Email l.a.kelley@imperial.ac.uk Description A1A580 Date Sat Jun 16 10:16:46 BST 2012 Unique Job ID 0461c513488a3b4f

Summary

Top model

Image coloured by rainbow N → C terminus Close Jmol

Model (left) based on template d2ersa1 Top template information Fold:Complement control module/SCR domain Superfamily:Complement control module/SCR domain Family:Complement control module/SCR domain Confidence and coverage Confidence: 23.5% Coverage: 28% 18 residues ( 28% of your sequence) have been modelled with 23.5% confidence by the single highest scoring template. You may wish to submit your sequence to Phyrealarm. This will automatically scan your sequence every week for new potential templates as they appear in the Phyre2 library. Please note: You must be registered and logged in to use Phyrealarm. 3D viewing Interactive 3D view in Jmol

Sequence analysis

Secondary structure and disorder prediction

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 2ers chain A domain 1 Region: 9 - 26 Aligned: 18 Modelled: 18 Confidence: 23.5% Identity: 44% Fold: Complement control module/SCR domain Superfamily: Complement control module/SCR domain Family: Complement control module/SCR domain Phyre2 PDB 2kgo chain A Region: 21 - 30 Aligned: 10 Modelled: 10 Confidence: 20.7% Identity: 60% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:uncharacterized protein ybii; PDBTitle: solution nmr structure of zn finger protein ybil from escherichia2 coli. nesg target et107, ocsp target ec0402 Phyre2 PDB 1tr6 chain A Region: 2 - 6 Aligned: 5 Modelled: 5 Confidence: 10.7% Identity: 100% PDB header:toxin Chain: A: PDB Molecule:omega-conotoxin gvia; PDBTitle: nmr solution structure of omega-conotoxin [k10]gvia, a cyclic cysteine2 knot peptide Phyre2 PDB 1omc chain A Region: 2 - 6 Aligned: 5 Modelled: 5 Confidence: 10.6% Identity: 100% PDB header:presynaptic neurotoxin Chain: A: PDB Molecule:omega-conotoxin gvia; PDBTitle: solution structure of omega-conotoxin gvia using 2-d nmr2 spectroscopy and relaxation matrix analysis Phyre2 PDB 1omc chain A Region: 2 - 6 Aligned: 5 Modelled: 5 Confidence: 10.6% Identity: 100% Fold: Knottins (small inhibitors, toxins, lectins) Superfamily: omega toxin-like Family: Conotoxin Phyre2 PDB 2cco chain A Region: 2 - 6 Aligned: 5 Modelled: 5 Confidence: 10.6% Identity: 100% PDB header:toxin Chain: A: PDB Molecule:omega-conotoxin gvia; PDBTitle: structure of the calcium channel blocker omega conotoxin2 gvia, nmr, 20 structures Phyre2 PDB 1ttl chain A Region: 2 - 6 Aligned: 5 Modelled: 5 Confidence: 10.5% Identity: 100% PDB header:toxin Chain: A: PDB Molecule:omega-conotoxin gvia; PDBTitle: omega-conotoxin gvia, a n-type calcium channel blocker Phyre2 PDB 2fiq chain A domain 1 Region: 40 - 51 Aligned: 12 Modelled: 12 Confidence: 7.5% Identity: 50% Fold: TIM beta/alpha-barrel Superfamily: Aldolase Family: GatZ-like Phyre2 1 d2ersa1 2 c2kgoA_ 3 c1tr6A_ 4 c1omcA_ 5 d1omca_ 6 c2ccoA_ 7 c1ttlA_ 8 d2fiqa1

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0