Phyre Home Retrieve Phyre Job Id
Emaill.a.kelley@imperial.ac.uk
DescriptionQ9VPU1
DateTue Jan 22 11:34:19 GMT 2013
Unique Job ID1e0757b109763eb9

Summary 

Top model
Image coloured by rainbow N → C terminus
Model (left) based on template c2fo0A_
Top template information
PDB header:transferase
Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase abl1 (1b isoform);
PDBTitle: organization of the sh3-sh2 unit in active and inactive forms of the2 c-abl tyrosine kinase
Confidence and coverage
Confidence:100.0% Coverage: 32%
174 residues ( 32% of your sequence) have been modelled with 100.0% confidence by the single highest scoring template.
Additional confident templates have been detected (see Domain analysis) which cover other regions of your sequence.
342 residues ( 62%) could be modelled at >90% confidence using multiple-templates.
You may wish to try resubmitting your sequence in "intensive" mode to model more of your sequence.
3D viewing
Interactive 3D view in Jmol

Sequence analysis 

Secondary structure and disorder prediction 

   1........10.........20.........30.........40.........50.........60
Sequence  MLEHPQRFVRNIPDSSASSQQYPQQQQHPPQLPQHQNLNLNQNQNLNQNQIYQYRPQVPV
Secondary structure 
























































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Disorder  ????????????????????????????????????????????????????????????
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   .........70.........80.........90.........100.........110.........120
Sequence  PVPGSPAHHQRHSSLSQQQQLHHHRTLSTASSCSAQHKSVTFGQPALDCGGNGSGSANGS
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Disorder  ????????????????????????????????????????????????????????????
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   .........130.........140.........150.........160.........170.........180
Sequence  GSGNSSSGSAAGNAGTQSMAGNMKHGKSQDDVCYVVAKYDYAAQGAQELDLRKNERYLLL
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Disorder  ????????????????????????????????











????
?









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   .........190.........200.........210.........220.........230.........240
Sequence  DDSKHWWRVQNSRNQSGYVPSNYVKKEKPSLFDSIKKKVKKGSGSKTLPNCSPSRQVESP
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Disorder 










?















?????

?
???????????????????????
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   .........250.........260.........270.........280.........290.........300
Sequence  TMSRRLPPDPAEAIGTAVVKYNYQAQQPDELSLTKGTRILILEKSNDGWWRGQSGNSVGW
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Disorder  ????????????
?









?
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   .........310.........320.........330.........340.........350.........360
Sequence  FPSNYTTEDCDNDGEIHTYAMAENVLDIVVALYSFTSNNDQELSFEKGDRLEIVDRPASD
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Disorder 









????????????????









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   .........370.........380.........390.........400.........410.........420
Sequence  PDWYKARNNQGQVGLVPRNYLQELNDYLATPYRNASASAGNGNGGGSNGGAGGGGGNDSM
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?
?????????????????


??






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   .........430.........440.........450.........460.........470.........480
Sequence  ERRNEGNKPAAQSSGQPIERPNLAGKSWYYGAITRSQCDTVLNGHGHDGDFLIRDSETNM
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?
?























???
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   .........490.........500.........510.........520.........530.........540
Sequence  GDYSVSLKAPGRNKHFRVHVEQNMYCIGQRKFHSLDQLVDHYQRAPIYTNKQGEKLYLVR
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??
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   ........
Sequence  SLPKANGT
Secondary structure 







SS confidence 







Disorder 

??????
Disorder confidence 







 

Confidence Key
High(9)                    Low (0)
?Disordered
Alpha helix
Beta strand

Domain analysis 

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

RankAligned region

PDB 2fo0 chain A

3D model

Region: 299 - 548
Aligned: 174
Modelled: 194
Confidence: 100.0%
Identity: 36%
PDB header:transferase
Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase abl1 (1b isoform);
PDBTitle: organization of the sh3-sh2 unit in active and inactive forms of the2 c-abl tyrosine kinase

Phyre2

PDB 1k9a chain B

3D model

Region: 320 - 546
Aligned: 170
Modelled: 177
Confidence: 100.0%
Identity: 41%
PDB header:transferase
Chain: B: PDB Molecule:carboxyl-terminal src kinase;
PDBTitle: crystal structure analysis of full-length carboxyl-terminal2 src kinase at 2.5 a resolution

Phyre2

PDB 1y57 chain A

3D model

Region: 325 - 548
Aligned: 161
Modelled: 168
Confidence: 100.0%
Identity: 37%
PDB header:transferase
Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase src;
PDBTitle: structure of unphosphorylated c-src in complex with an inhibitor

Phyre2

PDB 1opl chain A

3D model

Region: 327 - 548
Aligned: 158
Modelled: 166
Confidence: 100.0%
Identity: 37%
PDB header:transferase
Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase;
PDBTitle: structural basis for the auto-inhibition of c-abl tyrosine2 kinase

Phyre2

PDB 2h8h chain A

3D model

Region: 328 - 547
Aligned: 157
Modelled: 164
Confidence: 100.0%
Identity: 38%
PDB header:transferase
Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase src;
PDBTitle: src kinase in complex with a quinazoline inhibitor

Phyre2

PDB 2abl chain A

3D model

Region: 320 - 543
Aligned: 160
Modelled: 168
Confidence: 100.0%
Identity: 36%
PDB header:transferase
Chain: A: PDB Molecule:abl tyrosine kinase;
PDBTitle: sh3-sh2 domain fragment of human bcr-abl tyrosine kinase

Phyre2

PDB 2c0i chain A

3D model

Region: 328 - 548
Aligned: 157
Modelled: 165
Confidence: 100.0%
Identity: 36%
PDB header:transferase
Chain: A: PDB Molecule:tyrosine-protein kinase hck;
PDBTitle: src family kinase hck with bound inhibitor a-420983

Phyre2

PDB 1x27 chain F

3D model

Region: 327 - 543
Aligned: 153
Modelled: 161
Confidence: 100.0%
Identity: 36%
PDB header:signaling protein
Chain: F: PDB Molecule:proto-oncogene tyrosine-protein kinase lck;
PDBTitle: crystal structure of lck sh2-sh3 with sh2 binding site of2 p130cas

Phyre2

PDB 3nhn chain A

3D model

Region: 327 - 543
Aligned: 154
Modelled: 161
Confidence: 100.0%
Identity: 36%
PDB header:transferase
Chain: A: PDB Molecule:tyrosine-protein kinase hck;
PDBTitle: crystal structure of the src-family kinase hck sh3-sh2-linker2 regulatory region

Phyre2

PDB 1g83 chain A

3D model

Region: 327 - 541
Aligned: 152
Modelled: 159
Confidence: 100.0%
Identity: 38%
PDB header:transferase
Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase fyn;
PDBTitle: crystal structure of fyn sh3-sh2

Phyre2

PDB 2b3o chain A

3D model

Region: 324 - 543
Aligned: 163
Modelled: 164
Confidence: 100.0%
Identity: 27%
PDB header:hydrolase
Chain: A: PDB Molecule:tyrosine-protein phosphatase, non-receptor type
PDBTitle: crystal structure of human tyrosine phosphatase shp-1

Phyre2

PDB 3ps5 chain A

3D model

Region: 327 - 543
Aligned: 159
Modelled: 161
Confidence: 100.0%
Identity: 29%
PDB header:hydrolase, signaling protein
Chain: A: PDB Molecule:tyrosine-protein phosphatase non-receptor type 6;
PDBTitle: crystal structure of the full-length human protein tyrosine2 phosphatase shp-1

Phyre2

PDB 2shp chain A

3D model

Region: 324 - 543
Aligned: 163
Modelled: 164
Confidence: 100.0%
Identity: 23%
PDB header:tyrosine phosphatase
Chain: A: PDB Molecule:shp-2;
PDBTitle: tyrosine phosphatase shp-2

Phyre2

PDB 2ci8 chain A

3D model

Region: 447 - 542
Aligned: 96
Modelled: 96
Confidence: 100.0%
Identity: 60%
PDB header:translation
Chain: A: PDB Molecule:cytoplasmic protein nck1;
PDBTitle: sh2 domain of human nck1 adaptor protein - uncomplexed

Phyre2

PDB 2eo6 chain A

3D model

Region: 369 - 547
Aligned: 123
Modelled: 123
Confidence: 100.0%
Identity: 28%
PDB header:signaling protein
Chain: A: PDB Molecule:b-cell linker protein;
PDBTitle: solution structure of the sh2 domain from mouse b-cell2 linker protein blnk

Phyre2

PDB 2shp chain A domain 2

3D model

Region: 444 - 548
Aligned: 105
Modelled: 105
Confidence: 100.0%
Identity: 30%
Fold: SH2-like
Superfamily: SH2 domain
Family: SH2 domain

Phyre2

PDB 2eo3 chain A

3D model

Region: 369 - 544
Aligned: 109
Modelled: 116
Confidence: 100.0%
Identity: 35%
PDB header:signaling protein
Chain: A: PDB Molecule:crk-like protein;
PDBTitle: solution structure of the sh2 domain from human crk-like2 protein

Phyre2

PDB 2lqn chain A

3D model

Region: 437 - 548
Aligned: 111
Modelled: 112
Confidence: 100.0%
Identity: 28%
PDB header:signaling protein
Chain: A: PDB Molecule:crk-like protein;
PDBTitle: solution structure of crkl

Phyre2

PDB 1x6c chain A

3D model

Region: 441 - 545
Aligned: 104
Modelled: 105
Confidence: 100.0%
Identity: 29%
PDB header:signaling protein
Chain: A: PDB Molecule:tyrosine-protein phosphatase, non-receptor type
PDBTitle: solution structures of the sh2 domain of human protein-2 tyrosine phosphatase shp-1

Phyre2

PDB 1gri chain A

3D model

Region: 153 - 385
Aligned: 202
Modelled: 210
Confidence: 100.0%
Identity: 23%
PDB header:signal transduction adaptor
Chain: A: PDB Molecule:growth factor bound protein 2;
PDBTitle: grb2

Phyre2

PDB 2l3s chain A

3D model

Region: 152 - 310
Aligned: 159
Modelled: 159
Confidence: 99.9%
Identity: 20%
PDB header:structural protein
Chain: A: PDB Molecule:autoinhibited crk protein;
PDBTitle: structure of the autoinhibited crk

Phyre2
1

c2fo0A_
2

c1k9aB_
3

c1y57A_
4

c1oplA_
5

c2h8hA_
6

c2ablA_
7

c2c0iA_
8

c1x27F_
9

c3nhnA_
10

c1g83A_
11

c2b3oA_
12

c3ps5A_
13

c2shpA_
14

c2ci8A_
15

c2eo6A_
16

d2shpa2
17

c2eo3A_
18

c2lqnA_
19

c1x6cA_
20

c1griA_
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c2l3sA_
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Detailed template information 

#
Template Alignment Coverage3D Model Confidence
% i.d. Template Information
1c2fo0A_



100.0 36 PDB header:transferase
Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase abl1 (1b isoform);
PDBTitle: organization of the sh3-sh2 unit in active and inactive forms of the2 c-abl tyrosine kinase
2c1k9aB_



100.0 41 PDB header:transferase
Chain: B: PDB Molecule:carboxyl-terminal src kinase;
PDBTitle: crystal structure analysis of full-length carboxyl-terminal2 src kinase at 2.5 a resolution
3c1y57A_



100.0 37 PDB header:transferase
Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase src;
PDBTitle: structure of unphosphorylated c-src in complex with an inhibitor
4c1oplA_



100.0 37 PDB header:transferase
Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase;
PDBTitle: structural basis for the auto-inhibition of c-abl tyrosine2 kinase
5c2h8hA_



100.0 38 PDB header:transferase
Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase src;
PDBTitle: src kinase in complex with a quinazoline inhibitor
6c2ablA_



100.0 36 PDB header:transferase
Chain: A: PDB Molecule:abl tyrosine kinase;
PDBTitle: sh3-sh2 domain fragment of human bcr-abl tyrosine kinase
7c2c0iA_



100.0 36 PDB header:transferase
Chain: A: PDB Molecule:tyrosine-protein kinase hck;
PDBTitle: src family kinase hck with bound inhibitor a-420983
8c1x27F_



100.0 36 PDB header:signaling protein
Chain: F: PDB Molecule:proto-oncogene tyrosine-protein kinase lck;
PDBTitle: crystal structure of lck sh2-sh3 with sh2 binding site of2 p130cas
9c3nhnA_



100.0 36 PDB header:transferase
Chain: A: PDB Molecule:tyrosine-protein kinase hck;
PDBTitle: crystal structure of the src-family kinase hck sh3-sh2-linker2 regulatory region
10c1g83A_



100.0 38 PDB header:transferase
Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase fyn;
PDBTitle: crystal structure of fyn sh3-sh2
11c2b3oA_



100.0 27 PDB header:hydrolase
Chain: A: PDB Molecule:tyrosine-protein phosphatase, non-receptor type
PDBTitle: crystal structure of human tyrosine phosphatase shp-1
12c3ps5A_



100.0 29 PDB header:hydrolase, signaling protein
Chain: A: PDB Molecule:tyrosine-protein phosphatase non-receptor type 6;
PDBTitle: crystal structure of the full-length human protein tyrosine2 phosphatase shp-1
13c2shpA_



100.0 23 PDB header:tyrosine phosphatase
Chain: A: PDB Molecule:shp-2;
PDBTitle: tyrosine phosphatase shp-2
14c2ci8A_



100.0 60 PDB header:translation
Chain: A: PDB Molecule:cytoplasmic protein nck1;
PDBTitle: sh2 domain of human nck1 adaptor protein - uncomplexed
15c2eo6A_



100.0 28 PDB header:signaling protein
Chain: A: PDB Molecule:b-cell linker protein;
PDBTitle: solution structure of the sh2 domain from mouse b-cell2 linker protein blnk
16d2shpa2



100.0 30 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
17c2eo3A_



100.0 35 PDB header:signaling protein
Chain: A: PDB Molecule:crk-like protein;
PDBTitle: solution structure of the sh2 domain from human crk-like2 protein
18c2lqnA_



100.0 28 PDB header:signaling protein
Chain: A: PDB Molecule:crk-like protein;
PDBTitle: solution structure of crkl
19c1x6cA_



100.0 29 PDB header:signaling protein
Chain: A: PDB Molecule:tyrosine-protein phosphatase, non-receptor type
PDBTitle: solution structures of the sh2 domain of human protein-2 tyrosine phosphatase shp-1
20c1griA_



100.0 23 PDB header:signal transduction adaptor
Chain: A: PDB Molecule:growth factor bound protein 2;
PDBTitle: grb2
21c3hizB_



not modelled 100.0 29 PDB header:transferase/oncoprotein
Chain: B: PDB Molecule:phosphatidylinositol 3-kinase regulatory subunit
PDBTitle: crystal structure of p110alpha h1047r mutant in complex with2 nish2 of p85alpha
22c2crhA_



not modelled 100.0 21 PDB header:signaling protein
Chain: A: PDB Molecule:vav proto-oncogene;
PDBTitle: solution structure of the sh2 domain of human proto-2 oncogene protein vav1
23d3c7ia1



not modelled 100.0 33 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
24c2gsbA_



not modelled 100.0 29 PDB header:signaling protein
Chain: A: PDB Molecule:ras gtpase-activating protein 1;
PDBTitle: solution structure of the second sh2 domain of human ras2 gtpase-activating protein 1
25d2oq1a1



not modelled 100.0 27 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
26d1a81a1



not modelled 100.0 23 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
27c2dlyA_



not modelled 100.0 29 PDB header:transferase
Chain: A: PDB Molecule:fyn-related kinase;
PDBTitle: solution structure of the sh2 domain of murine fyn-related2 kinase
28c2dlzA_



not modelled 100.0 25 PDB header:signaling protein
Chain: A: PDB Molecule:protein vav-2;
PDBTitle: solution structure of the sh2 domain of human protein vav-2
29d1mila_



not modelled 100.0 24 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
30d1fhsa_



not modelled 100.0 32 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
31c2oq1A_



not modelled 100.0 27 PDB header:transferase
Chain: A: PDB Molecule:tyrosine-protein kinase zap-70;
PDBTitle: tandem sh2 domains of zap-70 with 19-mer zeta1 peptide
32c2hdxB_



not modelled 100.0 26 PDB header:signaling protein
Chain: B: PDB Molecule:sh2-b ph domain containing signaling mediator 1
PDBTitle: crystal structure of the src homology-2 domain of sh2-b in2 complex with jak2 ptyr813 phosphopeptide
33c3gqiB_



not modelled 100.0 31 PDB header:transferase/transferase inhibitor
Chain: B: PDB Molecule:phospholipase c-gamma-1;
PDBTitle: crystal structure of activated receptor tyrosine kinase in complex2 with substrates
34d1a81e1



not modelled 99.9 23 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
35c2y3aB_



not modelled 99.9 31 PDB header:transferase
Chain: B: PDB Molecule:phosphatidylinositol 3-kinase regulatory subunit beta;
PDBTitle: crystal structure of p110beta in complex with icsh2 of p85beta and2 the drug gdc-0941
36c2eobA_



not modelled 99.9 28 PDB header:hydrolase
Chain: A: PDB Molecule:1-phosphatidylinositol-4,5-bisphosphate
PDBTitle: solution structure of the second sh2 domain from rat plc2 gamma-2
37d1rjaa_



not modelled 99.9 27 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
38c2el8A_



not modelled 99.9 22 PDB header:signaling protein
Chain: A: PDB Molecule:signal-transducing adaptor protein 2;
PDBTitle: solution structure of the human stap2 sh2 domain
39c2kk6A_



not modelled 99.9 33 PDB header:transferase
Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase fer;
PDBTitle: solution structure of sh2 domain of proto-oncogene tyrosine-2 protein kinase fer from homo sapiens, northeast structural3 genomics consortium (nesg) target hr3461d
40c1ka6A_



not modelled 99.9 26 PDB header:immune system
Chain: A: PDB Molecule:sh2 domain protein 1a;
PDBTitle: sap/sh2d1a bound to peptide n-py
41d1ayaa_



not modelled 99.9 29 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
42d2izva2



not modelled 99.9 22 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
43d2oq1a2



not modelled 99.9 29 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
44d1d4ta_



not modelled 99.9 28 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
45c2ozoA_



not modelled 99.9 27 PDB header:transferase
Chain: A: PDB Molecule:tyrosine-protein kinase zap-70;
PDBTitle: autoinhibited intact human zap-70
46d2eyva1



not modelled 99.9 31 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
47c1ng2A_



not modelled 99.9 20 PDB header:oxidoreductase activator
Chain: A: PDB Molecule:neutrophil cytosolic factor 1;
PDBTitle: structure of autoinhibited p47phox
48c2vifA_



not modelled 99.9 29 PDB header:signaling protein
Chain: A: PDB Molecule:suppressor of cytokine signalling 6;
PDBTitle: crystal structure of socs6 sh2 domain in complex with a c-kit2 phosphopeptide
49d1a81e2



not modelled 99.9 29 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
50d1a81a2



not modelled 99.9 32 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
51d1nrva_



not modelled 99.9 29 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
52c4fl2A_



not modelled 99.9 24 PDB header:transferase
Chain: A: PDB Molecule:tyrosine-protein kinase syk;
PDBTitle: structural and biophysical characterization of the syk activation2 switch
53c2ysxA_



not modelled 99.9 29 PDB header:signaling protein
Chain: A: PDB Molecule:signaling inositol polyphosphate phosphatase
PDBTitle: solution structure of the human ship sh2 domain
54d1jwoa_



not modelled 99.9 29 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
55d1pica_



not modelled 99.9 26 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
56d1csya_



not modelled 99.9 27 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
57d1r1qa_



not modelled 99.9 32 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
58d1opka2



not modelled 99.9 34 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
59d1blja_



not modelled 99.9 27 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
60d1jyra_



not modelled 99.9 36 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
61d2shpa3



not modelled 99.9 29 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
62d2fcia1



not modelled 99.9 31 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
63c2dcrA_



not modelled 99.9 32 PDB header:transferase
Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase fes/fps;
PDBTitle: fully automated solution structure determination of the fes2 sh2 domain
64d1k9aa2



not modelled 99.9 31 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
65c2lctA_



not modelled 99.9 24 PDB header:signaling protein
Chain: A: PDB Molecule:proto-oncogene vav;
PDBTitle: solution structure of the vav1 sh2 domain complexed with a syk-derived2 doubly phosphorylated peptide
66c2hmhA_



not modelled 99.9 25 PDB header:cytokine regulator
Chain: A: PDB Molecule:suppressor of cytokine signaling 3;
PDBTitle: crystal structure of socs3 in complex with gp130(ptyr757)2 phosphopeptide.
67d1fu6a_



not modelled 99.9 29 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
68c1ov3A_



not modelled 99.9 24 PDB header:oxidoreductase activator
Chain: A: PDB Molecule:neutrophil cytosol factor 1;
PDBTitle: structure of the p22phox-p47phox complex
69c2c9wA_



not modelled 99.9 28 PDB header:transcription regulation
Chain: A: PDB Molecule:suppressor of cytokine signaling 2;
PDBTitle: crystal structure of socs-2 in complex with elongin-b and2 elongin-c at 1.9a resolution
70c2izvA_



not modelled 99.9 22 PDB header:transcription
Chain: A: PDB Molecule:suppressor of cytokine signaling 4;
PDBTitle: crystal structure of socs-4 in complex with elongin-b and2 elongin-c at 2.55a resolution
71c2ge9A_



not modelled 99.9 27 PDB header:transferase
Chain: A: PDB Molecule:tyrosine-protein kinase btk;
PDBTitle: solution structures of the sh2 domain of bruton's tyrosine2 kinase
72c2augB_



not modelled 99.9 27 PDB header:signaling protein
Chain: B: PDB Molecule:growth factor receptor-bound protein 14;
PDBTitle: crystal structure of the grb14 sh2 domain
73d1lkka_



not modelled 99.9 29 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
74d1qcfa2



not modelled 99.9 33 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
75d1i3za_



not modelled 99.9 29 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
76d1o48a_



not modelled 99.9 32 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
77d2qmsa1



not modelled 99.9 27 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
78c1a81E_



not modelled 99.9 29 PDB header:complex (transferase/peptide)
Chain: E: PDB Molecule:syk kinase;
PDBTitle: crystal structure of the tandem sh2 domain of the syk kinase bound to2 a dually tyrosine-phosphorylated itam
79d1qada_



not modelled 99.9 29 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
80d1f2fa_



not modelled 99.9 33 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
81c2knoA_



not modelled 99.9 29 PDB header:hydrolase
Chain: A: PDB Molecule:tensin-like c1 domain-containing phosphatase;
PDBTitle: nmr solution structure of sh2 domain of the human tensin like c12 domain containing phosphatase (tenc1)
82c2eyzA_



not modelled 99.9 14 PDB header:signaling protein
Chain: A: PDB Molecule:v-crk sarcoma virus ct10 oncogene homolog
PDBTitle: ct10-regulated kinase isoform ii
83d1bkla_



not modelled 99.9 32 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
84d1g83a2



not modelled 99.9 34 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
85d1luia_



not modelled 99.9 29 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
86c2cr4A_



not modelled 99.9 20 PDB header:signaling protein
Chain: A: PDB Molecule:sh3 domain-binding protein 2;
PDBTitle: solution structure of the sh2 domain of human sh3bp2 protein
87d1rpya_



not modelled 99.9 25 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
88c1rqqC_



not modelled 99.9 25 PDB header:transferase/signaling protein
Chain: C: PDB Molecule:adaptor protein aps;
PDBTitle: crystal structure of the insulin receptor kinase in complex2 with the sh2 domain of aps
89d2cs0a1



not modelled 99.9 30 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
90c2ekxA_



not modelled 99.9 32 PDB header:signaling protein
Chain: A: PDB Molecule:cytoplasmic tyrosine-protein kinase bmx;
PDBTitle: solution structure of the human bmx sh2 domain
91c3mazA_



not modelled 99.9 18 PDB header:signaling protein
Chain: A: PDB Molecule:signal-transducing adaptor protein 1;
PDBTitle: crystal structure of the human brdg1/stap-1 sh2 domain in complex with2 the ntal ptyr136 peptide
92d1xa6a2



not modelled 99.9 22 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
93d2c9wa2



not modelled 99.9 26 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
94c2l3sA_



99.9 20 PDB header:structural protein
Chain: A: PDB Molecule:autoinhibited crk protein;
PDBTitle: structure of the autoinhibited crk
95d1cwea_



not modelled 99.9 31 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
96c2dvjA_



not modelled 99.9 29 PDB header:signaling protein
Chain: A: PDB Molecule:v-crk sarcoma virus ct10 oncogene homolog,
PDBTitle: phosphorylated crk-ii
97c2dm0A_



not modelled 99.9 22 PDB header:transferase
Chain: A: PDB Molecule:tyrosine-protein kinase txk;
PDBTitle: solution structure of the sh2 domain of human tyrosine-2 protein kinase txk
98c2eyyA_



not modelled 99.9 29 PDB header:signaling protein
Chain: A: PDB Molecule:v-crk sarcoma virus ct10 oncogene homolog
PDBTitle: ct10-regulated kinase isoform i
99c3qwyA_



not modelled 99.9 20 PDB header:signaling protein
Chain: A: PDB Molecule:cell death abnormality protein 2;
PDBTitle: ced-2
100c3qwxX_



not modelled 99.9 20 PDB header:signaling protein
Chain: X: PDB Molecule:cell death abnormality protein 2;
PDBTitle: ced-2 1-174
101c3gxxB_



not modelled 99.9 21 PDB header:transcription
Chain: B: PDB Molecule:transcription elongation factor spt6;
PDBTitle: structure of the sh2 domain of the candida glabrata2 transcription elongation factor spt6, crystal form b
102c2dx0B_



not modelled 99.8 33 PDB header:hydrolase
Chain: B: PDB Molecule:phospholipase c, gamma 2;
PDBTitle: crystal structure of the n-terminal sh2 domain of mouse2 phospholipase c-gamma 2
103c3or8A_



not modelled 99.8 24 PDB header:transcription
Chain: A: PDB Molecule:transcription elongation factor spt6;
PDBTitle: a tandem sh2 domain in transcription elongation factor spt6
104c2xp1A_



not modelled 99.8 18 PDB header:transcription
Chain: A: PDB Molecule:spt6;
PDBTitle: structure of the tandem sh2 domains from antonospora locustae2 transcription elongation factor spt6
105c1xa6A_



not modelled 99.8 27 PDB header:signaling protein
Chain: A: PDB Molecule:beta2-chimaerin;
PDBTitle: crystal structure of the human beta2-chimaerin
106c2yt6A_



not modelled 99.8 33 PDB header:cell cycle
Chain: A: PDB Molecule:adult male urinary bladder cdna, riken full-
PDBTitle: solution structure of the sh3_1 domain of yamaguchi sarcoma2 viral (v-yes) oncogene homolog 1
107d1uura3



not modelled 99.8 22 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
108c1mv3A_



not modelled 99.8 13 PDB header:endocytosis/exocytosis
Chain: A: PDB Molecule:myc box dependent interacting protein 1;
PDBTitle: nmr structure of the tumor suppressor bin1: alternative2 splicing in melanoma and interaction with c-myc
109d1udla_



not modelled 99.7 31 Fold:SH3-like barrel
Superfamily:SH3-domain
Family:SH3-domain
110d1bf5a3



not modelled 99.7 17 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
111c1wx6A_



not modelled 99.7 37 PDB header:structural genomics, unknown function
Chain: A: PDB Molecule:cytoplasmic protein nck2;
PDBTitle: solution structure of the sh3 domain of the human2 cytoplasmic protein nck2
112d1ng2a2



not modelled 99.6 16 Fold:SH3-like barrel
Superfamily:SH3-domain
Family:SH3-domain
113d1u5sa1



not modelled 99.6 47 Fold:SH3-like barrel
Superfamily:SH3-domain
Family:SH3-domain
114c2jxbA_



not modelled 99.6 27 PDB header:signaling protein complex
Chain: A: PDB Molecule:t-cell surface glycoprotein cd3 epsilon chain,
PDBTitle: structure of cd3epsilon-nck2 first sh3 domain complex
115c2dlpA_



not modelled 99.6 26 PDB header:structural protein
Chain: A: PDB Molecule:kiaa1783 protein;
PDBTitle: solution structure of the sh3 domain of human kiaa17832 protein
116d1wiea_



not modelled 99.6 23 Fold:SH3-like barrel
Superfamily:SH3-domain
Family:SH3-domain
117c1u3oA_



not modelled 99.6 30 PDB header:signaling protein
Chain: A: PDB Molecule:huntingtin-associated protein-interacting
PDBTitle: solution structure of rat kalirin n-terminal sh3 domain
118c2e5kA_



not modelled 99.6 19 PDB header:protein binding
Chain: A: PDB Molecule:suppressor of t-cell receptor signaling 1;
PDBTitle: solution structure of sh3 domain in suppressor of t-cell2 receptor signaling 1
119c1x2qA_



not modelled 99.6 27 PDB header:signaling protein
Chain: A: PDB Molecule:signal transducing adapter molecule 2;
PDBTitle: solution structure of the sh3 domain of the signal2 transducing adaptor molecule 2
120c2dybA_



not modelled 99.6 21 PDB header:oxidoreductase
Chain: A: PDB Molecule:neutrophil cytosol factor 4;
PDBTitle: the crystal structure of human p40(phox)

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