Phyre Home Retrieve Phyre Job Id
Emaill.a.kelley@imperial.ac.uk
DescriptionA0FGR9
DateThu Apr 26 09:38:06 BST 2012
Unique Job ID4f054448a9455fdf

Summary 

Top model
Image coloured by rainbow N → C terminus
Model (left) based on template c2r83B_
Top template information
PDB header:endocytosis, exocytosis
Chain: B: PDB Molecule:synaptotagmin-1;
PDBTitle: crystal structure analysis of human synaptotagmin 1 c2a-c2b
Confidence and coverage
Confidence:100.0% Coverage: 27%
237 residues ( 27% of your sequence) have been modelled with 100.0% confidence by the single highest scoring template.
Additional confident templates have been detected (see Domain analysis) which cover other regions of your sequence.
334 residues ( 38%) could be modelled at >90% confidence using multiple-templates.
You may wish to try resubmitting your sequence in "intensive" mode to model more of your sequence.
3D viewing
Interactive 3D view in Jmol

Sequence analysis 

Secondary structure and disorder prediction 

   1........10.........20.........30.........40.........50.........60
Sequence  MRAEEPCAPGAPSALGAQRTPGPELRLSSQLLPELCTFVVRVLFYLGPVYLAGYLGLSIT
Secondary structure 
SS confidence 
Disorder  ???????????????????????????
?
Disorder confidence 
 
   .........70.........80.........90.........100.........110.........120
Sequence  WLLLGALLWMWWRRNRRGKLGRLAAAFEFLDNEREFISRELRGQHLPAWIHFPDVERVEW
Secondary structure 
SS confidence 
Disorder 
????
????
?
Disorder confidence 
 
   .........130.........140.........150.........160.........170.........180
Sequence  ANKIISQTWPYLSMIMESKFREKLEPKIREKSIHLRTFTFTKLYFGQKCPRVNGVKAHTN
Secondary structure 
SS confidence 
Disorder 
????
Disorder confidence 
 
   .........190.........200.........210.........220.........230.........240
Sequence  TCNRRRVTVDLQICYIGDCEISVELQKIQAGVNGIQLQGTLRVILEPLLVDKPFVGAVTV
Secondary structure 
SS confidence 
Disorder 
??
?
?
Disorder confidence 
 
   .........250.........260.........270.........280.........290.........300
Sequence  FFLQKPHLQINWTGLTNLLDAPGINDVSDSLLEDLIATHLVLPNRVTVPVKKGLDLTNLR
Secondary structure 
SS confidence 
Disorder 
???
?
????????????????
?
Disorder confidence 
 
   .........310.........320.........330.........340.........350.........360
Sequence  FPLPCGVIRVHLLEAEQLAQKDNFLGLRGKSDPYAKVSIGLQHFRSRTIYRNLNPTWNEV
Secondary structure 
SS confidence 
Disorder  ?
??????????
Disorder confidence 
 
   .........370.........380.........390.........400.........410.........420
Sequence  FEFMVYEVPGQDLEVDLYDEDTDRDDFLGSLQICLGDVMTNRVVDEWFVLNDTTSGRLHL
Secondary structure 
SS confidence 
Disorder 
?
??
?
Disorder confidence 
 
   .........430.........440.........450.........460.........470.........480
Sequence  RLEWLSLLTDQEVLTEDHGGLSTAILVVFLESACNLPRNPFDYLNGEYRAKKLSRFARNK
Secondary structure 
SS confidence 
Disorder 
???
?
????
?
????
????
?????
???????
Disorder confidence 
 
   .........490.........500.........510.........520.........530.........540
Sequence  VSKDPSSYVKLSVGKKTHTSKTCPHNKDPVWSQVFSFFVHNVATERLHLKVLDDDQECAL
Secondary structure 
SS confidence 
Disorder  ?
Disorder confidence 
 
   .........550.........560.........570.........580.........590.........600
Sequence  GMLEVPLCQILPYADLTLEQRFQLDHSGLDSLISMRLVLRFLQVEERELGSPYTGPEALK
Secondary structure 
SS confidence 
Disorder 
?
???????
????????????
Disorder confidence 
 
   .........610.........620.........630.........640.........650.........660
Sequence  KGPLLIKKVATNQGPKAQPQEEGPTDLPCPPDPASDTKDVSRSTTTTTSATTVATEPTSQ
Secondary structure 
SS confidence 
Disorder  ????????????????????????????
???????
???????????????
???????
Disorder confidence 
 
   .........670.........680.........690.........700.........710.........720
Sequence  ETGPEPKGKDSAKRFCEPIGEKKSPATIFLTVPGPHSPGPIKSPRPMKCPASPFAWPPKR
Secondary structure 
SS confidence 
Disorder  ????????????????????????????????????????????????????????????
Disorder confidence 
 
   .........730.........740.........750.........760.........770.........780
Sequence  LAPSMSSLNSLASSCFDLADISLNIEGGDLRRRQLGEIQLTVRYVCLRRCLSVLINGCRN
Secondary structure 
SS confidence 
Disorder  ????????????????????????????????
Disorder confidence 
 
   .........790.........800.........810.........820.........830.........840
Sequence  LTPCTSSGADPYVRVYLLPERKWACRKKTSVKRKTLEPLFDETFEFFVPMEEVKKRSLDV
Secondary structure 
SS confidence 
Disorder 
?????
????????
???
Disorder confidence 
 
   .........850.........860.........870.........880......
Sequence  AVKNSRPLGSHRRKELGKVLIDLSKEDLIKGFSQWYELTPNGQPRS
Secondary structure 
SS confidence 
Disorder 
?
???
??
?
??
???????
Disorder confidence 
 

Confidence Key
High(9)                    Low (0)
?Disordered
Alpha helix
Beta strand

Domain analysis 

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

RankAligned region

PDB 2r83 chain B

3D model

Region: 298 - 880
Aligned: 237
Modelled: 239
Confidence: 100.0%
Identity: 38%
PDB header:endocytosis, exocytosis
Chain: B: PDB Molecule:synaptotagmin-1;
PDBTitle: crystal structure analysis of human synaptotagmin 1 c2a-c2b

Phyre2

PDB 1dqv chain A

3D model

Region: 299 - 882
Aligned: 245
Modelled: 251
Confidence: 100.0%
Identity: 31%
PDB header:endocytosis/exocytosis
Chain: A: PDB Molecule:synaptotagmin iii;
PDBTitle: crystal structure of synaptotagmin iii c2a/c2b

Phyre2

PDB 2z0u chain B

3D model

Region: 754 - 878
Aligned: 123
Modelled: 125
Confidence: 99.9%
Identity: 22%
PDB header:lipid binding protein
Chain: B: PDB Molecule:ww domain-containing protein 1;
PDBTitle: crystal structure of c2 domain of kibra protein

Phyre2

PDB 2dmg chain A

3D model

Region: 747 - 886
Aligned: 140
Modelled: 140
Confidence: 99.9%
Identity: 47%
PDB header:lipid binding protein
Chain: A: PDB Molecule:kiaa1228 protein;
PDBTitle: solution structure of the third c2 domain of kiaa12282 protein

Phyre2

PDB 2d8k chain A

3D model

Region: 746 - 885
Aligned: 136
Modelled: 140
Confidence: 99.9%
Identity: 38%
PDB header:endocytosis/exocytosis
Chain: A: PDB Molecule:synaptotagmin vii;
PDBTitle: solution structure of the first c2 domain of synaptotagmin2 vii

Phyre2

PDB 1wfm chain A

3D model

Region: 746 - 882
Aligned: 131
Modelled: 137
Confidence: 99.9%
Identity: 21%
Fold: C2 domain-like
Superfamily: C2 domain (Calcium/lipid-binding domain, CaLB)
Family: Synaptotagmin-like (S variant)

Phyre2

PDB 2enp chain A

3D model

Region: 746 - 884
Aligned: 135
Modelled: 139
Confidence: 99.9%
Identity: 35%
PDB header:transport protein
Chain: A: PDB Molecule:b/k protein;
PDBTitle: solution structure of the first c2 domain from human b/k2 protein

Phyre2

PDB 2q3x chain A

3D model

Region: 753 - 881
Aligned: 121
Modelled: 126
Confidence: 99.9%
Identity: 31%
PDB header:transport protein
Chain: A: PDB Molecule:regulating synaptic membrane exocytosis protein 1;
PDBTitle: the rim1alpha c2b domain

Phyre2

PDB 1v27 chain A

3D model

Region: 749 - 886
Aligned: 137
Modelled: 138
Confidence: 99.9%
Identity: 26%
Fold: C2 domain-like
Superfamily: C2 domain (Calcium/lipid-binding domain, CaLB)
Family: Synaptotagmin-like (S variant)

Phyre2

PDB 1rsy chain A

3D model

Region: 749 - 880
Aligned: 128
Modelled: 132
Confidence: 99.9%
Identity: 32%
Fold: C2 domain-like
Superfamily: C2 domain (Calcium/lipid-binding domain, CaLB)
Family: Synaptotagmin-like (S variant)

Phyre2

PDB 2chd chain A

3D model

Region: 754 - 880
Aligned: 125
Modelled: 127
Confidence: 99.9%
Identity: 26%
PDB header:protein transport
Chain: A: PDB Molecule:rabphilin-3a;
PDBTitle: crystal structure of the c2a domain of rabphilin-3a

Phyre2

PDB 2bwq chain A domain 1

3D model

Region: 756 - 879
Aligned: 116
Modelled: 124
Confidence: 99.9%
Identity: 29%
Fold: C2 domain-like
Superfamily: C2 domain (Calcium/lipid-binding domain, CaLB)
Family: Synaptotagmin-like (S variant)

Phyre2

PDB 1gmi chain A

3D model

Region: 301 - 426
Aligned: 122
Modelled: 123
Confidence: 99.9%
Identity: 20%
Fold: C2 domain-like
Superfamily: C2 domain (Calcium/lipid-binding domain, CaLB)
Family: PLC-like (P variant)

Phyre2

PDB 1dsy chain A

3D model

Region: 756 - 880
Aligned: 119
Modelled: 125
Confidence: 99.9%
Identity: 31%
Fold: C2 domain-like
Superfamily: C2 domain (Calcium/lipid-binding domain, CaLB)
Family: Synaptotagmin-like (S variant)

Phyre2

PDB 3fbk chain B

3D model

Region: 756 - 881
Aligned: 122
Modelled: 126
Confidence: 99.9%
Identity: 27%
PDB header:signaling protein
Chain: B: PDB Molecule:regulator of g-protein signaling 3;
PDBTitle: crystal structure of the c2 domain of the human regulator2 of g-protein signaling 3 isoform 6 (rgp3), northeast3 structural genomics consortium target hr5550a

Phyre2

PDB 1ugk chain A

3D model

Region: 748 - 885
Aligned: 134
Modelled: 138
Confidence: 99.9%
Identity: 32%
Fold: C2 domain-like
Superfamily: C2 domain (Calcium/lipid-binding domain, CaLB)
Family: Synaptotagmin-like (S variant)

Phyre2

PDB 2r83 chain A domain 1

3D model

Region: 755 - 878
Aligned: 120
Modelled: 124
Confidence: 99.9%
Identity: 33%
Fold: C2 domain-like
Superfamily: C2 domain (Calcium/lipid-binding domain, CaLB)
Family: Synaptotagmin-like (S variant)

Phyre2

PDB 2fk9 chain A

3D model

Region: 303 - 424
Aligned: 118
Modelled: 119
Confidence: 99.9%
Identity: 24%
PDB header:transferase
Chain: A: PDB Molecule:protein kinase c, eta type;
PDBTitle: human protein kinase c, eta

Phyre2

PDB 3nsj chain A

3D model

Region: 248 - 447
Aligned: 188
Modelled: 200
Confidence: 99.9%
Identity: 24%
PDB header:immune system
Chain: A: PDB Molecule:perforin-1;
PDBTitle: the x-ray crystal structure of lymphocyte perforin

Phyre2

PDB 1rh8 chain A

3D model

Region: 755 - 880
Aligned: 122
Modelled: 126
Confidence: 99.9%
Identity: 39%
Fold: C2 domain-like
Superfamily: C2 domain (Calcium/lipid-binding domain, CaLB)
Family: Synaptotagmin-like (S variant)

Phyre2

PDB 2iub chain A domain 2

3D model

Region: 40 - 76
Aligned: 37
Modelled: 37
Confidence: 57.3%
Identity: 8%
Fold: Transmembrane helix hairpin
Superfamily: Magnesium transport protein CorA, transmembrane region
Family: Magnesium transport protein CorA, transmembrane region

Phyre2

PDB 2v6z chain M

3D model

Region: 110 - 128
Aligned: 19
Modelled: 19
Confidence: 52.6%
Identity: 21%
PDB header:transferase
Chain: M: PDB Molecule:dna polymerase epsilon subunit 2;
PDBTitle: solution structure of amino terminal domain of human dna2 polymerase epsilon subunit b

Phyre2
1
c2r83B_
2
c1dqvA_
3
c2z0uB_
4
c2dmgA_
5
c2d8kA_
6
d1wfma_
7
c2enpA_
8
c2q3xA_
9
d1v27a_
10
d1rsya_
11
c2chdA_
12
d2bwqa1
13
d1gmia_
14
d1dsya_
15
c3fbkB_
16
d1ugka_
17
d2r83a1
18
c2fk9A_
19
c3nsjA_
20
d1rh8a_
21
22
23
24
25
26
27
28
29
30
31
32
33
34
35
36
37
38
39
40
41
42
43
44
45
46
47
48
49
50
51
52
53
54
55
56
57
58
59
60
61
62
63
64
65
d2iuba2
66
c2v6zM_
67
68
69
70
71
72
73
74
75
76
77
78
79
80
81
82
83
84
85
86
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99



Detailed template information 

#
Template Alignment Coverage3D Model Confidence
% i.d. Template Information
1c2r83B_
100.0 38 PDB header:endocytosis, exocytosis
Chain: B: PDB Molecule:synaptotagmin-1;
PDBTitle: crystal structure analysis of human synaptotagmin 1 c2a-c2b
2c1dqvA_
100.0 31 PDB header:endocytosis/exocytosis
Chain: A: PDB Molecule:synaptotagmin iii;
PDBTitle: crystal structure of synaptotagmin iii c2a/c2b
3c2z0uB_
99.9 22 PDB header:lipid binding protein
Chain: B: PDB Molecule:ww domain-containing protein 1;
PDBTitle: crystal structure of c2 domain of kibra protein
4c2dmgA_
99.9 47 PDB header:lipid binding protein
Chain: A: PDB Molecule:kiaa1228 protein;
PDBTitle: solution structure of the third c2 domain of kiaa12282 protein
5c2d8kA_
99.9 38 PDB header:endocytosis/exocytosis
Chain: A: PDB Molecule:synaptotagmin vii;
PDBTitle: solution structure of the first c2 domain of synaptotagmin2 vii
6d1wfma_
99.9 21 Fold:C2 domain-like
Superfamily:C2 domain (Calcium/lipid-binding domain, CaLB)
Family:Synaptotagmin-like (S variant)
7c2enpA_
99.9 35 PDB header:transport protein
Chain: A: PDB Molecule:b/k protein;
PDBTitle: solution structure of the first c2 domain from human b/k2 protein
8c2q3xA_
99.9 31 PDB header:transport protein
Chain: A: PDB Molecule:regulating synaptic membrane exocytosis protein 1;
PDBTitle: the rim1alpha c2b domain
9d1v27a_
99.9 26 Fold:C2 domain-like
Superfamily:C2 domain (Calcium/lipid-binding domain, CaLB)
Family:Synaptotagmin-like (S variant)
10d1rsya_
99.9 32 Fold:C2 domain-like
Superfamily:C2 domain (Calcium/lipid-binding domain, CaLB)
Family:Synaptotagmin-like (S variant)
11c2chdA_
99.9 26 PDB header:protein transport
Chain: A: PDB Molecule:rabphilin-3a;
PDBTitle: crystal structure of the c2a domain of rabphilin-3a
12d2bwqa1
99.9 29 Fold:C2 domain-like
Superfamily:C2 domain (Calcium/lipid-binding domain, CaLB)
Family:Synaptotagmin-like (S variant)
13d1gmia_
99.9 20 Fold:C2 domain-like
Superfamily:C2 domain (Calcium/lipid-binding domain, CaLB)
Family:PLC-like (P variant)
14d1dsya_
99.9 31 Fold:C2 domain-like
Superfamily:C2 domain (Calcium/lipid-binding domain, CaLB)
Family:Synaptotagmin-like (S variant)
15c3fbkB_
99.9 27 PDB header:signaling protein
Chain: B: PDB Molecule:regulator of g-protein signaling 3;
PDBTitle: crystal structure of the c2 domain of the human regulator2 of g-protein signaling 3 isoform 6 (rgp3), northeast3 structural genomics consortium target hr5550a
16d1ugka_
99.9 32 Fold:C2 domain-like
Superfamily:C2 domain (Calcium/lipid-binding domain, CaLB)
Family:Synaptotagmin-like (S variant)
17d2r83a1
99.9 33 Fold:C2 domain-like
Superfamily:C2 domain (Calcium/lipid-binding domain, CaLB)
Family:Synaptotagmin-like (S variant)
18c2fk9A_
99.9 24 PDB header:transferase
Chain: A: PDB Molecule:protein kinase c, eta type;
PDBTitle: human protein kinase c, eta
19c3nsjA_
99.9 24 PDB header:immune system
Chain: A: PDB Molecule:perforin-1;
PDBTitle: the x-ray crystal structure of lymphocyte perforin
20d1rh8a_
99.9 39 Fold:C2 domain-like
Superfamily:C2 domain (Calcium/lipid-binding domain, CaLB)
Family:Synaptotagmin-like (S variant)
21c2b3rA_
not modelled 99.9 29 PDB header:transferase
Chain: A: PDB Molecule:phosphatidylinositol-4-phosphate 3-kinase c2 domain-
PDBTitle: crystal structure of the c2 domain of class ii phosphatidylinositide2 3-kinase c2
22c3m7fB_
not modelled 99.9 33 PDB header:signaling protein/ligase
Chain: B: PDB Molecule:e3 ubiquitin-protein ligase nedd4;
PDBTitle: crystal structure of the nedd4 c2/grb10 sh2 complex
23d1bdya_
not modelled 99.9 17 Fold:C2 domain-like
Superfamily:C2 domain (Calcium/lipid-binding domain, CaLB)
Family:PLC-like (P variant)
24c3jzyA_
not modelled 99.9 32 PDB header:endocytosis
Chain: A: PDB Molecule:intersectin 2;
PDBTitle: crystal structure of human intersectin 2 c2 domain
25d1dqva1
not modelled 99.9 36 Fold:C2 domain-like
Superfamily:C2 domain (Calcium/lipid-binding domain, CaLB)
Family:Synaptotagmin-like (S variant)
26c3fdwA_
not modelled 99.9 29 PDB header:lipid binding protein
Chain: A: PDB Molecule:synaptotagmin-like protein 4;
PDBTitle: crystal structure of a c2 domain from human synaptotagmin-2 like protein 4
27d1rlwa_
not modelled 99.9 27 Fold:C2 domain-like
Superfamily:C2 domain (Calcium/lipid-binding domain, CaLB)
Family:PLC-like (P variant)
28d1dqva2
not modelled 99.9 28 Fold:C2 domain-like
Superfamily:C2 domain (Calcium/lipid-binding domain, CaLB)
Family:Synaptotagmin-like (S variant)
29d1uowa_
not modelled 99.9 34 Fold:C2 domain-like
Superfamily:C2 domain (Calcium/lipid-binding domain, CaLB)
Family:Synaptotagmin-like (S variant)
30c2cm6A_
not modelled 99.9 30 PDB header:protein transport
Chain: A: PDB Molecule:rabphilin-3a;
PDBTitle: crystal structure of the c2b domain of rabphilin3a
31c2dmhA_
not modelled 99.9 23 PDB header:lipid binding protein
Chain: A: PDB Molecule:myoferlin;
PDBTitle: solution structure of the first c2 domain of human myoferlin
32d1byna_
not modelled 99.8 32 Fold:C2 domain-like
Superfamily:C2 domain (Calcium/lipid-binding domain, CaLB)
Family:Synaptotagmin-like (S variant)
33d1a25a_
not modelled 99.8 29 Fold:C2 domain-like
Superfamily:C2 domain (Calcium/lipid-binding domain, CaLB)
Family:Synaptotagmin-like (S variant)
34c3l9bA_
not modelled 99.8 23 PDB header:membrane protein
Chain: A: PDB Molecule:otoferlin;
PDBTitle: crystal structure of rat otoferlin c2a
35c3n5aA_
not modelled 99.8 32 PDB header:protein transport
Chain: A: PDB Molecule:synaptotagmin-7;
PDBTitle: synaptotagmin-7, c2b-domain, calcium bound
36d2cm5a1
not modelled 99.8 31 Fold:C2 domain-like
Superfamily:C2 domain (Calcium/lipid-binding domain, CaLB)
Family:Synaptotagmin-like (S variant)
37c3kwtA_
not modelled 99.8 35 PDB header:metal binding protein
Chain: A: PDB Molecule:munc13-1;
PDBTitle: munc13-1 c2b-domain, calcium-free
38d1wfja_
not modelled 99.8 19 Fold:C2 domain-like
Superfamily:C2 domain (Calcium/lipid-binding domain, CaLB)
Family:Synaptotagmin-like (S variant)
39c2nq3A_
not modelled 99.8 22 PDB header:ligase
Chain: A: PDB Molecule:itchy homolog e3 ubiquitin protein ligase;
PDBTitle: crystal structure of the c2 domain of human itchy homolog2 e3 ubiquitin protein ligase
40d2nq3a1
not modelled 99.8 22 Fold:C2 domain-like
Superfamily:C2 domain (Calcium/lipid-binding domain, CaLB)
Family:PLC-like (P variant)
41d2ep6a1
not modelled 99.8 33 Fold:C2 domain-like
Superfamily:C2 domain (Calcium/lipid-binding domain, CaLB)
Family:PLC-like (P variant)
42d2cjta1
not modelled 99.8 20 Fold:C2 domain-like
Superfamily:C2 domain (Calcium/lipid-binding domain, CaLB)
Family:PLC-like (P variant)
43c2enjA_
not modelled 99.8 14 PDB header:transferase
Chain: A: PDB Molecule:protein kinase c theta type;
PDBTitle: solution sturcture of the c2 domain from human protein2 kinase c theta
44d1w15a_
not modelled 99.8 31 Fold:C2 domain-like
Superfamily:C2 domain (Calcium/lipid-binding domain, CaLB)
Family:Synaptotagmin-like (S variant)
45c2nsqA_
not modelled 99.8 32 PDB header:ligase
Chain: A: PDB Molecule:e3 ubiquitin-protein ligase nedd4-like protein;
PDBTitle: crystal structure of the c2 domain of the human e3 ubiquitin-protein2 ligase nedd4-like protein
46d1qasa2
not modelled 99.7 20 Fold:C2 domain-like
Superfamily:C2 domain (Calcium/lipid-binding domain, CaLB)
Family:PLC-like (P variant)
47d2cjsa1
not modelled 99.7 19 Fold:C2 domain-like
Superfamily:C2 domain (Calcium/lipid-binding domain, CaLB)
Family:PLC-like (P variant)
48c1cjyB_
not modelled 99.7 27 PDB header:hydrolase
Chain: B: PDB Molecule:protein (cytosolic phospholipase a2);
PDBTitle: human cytosolic phospholipase a2
49c2jqzA_
not modelled 99.7 17 PDB header:ligase
Chain: A: PDB Molecule:e3 ubiquitin-protein ligase smurf2;
PDBTitle: solution structure of the c2 domain of human smurf2
50d2zkmx2
not modelled 99.6 28 Fold:C2 domain-like
Superfamily:C2 domain (Calcium/lipid-binding domain, CaLB)
Family:PLC-like (P variant)
51c1djyB_
not modelled 99.5 19 PDB header:lipid degradation
Chain: B: PDB Molecule:phosphoinositide-specific phospholipase c,
PDBTitle: phosphoinositide-specific phospholipase c-delta1 from rat2 complexed with inositol-2,4,5-trisphosphate
52c3ohmB_
not modelled 99.2 22 PDB header:signaling protein / hydrolase
Chain: B: PDB Molecule:1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase
PDBTitle: crystal structure of activated g alpha q bound to its effector2 phospholipase c beta 3
53c3qr0A_
not modelled 99.2 21 PDB header:hydrolase
Chain: A: PDB Molecule:phospholipase c-beta (plc-beta);
PDBTitle: crystal structure of s. officinalis plc21
54c2fjuB_
not modelled 99.0 32 PDB header:signaling protein,apoptosis/hydrolase
Chain: B: PDB Molecule:1-phosphatidylinositol-4,5-bisphosphate
PDBTitle: activated rac1 bound to its effector phospholipase c beta 2
55c3pfqA_
not modelled 98.6 27 PDB header:transferase
Chain: A: PDB Molecule:protein kinase c beta type;
PDBTitle: crystal structure and allosteric activation of protein kinase c beta2 ii
56d1e7ua2
not modelled 97.7 22 Fold:C2 domain-like
Superfamily:C2 domain (Calcium/lipid-binding domain, CaLB)
Family:PLC-like (P variant)
57c2enqA_
not modelled 97.5 12 PDB header:transferase
Chain: A: PDB Molecule:phosphatidylinositol-4,5-bisphosphate 3-kinase
PDBTitle: solution structure of the c2 domain from human pi3-kinase2 p110 subunit alpha
58d1e8ya2
not modelled 97.1 22 Fold:C2 domain-like
Superfamily:C2 domain (Calcium/lipid-binding domain, CaLB)
Family:PLC-like (P variant)
59c2wxoA_
not modelled 96.7 16 PDB header:transferase
Chain: A: PDB Molecule:phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic
PDBTitle: the crystal structure of the murine class ia pi 3-kinase2 p110delta in complex with as5.
60c1e8zA_
not modelled 96.4 22 PDB header:transferase
Chain: A: PDB Molecule:phosphatidylinositol 3-kinase catalytic subunit;
PDBTitle: structure determinants of phosphoinositide 3-kinase2 inhibition by wortmannin, ly294002, quercetin, myricetin3 and staurosporine
61c2rd0A_
not modelled 95.8 13 PDB header:transferase/oncoprotein
Chain: A: PDB Molecule:phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic
PDBTitle: structure of a human p110alpha/p85alpha complex
62c3l4cB_
not modelled 95.7 15 PDB header:cell adhesion, cell invasion, apoptosis
Chain: B: PDB Molecule:dedicator of cytokinesis protein 1;
PDBTitle: structural basis of membrane-targeting by dock180
63c2y3aA_
not modelled 93.2 16 PDB header:transferase
Chain: A: PDB Molecule:phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic
PDBTitle: crystal structure of p110beta in complex with icsh2 of p85beta and2 the drug gdc-0941
64d2yrba1
not modelled 81.7 8 Fold:C2 domain-like
Superfamily:C2 domain (Calcium/lipid-binding domain, CaLB)
Family:PLC-like (P variant)
65d2iuba2
57.3 8 Fold:Transmembrane helix hairpin
Superfamily:Magnesium transport protein CorA, transmembrane region
Family:Magnesium transport protein CorA, transmembrane region
66c2v6zM_
52.6 21 PDB header:transferase
Chain: M: PDB Molecule:dna polymerase epsilon subunit 2;
PDBTitle: solution structure of amino terminal domain of human dna2 polymerase epsilon subunit b
67c2kluA_
not modelled 49.9 27 PDB header:immune system, membrane protein
Chain: A: PDB Molecule:t-cell surface glycoprotein cd4;
PDBTitle: nmr structure of the transmembrane and cytoplasmic domains2 of human cd4
68d1ewfa1
not modelled 48.8 8 Fold:Aha1/BPI domain-like
Superfamily:Bactericidal permeability-increasing protein, BPI
Family:Bactericidal permeability-increasing protein, BPI
69d1d5ra1
not modelled 41.9 12 Fold:C2 domain-like
Superfamily:C2 domain (Calcium/lipid-binding domain, CaLB)
Family:PLC-like (P variant)
70c3c4mD_
not modelled 40.7 35 PDB header:membrane protein
Chain: D: PDB Molecule:parathyroid hormone;
PDBTitle: structure of human parathyroid hormone in complex with the2 extracellular domain of its g-protein-coupled receptor (pth1r)
71c3c4mC_
not modelled 40.7 35 PDB header:membrane protein
Chain: C: PDB Molecule:parathyroid hormone;
PDBTitle: structure of human parathyroid hormone in complex with the2 extracellular domain of its g-protein-coupled receptor (pth1r)
72c1bp1A_
not modelled 37.2 9 PDB header:bactericidal
Chain: A: PDB Molecule:bactericidal/permeability-increasing protein;
PDBTitle: crystal structure of bpi, the human bactericidal2 permeability-increasing protein
73c2r2cA_
not modelled 34.3 29 PDB header:membrane protein
Chain: A: PDB Molecule:28 kda outer membrane protein omp28;
PDBTitle: crystal structure of a domain of the outer membrane lipoprotein omp282 from porphyromonas gingivalis
74c1zwgA_
not modelled 23.0 32 PDB header:hormone
Chain: A: PDB Molecule:parathyroid hormone;
PDBTitle: succinyl human parathyroid hormone 4-37, nmr, 10 structures
75c3h8mB_
not modelled 20.8 37 PDB header:transferase
Chain: B: PDB Molecule:ephrin type-a receptor 7;
PDBTitle: sam domain of human ephrin type-a receptor 7 (epha7)
76c3snhA_
not modelled 18.9 29 PDB header:endocytosis
Chain: A: PDB Molecule:dynamin-1;
PDBTitle: crystal structure of nucleotide-free human dynamin1
77d1a8ra_
not modelled 16.3 19 Fold:T-fold
Superfamily:Tetrahydrobiopterin biosynthesis enzymes-like
Family:GTP cyclohydrolase I
78c2bbjB_
not modelled 16.0 14 PDB header:metal transport/membrane protein
Chain: B: PDB Molecule:divalent cation transport-related protein;
PDBTitle: crystal structure of the cora mg2+ transporter
79d1g0da2
not modelled 15.3 14 Fold:Immunoglobulin-like beta-sandwich
Superfamily:Transglutaminase, two C-terminal domains
Family:Transglutaminase, two C-terminal domains
80d1ciya3
not modelled 15.2 13 Fold:Toxins' membrane translocation domains
Superfamily:delta-Endotoxin (insectocide), N-terminal domain
Family:delta-Endotoxin (insectocide), N-terminal domain
81c1is7F_
not modelled 12.2 27 PDB header:hydrolase/protein binding
Chain: F: PDB Molecule:gtp cyclohydrolase i;
PDBTitle: crystal structure of rat gtpchi/gfrp stimulatory complex
82d1sdwa2
not modelled 12.0 22 Fold:Nucleoplasmin-like/VP (viral coat and capsid proteins)
Superfamily:PHM/PNGase F
Family:Peptidylglycine alpha-hydroxylating monooxygenase, PHM
83c1fvyA_
not modelled 11.8 44 PDB header:hormone/growth factor
Chain: A: PDB Molecule:parathyroid hormone;
PDBTitle: solution structure of the osteogenic 1-31 fragment of the2 human parathyroid hormone
84d1gmea_
not modelled 11.8 16 Fold:HSP20-like chaperones
Superfamily:HSP20-like chaperones
Family:HSP20
85d1jhna4
not modelled 11.7 15 Fold:Concanavalin A-like lectins/glucanases
Superfamily:Concanavalin A-like lectins/glucanases
Family:Calnexin/calreticulin
86c3kskA_
not modelled 11.5 13 PDB header:hydrolase
Chain: A: PDB Molecule:type-2 restriction enzyme pvuii;
PDBTitle: crystal structure of single chain pvuii
87c3zvrA_
not modelled 11.0 27 PDB header:hydrolase
Chain: A: PDB Molecule:dynamin-1;
PDBTitle: crystal structure of dynamin
88c3lkxB_
not modelled 10.7 30 PDB header:chaperone
Chain: B: PDB Molecule:nascent polypeptide-associated complex subunit alpha;
PDBTitle: human nac dimerization domain
89d1wpla_
not modelled 10.3 25 Fold:T-fold
Superfamily:Tetrahydrobiopterin biosynthesis enzymes-like
Family:GTP cyclohydrolase I
90d1dlca3
not modelled 10.2 25 Fold:Toxins' membrane translocation domains
Superfamily:delta-Endotoxin (insectocide), N-terminal domain
Family:delta-Endotoxin (insectocide), N-terminal domain
91c1wm9D_
not modelled 9.9 25 PDB header:hydrolase
Chain: D: PDB Molecule:gtp cyclohydrolase i;
PDBTitle: structure of gtp cyclohydrolase i from thermus thermophilus hb8
92d1wura1
not modelled 9.9 25 Fold:T-fold
Superfamily:Tetrahydrobiopterin biosynthesis enzymes-like
Family:GTP cyclohydrolase I
93c4e71A_
not modelled 9.5 22 PDB header:signaling protein
Chain: A: PDB Molecule:plexin-b2;
PDBTitle: crystal structure of the rho gtpase binding domain of plexin b2
94d2o8ra4
not modelled 9.4 17 Fold:Phospholipase D/nuclease
Superfamily:Phospholipase D/nuclease
Family:Polyphosphate kinase C-terminal domain
95c2op8A_
not modelled 9.2 33 PDB header:isomerase
Chain: A: PDB Molecule:probable tautomerase ywhb;
PDBTitle: crystal structure of ywhb- homologue of 4-oxalocrotonate tautomerase
96d1gmeb_
not modelled 9.2 16 Fold:HSP20-like chaperones
Superfamily:HSP20-like chaperones
Family:HSP20
97d1otfa_
not modelled 9.1 17 Fold:Tautomerase/MIF
Superfamily:Tautomerase/MIF
Family:4-oxalocrotonate tautomerase-like
98d1xdpa4
not modelled 8.9 11 Fold:Phospholipase D/nuclease
Superfamily:Phospholipase D/nuclease
Family:Polyphosphate kinase C-terminal domain
99c3pjvD_
not modelled 8.2 5 PDB header:lyase
Chain: D: PDB Molecule:cyclic dimeric gmp binding protein;
PDBTitle: structure of pseudomonas fluorescence lapd periplasmic domain

Binding site prediction 

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