Phyre 2 Results for P08100

Email	l.a.kelley@imperial.ac.uk
Description	P08100
Date	Wed Jun 6 09:21:49 BST 2012
Unique Job ID	4ec5c4e19584e9a3

Summary

Top model

Image coloured by rainbow N → C terminus

Model (left) based on template d1u19a_

Top template information

Fold:Family A G protein-coupled receptor-like
Superfamily:Family A G protein-coupled receptor-like
Family:Rhodopsin-like

Confidence and coverage

Confidence:

100.0%

Coverage:

100%

348 residues (100% of your sequence) have been modelled with 100.0% confidence by the single highest scoring template.

3D viewing

Interactive 3D view in Jmol

Sequence analysis

Secondary structure and disorder prediction

1 . . . . . . . . 10 . . . . . . . . . 20 . . . . . . . . . 30 . . . . . . . . . 40 . . . . . . . . . 50 . . . . . . . . . 60

Sequence M N G T E G P N F Y V P F S N A T G V V R S P F E Y P Q Y Y L A E P W Q F S M L A A Y M F L L I V L G F P I N F L T L Y

Secondary structure

SS confidence

Disorder ? ? ? ? ? ? ? ?
?
? ?
?
? ?

Disorder confidence

. . . . . . . . . 70 . . . . . . . . . 80 . . . . . . . . . 90 . . . . . . . . . 100 . . . . . . . . . 110 . . . . . . . . . 120

Sequence V T V Q H K K L R T P L N Y I L L N L A V A D L F M V L G G F T S T L Y T S L H G Y F V F G P T G C N L E G F F A T L G

Secondary structure

SS confidence

Disorder

Disorder confidence

. . . . . . . . . 130 . . . . . . . . . 140 . . . . . . . . . 150 . . . . . . . . . 160 . . . . . . . . . 170 . . . . . . . . . 180

Sequence G E I A L W S L V V L A I E R Y V V V C K P M S N F R F G E N H A I M G V A F T W V M A L A C A A P P L A G W S R Y I P

Secondary structure

SS confidence

Disorder
? ? ? ?

Disorder confidence

. . . . . . . . . 190 . . . . . . . . . 200 . . . . . . . . . 210 . . . . . . . . . 220 . . . . . . . . . 230 . . . . . . . . . 240

Sequence E G L Q C S C G I D Y Y T L K P E V N N E S F V I Y M F V V H F T I P M I I I F F C Y G Q L V F T V K E A A A Q Q Q E S

Secondary structure

SS confidence

Disorder
?
? ? ?
? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 250 . . . . . . . . . 260 . . . . . . . . . 270 . . . . . . . . . 280 . . . . . . . . . 290 . . . . . . . . . 300

Sequence A T T Q K A E K E V T R M V I I M V I A F L I C W V P Y A S V A F Y I F T H Q G S N F G P I F M T I P A F F A K S A A I

Secondary structure

SS confidence

Disorder

Disorder confidence

. . . . . . . . . 310 . . . . . . . . . 320 . . . . . . . . . 330 . . . . . . . . . 340 . . . . . . . .

Sequence Y N P V I Y I M M N K Q F R N C M L T T I C C G K N P L G D D E A S A T V S K T E T S Q V A P A

Secondary structure

SS confidence

Disorder
? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?

Disorder confidence

Confidence Key
High(9) Low (0)

? Disordered

Alpha helix

Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank	Aligned region

PDB 1u19 chain A

Region: 1 - 348
Aligned: 348
Modelled: 348
Confidence: 100.0%
Identity: 93%
Fold: Family A G protein-coupled receptor-like
Superfamily: Family A G protein-coupled receptor-like
Family: Rhodopsin-like

Phyre2

PDB 2rh1 chain A

Region: 32 - 322
Aligned: 287
Modelled: 291
Confidence: 100.0%
Identity: 25%
PDB header:membrane protein / hydrolase
Chain: A: PDB Molecule:beta-2-adrenergic receptor/t4-lysozyme chimera;
PDBTitle: high resolution crystal structure of human b2-adrenergic g protein-2 coupled receptor.

Phyre2

PDB 3pds chain A

Region: 33 - 322
Aligned: 288
Modelled: 290
Confidence: 100.0%
Identity: 23%
PDB header:membrane protein/hydrolase
Chain: A: PDB Molecule:fusion protein beta-2 adrenergic receptor/lysozyme;
PDBTitle: irreversible agonist-beta2 adrenoceptor complex

Phyre2

PDB 2ksa chain A

Region: 7 - 348
Aligned: 342
Modelled: 342
Confidence: 100.0%
Identity: 18%
PDB header:neuropeptide receptor/neuropeptide
Chain: A: PDB Molecule:substance-p receptor;
PDBTitle: substance p in dmpc/chaps isotropic q=0.25 bicelles as a ligand for2 nk1r

Phyre2

PDB 3uon chain A

Region: 35 - 321
Aligned: 282
Modelled: 283
Confidence: 100.0%
Identity: 26%
PDB header:signaling protein/antagonist
Chain: A: PDB Molecule:human m2 muscarinic acetylcholine, receptor t4 lysozyme
PDBTitle: structure of the human m2 muscarinic acetylcholine receptor bound to2 an antagonist

Phyre2

PDB 4djh chain A

Region: 33 - 322
Aligned: 286
Modelled: 290
Confidence: 100.0%
Identity: 23%
PDB header:hormone receptor/antagonist
Chain: A: PDB Molecule:kappa-type opioid receptor, lysozyme;
PDBTitle: structure of the human kappa opioid receptor in complex with jdtic

Phyre2

PDB 3eml chain A

Region: 38 - 328
Aligned: 289
Modelled: 291
Confidence: 100.0%
Identity: 20%
PDB header:membrane protein, receptor
Chain: A: PDB Molecule:human adenosine a2a receptor/t4 lysozyme chimera;
PDBTitle: the 2.6 a crystal structure of a human a2a adenosine2 receptor bound to zm241385.

Phyre2

PDB 1ln6 chain A

Region: 40 - 348
Aligned: 309
Modelled: 308
Confidence: 100.0%
Identity: 93%
Fold: Family A G protein-coupled receptor-like
Superfamily: Family A G protein-coupled receptor-like
Family: Rhodopsin-like

Phyre2

PDB 3pbl chain B

Region: 41 - 323
Aligned: 266
Modelled: 283
Confidence: 100.0%
Identity: 31%
PDB header:hydrolase/hydrolase inhibitor
Chain: B: PDB Molecule:d(3) dopamine receptor, lysozyme chimera;
PDBTitle: structure of the human dopamine d3 receptor in complex with2 eticlopride

Phyre2

PDB 2ziy chain A

Region: 8 - 348
Aligned: 341
Modelled: 341
Confidence: 100.0%
Identity: 18%
PDB header:signaling protein
Chain: A: PDB Molecule:rhodopsin;
PDBTitle: crystal structure of squid rhodopsin

Phyre2

PDB 3rze chain A

Region: 40 - 322
Aligned: 271
Modelled: 283
Confidence: 100.0%
Identity: 21%
PDB header:hydrolase
Chain: A: PDB Molecule:histamine h1 receptor, lysozyme chimera;
PDBTitle: structure of the human histamine h1 receptor in complex with doxepin

Phyre2

PDB 3sn6 chain R

Region: 30 - 322
Aligned: 287
Modelled: 293
Confidence: 100.0%
Identity: 19%
PDB header:signaling protein/hydrolase
Chain: R: PDB Molecule:lysozyme, beta-2 adrenergic receptor;
PDBTitle: crystal structure of the beta2 adrenergic receptor-gs protein complex

Phyre2

PDB 3ayn chain B

Region: 19 - 346
Aligned: 328
Modelled: 328
Confidence: 100.0%
Identity: 22%
PDB header:signaling protein
Chain: B: PDB Molecule:rhodopsin;
PDBTitle: crystal structure of squid isorhodopsin

Phyre2

PDB 3aym chain B

Region: 15 - 346
Aligned: 330
Modelled: 332
Confidence: 100.0%
Identity: 25%
PDB header:signaling protein
Chain: B: PDB Molecule:rhodopsin;
PDBTitle: crystal structure of the batho intermediate of squid rhodopsin

Phyre2

PDB 3v2y chain A

Region: 25 - 324
Aligned: 283
Modelled: 300
Confidence: 100.0%
Identity: 22%
PDB header:hydrolase
Chain: A: PDB Molecule:sphingosine 1-phosphate receptor 1, lysozyme chimera;
PDBTitle: crystal structure of a lipid g protein-coupled receptor at 2.80a

Phyre2

PDB 2z73 chain B

Region: 19 - 346
Aligned: 328
Modelled: 328
Confidence: 100.0%
Identity: 22%
PDB header:membrane protein
Chain: B: PDB Molecule:rhodopsin;
PDBTitle: crystal structure of squid rhodopsin

Phyre2

PDB 3ayn chain A

Region: 19 - 346
Aligned: 328
Modelled: 328
Confidence: 100.0%
Identity: 22%
PDB header:signaling protein
Chain: A: PDB Molecule:rhodopsin;
PDBTitle: crystal structure of squid isorhodopsin

Phyre2

PDB 2z73 chain A

Region: 19 - 346
Aligned: 328
Modelled: 328
Confidence: 100.0%
Identity: 22%
PDB header:membrane protein
Chain: A: PDB Molecule:rhodopsin;
PDBTitle: crystal structure of squid rhodopsin

Phyre2

PDB 3aym chain A

Phyre2

PDB 3oe6 chain A

Region: 35 - 316
Aligned: 276
Modelled: 282
Confidence: 100.0%
Identity: 25%
PDB header:signaling protein, hydrolase
Chain: A: PDB Molecule:c-x-c chemokine receptor type 4, lysozyme chimera;
PDBTitle: crystal structure of the cxcr4 chemokine receptor in complex with a2 small molecule antagonist it1t in i222 spacegroup

Phyre2

	1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence	M	N	G	T	E	G	P	N	F	Y	V	P	F	S	N	A	T	G	V	V	R	S	P	F	E	Y	P	Q	Y	Y	L	A	E	P	W	Q	F	S	M	L	A	A	Y	M	F	L	L	I	V	L	G	F	P	I	N	F	L	T	L	Y
Secondary structure
SS confidence
Disorder	?	?	?	?	?	?	?	?		?					?	?					?							?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence	V	T	V	Q	H	K	K	L	R	T	P	L	N	Y	I	L	L	N	L	A	V	A	D	L	F	M	V	L	G	G	F	T	S	T	L	Y	T	S	L	H	G	Y	F	V	F	G	P	T	G	C	N	L	E	G	F	F	A	T	L	G
Secondary structure
SS confidence
Disorder
Disorder confidence

	.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence	G	E	I	A	L	W	S	L	V	V	L	A	I	E	R	Y	V	V	V	C	K	P	M	S	N	F	R	F	G	E	N	H	A	I	M	G	V	A	F	T	W	V	M	A	L	A	C	A	A	P	P	L	A	G	W	S	R	Y	I	P
Secondary structure
SS confidence
Disorder																									?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence	E	G	L	Q	C	S	C	G	I	D	Y	Y	T	L	K	P	E	V	N	N	E	S	F	V	I	Y	M	F	V	V	H	F	T	I	P	M	I	I	I	F	F	C	Y	G	Q	L	V	F	T	V	K	E	A	A	A	Q	Q	Q	E	S
Secondary structure
SS confidence
Disorder														?		?	?	?																																		?	?	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence	A	T	T	Q	K	A	E	K	E	V	T	R	M	V	I	I	M	V	I	A	F	L	I	C	W	V	P	Y	A	S	V	A	F	Y	I	F	T	H	Q	G	S	N	F	G	P	I	F	M	T	I	P	A	F	F	A	K	S	A	A	I
Secondary structure
SS confidence
Disorder
Disorder confidence

	.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.
Sequence	Y	N	P	V	I	Y	I	M	M	N	K	Q	F	R	N	C	M	L	T	T	I	C	C	G	K	N	P	L	G	D	D	E	A	S	A	T	V	S	K	T	E	T	S	Q	V	A	P	A
Secondary structure
SS confidence
Disorder																										?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence