Phyre Home Retrieve Phyre Job Id
Emaill.a.kelley@imperial.ac.uk
DescriptionA0PJZ0
DateWed May 9 17:33:58 BST 2012
Unique Job IDedf03199eb65a42d

Summary 

Top model
Image coloured by rainbow N → C terminus
Model (left) based on template c3keaB_
Top template information
PDB header:viral protein
Chain: B: PDB Molecule:k1l;
PDBTitle: structure function studies of vaccinia virus host-range protein k12 reveal a novel ankyrin repeat interaction surface for k1s function
Confidence and coverage
Confidence: 99.9% Coverage: 95%
156 residues ( 95% of your sequence) have been modelled with 99.9% confidence by the single highest scoring template.
3D viewing
Interactive 3D view in Jmol

Sequence analysis 

Secondary structure and disorder prediction 

   1........10.........20.........30.........40.........50.........60
Sequence  MKLFGFRSRRGQTVLGSIDHLYTGSGYRIRYSELQKIHKAAVKGDAAEMERCLARRSGDL
Secondary structure 
SS confidence 
Disorder  ??????
Disorder confidence 
 
   .........70.........80.........90.........100.........110.........120
Sequence  DALDKQHRTALHLACASGHVKVVTLLVNRKCQIDIYDKENRTPLIQAVHCQEEACAVILL
Secondary structure 
SS confidence 
Disorder 
?
Disorder confidence 
 
   .........130.........140.........150.........160.....
Sequence  EHGANPNLKDIYGNTALHYAVYSESTSLAEKLLFHGENIEALDKV
Secondary structure 
SS confidence 
Disorder 
?
?
?????
Disorder confidence 
 

Confidence Key
High(9)                    Low (0)
?Disordered
Alpha helix
Beta strand

Domain analysis 

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

RankAligned region

PDB 3kea chain B

3D model

Region: 7 - 164
Aligned: 156
Modelled: 158
Confidence: 99.9%
Identity: 17%
PDB header:viral protein
Chain: B: PDB Molecule:k1l;
PDBTitle: structure function studies of vaccinia virus host-range protein k12 reveal a novel ankyrin repeat interaction surface for k1s function

Phyre2

PDB 1n11 chain A

3D model

Region: 1 - 164
Aligned: 161
Modelled: 164
Confidence: 99.9%
Identity: 27%
PDB header:structural protein
Chain: A: PDB Molecule:ankyrin;
PDBTitle: d34 region of human ankyrin-r and linker

Phyre2

PDB 1n11 chain A

3D model

Region: 1 - 164
Aligned: 161
Modelled: 164
Confidence: 99.9%
Identity: 27%
Fold: beta-hairpin-alpha-hairpin repeat
Superfamily: Ankyrin repeat
Family: Ankyrin repeat

Phyre2

PDB 3utm chain A

3D model

Region: 24 - 164
Aligned: 141
Modelled: 141
Confidence: 99.9%
Identity: 28%
PDB header:transferase/signaling protein
Chain: A: PDB Molecule:tankyrase-1;
PDBTitle: crystal structure of a mouse tankyrase-axin complex

Phyre2

PDB 1s70 chain B

3D model

Region: 1 - 164
Aligned: 163
Modelled: 164
Confidence: 99.9%
Identity: 25%
Fold: beta-hairpin-alpha-hairpin repeat
Superfamily: Ankyrin repeat
Family: Ankyrin repeat

Phyre2

PDB 1sw6 chain A

3D model

Region: 1 - 164
Aligned: 162
Modelled: 164
Confidence: 99.9%
Identity: 20%
PDB header:transcription regulation
Chain: A: PDB Molecule:regulatory protein swi6;
PDBTitle: s. cerevisiae swi6 ankyrin-repeat fragment

Phyre2

PDB 1sw6 chain A

3D model

Region: 1 - 164
Aligned: 162
Modelled: 164
Confidence: 99.9%
Identity: 20%
Fold: beta-hairpin-alpha-hairpin repeat
Superfamily: Ankyrin repeat
Family: Ankyrin repeat

Phyre2

PDB 1wdy chain A

3D model

Region: 32 - 165
Aligned: 133
Modelled: 134
Confidence: 99.9%
Identity: 27%
Fold: beta-hairpin-alpha-hairpin repeat
Superfamily: Ankyrin repeat
Family: Ankyrin repeat

Phyre2

PDB 2xai chain D

3D model

Region: 33 - 164
Aligned: 129
Modelled: 132
Confidence: 99.8%
Identity: 25%
PDB header:transcription
Chain: D: PDB Molecule:ankyrin repeat and socs box protein 9;
PDBTitle: crystal structure of ankyrin repeat and socs box-containing2 protein 9 (asb9) in complex with elonginb and elonginc

Phyre2

PDB 1blx chain B

3D model

Region: 33 - 159
Aligned: 127
Modelled: 127
Confidence: 99.8%
Identity: 20%
Fold: beta-hairpin-alpha-hairpin repeat
Superfamily: Ankyrin repeat
Family: Ankyrin repeat

Phyre2

PDB 2kbx chain A

3D model

Region: 34 - 164
Aligned: 131
Modelled: 131
Confidence: 99.8%
Identity: 24%
PDB header:cell adhesion
Chain: A: PDB Molecule:integrin-linked protein kinase;
PDBTitle: solution structure of ilk-pinch complex

Phyre2

PDB 2a5e chain A

3D model

Region: 24 - 165
Aligned: 140
Modelled: 142
Confidence: 99.8%
Identity: 15%
Fold: beta-hairpin-alpha-hairpin repeat
Superfamily: Ankyrin repeat
Family: Ankyrin repeat

Phyre2

PDB 2v5q chain C

3D model

Region: 35 - 161
Aligned: 126
Modelled: 127
Confidence: 99.8%
Identity: 32%
PDB header:transferase
Chain: C: PDB Molecule:design ankyrin repeat protein;
PDBTitle: crystal structure of wild-type plk-1 kinase domain in2 complex with a selective darpin

Phyre2

PDB 1ycs chain B

3D model

Region: 37 - 164
Aligned: 94
Modelled: 95
Confidence: 99.8%
Identity: 27%
PDB header:complex (anti-oncogene/ankyrin repeats)
Chain: B: PDB Molecule:53bp2;
PDBTitle: p53-53bp2 complex

Phyre2

PDB 2rfa chain A

3D model

Region: 35 - 159
Aligned: 125
Modelled: 125
Confidence: 99.8%
Identity: 16%
PDB header:membrane protein
Chain: A: PDB Molecule:transient receptor potential cation channel subfamily v
PDBTitle: crystal structure of the mouse trpv6 ankyrin repeat domain

Phyre2

PDB 3hra chain A

3D model

Region: 33 - 156
Aligned: 124
Modelled: 124
Confidence: 99.8%
Identity: 21%
PDB header:structural protein
Chain: A: PDB Molecule:ankyrin repeat family protein;
PDBTitle: crystal structure of ef0377 an ankyrin repeat protein

Phyre2

PDB 1k1a chain A

3D model

Region: 31 - 164
Aligned: 134
Modelled: 134
Confidence: 99.8%
Identity: 31%
Fold: beta-hairpin-alpha-hairpin repeat
Superfamily: Ankyrin repeat
Family: Ankyrin repeat

Phyre2

PDB 1uoh chain A

3D model

Region: 32 - 164
Aligned: 133
Modelled: 133
Confidence: 99.8%
Identity: 29%
Fold: beta-hairpin-alpha-hairpin repeat
Superfamily: Ankyrin repeat
Family: Ankyrin repeat

Phyre2

PDB 1ikn chain D

3D model

Region: 32 - 164
Aligned: 131
Modelled: 133
Confidence: 99.8%
Identity: 24%
Fold: beta-hairpin-alpha-hairpin repeat
Superfamily: Ankyrin repeat
Family: Ankyrin repeat

Phyre2

PDB 3b7b chain B

3D model

Region: 35 - 158
Aligned: 123
Modelled: 124
Confidence: 99.7%
Identity: 24%
PDB header:transferase
Chain: B: PDB Molecule:euchromatic histone-lysine n-methyltransferase 1;
PDBTitle: euhmt1 (glp) ankyrin repeat domain (structure 1)

Phyre2
1
c3keaB_
2
c1n11A_
3
d1n11a_
4
c3utmA_
5
d1s70b_
6
c1sw6A_
7
d1sw6a_
8
d1wdya_
9
c2xaiD_
10
d1blxb_
11
c2kbxA_
12
d2a5ea_
13
c2v5qC_
14
c1ycsB_
15
c2rfaA_
16
c3hraA_
17
d1k1aa_
18
d1uoha_
19
d1iknd_
20
c3b7bB_
21
22
23
24
25
26
27
28
29
30
31
32
33
34
35
36
37
38
39
40
41
42
43
44
45
46
47
48
49
50
51
52
53
54
55
56
57
58
59
60
61
62
63
64
65
66
67
68
69
70
71
72
73



Detailed template information 

#
Template Alignment Coverage3D Model Confidence
% i.d. Template Information
1c3keaB_
99.9 17 PDB header:viral protein
Chain: B: PDB Molecule:k1l;
PDBTitle: structure function studies of vaccinia virus host-range protein k12 reveal a novel ankyrin repeat interaction surface for k1s function
2c1n11A_
99.9 27 PDB header:structural protein
Chain: A: PDB Molecule:ankyrin;
PDBTitle: d34 region of human ankyrin-r and linker
3d1n11a_
99.9 27 Fold:beta-hairpin-alpha-hairpin repeat
Superfamily:Ankyrin repeat
Family:Ankyrin repeat
4c3utmA_
99.9 28 PDB header:transferase/signaling protein
Chain: A: PDB Molecule:tankyrase-1;
PDBTitle: crystal structure of a mouse tankyrase-axin complex
5d1s70b_
99.9 25 Fold:beta-hairpin-alpha-hairpin repeat
Superfamily:Ankyrin repeat
Family:Ankyrin repeat
6c1sw6A_
99.9 20 PDB header:transcription regulation
Chain: A: PDB Molecule:regulatory protein swi6;
PDBTitle: s. cerevisiae swi6 ankyrin-repeat fragment
7d1sw6a_
99.9 20 Fold:beta-hairpin-alpha-hairpin repeat
Superfamily:Ankyrin repeat
Family:Ankyrin repeat
8d1wdya_
99.9 27 Fold:beta-hairpin-alpha-hairpin repeat
Superfamily:Ankyrin repeat
Family:Ankyrin repeat
9c2xaiD_
99.8 25 PDB header:transcription
Chain: D: PDB Molecule:ankyrin repeat and socs box protein 9;
PDBTitle: crystal structure of ankyrin repeat and socs box-containing2 protein 9 (asb9) in complex with elonginb and elonginc
10d1blxb_
99.8 20 Fold:beta-hairpin-alpha-hairpin repeat
Superfamily:Ankyrin repeat
Family:Ankyrin repeat
11c2kbxA_
99.8 24 PDB header:cell adhesion
Chain: A: PDB Molecule:integrin-linked protein kinase;
PDBTitle: solution structure of ilk-pinch complex
12d2a5ea_
99.8 15 Fold:beta-hairpin-alpha-hairpin repeat
Superfamily:Ankyrin repeat
Family:Ankyrin repeat
13c2v5qC_
99.8 32 PDB header:transferase
Chain: C: PDB Molecule:design ankyrin repeat protein;
PDBTitle: crystal structure of wild-type plk-1 kinase domain in2 complex with a selective darpin
14c1ycsB_
99.8 27 PDB header:complex (anti-oncogene/ankyrin repeats)
Chain: B: PDB Molecule:53bp2;
PDBTitle: p53-53bp2 complex
15c2rfaA_
99.8 16 PDB header:membrane protein
Chain: A: PDB Molecule:transient receptor potential cation channel subfamily v
PDBTitle: crystal structure of the mouse trpv6 ankyrin repeat domain
16c3hraA_
99.8 21 PDB header:structural protein
Chain: A: PDB Molecule:ankyrin repeat family protein;
PDBTitle: crystal structure of ef0377 an ankyrin repeat protein
17d1k1aa_
99.8 31 Fold:beta-hairpin-alpha-hairpin repeat
Superfamily:Ankyrin repeat
Family:Ankyrin repeat
18d1uoha_
99.8 29 Fold:beta-hairpin-alpha-hairpin repeat
Superfamily:Ankyrin repeat
Family:Ankyrin repeat
19d1iknd_
99.8 24 Fold:beta-hairpin-alpha-hairpin repeat
Superfamily:Ankyrin repeat
Family:Ankyrin repeat
20c3b7bB_
99.7 24 PDB header:transferase
Chain: B: PDB Molecule:euchromatic histone-lysine n-methyltransferase 1;
PDBTitle: euhmt1 (glp) ankyrin repeat domain (structure 1)
21d1oy3d_
not modelled 99.7 30 Fold:beta-hairpin-alpha-hairpin repeat
Superfamily:Ankyrin repeat
Family:Ankyrin repeat
22c1oy3D_
not modelled 99.7 30 PDB header:dna binding protein
Chain: D: PDB Molecule:transcription factor inhibitor i-kappa-b-beta;
PDBTitle: crystal structure of an ikbbeta/nf-kb p65 homodimer complex
23c3eu9B_
not modelled 99.7 28 PDB header:protein binding, methyl-lysine-binding p
Chain: B: PDB Molecule:huntingtin-interacting protein 14;
PDBTitle: the ankyrin repeat domain of huntingtin interacting protein 14
24c3ljnA_
not modelled 99.7 28 PDB header:unknown function
Chain: A: PDB Molecule:hypothetical protein;
PDBTitle: ankyrin repeat protein from leishmania major
25d1ixva_
not modelled 99.7 25 Fold:beta-hairpin-alpha-hairpin repeat
Superfamily:Ankyrin repeat
Family:Ankyrin repeat
26c3t8kB_
not modelled 99.7 12 PDB header:structural genomics, unknown function
Chain: B: PDB Molecule:uncharacterized protein;
PDBTitle: the crystal structure of a functionally unknown protein lebu_0176 from2 leptotrichia buccalis c-1013-b
27c3d9hA_
not modelled 99.7 22 PDB header:structural protein, protein binding
Chain: A: PDB Molecule:cdna flj77766, highly similar to homo sapiens
PDBTitle: crystal structure of the splice variant of human asb92 (hasb9-2), an ankyrin repeat protein
28c2fo1E_
not modelled 99.7 18 PDB header:gene regulation/signalling protein/dna
Chain: E: PDB Molecule:lin-12 protein;
PDBTitle: crystal structure of the csl-notch-mastermind ternary2 complex bound to dna
29d1bd8a_
not modelled 99.7 22 Fold:beta-hairpin-alpha-hairpin repeat
Superfamily:Ankyrin repeat
Family:Ankyrin repeat
30c2jabC_
not modelled 99.7 31 PDB header:de novo protein
Chain: C: PDB Molecule:h10-2-g3;
PDBTitle: a designed ankyrin repeat protein evolved to picomolar2 affinity to her2
31c2ajaA_
not modelled 99.7 17 PDB header:protein binding
Chain: A: PDB Molecule:ankyrin repeat family protein;
PDBTitle: x-ray structure of an ankyrin repeat family protein q5zsv02 from legionella pneumophila. northeast structural genomics3 consortium target lgr21.
32c1ympB_
not modelled 99.7 22 PDB header:transcription
Chain: B: PDB Molecule:notch 1 protein;
PDBTitle: the crystal structure of a partial mouse notch-1 ankyrin2 domain: repeats 4 through 7 preserve an ankyrin fold
33d1ihba_
not modelled 99.7 16 Fold:beta-hairpin-alpha-hairpin repeat
Superfamily:Ankyrin repeat
Family:Ankyrin repeat
34c1ympA_
not modelled 99.7 22 PDB header:transcription
Chain: A: PDB Molecule:notch 1 protein;
PDBTitle: the crystal structure of a partial mouse notch-1 ankyrin2 domain: repeats 4 through 7 preserve an ankyrin fold
35d2fo1e1
not modelled 99.7 18 Fold:beta-hairpin-alpha-hairpin repeat
Superfamily:Ankyrin repeat
Family:Ankyrin repeat
36d1bi7b_
not modelled 99.7 16 Fold:beta-hairpin-alpha-hairpin repeat
Superfamily:Ankyrin repeat
Family:Ankyrin repeat
37c2l6bA_
not modelled 99.7 33 PDB header:de novo protein
Chain: A: PDB Molecule:nr1c;
PDBTitle: nrc consensus ankyrin repeat protein solution structure
38c2f8xK_
not modelled 99.7 21 PDB header:transcription/dna
Chain: K: PDB Molecule:neurogenic locus notch homolog protein 1;
PDBTitle: crystal structure of activated notch, csl and maml on hes-12 promoter dna sequence
39c3v30A_
not modelled 99.6 28 PDB header:protein binding
Chain: A: PDB Molecule:dna-binding protein rfxank;
PDBTitle: crystal structure of the peptide bound complex of the ankyrin repeat2 domains of human rfxank
40d2ajaa1
not modelled 99.6 13 Fold:alpha-alpha superhelix
Superfamily:Pseudo ankyrin repeat-like
Family:Pseudo ankyrin repeat
41c1n0rA_
not modelled 99.6 35 PDB header:structural protein
Chain: A: PDB Molecule:4 ankyrin repeats;
PDBTitle: 4ank: a designed ankyrin repeat protein with four identical2 consensus repeats
42c3ui2A_
not modelled 99.6 26 PDB header:transport protein
Chain: A: PDB Molecule:signal recognition particle 43 kda protein, chloroplastic;
PDBTitle: crystal structure of the cpsrp54 tail bound to cpsrp43
43c2b0oF_
not modelled 99.6 22 PDB header:metal binding protein
Chain: F: PDB Molecule:uplc1;
PDBTitle: crystal structure of uplc1 gap domain
44d1dcqa1
not modelled 99.6 23 Fold:beta-hairpin-alpha-hairpin repeat
Superfamily:Ankyrin repeat
Family:Ankyrin repeat
45c2vgeA_
not modelled 99.6 21 PDB header:transcription
Chain: A: PDB Molecule:rela-associated inhibitor;
PDBTitle: crystal structure of the c-terminal region of human iaspp
46c3deoA_
not modelled 99.6 31 PDB header:protein transport, membrane protein
Chain: A: PDB Molecule:signal recognition particle 43 kda protein;
PDBTitle: structural basis for specific substrate recognition by the2 chloroplast signal recognition particle protein cpsrp43
47c3ehrB_
not modelled 99.6 30 PDB header:signaling protein
Chain: B: PDB Molecule:osteoclast-stimulating factor 1;
PDBTitle: crystal structure of human osteoclast stimulating factor
48c2rfmB_
not modelled 99.6 21 PDB header:protein binding
Chain: B: PDB Molecule:putative ankyrin repeat protein tv1425;
PDBTitle: structure of a thermophilic ankyrin repeat protein
49c3jueA_
not modelled 99.6 21 PDB header:protein transport/endocytosis
Chain: A: PDB Molecule:arfgap with coiled-coil, ank repeat and ph domain-
PDBTitle: crystal structure of arfgap and ank repeat domain of acap1
50d1ot8a_
not modelled 99.5 26 Fold:beta-hairpin-alpha-hairpin repeat
Superfamily:Ankyrin repeat
Family:Ankyrin repeat
51c1n0qB_
not modelled 99.5 41 PDB header:structural protein
Chain: B: PDB Molecule:3 ankyrin repeats;
PDBTitle: 3ank: a designed ankyrin repeat protein with three identical consensus2 repeats
52c3lvrE_
not modelled 99.5 23 PDB header:protein transport
Chain: E: PDB Molecule:arf-gap with sh3 domain, ank repeat and ph domain-
PDBTitle: the crystal structure of asap3 in complex with arf6 in transition2 state soaked with calcium
53d1awcb_
not modelled 99.5 19 Fold:beta-hairpin-alpha-hairpin repeat
Superfamily:Ankyrin repeat
Family:Ankyrin repeat
54c3c5rB_
not modelled 99.5 30 PDB header:protein binding
Chain: B: PDB Molecule:brca1-associated ring domain protein 1;
PDBTitle: crystal structure of the bard1 ankyrin repeat domain and its2 functional consequences
55d1ycsb1
not modelled 99.5 23 Fold:beta-hairpin-alpha-hairpin repeat
Superfamily:Ankyrin repeat
Family:Ankyrin repeat
56c3twtD_
not modelled 99.5 24 PDB header:signaling protein/peptide
Chain: D: PDB Molecule:tankyrase-2;
PDBTitle: crystal structure of arc4 from human tankyrase 2 in complex with2 peptide from human mcl1 (chimeric peptide)
57c1dcqA_
not modelled 99.5 19 PDB header:metal binding protein
Chain: A: PDB Molecule:pyk2-associated protein beta;
PDBTitle: crystal structure of the arf-gap domain and ankyrin repeats2 of papbeta.
58d1myoa_
not modelled 99.5 26 Fold:beta-hairpin-alpha-hairpin repeat
Superfamily:Ankyrin repeat
Family:Ankyrin repeat
59c2zgdA_
not modelled 99.5 34 PDB header:de novo protein
Chain: A: PDB Molecule:3 repeat synthetic ankyrin;
PDBTitle: asn-hydroxylation stabilises the ankyrin repeat domain fold
60c2xenA_
not modelled 99.5 37 PDB header:de novo protein
Chain: A: PDB Molecule:ni1c mut4;
PDBTitle: structural determinants for improved thermal stability of2 designed ankyrin repeat proteins with a redesigned c-3 capping module.
61c2f37B_
not modelled 99.4 10 PDB header:membrane protein
Chain: B: PDB Molecule:transient receptor potential cation channel
PDBTitle: crystal structure of the ankyrin repeat domain of human2 trpv2
62c3jxiA_
not modelled 99.4 12 PDB header:membrane protein
Chain: A: PDB Molecule:vanilloid receptor-related osmotically activated channel
PDBTitle: crystal structure of the chicken trpv4 ankyrin repeat domain
63c2nyjA_
not modelled 99.2 14 PDB header:transport protein
Chain: A: PDB Molecule:transient receptor potential cation channel
PDBTitle: crystal structure of the ankyrin repeat domain of trpv1
64c2xumS_
not modelled 95.7 39 PDB header:oxidoreductase/peptide
Chain: S: PDB Molecule:asp-substrate peptide 2;
PDBTitle: factor inhibiting hif (fih) q239h mutant in complex with zn(ii), nog2 and asp-substrate peptide (20-mer)
65c2y0iS_
not modelled 68.1 38 PDB header:oxidoreductase/peptide
Chain: S: PDB Molecule:tankyrase-2;
PDBTitle: factor inhibiting hif-1 alpha in complex with tankyrase-2 (tnks2)2 fragment peptide (21-mer)
66c2auaB_
not modelled 13.8 8 PDB header:structural genomics, unknown function
Chain: B: PDB Molecule:hypothetical protein;
PDBTitle: structure of bc2332: a protein of unknown function from bacillus2 cereus
67c3zrhA_
not modelled 11.7 25 PDB header:hydrolase
Chain: A: PDB Molecule:ubiquitin thioesterase zranb1;
PDBTitle: crystal structure of the lys29, lys33-linkage-specific trabid otu2 deubiquitinase domain reveals an ankyrin-repeat ubiquitin binding3 domain (ankubd)
68d2hoea1
not modelled 10.5 29 Fold:DNA/RNA-binding 3-helical bundle
Superfamily:"Winged helix" DNA-binding domain
Family:ROK associated domain
69d1mv8a3
not modelled 9.6 33 Fold:Adenine nucleotide alpha hydrolase-like
Superfamily:UDP-glucose/GDP-mannose dehydrogenase C-terminal domain
Family:UDP-glucose/GDP-mannose dehydrogenase C-terminal domain
70c3sviA_
not modelled 9.4 14 PDB header:signaling protein
Chain: A: PDB Molecule:type iii effector hopab2;
PDBTitle: structure of the pto-binding domain of hoppmal generated by limited2 thermolysin digestion
71c3hgkE_
not modelled 8.5 29 PDB header:transferase
Chain: E: PDB Molecule:effector protein hopab2;
PDBTitle: crystal structure of effect protein avrptob complexed with2 kinase pto
72c1x3lA_
not modelled 5.8 22 PDB header:transferase
Chain: A: PDB Molecule:hypothetical protein ph0495;
PDBTitle: crystal structure of the ph0495 protein from pyrococccus horikoshii2 ot3
73d2b8na1
not modelled 5.4 33 Fold:GckA/TtuD-like
Superfamily:GckA/TtuD-like
Family:GckA/TtuD-like

Binding site prediction 

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite