Phyre 2 Results for Q61070

Email	l.a.kelley@imperial.ac.uk
Description	Q61070
Date	Tue Jul 30 13:06:05 BST 2013
Unique Job ID	9248d0d2e399ca15
Sequence	MADSVKTFLQ ... Download FASTA

Summary

Top model

Image coloured by rainbow N → C terminus

Model dimensions (Å):

X:13.294 Y:13.730 Z:15.768

Model (left) based on template d1oe4a_

Top template information

Fold:Uracil-DNA glycosylase-like
Superfamily:Uracil-DNA glycosylase-like
Family:Single-strand selective monofunctional uracil-DNA glycosylase SMUG1

Confidence and coverage

Confidence:

18.8%

Coverage:

13 residues ( 4% of your sequence) have been modelled with 18.8% confidence by the single highest scoring template.

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3D viewing

Interactive 3D view in Jmol

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Sequence analysis

Secondary structure and disorder prediction

1 . . . . . . . . 10 . . . . . . . . . 20 . . . . . . . . . 30 . . . . . . . . . 40 . . . . . . . . . 50 . . . . . . . . . 60

Sequence M A D S V K T F L Q D L G R G I K D S I W G I C T I S K L D A R I Q Q K R E E Q R R R R A S S L L A Q R R P Q S V E R K

Secondary structure

SS confidence

Disorder ? ? ? ?
? ? ? ? ? ? ?
? ? ? ? ? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 70 . . . . . . . . . 80 . . . . . . . . . 90 . . . . . . . . . 100 . . . . . . . . . 110 . . . . . . . . . 120

Sequence Q E S E P R I V S R I F Q C C A W N G G V F W F S L L L F Y R V F I P V L Q S V T A R I I G D P S L H G D V W S W L E F

Secondary structure

SS confidence

Disorder ? ? ? ?
?
? ? ? ? ?
?

Disorder confidence

. . . . . . . . . 130 . . . . . . . . . 140 . . . . . . . . . 150 . . . . . . . . . 160 . . . . . . . . . 170 . . . . . . . . . 180

Sequence F L T S I F S A L W V L P L F V L S K V V N A I W F Q D I A D L A F E V S G R K P H P F P S V S K I I A D M L F N L L L

Secondary structure

SS confidence

Disorder
? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 190 . . . . . . . . . 200 . . . . . . . . . 210 . . . . . . . . . 220 . . . . . . . . . 230 . . . . . . . . . 240

Sequence Q A L F L I Q G M F V S L F P I H L V G Q L V S L L H M S L L Y S L Y C F E Y R W F N K G I E M H Q R L S N I E R N W P

Secondary structure

SS confidence

Disorder

Disorder confidence

. . . . . . . . . 250 . . . . . . . . . 260 . . . . . . . . . 270 . . . . . . . . . 280 . . . . . . . . . 290 . . . . . . . . . 300

Sequence Y Y F G F G L P L A F L T A M Q S S Y I I S G C L F S I L F P L F I I S A N E A K T P G K A Y L F Q L R L F S L V V F L

Secondary structure

SS confidence

Disorder
?
? ? ? ? ? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 310 . . . . . . . . . 320 . . . . . . . . . 330 . . . . . . . . . 340

Sequence S N R L F H K T V Y L Q S A L S S S S S A E K F P S P H P S P A K L K A A A G H

Secondary structure

SS confidence

Disorder
? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?

Disorder confidence

Confidence Key
High(9) Low (0)

? Disordered ( 24%)

Alpha helix ( 79%)

Beta strand ( 0%)

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank	Aligned region

PDB 1oe4 chain A

Region: 327 - 339
Aligned: 13
Modelled: 13
Confidence: 18.8%
Identity: 46%
Fold: Uracil-DNA glycosylase-like
Superfamily: Uracil-DNA glycosylase-like
Family: Single-strand selective monofunctional uracil-DNA glycosylase SMUG1

Phyre2

PDB 3bpy chain A domain 1

Region: 224 - 242
Aligned: 19
Modelled: 19
Confidence: 15.4%
Identity: 26%
Fold: DNA/RNA-binding 3-helical bundle
Superfamily: "Winged helix" DNA-binding domain
Family: Forkhead DNA-binding domain

Phyre2

PDB 1e17 chain A

Region: 224 - 242
Aligned: 19
Modelled: 19
Confidence: 15.0%
Identity: 26%
PDB header:dna binding domain
Chain: A: PDB Molecule:afx;
PDBTitle: solution structure of the dna binding domain of the human2 forkhead transcription factor afx (foxo4)

Phyre2

PDB 2c6y chain A domain 1

Region: 201 - 242
Aligned: 34
Modelled: 42
Confidence: 14.1%
Identity: 21%
Fold: DNA/RNA-binding 3-helical bundle
Superfamily: "Winged helix" DNA-binding domain
Family: Forkhead DNA-binding domain

Phyre2

PDB 3g73 chain A

Region: 223 - 242
Aligned: 20
Modelled: 20
Confidence: 11.9%
Identity: 25%
PDB header:transcription/dna
Chain: A: PDB Molecule:forkhead box protein m1;
PDBTitle: structure of the foxm1 dna binding

Phyre2

PDB 3ikb chain B

Region: 324 - 331
Aligned: 8
Modelled: 8
Confidence: 11.8%
Identity: 75%
PDB header:structural genomics, unknown function
Chain: B: PDB Molecule:uncharacterized conserved protein;
PDBTitle: the structure of a conserved protein from streptococcus2 mutans ua159.

Phyre2

PDB 2a07 chain F domain 1

Region: 224 - 242
Aligned: 19
Modelled: 19
Confidence: 11.5%
Identity: 16%
Fold: DNA/RNA-binding 3-helical bundle
Superfamily: "Winged helix" DNA-binding domain
Family: Forkhead DNA-binding domain

Phyre2

PDB 2khr chain A

Region: 232 - 240
Aligned: 9
Modelled: 9
Confidence: 11.5%
Identity: 44%
PDB header:biosynthetic protein
Chain: A: PDB Molecule:protein mbth;
PDBTitle: solution structure of rv2377c, a mbth-like protein from mycobacterium2 tuberculosis

Phyre2

PDB 2gpf chain A domain 1

Region: 232 - 239
Aligned: 8
Modelled: 8
Confidence: 11.3%
Identity: 50%
Fold: MbtH/L9 domain-like
Superfamily: MbtH-like
Family: MbtH-like

Phyre2

PDB 3co7 chain C

Region: 224 - 242
Aligned: 19
Modelled: 19
Confidence: 11.2%
Identity: 21%
PDB header:transcription/dna
Chain: C: PDB Molecule:forkhead box protein o1;
PDBTitle: crystal structure of foxo1 dbd bound to dbe2 dna

Phyre2

PDB 3cz3 chain B

Region: 26 - 63
Aligned: 38
Modelled: 38
Confidence: 10.7%
Identity: 21%
PDB header:viral protein/rna
Chain: B: PDB Molecule:protein 2b;
PDBTitle: crystal structure of tomato aspermy virus 2b in complex2 with sirna

Phyre2

PDB 2pst chain X domain 1

Region: 232 - 239
Aligned: 8
Modelled: 8
Confidence: 10.3%
Identity: 50%
Fold: MbtH/L9 domain-like
Superfamily: MbtH-like
Family: MbtH-like

Phyre2

PDB 1kq8 chain A

Region: 224 - 242
Aligned: 19
Modelled: 19
Confidence: 9.8%
Identity: 5%
Fold: DNA/RNA-binding 3-helical bundle
Superfamily: "Winged helix" DNA-binding domain
Family: Forkhead DNA-binding domain

Phyre2

PDB 1kq8 chain A

Region: 224 - 242
Aligned: 19
Modelled: 19
Confidence: 9.8%
Identity: 5%
PDB header:transcription
Chain: A: PDB Molecule:hepatocyte nuclear factor 3 forkhead homolog 1;
PDBTitle: solution structure of winged helix protein hfh-1

Phyre2

PDB 2zi0 chain B

Region: 26 - 63
Aligned: 38
Modelled: 38
Confidence: 9.7%
Identity: 21%
PDB header:gene regulation/rna
Chain: B: PDB Molecule:protein 2b;
PDBTitle: crystal structure of tav2b/sirna complex

Phyre2

PDB 1dlc chain A domain 3

Region: 177 - 208
Aligned: 32
Modelled: 32
Confidence: 9.1%
Identity: 19%
Fold: Toxins' membrane translocation domains
Superfamily: delta-Endotoxin (insectocide), N-terminal domain
Family: delta-Endotoxin (insectocide), N-terminal domain

Phyre2

PDB 1m5h chain A domain 1

Region: 58 - 76
Aligned: 19
Modelled: 19
Confidence: 8.8%
Identity: 26%
Fold: Ferredoxin-like
Superfamily: Formylmethanofuran:tetrahydromethanopterin formyltransferase
Family: Formylmethanofuran:tetrahydromethanopterin formyltransferase

Phyre2

PDB 1ji6 chain A domain 3

Region: 180 - 210
Aligned: 31
Modelled: 31
Confidence: 8.2%
Identity: 16%
Fold: Toxins' membrane translocation domains
Superfamily: delta-Endotoxin (insectocide), N-terminal domain
Family: delta-Endotoxin (insectocide), N-terminal domain

Phyre2

PDB 1d5v chain A

Region: 224 - 242
Aligned: 19
Modelled: 19
Confidence: 8.1%
Identity: 26%
Fold: DNA/RNA-binding 3-helical bundle
Superfamily: "Winged helix" DNA-binding domain
Family: Forkhead DNA-binding domain

Phyre2

PDB 1b9u chain A

Region: 194 - 221
Aligned: 24
Modelled: 28
Confidence: 7.9%
Identity: 33%
PDB header:hydrolase
Chain: A: PDB Molecule:protein (atp synthase);
PDBTitle: membrane domain of the subunit b of the e.coli atp synthase

Phyre2

	1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence	M	A	D	S	V	K	T	F	L	Q	D	L	G	R	G	I	K	D	S	I	W	G	I	C	T	I	S	K	L	D	A	R	I	Q	Q	K	R	E	E	Q	R	R	R	R	A	S	S	L	L	A	Q	R	R	P	Q	S	V	E	R	K
Secondary structure
SS confidence
Disorder	?	?	?	?																																			?	?	?	?	?	?	?				?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence	Q	E	S	E	P	R	I	V	S	R	I	F	Q	C	C	A	W	N	G	G	V	F	W	F	S	L	L	L	F	Y	R	V	F	I	P	V	L	Q	S	V	T	A	R	I	I	G	D	P	S	L	H	G	D	V	W	S	W	L	E	F
Secondary structure
SS confidence
Disorder	?	?	?	?																																							?			?	?	?	?	?			?
Disorder confidence

	.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence	F	L	T	S	I	F	S	A	L	W	V	L	P	L	F	V	L	S	K	V	V	N	A	I	W	F	Q	D	I	A	D	L	A	F	E	V	S	G	R	K	P	H	P	F	P	S	V	S	K	I	I	A	D	M	L	F	N	L	L	L
Secondary structure
SS confidence
Disorder																																							?	?	?	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence	Q	A	L	F	L	I	Q	G	M	F	V	S	L	F	P	I	H	L	V	G	Q	L	V	S	L	L	H	M	S	L	L	Y	S	L	Y	C	F	E	Y	R	W	F	N	K	G	I	E	M	H	Q	R	L	S	N	I	E	R	N	W	P
Secondary structure
SS confidence
Disorder
Disorder confidence

	.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence	Y	Y	F	G	F	G	L	P	L	A	F	L	T	A	M	Q	S	S	Y	I	I	S	G	C	L	F	S	I	L	F	P	L	F	I	I	S	A	N	E	A	K	T	P	G	K	A	Y	L	F	Q	L	R	L	F	S	L	V	V	F	L
Secondary structure
SS confidence
Disorder																	?																					?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340
Sequence	S	N	R	L	F	H	K	T	V	Y	L	Q	S	A	L	S	S	S	S	S	A	E	K	F	P	S	P	H	P	S	P	A	K	L	K	A	A	A	G	H
Secondary structure
SS confidence
Disorder														?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence