Phyre Home Retrieve Phyre Job Id
Emaill.a.kelley@imperial.ac.uk
DescriptionQ9N6D8
DateWed Feb 13 11:38:56 GMT 2013
Unique Job IDfb766fabc982a79e

Summary 

Top model
Image coloured by rainbow N → C terminus
Model (left) based on template c2xipA_
Top template information
PDB header:cell cycle
Chain: A: PDB Molecule:tumour protein p73;
PDBTitle: crystal structure of the dna binding domain of human tp732 refined at 1.8 a resolution
Confidence and coverage
Confidence:100.0% Coverage: 51%
195 residues ( 51% of your sequence) have been modelled with 100.0% confidence by the single highest scoring template.
Additional confident templates have been detected (see Domain analysis) which cover other regions of your sequence.
288 residues ( 75%) could be modelled at >90% confidence using multiple-templates.
You may wish to try resubmitting your sequence in "intensive" mode to model more of your sequence.
3D viewing
Interactive 3D view in Jmol

Sequence analysis 

Secondary structure and disorder prediction 

   1........10.........20.........30.........40.........50.........60
Sequence  MYISQPMSWHKESTDSEDDSTEVDIKEDIPKTVEVSGSELTTEPMAFLQGLNSGNLMQFS
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Disorder  ???????
?
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?????
???????
???????????
?
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   .........70.........80.........90.........100.........110.........120
Sequence  QQSVLREMMLQDIQIQANTLPKLENHNIGGYCFSMVLDEPPKSLWMYSIPLNKLYIRMNK
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Disorder 

????????????????????














?
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   .........130.........140.........150.........160.........170.........180
Sequence  AFNVDVQFKSKMPIQPLNLRVFLCFSNDVSAPVVRCQNHLSVEPLTANNAKMRESLLRSE
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   .........190.........200.........210.........220.........230.........240
Sequence  NPNSVYCGNAQGKGISERFSVVVPLNMSRSVTRSGLTRQTLAFKFVCQNSCIGRKETSLV
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   .........250.........260.........270.........280.........290.........300
Sequence  FCLEKACGDIVGQHVIHVKICTCPKRDRIQDERQLNSKKRKSVPEAAEEDEPSKVRRCIA
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????


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   .........310.........320.........330.........340.........350.........360
Sequence  IKTEDTESNDSRDCDDSAAEWNVSRTPDGDYRLAITCPNKEWLLQSIEGMIKEAAAEVLR
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Disorder  ??????????????????
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   .........370.........380.....
Sequence  NPNQENLRRHANKLLSLKKRAYELP
Secondary structure 





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Confidence Key
High(9)                    Low (0)
?Disordered
Alpha helix
Beta strand

Domain analysis 

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

RankAligned region

PDB 2xip chain A

3D model

Region: 77 - 280
Aligned: 195
Modelled: 204
Confidence: 100.0%
Identity: 27%
PDB header:cell cycle
Chain: A: PDB Molecule:tumour protein p73;
PDBTitle: crystal structure of the dna binding domain of human tp732 refined at 1.8 a resolution

Phyre2

PDB 2rmn chain A

3D model

Region: 72 - 300
Aligned: 215
Modelled: 229
Confidence: 100.0%
Identity: 24%
PDB header:cell cycle, antitumor protein
Chain: A: PDB Molecule:tumor protein 63;
PDBTitle: the solution structure of the p63 dna-binding domain

Phyre2

PDB 3q06 chain B

3D model

Region: 79 - 282
Aligned: 191
Modelled: 202
Confidence: 100.0%
Identity: 28%
PDB header:cell cycle/dna
Chain: B: PDB Molecule:cellular tumor antigen p53;
PDBTitle: an induced fit mechanism regulates p53 dna binding kinetics to confer2 sequence specificity

Phyre2

PDB 2ac0 chain A domain 1

3D model

Region: 79 - 275
Aligned: 185
Modelled: 197
Confidence: 100.0%
Identity: 26%
Fold: Common fold of diphtheria toxin/transcription factors/cytochrome f
Superfamily: p53-like transcription factors
Family: p53 DNA-binding domain-like

Phyre2

PDB 2j1x chain A

3D model

Region: 79 - 275
Aligned: 185
Modelled: 197
Confidence: 100.0%
Identity: 27%
PDB header:nuclear protein
Chain: A: PDB Molecule:cellular tumor antigen p53;
PDBTitle: human p53 core domain mutant m133l-v203a-y220c-n239y-n268d

Phyre2

PDB 1hu8 chain A

3D model

Region: 87 - 273
Aligned: 176
Modelled: 187
Confidence: 100.0%
Identity: 29%
Fold: Common fold of diphtheria toxin/transcription factors/cytochrome f
Superfamily: p53-like transcription factors
Family: p53 DNA-binding domain-like

Phyre2

PDB 2rp4 chain C

3D model

Region: 315 - 385
Aligned: 71
Modelled: 71
Confidence: 100.0%
Identity: 100%
PDB header:transcription
Chain: C: PDB Molecule:transcription factor p53;
PDBTitle: solution structure of the oligomerization domain in dmp53

Phyre2

PDB 1t4w chain A

3D model

Region: 90 - 270
Aligned: 164
Modelled: 181
Confidence: 98.7%
Identity: 21%
Fold: Common fold of diphtheria toxin/transcription factors/cytochrome f
Superfamily: p53-like transcription factors
Family: p53 DNA-binding domain-like

Phyre2

PDB 3k2k chain A

3D model

Region: 43 - 115
Aligned: 65
Modelled: 72
Confidence: 38.4%
Identity: 8%
PDB header:hydrolase
Chain: A: PDB Molecule:putative carboxypeptidase;
PDBTitle: crystal structure of putative carboxypeptidase (yp_103406.1) from2 burkholderia mallei atcc 23344 at 2.49 a resolution

Phyre2

PDB 4gop chain B

3D model

Region: 232 - 254
Aligned: 23
Modelled: 23
Confidence: 21.8%
Identity: 26%
PDB header:dna binding protein/dna
Chain: B: PDB Molecule:putative uncharacterized protein;
PDBTitle: structure and conformational change of a replication protein a2 heterotrimer bound to ssdna

Phyre2

PDB 4a37 chain A

3D model

Region: 45 - 115
Aligned: 63
Modelled: 71
Confidence: 21.5%
Identity: 16%
PDB header:hydrolase
Chain: A: PDB Molecule:metallo-carboxypeptidase;
PDBTitle: metallo-carboxypeptidase from pseudomonas aeruginosa

Phyre2

PDB 3l2n chain A

3D model

Region: 50 - 115
Aligned: 58
Modelled: 66
Confidence: 19.2%
Identity: 16%
PDB header:hydrolase
Chain: A: PDB Molecule:peptidase m14, carboxypeptidase a;
PDBTitle: crystal structure of putative carboxypeptidase a (yp_562911.1) from2 shewanella denitrificans os-217 at 2.39 a resolution

Phyre2

PDB 2kum chain A

3D model

Region: 238 - 293
Aligned: 44
Modelled: 56
Confidence: 18.6%
Identity: 14%
PDB header:signaling protein
Chain: A: PDB Molecule:c-c motif chemokine 27;
PDBTitle: solution structure of the human chemokine ccl27

Phyre2

PDB 2b5d chain X domain 1

3D model

Region: 341 - 384
Aligned: 40
Modelled: 44
Confidence: 18.6%
Identity: 18%
Fold: immunoglobulin/albumin-binding domain-like
Superfamily: Families 57/38 glycoside transferase middle domain
Family: AmyC C-terminal domain-like

Phyre2

PDB 2l4n chain A

3D model

Region: 238 - 265
Aligned: 19
Modelled: 19
Confidence: 17.3%
Identity: 26%
PDB header:cytokine
Chain: A: PDB Molecule:c-c motif chemokine 21;
PDBTitle: solution structure of the chemokine ccl21

Phyre2

PDB 3gyc chain B

3D model

Region: 258 - 264
Aligned: 7
Modelled: 7
Confidence: 17.0%
Identity: 29%
PDB header:hydrolase
Chain: B: PDB Molecule:putative glycoside hydrolase;
PDBTitle: crystal structure of putative glycoside hydrolase (yp_001304622.1)2 from parabacteroides distasonis atcc 8503 at 1.85 a resolution

Phyre2

PDB 1ufa chain A domain 1

3D model

Region: 338 - 384
Aligned: 38
Modelled: 43
Confidence: 15.3%
Identity: 13%
Fold: immunoglobulin/albumin-binding domain-like
Superfamily: Families 57/38 glycoside transferase middle domain
Family: AmyC C-terminal domain-like

Phyre2

PDB 3cgu chain B

3D model

Region: 259 - 267
Aligned: 9
Modelled: 9
Confidence: 15.0%
Identity: 33%
PDB header:hormone/signaling protein
Chain: B: PDB Molecule:protein giant-lens;
PDBTitle: crystal structure of unliganded argos

Phyre2

PDB 2bsj chain B

3D model

Region: 328 - 343
Aligned: 16
Modelled: 16
Confidence: 14.3%
Identity: 31%
PDB header:chaperone
Chain: B: PDB Molecule:chaperone protein syct;
PDBTitle: native crystal structure of the type iii secretion2 chaperone syct from yersinia enterocolitica

Phyre2

PDB 2jo1 chain A

3D model

Region: 276 - 297
Aligned: 22
Modelled: 22
Confidence: 12.8%
Identity: 32%
PDB header:hydrolase regulator
Chain: A: PDB Molecule:phospholemman;
PDBTitle: structure of the na,k-atpase regulatory protein fxyd1 in2 micelles

Phyre2
1

c2xipA_
2

c2rmnA_
3

c3q06B_
4

d2ac0a1
5

c2j1xA_
6

d1hu8a_
7

c2rp4C_
8

d1t4wa_
9

c3k2kA_
10

c4gopB_
11

c4a37A_
12

c3l2nA_
13

c2kumA_
14

d2b5dx1
15

c2l4nA_
16

c3gycB_
17

d1ufaa1
18

c3cguB_
19

c2bsjB_
20

c2jo1A_
21



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Detailed template information 

#
Template Alignment Coverage3D Model Confidence
% i.d. Template Information
1c2xipA_



100.0 27 PDB header:cell cycle
Chain: A: PDB Molecule:tumour protein p73;
PDBTitle: crystal structure of the dna binding domain of human tp732 refined at 1.8 a resolution
2c2rmnA_



100.0 24 PDB header:cell cycle, antitumor protein
Chain: A: PDB Molecule:tumor protein 63;
PDBTitle: the solution structure of the p63 dna-binding domain
3c3q06B_



100.0 28 PDB header:cell cycle/dna
Chain: B: PDB Molecule:cellular tumor antigen p53;
PDBTitle: an induced fit mechanism regulates p53 dna binding kinetics to confer2 sequence specificity
4d2ac0a1



100.0 26 Fold:Common fold of diphtheria toxin/transcription factors/cytochrome f
Superfamily:p53-like transcription factors
Family:p53 DNA-binding domain-like
5c2j1xA_



100.0 27 PDB header:nuclear protein
Chain: A: PDB Molecule:cellular tumor antigen p53;
PDBTitle: human p53 core domain mutant m133l-v203a-y220c-n239y-n268d
6d1hu8a_



100.0 29 Fold:Common fold of diphtheria toxin/transcription factors/cytochrome f
Superfamily:p53-like transcription factors
Family:p53 DNA-binding domain-like
7c2rp4C_



100.0 100 PDB header:transcription
Chain: C: PDB Molecule:transcription factor p53;
PDBTitle: solution structure of the oligomerization domain in dmp53
8d1t4wa_



98.7 21 Fold:Common fold of diphtheria toxin/transcription factors/cytochrome f
Superfamily:p53-like transcription factors
Family:p53 DNA-binding domain-like
9c3k2kA_



38.4 8 PDB header:hydrolase
Chain: A: PDB Molecule:putative carboxypeptidase;
PDBTitle: crystal structure of putative carboxypeptidase (yp_103406.1) from2 burkholderia mallei atcc 23344 at 2.49 a resolution
10c4gopB_



21.8 26 PDB header:dna binding protein/dna
Chain: B: PDB Molecule:putative uncharacterized protein;
PDBTitle: structure and conformational change of a replication protein a2 heterotrimer bound to ssdna
11c4a37A_



21.5 16 PDB header:hydrolase
Chain: A: PDB Molecule:metallo-carboxypeptidase;
PDBTitle: metallo-carboxypeptidase from pseudomonas aeruginosa
12c3l2nA_



19.2 16 PDB header:hydrolase
Chain: A: PDB Molecule:peptidase m14, carboxypeptidase a;
PDBTitle: crystal structure of putative carboxypeptidase a (yp_562911.1) from2 shewanella denitrificans os-217 at 2.39 a resolution
13c2kumA_



18.6 14 PDB header:signaling protein
Chain: A: PDB Molecule:c-c motif chemokine 27;
PDBTitle: solution structure of the human chemokine ccl27
14d2b5dx1



18.6 18 Fold:immunoglobulin/albumin-binding domain-like
Superfamily:Families 57/38 glycoside transferase middle domain
Family:AmyC C-terminal domain-like
15c2l4nA_



17.3 26 PDB header:cytokine
Chain: A: PDB Molecule:c-c motif chemokine 21;
PDBTitle: solution structure of the chemokine ccl21
16c3gycB_



17.0 29 PDB header:hydrolase
Chain: B: PDB Molecule:putative glycoside hydrolase;
PDBTitle: crystal structure of putative glycoside hydrolase (yp_001304622.1)2 from parabacteroides distasonis atcc 8503 at 1.85 a resolution
17d1ufaa1



15.3 13 Fold:immunoglobulin/albumin-binding domain-like
Superfamily:Families 57/38 glycoside transferase middle domain
Family:AmyC C-terminal domain-like
18c3cguB_



15.0 33 PDB header:hormone/signaling protein
Chain: B: PDB Molecule:protein giant-lens;
PDBTitle: crystal structure of unliganded argos
19c2bsjB_



14.3 31 PDB header:chaperone
Chain: B: PDB Molecule:chaperone protein syct;
PDBTitle: native crystal structure of the type iii secretion2 chaperone syct from yersinia enterocolitica
20c2jo1A_



12.8 32 PDB header:hydrolase regulator
Chain: A: PDB Molecule:phospholemman;
PDBTitle: structure of the na,k-atpase regulatory protein fxyd1 in2 micelles
21d2pi2a1



not modelled 12.2 9 Fold:OB-fold
Superfamily:Nucleic acid-binding proteins
Family:Single strand DNA-binding domain, SSB
22c1y6zA_



not modelled 12.2 28 PDB header:structural genomics, unknown function
Chain: A: PDB Molecule:heat shock protein, putative;
PDBTitle: middle domain of plasmodium falciparum putative heat shock protein2 pf14_0417
23c2pi2A_



not modelled 12.1 9 PDB header:replication, dna binding protein
Chain: A: PDB Molecule:replication protein a 32 kda subunit;
PDBTitle: full-length replication protein a subunits rpa14 and rpa32
24d1iknc_



not modelled 11.8 19 Fold:Immunoglobulin-like beta-sandwich
Superfamily:E set domains
Family:NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain
25c3isyA_



not modelled 11.7 15 PDB header:protein binding
Chain: A: PDB Molecule:intracellular proteinase inhibitor;
PDBTitle: crystal structure of an intracellular proteinase inhibitor (ipi,2 bsu11130) from bacillus subtilis at 2.61 a resolution
26d1eiga_



not modelled 10.9 33 Fold:IL8-like
Superfamily:Interleukin 8-like chemokines
Family:Interleukin 8-like chemokines
27c3ulcA_



not modelled 10.6 60 PDB header:membrane protein
Chain: A: PDB Molecule:target of rapamycin complex 2 subunit avo1;
PDBTitle: crystal structure of the pleckstrin homology domain of saccharomyces2 cerevisiae avo1, a torc2 subunit, in the p3121 crystal form
28d1ft8a2



not modelled 10.5 38 Fold:Ferredoxin-like
Superfamily:RNA-binding domain, RBD
Family:Non-canonical RBD domain
29c1svcP_



not modelled 9.8 19 PDB header:transcription/dna
Chain: P: PDB Molecule:protein (nuclear factor kappa-b (nf-kb));
PDBTitle: nfkb p50 homodimer bound to dna
30c3u5gh_



not modelled 9.7 35 PDB header:ribosome
Chain: H: PDB Molecule:40s ribosomal protein s7-a;
PDBTitle: the structure of the eukaryotic ribosome at 3.0 a resolution. this2 entry contains proteins of the 40s subunit, ribosome b
31d1ytla1



not modelled 9.4 17 Fold:DHS-like NAD/FAD-binding domain
Superfamily:DHS-like NAD/FAD-binding domain
Family:ACDE2-like
32c3mxtA_



not modelled 9.4 13 PDB header:ligase
Chain: A: PDB Molecule:pantothenate synthetase;
PDBTitle: crystal structure of pantoate-beta-alanine ligase from campylobacter2 jejuni
33c3hyjD_



not modelled 9.0 20 PDB header:transcription regulator
Chain: D: PDB Molecule:protein duf199/whia;
PDBTitle: crystal structure of the n-terminal laglidadg domain of duf199/whia
34d1ylea1



not modelled 8.8 38 Fold:Acyl-CoA N-acyltransferases (Nat)
Superfamily:Acyl-CoA N-acyltransferases (Nat)
Family:AstA-like
35d1ifva_



not modelled 8.7 26 Fold:TBP-like
Superfamily:Bet v1-like
Family:Pathogenesis-related protein 10 (PR10)-like
36d1mi2a_



not modelled 8.4 29 Fold:IL8-like
Superfamily:Interleukin 8-like chemokines
Family:Interleukin 8-like chemokines
37d1esra_



not modelled 7.9 25 Fold:IL8-like
Superfamily:Interleukin 8-like chemokines
Family:Interleukin 8-like chemokines
38d1mgsa_



not modelled 7.7 24 Fold:IL8-like
Superfamily:Interleukin 8-like chemokines
Family:Interleukin 8-like chemokines
39c2xueB_



not modelled 7.4 12 PDB header:oxidoreductase
Chain: B: PDB Molecule:lysine-specific demethylase 6b;
PDBTitle: crystal structure of jmjd3
40c2xzbB_



not modelled 7.4 17 PDB header:hydrolase
Chain: B: PDB Molecule:potassium-transporting atpase subunit beta;
PDBTitle: pig gastric h,k-atpase with bound bef and sch28080
41c1nfkA_



not modelled 7.4 19 PDB header:transcription/dna
Chain: A: PDB Molecule:protein (nuclear factor kappa-b (nf-kb));
PDBTitle: structure of the nuclear factor kappa-b (nf-kb) p502 homodimer
42c3ag5A_



not modelled 7.2 10 PDB header:ligase
Chain: A: PDB Molecule:pantothenate synthetase;
PDBTitle: crystal structure of pantothenate synthetase from staphylococcus2 aureus
43c2ejcA_



not modelled 7.1 10 PDB header:ligase
Chain: A: PDB Molecule:pantoate--beta-alanine ligase;
PDBTitle: crystal structure of pantoate--beta-alanine ligase (panc)2 from thermotoga maritima
44d1z0jb1



not modelled 7.1 23 Fold:Long alpha-hairpin
Superfamily:Rabenosyn-5 Rab-binding domain-like
Family:Rabenosyn-5 Rab-binding domain-like
45c3uk2B_



not modelled 7.0 15 PDB header:ligase
Chain: B: PDB Molecule:pantothenate synthetase;
PDBTitle: the structure of pantothenate synthetase from burkholderia2 thailandensis
46d1pvma3



not modelled 6.7 31 Fold:Rubredoxin-like
Superfamily:Hypothetical protein Ta0289 C-terminal domain
Family:Hypothetical protein Ta0289 C-terminal domain
47d2auwa2



not modelled 6.6 22 Fold:NE0471 N-terminal domain-like
Superfamily:NE0471 N-terminal domain-like
Family:NE0471 N-terminal domain-like
48d1kshb_



not modelled 6.6 13 Fold:Immunoglobulin-like beta-sandwich
Superfamily:E set domains
Family:RhoGDI-like
49c3rh0A_



not modelled 6.4 25 PDB header:oxidoreductase
Chain: A: PDB Molecule:arsenate reductase;
PDBTitle: corynebacterium glutamicum mycothiol/mycoredoxin1-dependent arsenate2 reductase cg_arsc2
50d1qnka_



not modelled 6.3 29 Fold:IL8-like
Superfamily:Interleukin 8-like chemokines
Family:Interleukin 8-like chemokines
51c2fd4A_



not modelled 6.3 19 PDB header:ligase
Chain: A: PDB Molecule:avirulence protein avrptob;
PDBTitle: crystal structure of avrptob (436-553)
52d1icwa_



not modelled 6.1 17 Fold:IL8-like
Superfamily:Interleukin 8-like chemokines
Family:Interleukin 8-like chemokines
53c1ixtA_



not modelled 5.9 80 PDB header:toxin
Chain: A: PDB Molecule:spasmodic protein tx9a-like protein;
PDBTitle: structure of a novel p-superfamily spasmodic conotoxin2 reveals an inhibitory cystine knot motif
54d1ixta_



not modelled 5.9 80 Fold:Knottins (small inhibitors, toxins, lectins)
Superfamily:omega toxin-like
Family:Conotoxin
55d1e6vc_



not modelled 5.9 29 Fold:Ferredoxin-like
Superfamily:Methyl-coenzyme M reductase subunits
Family:Methyl-coenzyme M reductase gamma chain
56d1hn6a_



not modelled 5.8 30 Fold:Apical membrane antigen 1
Superfamily:Apical membrane antigen 1
Family:Apical membrane antigen 1
57c2cwoD_



not modelled 5.8 44 PDB header:rna binding protein
Chain: D: PDB Molecule:rna silencing suppressor;
PDBTitle: crystal structure of rna silencing suppressor p21 from beet yellows2 virus
58d1itxa2



not modelled 5.7 20 Fold:FKBP-like
Superfamily:Chitinase insertion domain
Family:Chitinase insertion domain
59c1lj2C_



not modelled 5.7 57 PDB header:viral protein/ translation
Chain: C: PDB Molecule:eukaryotic protein synthesis initiation factor;
PDBTitle: recognition of eif4g by rotavirus nsp3 reveals a basis for2 mrna circularization
60d1xwea_



not modelled 5.6 14 Fold:OB-fold
Superfamily:TIMP-like
Family:Netrin-like domain (NTR/C345C module)
61d1v8fa_



not modelled 5.5 19 Fold:Adenine nucleotide alpha hydrolase-like
Superfamily:Nucleotidylyl transferase
Family:Pantothenate synthetase (Pantoate-beta-alanine ligase, PanC)
62d1f9ra_



not modelled 5.5 26 Fold:IL8-like
Superfamily:Interleukin 8-like chemokines
Family:Interleukin 8-like chemokines
63d1koha2



not modelled 5.5 42 Fold:Ferredoxin-like
Superfamily:RNA-binding domain, RBD
Family:Non-canonical RBD domain
64d1k6za_



not modelled 5.4 14 Fold:Secretion chaperone-like
Superfamily:Type III secretory system chaperone-like
Family:Type III secretory system chaperone
65c4f02F_



not modelled 5.3 57 PDB header:translation/rna
Chain: F: PDB Molecule:eukaryotic translation initiation factor 4 gamma 1;
PDBTitle: crystal structure of the pabp-binding site of eif4g in complex with2 rrm1-2 of pabp and poly(a)
66c4f02C_



not modelled 5.3 57 PDB header:translation/rna
Chain: C: PDB Molecule:eukaryotic translation initiation factor 4 gamma 1;
PDBTitle: crystal structure of the pabp-binding site of eif4g in complex with2 rrm1-2 of pabp and poly(a)
67d1fs1b1



not modelled 5.3 31 Fold:Skp1 dimerisation domain-like
Superfamily:Skp1 dimerisation domain-like
Family:Skp1 dimerisation domain-like
68d2eota_



not modelled 5.1 31 Fold:IL8-like
Superfamily:Interleukin 8-like chemokines
Family:Interleukin 8-like chemokines
69c3rpjA_



not modelled 5.0 36 PDB header:transcription regulator
Chain: A: PDB Molecule:curlin genes transcriptional regulator;
PDBTitle: structure of a curlin genes transcriptional regulator protein from2 proteus mirabilis hi4320.
70c3ve5D_



not modelled 5.0 36 PDB header:recombination
Chain: D: PDB Molecule:recombination protein recr;
PDBTitle: structure of recombination mediator protein recr16-196 deletion mutant

Binding site prediction 

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite