Phyre 2 Results for A1A5C7

Email	l.a.kelley@imperial.ac.uk
Description	A1A5C7
Date	Wed May 9 18:02:57 BST 2012
Unique Job ID	7e23fddf87cb6512

Summary

Top model

Image coloured by rainbow N → C terminus

Model (left) based on template c3o7pA_

Top template information

PDB header:transport protein
Chain: A: PDB Molecule:l-fucose-proton symporter;
PDBTitle: crystal structure of the e.coli fucose:proton symporter, fucp (n162a)

Confidence and coverage

Confidence:

100.0%

Coverage:

55%

376 residues ( 55% of your sequence) have been modelled with 100.0% confidence by the single highest scoring template.

You may wish to submit your sequence to Phyrealarm. This will automatically scan your sequence every week for new potential templates as they appear in the Phyre2 library.

3D viewing

Interactive 3D view in Jmol

Sequence analysis

Secondary structure and disorder prediction

1 . . . . . . . . 10 . . . . . . . . . 20 . . . . . . . . . 30 . . . . . . . . . 40 . . . . . . . . . 50 . . . . . . . . . 60

Sequence M A I D R R R E A A G G G P G R Q P A P A E E N G S L P P G D A A A S A P L G G R A G P G G G A E I Q P L P P L H P G G

Secondary structure

SS confidence

Disorder ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 70 . . . . . . . . . 80 . . . . . . . . . 90 . . . . . . . . . 100 . . . . . . . . . 110 . . . . . . . . . 120

Sequence G P H P S C C S A A A A P S L L L L D Y D G S V L P F L G G L G G G Y Q K T L V L L T W I P A L F I G F S Q F S D S F L

Secondary structure

SS confidence

Disorder ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 130 . . . . . . . . . 140 . . . . . . . . . 150 . . . . . . . . . 160 . . . . . . . . . 170 . . . . . . . . . 180

Sequence L D Q P N F W C R G A G K G T E L A G V T T T G R G G D M G N W T S L P T T P F A T A P W E A A G N R S N S S G A D G G

Secondary structure

SS confidence

Disorder
?
?
? ?
? ? ?
?
? ? ? ? ? ? ?
?

Disorder confidence

. . . . . . . . . 190 . . . . . . . . . 200 . . . . . . . . . 210 . . . . . . . . . 220 . . . . . . . . . 230 . . . . . . . . . 240

Sequence D T P P L P S P P D K G D N A S N C D C R A W D Y G I R A G L V Q N V V S K W D L V C D N A W K V H I A K F S L L V G L

Secondary structure

SS confidence

Disorder ? ?
?
? ? ? ? ?

Disorder confidence

. . . . . . . . . 250 . . . . . . . . . 260 . . . . . . . . . 270 . . . . . . . . . 280 . . . . . . . . . 290 . . . . . . . . . 300

Sequence I F G Y L I T G C I A D W V G R R P V L L F S I I F I L I F G L T V A L S V N V T M F S T L R F F E G F C L A G I I L T

Secondary structure

SS confidence

Disorder

Disorder confidence

. . . . . . . . . 310 . . . . . . . . . 320 . . . . . . . . . 330 . . . . . . . . . 340 . . . . . . . . . 350 . . . . . . . . . 360

Sequence L Y A L R I E L C P P G K R F M I T M V A S F V A M A G Q F L M P G L A A L C R D W Q V L Q A L I I C P F L L M L L Y W

Secondary structure

SS confidence

Disorder

Disorder confidence

. . . . . . . . . 370 . . . . . . . . . 380 . . . . . . . . . 390 . . . . . . . . . 400 . . . . . . . . . 410 . . . . . . . . . 420

Sequence S I F P E S L R W L M A T Q Q F E S A K R L I L H F T Q K N R M N P E G D I K G V I P E L E K E L S R R P K K V C I V K

Secondary structure

SS confidence

Disorder
? ? ?
? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 430 . . . . . . . . . 440 . . . . . . . . . 450 . . . . . . . . . 460 . . . . . . . . . 470 . . . . . . . . . 480

Sequence V V G T R N L W K N I V V L C V N S L T G Y G I H H C F A R S M M G H E V K V P L L E N F Y A D Y Y T T A S I A L V S C

Secondary structure

SS confidence

Disorder
? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 490 . . . . . . . . . 500 . . . . . . . . . 510 . . . . . . . . . 520 . . . . . . . . . 530 . . . . . . . . . 540

Sequence L A M C V V V R F L G R R G G L L L F M I L T A L A S L L Q L G L L N L I G K Y S Q H P D S G M S D S V K D K F S I A F

Secondary structure

SS confidence

Disorder

Disorder confidence

. . . . . . . . . 550 . . . . . . . . . 560 . . . . . . . . . 570 . . . . . . . . . 580 . . . . . . . . . 590 . . . . . . . . . 600

Sequence S I V G M F A S H A V G S L S V F F C A E I T P T V I R C G G L G L V L A S A G F G M L T A P I I E L H N Q K G Y F L H

Secondary structure

SS confidence

Disorder
? ?

Disorder confidence

. . . . . . . . . 610 . . . . . . . . . 620 . . . . . . . . . 630 . . . . . . . . . 640 . . . . . . . . . 650 . . . . . . . . . 660

Sequence H I I F A C C T L I C I I C I L L L P E S R D Q N L P E N I S N G E H Y T R Q P L L P H K K G E Q P L L L T N A E L K D

Secondary structure

SS confidence

Disorder
?
? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 670 . . . . . . . . . 680 . . . . . .

Sequence Y S G L H D A A A A G D T L P E G A T A N G M K A M

Secondary structure

SS confidence

Disorder ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?

Disorder confidence

Confidence Key
High(9) Low (0)

? Disordered

Alpha helix

Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank	Aligned region

PDB 3o7p chain A

Region: 213 - 621
Aligned: 376
Modelled: 390
Confidence: 100.0%
Identity: 8%
PDB header:transport protein
Chain: A: PDB Molecule:l-fucose-proton symporter;
PDBTitle: crystal structure of the e.coli fucose:proton symporter, fucp (n162a)

Phyre2

PDB 1pw4 chain A

Region: 229 - 632
Aligned: 359
Modelled: 361
Confidence: 100.0%
Identity: 16%
Fold: MFS general substrate transporter
Superfamily: MFS general substrate transporter
Family: Glycerol-3-phosphate transporter

Phyre2

PDB 2xut chain C

Region: 225 - 614
Aligned: 381
Modelled: 390
Confidence: 100.0%
Identity: 11%
PDB header:transport protein
Chain: C: PDB Molecule:proton/peptide symporter family protein;
PDBTitle: crystal structure of a proton dependent oligopeptide (pot)2 family transporter.

Phyre2

PDB 2gfp chain A

Region: 213 - 618
Aligned: 351
Modelled: 357
Confidence: 99.9%
Identity: 13%
PDB header:membrane protein
Chain: A: PDB Molecule:multidrug resistance protein d;
PDBTitle: structure of the multidrug transporter emrd from2 escherichia coli

Phyre2

PDB 1pv7 chain A

Region: 225 - 635
Aligned: 366
Modelled: 367
Confidence: 99.9%
Identity: 9%
Fold: MFS general substrate transporter
Superfamily: MFS general substrate transporter
Family: LacY-like proton/sugar symporter

Phyre2

PDB 1vhi chain B

Region: 10 - 23
Aligned: 14
Modelled: 14
Confidence: 32.5%
Identity: 50%
Fold: Ferredoxin-like
Superfamily: Viral DNA-binding domain
Family: Viral DNA-binding domain

Phyre2

PDB 1b3t chain A

Region: 10 - 23
Aligned: 14
Modelled: 14
Confidence: 28.7%
Identity: 50%
Fold: Ferredoxin-like
Superfamily: Viral DNA-binding domain
Family: Viral DNA-binding domain

Phyre2

PDB 2jm2 chain A

Region: 8 - 22
Aligned: 15
Modelled: 15
Confidence: 27.7%
Identity: 47%
PDB header:hormone/growth factor
Chain: A: PDB Molecule:insulin-like growth factor-binding protein 6;
PDBTitle: structure of the n-terminal subdomain of insulin-like2 growth factor (igf) binding protein-6 and its interactions3 with igfs

Phyre2

PDB 1z8g chain A domain 2

Region: 218 - 235
Aligned: 18
Modelled: 18
Confidence: 26.4%
Identity: 28%
Fold: SRCR-like
Superfamily: SRCR-like
Family: Hepsin, N-terminal domain

Phyre2

PDB 2oya chain A

Region: 218 - 235
Aligned: 18
Modelled: 18
Confidence: 22.2%
Identity: 28%
PDB header:ligand binding protein
Chain: A: PDB Molecule:macrophage receptor marco;
PDBTitle: crystal structure analysis of the dimeric form of the srcr domain of2 mouse marco

Phyre2

PDB 3rnv chain A

Region: 604 - 635
Aligned: 32
Modelled: 32
Confidence: 20.4%
Identity: 13%
PDB header:hydrolase
Chain: A: PDB Molecule:helper component proteinase;
PDBTitle: structure of the autocatalytic cysteine protease domain of potyvirus2 helper-component proteinase

Phyre2

PDB 1r7g chain A

Region: 219 - 224
Aligned: 6
Modelled: 6
Confidence: 18.9%
Identity: 50%
PDB header:membrane protein
Chain: A: PDB Molecule:genome polyprotein;
PDBTitle: nmr structure of the membrane anchor domain (1-31) of the2 nonstructural protein 5a (ns5a) of hepatitis c virus3 (minimized average structure, sample in 100mm dpc)

Phyre2

PDB 1z8g chain A

Region: 218 - 235
Aligned: 18
Modelled: 18
Confidence: 18.0%
Identity: 28%
PDB header:hydrolase/hydrolase inhibitor
Chain: A: PDB Molecule:serine protease hepsin;
PDBTitle: crystal structure of the extracellular region of the transmembrane2 serine protease hepsin with covalently bound preferred substrate.

Phyre2

PDB 1rie chain A

Region: 198 - 206
Aligned: 9
Modelled: 9
Confidence: 16.5%
Identity: 33%
Fold: ISP domain
Superfamily: ISP domain
Family: Rieske iron-sulfur protein (ISP)

Phyre2

PDB 1tkl chain A

Region: 218 - 228
Aligned: 11
Modelled: 11
Confidence: 15.8%
Identity: 18%
Fold: Coproporphyrinogen III oxidase
Superfamily: Coproporphyrinogen III oxidase
Family: Coproporphyrinogen III oxidase

Phyre2

PDB 1s6x chain A

Region: 220 - 228
Aligned: 9
Modelled: 9
Confidence: 15.7%
Identity: 67%
PDB header:toxin
Chain: A: PDB Molecule:kvap channel;
PDBTitle: solution structure of vstx

Phyre2

PDB 2nvg chain A

Region: 198 - 206
Aligned: 9
Modelled: 9
Confidence: 15.6%
Identity: 33%
PDB header:oxidoreductase
Chain: A: PDB Molecule:ubiquinol-cytochrome c reductase iron-sulfur subunit;
PDBTitle: soluble domain of rieske iron sulfur protein.

Phyre2

PDB 2g9p chain A

Region: 246 - 259
Aligned: 14
Modelled: 14
Confidence: 15.5%
Identity: 21%
PDB header:antimicrobial protein
Chain: A: PDB Molecule:antimicrobial peptide latarcin 2a;
PDBTitle: nmr structure of a novel antimicrobial peptide, latarcin 2a,2 from spider (lachesana tarabaevi) venom

Phyre2

PDB 2nef chain A

Region: 52 - 95
Aligned: 33
Modelled: 44
Confidence: 14.9%
Identity: 27%
Fold: Regulatory factor Nef
Superfamily: Regulatory factor Nef
Family: Regulatory factor Nef

Phyre2

PDB 2aex chain A

Region: 218 - 225
Aligned: 8
Modelled: 8
Confidence: 14.4%
Identity: 25%
PDB header:oxidoreductase
Chain: A: PDB Molecule:coproporphyrinogen iii oxidase, mitochondrial;
PDBTitle: the 1.58a crystal structure of human coproporphyrinogen oxidase2 reveals the structural basis of hereditary coproporphyria

Phyre2

	1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence	M	A	I	D	R	R	R	E	A	A	G	G	G	P	G	R	Q	P	A	P	A	E	E	N	G	S	L	P	P	G	D	A	A	A	S	A	P	L	G	G	R	A	G	P	G	G	G	A	E	I	Q	P	L	P	P	L	H	P	G	G
Secondary structure
SS confidence
Disorder	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence	G	P	H	P	S	C	C	S	A	A	A	A	P	S	L	L	L	L	D	Y	D	G	S	V	L	P	F	L	G	G	L	G	G	G	Y	Q	K	T	L	V	L	L	T	W	I	P	A	L	F	I	G	F	S	Q	F	S	D	S	F	L
Secondary structure
SS confidence
Disorder	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence	L	D	Q	P	N	F	W	C	R	G	A	G	K	G	T	E	L	A	G	V	T	T	T	G	R	G	G	D	M	G	N	W	T	S	L	P	T	T	P	F	A	T	A	P	W	E	A	A	G	N	R	S	N	S	S	G	A	D	G	G
Secondary structure
SS confidence
Disorder																			?		?			?	?			?	?	?		?		?	?	?	?	?	?	?																				?
Disorder confidence

	.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence	D	T	P	P	L	P	S	P	P	D	K	G	D	N	A	S	N	C	D	C	R	A	W	D	Y	G	I	R	A	G	L	V	Q	N	V	V	S	K	W	D	L	V	C	D	N	A	W	K	V	H	I	A	K	F	S	L	L	V	G	L
Secondary structure
SS confidence
Disorder	?	?		?					?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence	I	F	G	Y	L	I	T	G	C	I	A	D	W	V	G	R	R	P	V	L	L	F	S	I	I	F	I	L	I	F	G	L	T	V	A	L	S	V	N	V	T	M	F	S	T	L	R	F	F	E	G	F	C	L	A	G	I	I	L	T
Secondary structure
SS confidence
Disorder
Disorder confidence

	.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence	L	Y	A	L	R	I	E	L	C	P	P	G	K	R	F	M	I	T	M	V	A	S	F	V	A	M	A	G	Q	F	L	M	P	G	L	A	A	L	C	R	D	W	Q	V	L	Q	A	L	I	I	C	P	F	L	L	M	L	L	Y	W
Secondary structure
SS confidence
Disorder
Disorder confidence

	.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence	S	I	F	P	E	S	L	R	W	L	M	A	T	Q	Q	F	E	S	A	K	R	L	I	L	H	F	T	Q	K	N	R	M	N	P	E	G	D	I	K	G	V	I	P	E	L	E	K	E	L	S	R	R	P	K	K	V	C	I	V	K
Secondary structure
SS confidence
Disorder																																		?	?	?													?	?	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480
Sequence	V	V	G	T	R	N	L	W	K	N	I	V	V	L	C	V	N	S	L	T	G	Y	G	I	H	H	C	F	A	R	S	M	M	G	H	E	V	K	V	P	L	L	E	N	F	Y	A	D	Y	Y	T	T	A	S	I	A	L	V	S	C
Secondary structure
SS confidence
Disorder																																			?	?	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	490	.	.	.	.	.	.	.	.	.	500	.	.	.	.	.	.	.	.	.	510	.	.	.	.	.	.	.	.	.	520	.	.	.	.	.	.	.	.	.	530	.	.	.	.	.	.	.	.	.	540
Sequence	L	A	M	C	V	V	V	R	F	L	G	R	R	G	G	L	L	L	F	M	I	L	T	A	L	A	S	L	L	Q	L	G	L	L	N	L	I	G	K	Y	S	Q	H	P	D	S	G	M	S	D	S	V	K	D	K	F	S	I	A	F
Secondary structure
SS confidence
Disorder
Disorder confidence

	.	.	.	.	.	.	.	.	.	550	.	.	.	.	.	.	.	.	.	560	.	.	.	.	.	.	.	.	.	570	.	.	.	.	.	.	.	.	.	580	.	.	.	.	.	.	.	.	.	590	.	.	.	.	.	.	.	.	.	600
Sequence	S	I	V	G	M	F	A	S	H	A	V	G	S	L	S	V	F	F	C	A	E	I	T	P	T	V	I	R	C	G	G	L	G	L	V	L	A	S	A	G	F	G	M	L	T	A	P	I	I	E	L	H	N	Q	K	G	Y	F	L	H
Secondary structure
SS confidence
Disorder																																																						?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	610	.	.	.	.	.	.	.	.	.	620	.	.	.	.	.	.	.	.	.	630	.	.	.	.	.	.	.	.	.	640	.	.	.	.	.	.	.	.	.	650	.	.	.	.	.	.	.	.	.	660
Sequence	H	I	I	F	A	C	C	T	L	I	C	I	I	C	I	L	L	L	P	E	S	R	D	Q	N	L	P	E	N	I	S	N	G	E	H	Y	T	R	Q	P	L	L	P	H	K	K	G	E	Q	P	L	L	L	T	N	A	E	L	K	D
Secondary structure
SS confidence
Disorder																																				?		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	670	.	.	.	.	.	.	.	.	.	680	.	.	.	.	.	.
Sequence	Y	S	G	L	H	D	A	A	A	A	G	D	T	L	P	E	G	A	T	A	N	G	M	K	A	M
Secondary structure
SS confidence
Disorder	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence