure

SS confidence

Disorder ? ? ?
?
? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 70 . . . . . . . . . 80 . . . . . . . . . 90 . . . . . . . . . 100 . . . . . . . . . 110 . . . . . . . . . 120

Sequence M M Y E H L Q K W G P R R E E V K F F L R H E D S P T E S S E Q G A R Q T Q E Q R T Q R S V V N V P G E K R T E N G V G

Secondary structure

SS confidence

Disorder
?
? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 130 . . . . . . . . . 140 . . . . . . . . . 150 . . . . . . . . . 160 . . . . . . . . . 170 . . . . . . . . . 180

Sequence N P R V E L T L S E L Q D M A A R Q Q Q Q I E N Q Q Q M L V A K E Q R L H F L K Q Q E R R Q Q Q S V S E N E K L Q K L K

Secondary structure

SS confidence

Disorder ? ?

Disorder confidence

. . . . . . . . . 190 . . . . . . . . . 200 . . . . . . . . . 210 . . . . . . . . . 220 . . . . . . . . . 230 . . . . . . . . . 240

Sequence E R V E A Q E N K L K K I R A M R G Q V D Y S K I M N G N L S A E I E R F S A M F Q E K K Q E V Q T A I L R V D Q L S Q

Secondary structure

SS confidence

Disorder
? ? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 250 . . . . . . . . . 260 . . . . . . . . . 270 . . . . . . . . . 280 . . . . . . . . . 290 . . . . . . . . . 300

Sequence Q L E D L K K G K L N G F Q S Y N G R L T G P A A V E L K R L Y Q E L Q I R N Q L N Q E Q N S K L Q Q Q K E L L N K R N

Secondary structure

SS confidence

Disorder
? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?
? ? ?

Disorder confidence

. . . . . . . . . 310 . . . . . . . . . 320 . . . . . . . . . 330 . . . . . . . . . 340 . . . . . . . . . 350 . . . . . . . . . 360

Sequence M E V A M M D K R I S E L R E R L Y G K K I Q L N R V N G T S S P Q S P L S T S G R V A A V G P Y I Q V P S T G G F P L

Secondary structure

SS confidence

Disorder
? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 370 . . . . . . . . . 380 . . . . . . . . . 390 . . . . . . . . . 400 . . . . . . . . . 410 . . . . . . . . . 420

Sequence P G D P V K P Q S L T I A S S A A H G R S K S A N D G N W P P L K Q N S A S V K S T Q M T G D W K D S G M E G T L K Q G

Secondary structure

SS confidence

Disorder ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 430 . . . . . . . . . 440 . . . . . . . . . 450 . . . . . . . . . 460 . . . . . . . . . 470 . . . . . . . . . 480

Sequence A I S S Q P L P L S A L G A T E K L G I E I G K G P P P I P G V G K P L P P S Y G T Y P S S G P L G P G S T S S L E R R

Secondary structure

SS confidence

Disorder ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 490 . . . . . . . . . 500 . . . . . . . . . 510 . . . . . . . . . 520 . . . . . . . . . 530 . . . . . . . . . 540

Sequence K E G S L P R P G A G P P S R Q K P A P L P P A S N A P Q P G S S Q Q I Q Q R I S V P P S P T Y P P A G P P A F P T G D

Secondary structure

SS confidence

Disorder ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 550 . . . . . . . . . 560 . . . . . . . . . 570 . . . . . . . . . 580 . . . . . . . . . 590 . . . . . . . . . 600

Sequence G K P E L P L T V A I R P F L A D K G S R P Q S P R K G P Q T V N S S S I Y S M Y L Q Q A T P P K N Y Q P P A H G T L N

Secondary structure

SS confidence

Disorder ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 610 . . . . . . . . . 620 . . . . . . . . . 630 . . . . . . . . . 640 . . . . . . . . . 650 . . . . . . . . . 660

Sequence K S V K A V Y G K P V L P S G S A S P S P L P F L H G S L G T G T A Q P Q P P S D S A E K E P E Q E G P S V P G E G S T

Secondary structure

SS confidence

Disorder ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 670 . . . . . . . . . 680 . . . . . . . . . 690 . . . . . . . . . 700 . . . . . . . . . 710 . . . . . . . . . 720

Sequence V E S L P R P L S P T K L T P I V H S P L R Y Q S D A D L E A L R R K L A N A P R P L K K R S S I T E P E G P G G P N I

Secondary structure

SS confidence

Disorder ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?
? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 730 . . . . . . . . . 740 . . . . . . . . . 750 . . . . . . . . . 760 . . . . . . . . . 770 . . . . . . . . . 780

Sequence Q K L L Y Q R F N T L A G G M E G T P F Y Q P S P S Q D F V G T L A D M D N G N T N A N G N L D E P F P P R P T A P L P

Secondary structure

SS confidence

Disorder
? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 790 . . . . . . . . . 800 . . . . . . . . . 810 . . . . . . . . . 820 . . . . . . . . . 830 . . . . . . . . . 840

Sequence E E L A P S S D A N D N E L P S P E P E E L I C P Q T T H Q T A E P T E D N N N N V A P V P S T E Q I P S P V A E A P S

Secondary structure

SS confidence

Disorder ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?
? ? ? ? ? ? ? ?
? ? ? ? ? ? ? ? ?
? ? ? ?
? ?

Disorder confidence

. . . . . . . . . 850 . . . . . . . . . 860 . . . . . . . . . 870 . . . . . . . . . 880 . . . . . . . . . 890 . . . . . . . . . 900

Sequence E E D Q V P P A P L S P V I H P P A A S A S K R T N L K K P N S E R T G H G L R V R F N P L A L L L D A S L E G E F D L

Secondary structure

SS confidence

Disorder ? ? ? ?
? ?
? ? ? ?

Disorder confidence

. . . . . . . . . 910 . . . . . . . . . 920 . . . . . . . . . 930 . . . . . . . . . 940 . . . . . . . . . 950 . . . . . . . . . 960

Sequence V Q R I I Y E V E D P S K P N D E G I T P L H N A V C A G H H H I V K F L L D F G V N V N A A D S D G W T P L H C A A S

Secondary structure

SS confidence

Disorder
?
?

Disorder confidence

. . . . . . . . . 970 . . . . . . . . . 980 . . . . . . . . . 990 . . . . . . . . . 1000 . . . . . . . . . 1010 . . . . . . . . . 1020

Sequence C N S V H L C K Q L V E S G A A I F A S T I S D I E T A A D K C E E M E E G Y I Q C S Q F L Y G V Q E K L G V M N K G T

Secondary structure

SS confidence

Disorder
?
? ?

Disorder confidence

. . . . . . . . . 1030 . . . . . . . . . 1040 . . . . . . . . . 1050 . . . . . . . . . 1060 . . . . . . . . . 1070 . . . . . . . . . 1080

Sequence V Y A L W D Y E A Q N S D E L S F H E G D A I T I L R R K D E N E T E W W W A R L G D R E G Y V P K N L L G L Y P R I K

Secondary structure

SS confidence

Disorder
? ?
?
?

Disorder confidence

. . . . . . .

Sequence P R Q R T L A

Secondary structure

SS confidence

Disorder ? ? ? ? ? ? ?

Disorder confidence

Confidence Key
High(9) Low (0)

? Disordered ( 56%)

Alpha helix ( 35%)

Beta strand ( 2%)

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank	Aligned region

PDB 1ycs chain B

Region: 885 - 1077
Aligned: 193
Modelled: 193
Confidence: 100.0%
Identity: 81%
PDB header:complex (anti-oncogene/ankyrin repeats)
Chain: B: PDB Molecule:53bp2;
PDBTitle: p53-53bp2 complex

Phyre2

PDB 2vge chain A

Region: 874 - 1080
Aligned: 207
Modelled: 207
Confidence: 99.9%
Identity: 56%
PDB header:transcription
Chain: A: PDB Molecule:rela-associated inhibitor;
PDBTitle: crystal structure of the c-terminal region of human iaspp

Phyre2

PDB 2uwq chain A

Region: 1 - 83
Aligned: 83
Modelled: 83
Confidence: 99.8%
Identity: 69%
PDB header:apoptosis
Chain: A: PDB Molecule:apoptosis-stimulating of p53 protein 2;
PDBTitle: solution structure of aspp2 n-terminus

Phyre2

PDB 1mv3 chain A

Region: 1012 - 1077
Aligned: 63
Modelled: 66
Confidence: 99.7%
Identity: 30%
PDB header:endocytosis/exocytosis
Chain: A: PDB Molecule:myc box dependent interacting protein 1;
PDBTitle: nmr structure of the tumor suppressor bin1: alternative2 splicing in melanoma and interaction with c-myc

Phyre2

PDB 1ycs chain B domain 2

Region: 1015 - 1077
Aligned: 63
Modelled: 63
Confidence: 99.7%
Identity: 71%
Fold: SH3-like barrel
Superfamily: SH3-domain
Family: SH3-domain

Phyre2

PDB 1gri chain A

Region: 948 - 1078
Aligned: 128
Modelled: 131
Confidence: 99.7%
Identity: 17%
PDB header:signal transduction adaptor
Chain: A: PDB Molecule:growth factor bound protein 2;
PDBTitle: grb2

Phyre2

PDB 2lqn chain A

Region: 946 - 1077
Aligned: 129
Modelled: 132
Confidence: 99.7%
Identity: 12%
PDB header:signaling protein
Chain: A: PDB Molecule:crk-like protein;
PDBTitle: solution structure of crkl

Phyre2

PDB 1ng2 chain A

Region: 944 - 1087
Aligned: 133
Modelled: 144
Confidence: 99.7%
Identity: 20%
PDB header:oxidoreductase activator
Chain: A: PDB Molecule:neutrophil cytosolic factor 1;
PDBTitle: structure of autoinhibited p47phox

Phyre2

PDB 2eyz chain A

Region: 948 - 1081
Aligned: 131
Modelled: 134
Confidence: 99.6%
Identity: 14%
PDB header:signaling protein
Chain: A: PDB Molecule:v-crk sarcoma virus ct10 oncogene homolog
PDBTitle: ct10-regulated kinase isoform ii

Phyre2

PDB 3jv3 chain A

Region: 1020 - 1085
Aligned: 63
Modelled: 66
Confidence: 99.6%
Identity: 35%
PDB header:protein binding
Chain: A: PDB Molecule:intersectin-1;
PDBTitle: structure of sh3e-dh unit of murine intersectin-1l

Phyre2

PDB 2l3s chain A

Region: 946 - 1075
Aligned: 127
Modelled: 130
Confidence: 99.6%
Identity: 13%
PDB header:structural protein
Chain: A: PDB Molecule:autoinhibited crk protein;
PDBTitle: structure of the autoinhibited crk

Phyre2

PDB 1ov3 chain A

Region: 944 - 1074
Aligned: 120
Modelled: 123
Confidence: 99.6%
Identity: 23%
PDB header:oxidoreductase activator
Chain: A: PDB Molecule:neutrophil cytosol factor 1;
PDBTitle: structure of the p22phox-p47phox complex

Phyre2

PDB 1udl chain A

Region: 978 - 1082
Aligned: 93
Modelled: 105
Confidence: 99.6%
Identity: 24%
Fold: SH3-like barrel
Superfamily: SH3-domain
Family: SH3-domain

Phyre2

PDB 3nmz chain D

Region: 995 - 1078
Aligned: 79
Modelled: 84
Confidence: 99.6%
Identity: 28%
PDB header:cell adhesion/cell cycle
Chain: D: PDB Molecule:rho guanine nucleotide exchange factor 4;
PDBTitle: crytal structure of apc complexed with asef

Phyre2

PDB 2dx1 chain A

Region: 1020 - 1075
Aligned: 53
Modelled: 56
Confidence: 99.6%
Identity: 38%
PDB header:signaling protein
Chain: A: PDB Molecule:rho guanine nucleotide exchange factor 4;
PDBTitle: crystal structure of rhogef protein asef

Phyre2

PDB 1ng2 chain A domain 2

Region: 1018 - 1078
Aligned: 58
Modelled: 61
Confidence: 99.6%
Identity: 29%
Fold: SH3-like barrel
Superfamily: SH3-domain
Family: SH3-domain

Phyre2

PDB 2rqr chain A

Region: 995 - 1078
Aligned: 80
Modelled: 84
Confidence: 99.6%
Identity: 15%
PDB header:protein binding
Chain: A: PDB Molecule:engulfment and cell motility protein 1, linker, dedicator
PDBTitle: the solution structure of human dock2 sh3 domain - elmo1 peptide2 chimera complex

Phyre2

PDB 2kym chain A

Region: 1016 - 1081
Aligned: 63
Modelled: 66
Confidence: 99.6%
Identity: 25%
PDB header:signaling protein
Chain: A: PDB Molecule:bud emergence protein 1;
PDBTitle: solution structure of the bem1p sh3-ci domain from l.elongisporus in2 complex with ste20p peptide

Phyre2

PDB 1wyx chain A

Region: 1020 - 1082
Aligned: 63
Modelled: 63
Confidence: 99.6%
Identity: 35%
PDB header:cell adhesion
Chain: A: PDB Molecule:crk-associated substrate;
PDBTitle: the crystal structure of the p130cas sh3 domain at 1.1 a2 resolution

Phyre2

PDB 1i1j chain A

Region: 1020 - 1086
Aligned: 67
Modelled: 67
Confidence: 99.6%
Identity: 24%
Fold: SH3-like barrel
Superfamily: SH3-domain
Family: SH3-domain

Phyre2

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