Phyre 2 Results for Q5BN45

Email	l.a.kelley@imperial.ac.uk
Description	Q5BN45
Date	Tue Jul 30 13:19:44 BST 2013
Unique Job ID	2c34026662aeb7fe
Sequence	MSEEKPQQSA ... Download FASTA

Summary

Top model

Image coloured by rainbow N → C terminus

Model dimensions (Å):

X:27.449 Y:23.185 Z:37.351

Model (left) based on template c4gafA_

Top template information

PDB header:signaling protein
Chain: A: PDB Molecule:ebi-005;
PDBTitle: crystal structure of ebi-005, a chimera of human il-1beta and il-1ra,2 bound to human interleukin-1 receptor type 1

Confidence and coverage

Confidence:

12.8%

Coverage:

20%

33 residues ( 20% of your sequence) have been modelled with 12.8% confidence by the single highest scoring template.

You may wish to submit your sequence to Phyrealarm. This will automatically scan your sequence every week for new potential templates as they appear in the Phyre2 library.

Please note: You must be registered and logged in to use Phyrealarm.

Warning: 60% of your sequence is predicted disordered. Disordered regions cannot be meaningfully predicted.

3D viewing

Interactive 3D view in Jmol

Sequence analysis

Secondary structure and disorder prediction

1 . . . . . . . . 10 . . . . . . . . . 20 . . . . . . . . . 30 . . . . . . . . . 40 . . . . . . . . . 50 . . . . . . . . . 60

Sequence M S E E K P Q Q S A E E P E P G E P K A K P A P E E P E P G E P K A K P A P E E P E P G E P K A K P A P E K T S D Y Y R

Secondary structure

SS confidence

Disorder ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 70 . . . . . . . . . 80 . . . . . . . . . 90 . . . . . . . . . 100 . . . . . . . . . 110 . . . . . . . . . 120

Sequence I S E K L P V R F N N P G W F H G Y G T K E A V S M Y R T S N Q T Y G S R A P T V H E M P K V F Y P S S N K F S R Q H A

Secondary structure

SS confidence

Disorder ? ? ? ? ?
? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?
? ? ? ?

Disorder confidence

. . . . . . . . . 130 . . . . . . . . . 140 . . . . . . . . . 150 . . . . . . . . . 160 . . . . . . .

Sequence A F G M F Q S H N I N V T L E K S L V T G P D N H I T H Y D R L N F H P S Y N V N R P S I C D

Secondary structure

SS confidence

Disorder
?
? ? ? ? ? ? ?

Disorder confidence

Confidence Key
High(9) Low (0)

? Disordered ( 60%)

Alpha helix ( 7%)

Beta strand ( 8%)

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank	Aligned region

PDB 4gaf chain A

Region: 58 - 90
Aligned: 33
Modelled: 33
Confidence: 12.8%
Identity: 18%
PDB header:signaling protein
Chain: A: PDB Molecule:ebi-005;
PDBTitle: crystal structure of ebi-005, a chimera of human il-1beta and il-1ra,2 bound to human interleukin-1 receptor type 1

Phyre2

PDB 2cw1 chain A

Region: 91 - 142
Aligned: 42
Modelled: 52
Confidence: 12.3%
Identity: 31%
PDB header:de novo protein
Chain: A: PDB Molecule:sn4m;
PDBTitle: solution structure of the de novo-designed lambda cro fold2 protein

Phyre2

PDB 1s21 chain A

Region: 78 - 94
Aligned: 17
Modelled: 17
Confidence: 9.8%
Identity: 35%
PDB header:chaperone
Chain: A: PDB Molecule:orf2;
PDBTitle: crystal structure of avrpphf orf2, a type iii effector from2 p. syringae

Phyre2

PDB 1s21 chain A

Region: 78 - 94
Aligned: 17
Modelled: 17
Confidence: 9.8%
Identity: 35%
Fold: ADP-ribosylation
Superfamily: ADP-ribosylation
Family: AvrPphF ORF2, a type III effector

Phyre2

PDB 3dv0 chain I

Region: 130 - 154
Aligned: 25
Modelled: 25
Confidence: 9.6%
Identity: 20%
PDB header:oxidoreductase/transferase
Chain: I: PDB Molecule:dihydrolipoyllysine-residue acetyltransferase
PDBTitle: snapshots of catalysis in the e1 subunit of the pyruvate2 dehydrogenase multi-enzyme complex

Phyre2

PDB 4a4y chain A

Region: 123 - 129
Aligned: 7
Modelled: 7
Confidence: 9.4%
Identity: 43%
PDB header:protein binding
Chain: A: PDB Molecule:protein mxig;
PDBTitle: structure of the cytosolic domain of the shigella t3ss2 component mxig

Phyre2

PDB 2dt7 chain A

Region: 135 - 152
Aligned: 18
Modelled: 18
Confidence: 9.1%
Identity: 33%
PDB header:rna binding protein
Chain: A: PDB Molecule:splicing factor 3a subunit 3;
PDBTitle: solution structure of the second surp domain of human2 splicing factor sf3a120 in complex with a fragment of3 human splicing factor sf3a60

Phyre2

PDB 1v0d chain A

Region: 68 - 77
Aligned: 10
Modelled: 10
Confidence: 8.9%
Identity: 50%
Fold: His-Me finger endonucleases
Superfamily: His-Me finger endonucleases
Family: Caspase-activated DNase, CAD (DffB, DFF40)

Phyre2

PDB 1v0d chain A

Region: 68 - 77
Aligned: 10
Modelled: 10
Confidence: 8.9%
Identity: 50%
PDB header:hydrolase
Chain: A: PDB Molecule:dna fragmentation factor 40 kda subunit;
PDBTitle: crystal structure of caspase-activated dnase (cad)

Phyre2

PDB 1w4h chain A domain 1

Region: 130 - 154
Aligned: 25
Modelled: 25
Confidence: 8.8%
Identity: 20%
Fold: Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex
Superfamily: Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex
Family: Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex

Phyre2

PDB 1bal chain A

Region: 130 - 154
Aligned: 25
Modelled: 25
Confidence: 8.6%
Identity: 20%
Fold: Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex
Superfamily: Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex
Family: Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex

Phyre2

PDB 3ka5 chain A

Region: 75 - 95
Aligned: 21
Modelled: 21
Confidence: 8.3%
Identity: 24%
PDB header:chaperone
Chain: A: PDB Molecule:ribosome-associated protein y (psrp-1);
PDBTitle: crystal structure of ribosome-associated protein y (psrp-1)2 from clostridium acetobutylicum. northeast structural3 genomics consortium target id car123a

Phyre2

PDB 1v58 chain A domain 2

Region: 67 - 94
Aligned: 28
Modelled: 28
Confidence: 8.2%
Identity: 32%
Fold: Cystatin-like
Superfamily: DsbC/DsbG N-terminal domain-like
Family: DsbC/DsbG N-terminal domain-like

Phyre2

PDB 3aa6 chain C

Region: 65 - 70
Aligned: 6
Modelled: 6
Confidence: 8.2%
Identity: 83%
PDB header:protein binding
Chain: C: PDB Molecule:23mer peptide from cd2-associated protein;
PDBTitle: crystal structure of actin capping protein in complex with the cp-2 binding motif derived from cd2ap

Phyre2

PDB 3k2t chain A

Region: 75 - 95
Aligned: 21
Modelled: 21
Confidence: 7.7%
Identity: 19%
PDB header:structural genomics, unknown function
Chain: A: PDB Molecule:lmo2511 protein;
PDBTitle: crystal structure of lmo2511 protein from listeria2 monocytogenes, northeast structural genomics consortium3 target lkr84a

Phyre2

PDB 1sfu chain A

Region: 70 - 79
Aligned: 10
Modelled: 10
Confidence: 7.5%
Identity: 50%
Fold: DNA/RNA-binding 3-helical bundle
Superfamily: "Winged helix" DNA-binding domain
Family: Z-DNA binding domain

Phyre2

PDB 3w0d chain A

Region: 138 - 155
Aligned: 18
Modelled: 18
Confidence: 6.9%
Identity: 39%
PDB header:hydrolase inhibitor
Chain: A: PDB Molecule:elastase inhibitor afuei;
PDBTitle: structure of elastase inhibitor afuei (cyrstal form i)

Phyre2

PDB 2eq8 chain C

Region: 130 - 154
Aligned: 25
Modelled: 25
Confidence: 6.8%
Identity: 28%
PDB header:oxidoreductase
Chain: C: PDB Molecule:pyruvate dehydrogenase complex, dihydrolipoamide
PDBTitle: crystal structure of lipoamide dehydrogenase from thermus thermophilus2 hb8 with psbdp

Phyre2

PDB 2coo chain A

Region: 130 - 154
Aligned: 25
Modelled: 25
Confidence: 6.7%
Identity: 32%
PDB header:transferase
Chain: A: PDB Molecule:lipoamide acyltransferase component of branched-
PDBTitle: solution structure of the e3_binding domain of2 dihydrolipoamide branched chaintransacylase

Phyre2

PDB 1w85 chain I

Region: 130 - 154
Aligned: 25
Modelled: 25
Confidence: 6.5%
Identity: 20%
Fold: Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex
Superfamily: Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex
Family: Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex

Phyre2