Phyre Home Retrieve Phyre Job Id
Emaill.a.kelley@imperial.ac.uk
DescriptionA0PJX4
DateFri May 25 09:46:33 BST 2012
Unique Job ID7e12dc0df08ceb1b

Summary 

Top model
Image coloured by rainbow N → C terminus
Model (left) based on template c1m4fA_
Top template information
PDB header:antimicrobial protein
Chain: A: PDB Molecule:hepcidin;
PDBTitle: solution structure of hepcidin-25
Confidence and coverage
Confidence: 48.3% Coverage: 5%
12 residues ( 5% of your sequence) have been modelled with 48.3% confidence by the single highest scoring template.
You may wish to submit your sequence to Phyrealarm. This will automatically scan your sequence every week for new potential templates as they appear in the Phyre2 library.
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Warning: 61% of your sequence is predicted disordered. Disordered regions cannot be meaningfully predicted.
3D viewing
Interactive 3D view in Jmol

Sequence analysis 

Secondary structure and disorder prediction 

   1........10.........20.........30.........40.........50.........60
Sequence  MRALLALCLLLGWLRWGPAGAQQSGEYCHGWVDVQGNYHEGFQCPEDFDTLDATICCGSC
Secondary structure 
SS confidence 
Disorder  ??
???????????
?
?
?
?
???
Disorder confidence 
 
   .........70.........80.........90.........100.........110.........120
Sequence  ALRYCCAAADARLEQGGCTNDRRELEHPGITAQPVYVPFLIVGSIFIAFIILGSVVAIYC
Secondary structure 
SS confidence 
Disorder 
?
??????????????????????????
Disorder confidence 
 
   .........130.........140.........150.........160.........170.........180
Sequence  CTCLRPKEPSQQPIRFSLRSYQTETLPMILTSTSPRAPSRQSSTATSSSSTGGSIRRFSF
Secondary structure 
SS confidence 
Disorder 
????????????????????
???????????????????????????????????
Disorder confidence 
 
   .........190.........200.........210.........220.........230........
Sequence  ARAEPGCLVPSPPPPYTTSHSIHLAQPSGFLVSPQYFAYPLQQEPPLPGKSCPDFSSS
Secondary structure 
SS confidence 
Disorder  ????????????????????????
??
?
????????????????
Disorder confidence 
 

Confidence Key
High(9)                    Low (0)
?Disordered
Alpha helix
Beta strand

Domain analysis 

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

RankAligned region

PDB 1m4f chain A

3D model

Region: 54 - 65
Aligned: 12
Modelled: 12
Confidence: 48.3%
Identity: 42%
PDB header:antimicrobial protein
Chain: A: PDB Molecule:hepcidin;
PDBTitle: solution structure of hepcidin-25

Phyre2

PDB 3h0t chain C

3D model

Region: 54 - 65
Aligned: 12
Modelled: 12
Confidence: 47.0%
Identity: 42%
PDB header:immune system/antimicrobial protein
Chain: C: PDB Molecule:hepcidin;
PDBTitle: hepcidin-fab complex

Phyre2

PDB 2kef chain A

3D model

Region: 54 - 65
Aligned: 12
Modelled: 12
Confidence: 46.9%
Identity: 42%
PDB header:antibiotic, hormone
Chain: A: PDB Molecule:hepcidin;
PDBTitle: solution nmr structures of human hepcidin at 325k

Phyre2

PDB 1m4e chain A

3D model

Region: 54 - 65
Aligned: 12
Modelled: 12
Confidence: 46.0%
Identity: 42%
PDB header:antimicrobial protein
Chain: A: PDB Molecule:hepcidin;
PDBTitle: solution structure of hepcidin-20

Phyre2

PDB 2dlq chain A domain 2

3D model

Region: 41 - 63
Aligned: 13
Modelled: 23
Confidence: 34.2%
Identity: 54%
Fold: beta-beta-alpha zinc fingers
Superfamily: beta-beta-alpha zinc fingers
Family: Classic zinc finger, C2H2

Phyre2

PDB 2xrg chain A

3D model

Region: 19 - 105
Aligned: 79
Modelled: 87
Confidence: 33.0%
Identity: 24%
PDB header:hydrolase
Chain: A: PDB Molecule:ectonucleotide pyrophosphatase/phosphodiesterase family
PDBTitle: crystal structure of autotaxin (enpp2) in complex with the2 ha155 boronic acid inhibitor

Phyre2

PDB 1kg1 chain A

3D model

Region: 18 - 65
Aligned: 34
Modelled: 34
Confidence: 28.0%
Identity: 38%
Fold: Necrosis inducing protein 1, NIP1
Superfamily: Necrosis inducing protein 1, NIP1
Family: Necrosis inducing protein 1, NIP1

Phyre2

PDB 1i71 chain A

3D model

Region: 17 - 56
Aligned: 40
Modelled: 40
Confidence: 27.6%
Identity: 18%
Fold: Kringle-like
Superfamily: Kringle-like
Family: Kringle modules

Phyre2

PDB 3hh7 chain A

3D model

Region: 41 - 59
Aligned: 19
Modelled: 19
Confidence: 25.0%
Identity: 32%
PDB header:toxin
Chain: A: PDB Molecule:muscarinic toxin-like protein 3 homolog;
PDBTitle: structural and functional characterization of a novel2 homodimeric three-finger neurotoxin from the venom of3 ophiophagus hannah (king cobra)

Phyre2

PDB 1sfk chain B

3D model

Region: 1 - 22
Aligned: 22
Modelled: 22
Confidence: 20.5%
Identity: 27%
Fold: Flavivirus capsid protein C
Superfamily: Flavivirus capsid protein C
Family: Flavivirus capsid protein C

Phyre2

PDB 2hpp chain P

3D model

Region: 17 - 56
Aligned: 40
Modelled: 40
Confidence: 15.8%
Identity: 23%
Fold: Kringle-like
Superfamily: Kringle-like
Family: Kringle modules

Phyre2

PDB 2pf2 chain A

3D model

Region: 17 - 56
Aligned: 40
Modelled: 40
Confidence: 15.1%
Identity: 20%
PDB header:hydrolase(serine protease)
Chain: A: PDB Molecule:prothrombin fragment 1;
PDBTitle: the ca+2 ion and membrane binding structure of the gla domain of ca-2 prothrombin fragment 1

Phyre2

PDB 2fqh chain A

3D model

Region: 36 - 64
Aligned: 23
Modelled: 29
Confidence: 14.7%
Identity: 39%
PDB header:structural genomics, unknown function
Chain: A: PDB Molecule:hypothetical protein ta0938;
PDBTitle: nmr structure of hypothetical protein ta0938 from2 termoplasma acidophilum

Phyre2

PDB 1x4s chain A

3D model

Region: 52 - 89
Aligned: 36
Modelled: 38
Confidence: 14.6%
Identity: 22%
PDB header:metal binding protein
Chain: A: PDB Molecule:zinc finger hit domain containing protein 2;
PDBTitle: solution structure of zinc finger hit domain in protein fon

Phyre2

PDB 1tv0 chain A

3D model

Region: 58 - 69
Aligned: 12
Modelled: 12
Confidence: 14.5%
Identity: 50%
Fold: Defensin-like
Superfamily: Defensin-like
Family: Defensin

Phyre2

PDB 2pf1 chain A domain 1

3D model

Region: 17 - 56
Aligned: 40
Modelled: 40
Confidence: 14.4%
Identity: 20%
Fold: Kringle-like
Superfamily: Kringle-like
Family: Kringle modules

Phyre2

PDB 1ki0 chain A domain 3

3D model

Region: 17 - 56
Aligned: 40
Modelled: 40
Confidence: 11.9%
Identity: 25%
Fold: Kringle-like
Superfamily: Kringle-like
Family: Kringle modules

Phyre2

PDB 2xr9 chain A

3D model

Region: 19 - 105
Aligned: 79
Modelled: 87
Confidence: 11.9%
Identity: 24%
PDB header:hydrolase
Chain: A: PDB Molecule:ectonucleotide pyrophosphatase/phosphodiesterase family
PDBTitle: crystal structure of autotaxin (enpp2)

Phyre2

PDB 2lew chain A

3D model

Region: 58 - 69
Aligned: 12
Modelled: 12
Confidence: 11.8%
Identity: 50%
PDB header:antimicrobial protein
Chain: A: PDB Molecule:alpha-defensin 4;
PDBTitle: structural plasticity of paneth cell alpha-defensins: characterization2 of salt-bridge deficient analogues of mouse cryptdin-4

Phyre2

PDB 1zu1 chain A domain 2

3D model

Region: 46 - 64
Aligned: 19
Modelled: 19
Confidence: 11.6%
Identity: 32%
Fold: beta-beta-alpha zinc fingers
Superfamily: beta-beta-alpha zinc fingers
Family: HkH motif-containing C2H2 finger

Phyre2
1
c1m4fA_
2
c3h0tC_
3
c2kefA_
4
c1m4eA_
5
d2dlqa2
6
c2xrgA_
7
d1kg1a_
8
d1i71a_
9
c3hh7A_
10
d1sfkb_
11
d2hppp_
12
c2pf2A_
13
c2fqhA_
14
c1x4sA_
15
d1tv0a_
16
d2pf1a1
17
d1ki0a3
18
c2xr9A_
19
c2lewA_
20
d1zu1a2
21
22
23
24
25
26
27
28
29
30
31
32
33
34
35
36
37
38
39
40
41
42
43
44
45
46
47
48
49
50
51
52
53



Detailed template information 

#
Template Alignment Coverage3D Model Confidence
% i.d. Template Information
1c1m4fA_
48.3 42 PDB header:antimicrobial protein
Chain: A: PDB Molecule:hepcidin;
PDBTitle: solution structure of hepcidin-25
2c3h0tC_
47.0 42 PDB header:immune system/antimicrobial protein
Chain: C: PDB Molecule:hepcidin;
PDBTitle: hepcidin-fab complex
3c2kefA_
46.9 42 PDB header:antibiotic, hormone
Chain: A: PDB Molecule:hepcidin;
PDBTitle: solution nmr structures of human hepcidin at 325k
4c1m4eA_
46.0 42 PDB header:antimicrobial protein
Chain: A: PDB Molecule:hepcidin;
PDBTitle: solution structure of hepcidin-20
5d2dlqa2
34.2 54 Fold:beta-beta-alpha zinc fingers
Superfamily:beta-beta-alpha zinc fingers
Family:Classic zinc finger, C2H2
6c2xrgA_
33.0 24 PDB header:hydrolase
Chain: A: PDB Molecule:ectonucleotide pyrophosphatase/phosphodiesterase family
PDBTitle: crystal structure of autotaxin (enpp2) in complex with the2 ha155 boronic acid inhibitor
7d1kg1a_
28.0 38 Fold:Necrosis inducing protein 1, NIP1
Superfamily:Necrosis inducing protein 1, NIP1
Family:Necrosis inducing protein 1, NIP1
8d1i71a_
27.6 18 Fold:Kringle-like
Superfamily:Kringle-like
Family:Kringle modules
9c3hh7A_
25.0 32 PDB header:toxin
Chain: A: PDB Molecule:muscarinic toxin-like protein 3 homolog;
PDBTitle: structural and functional characterization of a novel2 homodimeric three-finger neurotoxin from the venom of3 ophiophagus hannah (king cobra)
10d1sfkb_
20.5 27 Fold:Flavivirus capsid protein C
Superfamily:Flavivirus capsid protein C
Family:Flavivirus capsid protein C
11d2hppp_
15.8 23 Fold:Kringle-like
Superfamily:Kringle-like
Family:Kringle modules
12c2pf2A_
15.1 20 PDB header:hydrolase(serine protease)
Chain: A: PDB Molecule:prothrombin fragment 1;
PDBTitle: the ca+2 ion and membrane binding structure of the gla domain of ca-2 prothrombin fragment 1
13c2fqhA_
14.7 39 PDB header:structural genomics, unknown function
Chain: A: PDB Molecule:hypothetical protein ta0938;
PDBTitle: nmr structure of hypothetical protein ta0938 from2 termoplasma acidophilum
14c1x4sA_
14.6 22 PDB header:metal binding protein
Chain: A: PDB Molecule:zinc finger hit domain containing protein 2;
PDBTitle: solution structure of zinc finger hit domain in protein fon
15d1tv0a_
14.5 50 Fold:Defensin-like
Superfamily:Defensin-like
Family:Defensin
16d2pf1a1
14.4 20 Fold:Kringle-like
Superfamily:Kringle-like
Family:Kringle modules
17d1ki0a3
11.9 25 Fold:Kringle-like
Superfamily:Kringle-like
Family:Kringle modules
18c2xr9A_
11.9 24 PDB header:hydrolase
Chain: A: PDB Molecule:ectonucleotide pyrophosphatase/phosphodiesterase family
PDBTitle: crystal structure of autotaxin (enpp2)
19c2lewA_
11.8 50 PDB header:antimicrobial protein
Chain: A: PDB Molecule:alpha-defensin 4;
PDBTitle: structural plasticity of paneth cell alpha-defensins: characterization2 of salt-bridge deficient analogues of mouse cryptdin-4
20d1zu1a2
11.6 32 Fold:beta-beta-alpha zinc fingers
Superfamily:beta-beta-alpha zinc fingers
Family:HkH motif-containing C2H2 finger
21d2hpqp_
not modelled 11.2 20 Fold:Kringle-like
Superfamily:Kringle-like
Family:Kringle modules
22c2fwtA_
not modelled 11.0 38 PDB header:electron transport
Chain: A: PDB Molecule:dhc, diheme cytochrome c;
PDBTitle: crystal structure of dhc purified from rhodobacter2 sphaeroides
23c1zzpA_
not modelled 10.8 24 PDB header:transferase
Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase abl1;
PDBTitle: solution structure of the f-actin binding domain of bcr-2 abl/c-abl
24d1e4ta_
not modelled 10.1 37 Fold:Defensin-like
Superfamily:Defensin-like
Family:Defensin
25d1wiia_
not modelled 10.0 26 Fold:Rubredoxin-like
Superfamily:Zinc beta-ribbon
Family:Putative zinc binding domain
26d1jgka_
not modelled 9.8 24 Fold:Snake toxin-like
Superfamily:Snake toxin-like
Family:Snake venom toxins
27d1sfka_
not modelled 9.5 29 Fold:Flavivirus capsid protein C
Superfamily:Flavivirus capsid protein C
Family:Flavivirus capsid protein C
28d1ki0a2
not modelled 9.5 20 Fold:Kringle-like
Superfamily:Kringle-like
Family:Kringle modules
29c1gmoC_
not modelled 9.4 20 PDB header:hormone
Chain: C: PDB Molecule:hepatocyte growth factor;
PDBTitle: crystal structures of nk1-heparin complexes reveal the basis for nk12 activity and enable engineering of potent agonists of the met3 receptor
30c1znmA_
not modelled 8.9 88 PDB header:zinc finger
Chain: A: PDB Molecule:yy1;
PDBTitle: a zinc finger with an artificial beta-turn, original2 sequence taken from the third zinc finger domain of the3 human transcriptional repressor protein yy1 (ying and yang4 1, a delta transcription factor), nmr, 34 structures
31c1r6rA_
not modelled 8.9 24 PDB header:viral protein
Chain: A: PDB Molecule:genome polyprotein;
PDBTitle: solution structure of dengue virus capsid protein reveals a2 new fold
32d1r6ra_
not modelled 8.9 24 Fold:Flavivirus capsid protein C
Superfamily:Flavivirus capsid protein C
Family:Flavivirus capsid protein C
33d1nl1a1
not modelled 8.8 20 Fold:Kringle-like
Superfamily:Kringle-like
Family:Kringle modules
34c2e72A_
not modelled 8.8 21 PDB header:structural genomics, unknown function
Chain: A: PDB Molecule:pogo transposable element with znf domain;
PDBTitle: solution structure of the zinc finger domain of human2 kiaa0461
35d1wffa_
not modelled 8.7 36 Fold:AN1-like Zinc finger
Superfamily:AN1-like Zinc finger
Family:AN1-like Zinc finger
36c2leyA_
not modelled 8.5 50 PDB header:antimicrobial protein
Chain: A: PDB Molecule:alpha-defensin 4;
PDBTitle: solution structure of (r7g)-crp4
37d1wfla_
not modelled 8.5 21 Fold:AN1-like Zinc finger
Superfamily:AN1-like Zinc finger
Family:AN1-like Zinc finger
38c2kk1A_
not modelled 8.3 35 PDB header:transferase
Chain: A: PDB Molecule:tyrosine-protein kinase abl2;
PDBTitle: solution structure of c-terminal domain of tyrosine-protein2 kinase abl2 from homo sapiens, northeast structural3 genomics consortium (nesg) target hr5537a
39d1jfna_
not modelled 8.2 18 Fold:Kringle-like
Superfamily:Kringle-like
Family:Kringle modules
40d1krna_
not modelled 8.1 18 Fold:Kringle-like
Superfamily:Kringle-like
Family:Kringle modules
41c1zmmD_
not modelled 7.5 40 PDB header:antimicrobial protein
Chain: D: PDB Molecule:neutrophil defensin 4;
PDBTitle: crystal structure of human alpha-defensin-4
42d1i5ka_
not modelled 7.3 20 Fold:Kringle-like
Superfamily:Kringle-like
Family:Kringle modules
43d1e4ua_
not modelled 7.3 21 Fold:RING/U-box
Superfamily:RING/U-box
Family:RING finger domain, C3HC4
44d1e4qa_
not modelled 7.1 41 Fold:Defensin-like
Superfamily:Defensin-like
Family:Defensin
45c3kv1A_
not modelled 6.9 11 PDB header:transcription
Chain: A: PDB Molecule:transcriptional repressor;
PDBTitle: crystal structure of putative sugar-binding domain of transcriptional2 repressor from vibrio fischeri
46d2qj2a2
not modelled 6.9 20 Fold:Kringle-like
Superfamily:Kringle-like
Family:Kringle modules
47d1atxa_
not modelled 6.7 38 Fold:Defensin-like
Superfamily:Defensin-like
Family:Defensin
48d1a0ha1
not modelled 6.7 20 Fold:Kringle-like
Superfamily:Kringle-like
Family:Kringle modules
49c1zmmA_
not modelled 6.6 46 PDB header:antimicrobial protein
Chain: A: PDB Molecule:neutrophil defensin 4;
PDBTitle: crystal structure of human alpha-defensin-4
50c3qteA_
not modelled 5.5 28 PDB header:antimicrobial protein
Chain: A: PDB Molecule:defensin-6;
PDBTitle: crystal structure of human alpha-defensin 6 (h27w mutant)
51d1xpaa2
not modelled 5.4 19 Fold:Glucocorticoid receptor-like (DNA-binding domain)
Superfamily:Glucocorticoid receptor-like (DNA-binding domain)
Family:DNA repair factor XPA DNA- and RPA-binding domain, N-terminal subdomain
52c1v5aA_
not modelled 5.3 60 PDB header:toxin
Chain: A: PDB Molecule:covalitoxin-i;
PDBTitle: solution structure of covalitoxin i
53d3kiva_
not modelled 5.2 20 Fold:Kringle-like
Superfamily:Kringle-like
Family:Kringle modules

Binding site prediction 

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If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite