Phyre 2 Results for O14681

Email	l.a.kelley@imperial.ac.uk
Description	O14681
Date	Thu Apr 26 09:49:22 BST 2012
Unique Job ID	1edd4496cdb40a65

Summary

Top model

Image coloured by rainbow N → C terminus

Model (left) based on template d3bpya1

Top template information

Fold:DNA/RNA-binding 3-helical bundle
Superfamily:"Winged helix" DNA-binding domain
Family:Forkhead DNA-binding domain

Confidence and coverage

Confidence:

12.6%

Coverage:

19 residues ( 6% of your sequence) have been modelled with 12.6% confidence by the single highest scoring template.

You may wish to submit your sequence to Phyrealarm. This will automatically scan your sequence every week for new potential templates as they appear in the Phyre2 library.

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3D viewing

Interactive 3D view in Jmol

Sequence analysis

Secondary structure and disorder prediction

1 . . . . . . . . 10 . . . . . . . . . 20 . . . . . . . . . 30 . . . . . . . . . 40 . . . . . . . . . 50 . . . . . . . . . 60

Sequence M A D S V K T F L Q D L A R G I K D S I W G I C T I S K L D A R I Q Q K R E E Q R R R R A S S V L A Q R R A Q S I E R K

Secondary structure

SS confidence

Disorder ? ? ? ?
? ? ? ? ? ? ? ?
? ? ? ? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 70 . . . . . . . . . 80 . . . . . . . . . 90 . . . . . . . . . 100 . . . . . . . . . 110 . . . . . . . . . 120

Sequence Q E S E P R I V S R I F Q C C A W N G G V F W F S L L L F Y R V F I P V L Q S V T A R I I G D P S L H G D V W S W L E F

Secondary structure

SS confidence

Disorder ? ? ? ?
? ? ? ?
?

Disorder confidence

. . . . . . . . . 130 . . . . . . . . . 140 . . . . . . . . . 150 . . . . . . . . . 160 . . . . . . . . . 170 . . . . . . . . . 180

Sequence F L T S I F S A L W V L P L F V L S K V V N A I W F Q D I A D L A F E V S G R K P H P F P S V S K I I A D M L F N L L L

Secondary structure

SS confidence

Disorder
? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 190 . . . . . . . . . 200 . . . . . . . . . 210 . . . . . . . . . 220 . . . . . . . . . 230 . . . . . . . . . 240

Sequence Q A L F L I Q G M F V S L F P I H L V G Q L V S L L H M S L L Y S L Y C F E Y R W F N K G I E M H Q R L S N I E R N W P

Secondary structure

SS confidence

Disorder

Disorder confidence

. . . . . . . . . 250 . . . . . . . . . 260 . . . . . . . . . 270 . . . . . . . . . 280 . . . . . . . . . 290 . . . . . . . . . 300

Sequence Y Y F G F G L P L A F L T A M Q S S Y I I S G C L F S I L F P L F I I S A N E A K T P G K A Y L F Q L R L F S L V V F L

Secondary structure

SS confidence

Disorder
?
? ? ? ? ? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 310 . . . . . . . . . 320 . . . . . . . . . 330 . . . . . . . . . 340

Sequence S N R L F H K T V Y L Q S A L S S S T S A E K F P S P H P S P A K L K A T A G H

Secondary structure

SS confidence

Disorder
? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?

Disorder confidence

Confidence Key
High(9) Low (0)

? Disordered

Alpha helix

Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank	Aligned region

PDB 3bpy chain A domain 1

Region: 224 - 242
Aligned: 19
Modelled: 19
Confidence: 12.6%
Identity: 26%
Fold: DNA/RNA-binding 3-helical bundle
Superfamily: "Winged helix" DNA-binding domain
Family: Forkhead DNA-binding domain

Phyre2

PDB 1e17 chain A

Region: 224 - 242
Aligned: 19
Modelled: 19
Confidence: 12.4%
Identity: 26%
PDB header:dna binding domain
Chain: A: PDB Molecule:afx;
PDBTitle: solution structure of the dna binding domain of the human2 forkhead transcription factor afx (foxo4)

Phyre2

PDB 2c6y chain A domain 1

Region: 201 - 242
Aligned: 34
Modelled: 42
Confidence: 12.1%
Identity: 21%
Fold: DNA/RNA-binding 3-helical bundle
Superfamily: "Winged helix" DNA-binding domain
Family: Forkhead DNA-binding domain

Phyre2

PDB 2zi0 chain B

Region: 26 - 63
Aligned: 38
Modelled: 38
Confidence: 11.7%
Identity: 21%
PDB header:gene regulation/rna
Chain: B: PDB Molecule:protein 2b;
PDBTitle: crystal structure of tav2b/sirna complex

Phyre2

PDB 2khr chain A

Region: 232 - 240
Aligned: 9
Modelled: 9
Confidence: 10.6%
Identity: 44%
PDB header:biosynthetic protein
Chain: A: PDB Molecule:protein mbth;
PDBTitle: solution structure of rv2377c, a mbth-like protein from mycobacterium2 tuberculosis

Phyre2

PDB 2gpf chain A domain 1

Region: 232 - 239
Aligned: 8
Modelled: 8
Confidence: 10.3%
Identity: 50%
Fold: MbtH/L9 domain-like
Superfamily: MbtH-like
Family: MbtH-like

Phyre2

PDB 1b74 chain A domain 1

Region: 15 - 75
Aligned: 52
Modelled: 61
Confidence: 9.8%
Identity: 23%
Fold: ATC-like
Superfamily: Aspartate/glutamate racemase
Family: Aspartate/glutamate racemase

Phyre2

PDB 2pst chain X domain 1

Region: 232 - 239
Aligned: 8
Modelled: 8
Confidence: 9.7%
Identity: 50%
Fold: MbtH/L9 domain-like
Superfamily: MbtH-like
Family: MbtH-like

Phyre2

PDB 3g73 chain A

Region: 223 - 242
Aligned: 20
Modelled: 20
Confidence: 9.6%
Identity: 25%
PDB header:transcription/dna
Chain: A: PDB Molecule:forkhead box protein m1;
PDBTitle: structure of the foxm1 dna binding

Phyre2

PDB 2a07 chain F domain 1

Region: 224 - 242
Aligned: 19
Modelled: 19
Confidence: 9.2%
Identity: 16%
Fold: DNA/RNA-binding 3-helical bundle
Superfamily: "Winged helix" DNA-binding domain
Family: Forkhead DNA-binding domain

Phyre2

PDB 3co7 chain C

Region: 224 - 242
Aligned: 19
Modelled: 19
Confidence: 9.0%
Identity: 21%
PDB header:transcription/dna
Chain: C: PDB Molecule:forkhead box protein o1;
PDBTitle: crystal structure of foxo1 dbd bound to dbe2 dna

Phyre2

PDB 1m5h chain A domain 1

Region: 58 - 76
Aligned: 19
Modelled: 19
Confidence: 8.9%
Identity: 26%
Fold: Ferredoxin-like
Superfamily: Formylmethanofuran:tetrahydromethanopterin formyltransferase
Family: Formylmethanofuran:tetrahydromethanopterin formyltransferase

Phyre2

PDB 1dlc chain A domain 3

Region: 177 - 208
Aligned: 32
Modelled: 32
Confidence: 7.9%
Identity: 19%
Fold: Toxins' membrane translocation domains
Superfamily: delta-Endotoxin (insectocide), N-terminal domain
Family: delta-Endotoxin (insectocide), N-terminal domain

Phyre2

PDB 1kq8 chain A

Region: 224 - 242
Aligned: 19
Modelled: 19
Confidence: 7.9%
Identity: 5%
PDB header:transcription
Chain: A: PDB Molecule:hepatocyte nuclear factor 3 forkhead homolog 1;
PDBTitle: solution structure of winged helix protein hfh-1

Phyre2

PDB 1kq8 chain A

Region: 224 - 242
Aligned: 19
Modelled: 19
Confidence: 7.9%
Identity: 5%
Fold: DNA/RNA-binding 3-helical bundle
Superfamily: "Winged helix" DNA-binding domain
Family: Forkhead DNA-binding domain

Phyre2

PDB 1ftr chain A domain 1

Region: 58 - 76
Aligned: 19
Modelled: 19
Confidence: 7.6%
Identity: 26%
Fold: Ferredoxin-like
Superfamily: Formylmethanofuran:tetrahydromethanopterin formyltransferase
Family: Formylmethanofuran:tetrahydromethanopterin formyltransferase

Phyre2

PDB 1m5s chain A domain 1

Region: 58 - 76
Aligned: 19
Modelled: 19
Confidence: 7.3%
Identity: 26%
Fold: Ferredoxin-like
Superfamily: Formylmethanofuran:tetrahydromethanopterin formyltransferase
Family: Formylmethanofuran:tetrahydromethanopterin formyltransferase

Phyre2

PDB 3j01 chain A

Region: 40 - 89
Aligned: 50
Modelled: 50
Confidence: 7.3%
Identity: 12%
PDB header:ribosome/ribosomal protein
Chain: A: PDB Molecule:preprotein translocase secy subunit;
PDBTitle: structure of the ribosome-secye complex in the membrane environment

Phyre2

PDB 1ji6 chain A domain 3

Region: 180 - 210
Aligned: 31
Modelled: 31
Confidence: 7.1%
Identity: 16%
Fold: Toxins' membrane translocation domains
Superfamily: delta-Endotoxin (insectocide), N-terminal domain
Family: delta-Endotoxin (insectocide), N-terminal domain

Phyre2

PDB 2lpd chain A

Region: 232 - 239
Aligned: 8
Modelled: 8
Confidence: 6.4%
Identity: 50%
PDB header:structural genomics, unknown function
Chain: A: PDB Molecule:uncharacterized protein;
PDBTitle: solution structure of a mbth-like protein from burkholderia2 pseudomallei, the etiological agent responsible for melioidosis,3 seattle structural genomics center for infectious disease target4 bupsa.13472.b

Phyre2

	1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence	M	A	D	S	V	K	T	F	L	Q	D	L	A	R	G	I	K	D	S	I	W	G	I	C	T	I	S	K	L	D	A	R	I	Q	Q	K	R	E	E	Q	R	R	R	R	A	S	S	V	L	A	Q	R	R	A	Q	S	I	E	R	K
Secondary structure
SS confidence
Disorder	?	?	?	?																																		?	?	?	?	?	?	?	?					?	?	?	?	?	?	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence	Q	E	S	E	P	R	I	V	S	R	I	F	Q	C	C	A	W	N	G	G	V	F	W	F	S	L	L	L	F	Y	R	V	F	I	P	V	L	Q	S	V	T	A	R	I	I	G	D	P	S	L	H	G	D	V	W	S	W	L	E	F
Secondary structure
SS confidence
Disorder	?	?	?	?																																											?	?	?	?			?
Disorder confidence

	.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence	F	L	T	S	I	F	S	A	L	W	V	L	P	L	F	V	L	S	K	V	V	N	A	I	W	F	Q	D	I	A	D	L	A	F	E	V	S	G	R	K	P	H	P	F	P	S	V	S	K	I	I	A	D	M	L	F	N	L	L	L
Secondary structure
SS confidence
Disorder																																							?	?	?	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence	Q	A	L	F	L	I	Q	G	M	F	V	S	L	F	P	I	H	L	V	G	Q	L	V	S	L	L	H	M	S	L	L	Y	S	L	Y	C	F	E	Y	R	W	F	N	K	G	I	E	M	H	Q	R	L	S	N	I	E	R	N	W	P
Secondary structure
SS confidence
Disorder
Disorder confidence

	.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence	Y	Y	F	G	F	G	L	P	L	A	F	L	T	A	M	Q	S	S	Y	I	I	S	G	C	L	F	S	I	L	F	P	L	F	I	I	S	A	N	E	A	K	T	P	G	K	A	Y	L	F	Q	L	R	L	F	S	L	V	V	F	L
Secondary structure
SS confidence
Disorder																	?																					?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340
Sequence	S	N	R	L	F	H	K	T	V	Y	L	Q	S	A	L	S	S	S	T	S	A	E	K	F	P	S	P	H	P	S	P	A	K	L	K	A	T	A	G	H
Secondary structure
SS confidence
Disorder									?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence