Email l.a.kelley@imperial.ac.uk Description A0ZSE6 Date Wed Jun 6 09:28:32 BST 2012 Unique Job ID 97f40003d49e1245

Summary

Top model

Image coloured by rainbow N → C terminus Close Jmol

Model (left) based on template c2jp3A_ Top template information PDB header:transcription Chain: A: PDB Molecule:fxyd domain-containing ion transport regulator 4; PDBTitle: solution structure of the human fxyd4 (chif) protein in sds2 micelles Confidence and coverage Confidence: 22.8% Coverage: 17% 19 residues ( 17% of your sequence) have been modelled with 22.8% confidence by the single highest scoring template. You may wish to submit your sequence to Phyrealarm. This will automatically scan your sequence every week for new potential templates as they appear in the Phyre2 library. Please note: You must be registered and logged in to use Phyrealarm. 3D viewing Interactive 3D view in Jmol

Sequence analysis

Secondary structure and disorder prediction

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 2jp3 chain A Region: 40 - 58 Aligned: 19 Modelled: 19 Confidence: 22.8% Identity: 32% PDB header:transcription Chain: A: PDB Molecule:fxyd domain-containing ion transport regulator 4; PDBTitle: solution structure of the human fxyd4 (chif) protein in sds2 micelles Phyre2 PDB 2zxe chain G Region: 40 - 58 Aligned: 19 Modelled: 19 Confidence: 21.1% Identity: 21% PDB header:hydrolase/transport protein Chain: G: PDB Molecule:phospholemman-like protein; PDBTitle: crystal structure of the sodium - potassium pump in the e2.2k+.pi2 state Phyre2 PDB 2axt chain E domain 1 Region: 33 - 56 Aligned: 24 Modelled: 24 Confidence: 20.5% Identity: 13% Fold: Single transmembrane helix Superfamily: Cytochrome b559 subunits Family: Cytochrome b559 subunits Phyre2 PDB 2jo1 chain A Region: 40 - 56 Aligned: 17 Modelled: 17 Confidence: 19.8% Identity: 24% PDB header:hydrolase regulator Chain: A: PDB Molecule:phospholemman; PDBTitle: structure of the na,k-atpase regulatory protein fxyd1 in2 micelles Phyre2 PDB 1x0g chain A Region: 64 - 98 Aligned: 34 Modelled: 35 Confidence: 17.0% Identity: 21% PDB header:metal binding protein Chain: A: PDB Molecule:isca; PDBTitle: crystal structure of isca with the [2fe-2s] cluster Phyre2 PDB 2e74 chain G domain 1 Region: 40 - 56 Aligned: 17 Modelled: 17 Confidence: 15.5% Identity: 12% Fold: Single transmembrane helix Superfamily: PetG subunit of the cytochrome b6f complex Family: PetG subunit of the cytochrome b6f complex Phyre2 PDB 1vf5 chain G Region: 40 - 56 Aligned: 17 Modelled: 17 Confidence: 15.0% Identity: 12% PDB header:photosynthesis Chain: G: PDB Molecule:protein pet g; PDBTitle: crystal structure of cytochrome b6f complex from m.laminosus Phyre2 PDB 1vf5 chain G Region: 40 - 56 Aligned: 17 Modelled: 17 Confidence: 15.0% Identity: 12% Fold: Single transmembrane helix Superfamily: PetG subunit of the cytochrome b6f complex Family: PetG subunit of the cytochrome b6f complex Phyre2 PDB 1nt0 chain A domain 3 Region: 69 - 99 Aligned: 29 Modelled: 31 Confidence: 12.3% Identity: 17% Fold: Knottins (small inhibitors, toxins, lectins) Superfamily: EGF/Laminin Family: EGF-type module Phyre2 PDB 2jox chain A Region: 62 - 80 Aligned: 19 Modelled: 19 Confidence: 10.7% Identity: 26% PDB header:transcription Chain: A: PDB Molecule:churchill protein; PDBTitle: embryonic neural inducing factor churchill is not a dna-2 binding zinc finger protein: solution structure reveals a3 solvent-exposed beta-sheet and zinc binuclear cluster Phyre2 PDB 2d2a chain A Region: 64 - 96 Aligned: 32 Modelled: 33 Confidence: 10.0% Identity: 22% PDB header:metal transport Chain: A: PDB Molecule:sufa protein; PDBTitle: crystal structure of escherichia coli sufa involved in2 biosynthesis of iron-sulfur clusters Phyre2 PDB 1ncf chain A domain 3 Region: 71 - 98 Aligned: 28 Modelled: 28 Confidence: 8.3% Identity: 25% Fold: TNF receptor-like Superfamily: TNF receptor-like Family: TNF receptor-like Phyre2 PDB 1so9 chain A Region: 18 - 27 Aligned: 10 Modelled: 10 Confidence: 8.1% Identity: 10% PDB header:metal transport Chain: A: PDB Molecule:cytochrome c oxidase assembly protein ctag; PDBTitle: solution structure of apocox11, 30 structures Phyre2 PDB 1so9 chain A Region: 18 - 27 Aligned: 10 Modelled: 10 Confidence: 8.1% Identity: 10% Fold: Ctag/Cox11 Superfamily: Ctag/Cox11 Family: Ctag/Cox11 Phyre2 PDB 1axh chain A Region: 69 - 88 Aligned: 20 Modelled: 20 Confidence: 8.1% Identity: 25% Fold: Knottins (small inhibitors, toxins, lectins) Superfamily: omega toxin-like Family: Spider toxins Phyre2 PDB 1p58 chain C Region: 42 - 60 Aligned: 19 Modelled: 19 Confidence: 7.9% Identity: 11% PDB header:virus Chain: C: PDB Molecule:major envelope protein e; PDBTitle: complex organization of dengue virus membrane proteins as revealed by2 9.5 angstrom cryo-em reconstruction Phyre2 PDB 1c99 chain A Region: 25 - 55 Aligned: 31 Modelled: 31 Confidence: 7.9% Identity: 13% Fold: Transmembrane helix hairpin Superfamily: F1F0 ATP synthase subunit C Family: F1F0 ATP synthase subunit C Phyre2 PDB 2d1e chain A Region: 1 - 32 Aligned: 32 Modelled: 32 Confidence: 7.8% Identity: 25% PDB header:oxidoreductase Chain: A: PDB Molecule:phycocyanobilin:ferredoxin oxidoreductase; PDBTitle: crystal structure of pcya-biliverdin complex Phyre2 PDB 1ob1 chain C domain 1 Region: 68 - 94 Aligned: 25 Modelled: 27 Confidence: 7.7% Identity: 20% Fold: Knottins (small inhibitors, toxins, lectins) Superfamily: EGF/Laminin Family: Merozoite surface protein 1 (MSP-1) Phyre2 PDB 1n1i chain A domain 1 Region: 68 - 94 Aligned: 25 Modelled: 27 Confidence: 7.6% Identity: 28% Fold: Knottins (small inhibitors, toxins, lectins) Superfamily: EGF/Laminin Family: Merozoite surface protein 1 (MSP-1) Phyre2 1 c2jp3A_ 2 c2zxeG_ 3 d2axte1 4 c2jo1A_ 5 c1x0gA_ 6 d2e74g1 7 c1vf5G_ 8 d1vf5g_ 9 d1nt0a3 10 c2joxA_ 11 c2d2aA_ 12 d1ncfa3 13 c1so9A_ 14 d1so9a_ 15 d1axha_ 16 c1p58C_ 17 d1c99a_ 18 c2d1eA_ 19 d1ob1c1 20 d1n1ia1 21 22 23 24 25 26 27 28 29 30 31 32 33 34

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0