Phyre Home Retrieve Phyre Job Id
Emaill.a.kelley@imperial.ac.uk
DescriptionP29349
DateTue Jan 22 11:46:53 GMT 2013
Unique Job IDce9635f9a3e2e77d

Summary 

Top model
Image coloured by rainbow N → C terminus
Model (left) based on template c3ps5A_
Top template information
PDB header:hydrolase, signaling protein
Chain: A: PDB Molecule:tyrosine-protein phosphatase non-receptor type 6;
PDBTitle: crystal structure of the full-length human protein tyrosine2 phosphatase shp-1
Confidence and coverage
Confidence:100.0% Coverage: 59%
499 residues ( 59% of your sequence) have been modelled with 100.0% confidence by the single highest scoring template.
You may wish to submit your sequence to Phyrealarm. This will automatically scan your sequence every week for new potential templates as they appear in the Phyre2 library.
3D viewing
Interactive 3D view in Jmol

Sequence analysis 

Secondary structure and disorder prediction 

   1........10.........20.........30.........40.........50.........60
Sequence  MSSRRWFHPTISGIEAEKLLQEQGFDGSFLARLSSSNPGAFTLSVRRGNEVTHIKIQNNG
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Disorder  ???????

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   .........70.........80.........90.........100.........110.........120
Sequence  DFFDLYGGEKFATLPELVQYYMENGELKEKNGQAIELKQPLICAEPTTERWFHGNLSGKE
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   .........130.........140.........150.........160.........170.........180
Sequence  AEKLILERGKNGSFLVRESQSKPGDFVLSVRTDDKVTHVMIRWQDKKYDVGGGESFGTLS
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??

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   .........190.........200.........210.........220.........230.........240
Sequence  ELIDHYKRNPMVETCGTVVHLRQPFNATRITAAGINARVEQLVKGGFWEEFESLQQDSRD
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   .........250.........260.........270.........280.........290.........300
Sequence  TFSRNEGYKQENRLKNRYRNILPYDHTRVKLLDVEHSVAGAEYINANYIRLPTDGDLYNM
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   .........310.........320.........330.........340.........350.........360
Sequence  SSSSESLNSSVPSCPACTAAQTQRNCSNCQLQNKTCVQCAVKSAILPYSNCATCSRKSDS
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?
?
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   .........370.........380.........390.........400.........410.........420
Sequence  LSKHKRSESSASSSPSSGSGSGPGSSGTSGVSSVNGPGTPTNLTSGTAGCLVGLLKRHSN
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   .........430.........440.........450.........460.........470.........480
Sequence  DSSGAVSISMAEREREREREMFKTYIATQGCLLTQQVNTVTDFWNMVWQENTRVIVMTTK
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Disorder  ??












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   .........490.........500.........510.........520.........530.........540
Sequence  EYERGKEKCARYWPDEGRSEQFGHARIQCVSENSTSDYTLREFLVSWRDQPARRIFHYHF
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   .........550.........560.........570.........580.........590.........600
Sequence  QVWPDHGVPADPGCVLNFLQDVNTRQSHLAQAGEKPGPICVHCSAGIGRTGTFIVIDMIL
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   .........610.........620.........630.........640.........650.........660
Sequence  DQIVRNGLDTEIDIQRTIQMVRSQRSGLVQTEAQYKFVYYAVQHYIQTLIARKRAEEQSL
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   .........670.........680.........690.........700.........710.........720
Sequence  QVGREYTNIKYTGEIGNDSQRSPLPPAISSISLVPSKTPLTPTSADLGTGMGLSMGVGMG
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Disorder  ?
??????????????????????????????????????????????????????????
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   .........730.........740.........750.........760.........770.........780
Sequence  VGNKHASKQQPPLPVVNCNNNNNGIGNSGCSNGGGSSTTSSSNGSSNGNINALLGGIGLG
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Disorder  ????????????????????????????
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??????
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   .........790.........800.........810.........820.........830.........840
Sequence  LGGNMRKSNFYSDSLKQQQQREEQAPAGAGKMQQPAPPLRPRPGILKLLTSPVIFQQNSK
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Disorder  ?????????????????????????????????????????












??????
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   .....
Sequence  TFPKT
Secondary structure 




SS confidence 




Disorder  ?????
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Confidence Key
High(9)                    Low (0)
?Disordered
Alpha helix
Beta strand

Domain analysis 

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

RankAligned region

PDB 3ps5 chain A

3D model

Region: 5 - 658
Aligned: 499
Modelled: 505
Confidence: 100.0%
Identity: 55%
PDB header:hydrolase, signaling protein
Chain: A: PDB Molecule:tyrosine-protein phosphatase non-receptor type 6;
PDBTitle: crystal structure of the full-length human protein tyrosine2 phosphatase shp-1

Phyre2

PDB 2b3o chain A

3D model

Region: 5 - 655
Aligned: 488
Modelled: 502
Confidence: 100.0%
Identity: 55%
PDB header:hydrolase
Chain: A: PDB Molecule:tyrosine-protein phosphatase, non-receptor type
PDBTitle: crystal structure of human tyrosine phosphatase shp-1

Phyre2

PDB 2shp chain A

3D model

Region: 2 - 649
Aligned: 482
Modelled: 496
Confidence: 100.0%
Identity: 75%
PDB header:tyrosine phosphatase
Chain: A: PDB Molecule:shp-2;
PDBTitle: tyrosine phosphatase shp-2

Phyre2

PDB 3sr9 chain A

3D model

Region: 210 - 648
Aligned: 422
Modelled: 439
Confidence: 100.0%
Identity: 29%
PDB header:hydrolase
Chain: A: PDB Molecule:receptor-type tyrosine-protein phosphatase s;
PDBTitle: crystal structure of mouse ptpsigma

Phyre2

PDB 1ygu chain A

3D model

Region: 206 - 645
Aligned: 421
Modelled: 440
Confidence: 100.0%
Identity: 26%
PDB header:hydrolase
Chain: A: PDB Molecule:leukocyte common antigen;
PDBTitle: crystal structure of the tandem phosphatase domains of rptp2 cd45 with a ptyr peptide

Phyre2

PDB 1lar chain B

3D model

Region: 243 - 648
Aligned: 391
Modelled: 406
Confidence: 100.0%
Identity: 30%
PDB header:hydrolase
Chain: B: PDB Molecule:protein (lar);
PDBTitle: crystal structure of the tandem phosphatase domains of rptp2 lar

Phyre2

PDB 2jjd chain A

3D model

Region: 220 - 647
Aligned: 410
Modelled: 428
Confidence: 100.0%
Identity: 29%
PDB header:hydrolase
Chain: A: PDB Molecule:receptor-type tyrosine-protein phosphatase epsilon;
PDBTitle: protein tyrosine phosphatase, receptor type, e isoform

Phyre2

PDB 2nlk chain A

3D model

Region: 210 - 646
Aligned: 406
Modelled: 433
Confidence: 100.0%
Identity: 25%
PDB header:hydrolase
Chain: A: PDB Molecule:protein tyrosine phosphatase, receptor type, g variant
PDBTitle: crystal structure of d1 and d2 catalytic domains of human protein2 tyrosine phosphatase gamma (d1+d2 ptprg)

Phyre2

PDB 1wch chain A

3D model

Region: 197 - 654
Aligned: 291
Modelled: 303
Confidence: 100.0%
Identity: 38%
Fold: (Phosphotyrosine protein) phosphatases II
Superfamily: (Phosphotyrosine protein) phosphatases II
Family: Higher-molecular-weight phosphotyrosine protein phosphatases

Phyre2

PDB 1jln chain A

3D model

Region: 206 - 649
Aligned: 277
Modelled: 295
Confidence: 100.0%
Identity: 35%
Fold: (Phosphotyrosine protein) phosphatases II
Superfamily: (Phosphotyrosine protein) phosphatases II
Family: Higher-molecular-weight phosphotyrosine protein phosphatases

Phyre2

PDB 3s3f chain A

3D model

Region: 210 - 648
Aligned: 276
Modelled: 284
Confidence: 100.0%
Identity: 38%
PDB header:hydrolase/hydrolase inhibitor
Chain: A: PDB Molecule:tyrosine-protein phosphatase 10d;
PDBTitle: crystal structure of the catalytic domain of ptp10d from drosophila2 melanogaster with a small molecule inhibitor vanadate

Phyre2

PDB 2nz6 chain A

3D model

Region: 207 - 648
Aligned: 265
Modelled: 293
Confidence: 100.0%
Identity: 40%
PDB header:hydrolase
Chain: A: PDB Molecule:receptor-type tyrosine-protein phosphatase eta;
PDBTitle: crystal structure of the ptprj inactivating mutant c1239s

Phyre2

PDB 2pa5 chain A

3D model

Region: 199 - 648
Aligned: 286
Modelled: 301
Confidence: 100.0%
Identity: 36%
PDB header:hydrolase
Chain: A: PDB Molecule:tyrosine-protein phosphatase non-receptor type 9;
PDBTitle: crystal structure of human protein tyrosine phosphatase ptpn9

Phyre2

PDB 2shp chain A domain 1

3D model

Region: 208 - 649
Aligned: 276
Modelled: 290
Confidence: 100.0%
Identity: 75%
Fold: (Phosphotyrosine protein) phosphatases II
Superfamily: (Phosphotyrosine protein) phosphatases II
Family: Higher-molecular-weight phosphotyrosine protein phosphatases

Phyre2

PDB 1fpr chain A

3D model

Region: 226 - 655
Aligned: 280
Modelled: 288
Confidence: 100.0%
Identity: 55%
Fold: (Phosphotyrosine protein) phosphatases II
Superfamily: (Phosphotyrosine protein) phosphatases II
Family: Higher-molecular-weight phosphotyrosine protein phosphatases

Phyre2

PDB 1lar chain A domain 1

3D model

Region: 212 - 679
Aligned: 300
Modelled: 319
Confidence: 100.0%
Identity: 36%
Fold: (Phosphotyrosine protein) phosphatases II
Superfamily: (Phosphotyrosine protein) phosphatases II
Family: Higher-molecular-weight phosphotyrosine protein phosphatases

Phyre2

PDB 2f71 chain A domain 1

3D model

Region: 214 - 665
Aligned: 291
Modelled: 303
Confidence: 100.0%
Identity: 35%
Fold: (Phosphotyrosine protein) phosphatases II
Superfamily: (Phosphotyrosine protein) phosphatases II
Family: Higher-molecular-weight phosphotyrosine protein phosphatases

Phyre2

PDB 2bzl chain A

3D model

Region: 223 - 648
Aligned: 271
Modelled: 277
Confidence: 100.0%
Identity: 32%
PDB header:hydrolase
Chain: A: PDB Molecule:tyrosine-protein phosphatase, non-receptor type
PDBTitle: crystal structure of the human protein tyrosine phosphatase2 n14 at 1.65 a resolution

Phyre2

PDB 2vex chain A

3D model

Region: 215 - 665
Aligned: 290
Modelled: 302
Confidence: 100.0%
Identity: 36%
PDB header:hydrolase
Chain: A: PDB Molecule:tyrosine-protein phosphatase non-receptor type 1;
PDBTitle: crystal strucutre of protein tyrosine phosphatase 1b in2 complex with an isothiazolidinone-containing inhibitor

Phyre2

PDB 3i36 chain A

3D model

Region: 207 - 648
Aligned: 280
Modelled: 292
Confidence: 100.0%
Identity: 40%
PDB header:hydrolase
Chain: A: PDB Molecule:vascular protein tyrosine phosphatase 1;
PDBTitle: crystal structure of rat protein tyrosine phosphatase eta catalytic2 domain

Phyre2
1

c3ps5A_
2

c2b3oA_
3

c2shpA_
4

c3sr9A_
5

c1yguA_
6

c1larB_
7

c2jjdA_
8

c2nlkA_
9

d1wcha_
10

d1jlna_
11

c3s3fA_
12

c2nz6A_
13

c2pa5A_
14

d2shpa1
15

d1fpra_
16

d1lara1
17

d2f71a1
18

c2bzlA_
19

c2vexA_
20

c3i36A_
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Detailed template information 

#
Template Alignment Coverage3D Model Confidence
% i.d. Template Information
1c3ps5A_



100.0 55 PDB header:hydrolase, signaling protein
Chain: A: PDB Molecule:tyrosine-protein phosphatase non-receptor type 6;
PDBTitle: crystal structure of the full-length human protein tyrosine2 phosphatase shp-1
2c2b3oA_



100.0 55 PDB header:hydrolase
Chain: A: PDB Molecule:tyrosine-protein phosphatase, non-receptor type
PDBTitle: crystal structure of human tyrosine phosphatase shp-1
3c2shpA_



100.0 75 PDB header:tyrosine phosphatase
Chain: A: PDB Molecule:shp-2;
PDBTitle: tyrosine phosphatase shp-2
4c3sr9A_



100.0 29 PDB header:hydrolase
Chain: A: PDB Molecule:receptor-type tyrosine-protein phosphatase s;
PDBTitle: crystal structure of mouse ptpsigma
5c1yguA_



100.0 26 PDB header:hydrolase
Chain: A: PDB Molecule:leukocyte common antigen;
PDBTitle: crystal structure of the tandem phosphatase domains of rptp2 cd45 with a ptyr peptide
6c1larB_



100.0 30 PDB header:hydrolase
Chain: B: PDB Molecule:protein (lar);
PDBTitle: crystal structure of the tandem phosphatase domains of rptp2 lar
7c2jjdA_



100.0 29 PDB header:hydrolase
Chain: A: PDB Molecule:receptor-type tyrosine-protein phosphatase epsilon;
PDBTitle: protein tyrosine phosphatase, receptor type, e isoform
8c2nlkA_



100.0 25 PDB header:hydrolase
Chain: A: PDB Molecule:protein tyrosine phosphatase, receptor type, g variant
PDBTitle: crystal structure of d1 and d2 catalytic domains of human protein2 tyrosine phosphatase gamma (d1+d2 ptprg)
9d1wcha_



100.0 38 Fold:(Phosphotyrosine protein) phosphatases II
Superfamily:(Phosphotyrosine protein) phosphatases II
Family:Higher-molecular-weight phosphotyrosine protein phosphatases
10d1jlna_



100.0 35 Fold:(Phosphotyrosine protein) phosphatases II
Superfamily:(Phosphotyrosine protein) phosphatases II
Family:Higher-molecular-weight phosphotyrosine protein phosphatases
11c3s3fA_



100.0 38 PDB header:hydrolase/hydrolase inhibitor
Chain: A: PDB Molecule:tyrosine-protein phosphatase 10d;
PDBTitle: crystal structure of the catalytic domain of ptp10d from drosophila2 melanogaster with a small molecule inhibitor vanadate
12c2nz6A_



100.0 40 PDB header:hydrolase
Chain: A: PDB Molecule:receptor-type tyrosine-protein phosphatase eta;
PDBTitle: crystal structure of the ptprj inactivating mutant c1239s
13c2pa5A_



100.0 36 PDB header:hydrolase
Chain: A: PDB Molecule:tyrosine-protein phosphatase non-receptor type 9;
PDBTitle: crystal structure of human protein tyrosine phosphatase ptpn9
14d2shpa1



100.0 75 Fold:(Phosphotyrosine protein) phosphatases II
Superfamily:(Phosphotyrosine protein) phosphatases II
Family:Higher-molecular-weight phosphotyrosine protein phosphatases
15d1fpra_



100.0 55 Fold:(Phosphotyrosine protein) phosphatases II
Superfamily:(Phosphotyrosine protein) phosphatases II
Family:Higher-molecular-weight phosphotyrosine protein phosphatases
16d1lara1



100.0 36 Fold:(Phosphotyrosine protein) phosphatases II
Superfamily:(Phosphotyrosine protein) phosphatases II
Family:Higher-molecular-weight phosphotyrosine protein phosphatases
17d2f71a1



100.0 35 Fold:(Phosphotyrosine protein) phosphatases II
Superfamily:(Phosphotyrosine protein) phosphatases II
Family:Higher-molecular-weight phosphotyrosine protein phosphatases
18c2bzlA_



100.0 32 PDB header:hydrolase
Chain: A: PDB Molecule:tyrosine-protein phosphatase, non-receptor type
PDBTitle: crystal structure of the human protein tyrosine phosphatase2 n14 at 1.65 a resolution
19c2vexA_



100.0 36 PDB header:hydrolase
Chain: A: PDB Molecule:tyrosine-protein phosphatase non-receptor type 1;
PDBTitle: crystal strucutre of protein tyrosine phosphatase 1b in2 complex with an isothiazolidinone-containing inhibitor
20c3i36A_



100.0 40 PDB header:hydrolase
Chain: A: PDB Molecule:vascular protein tyrosine phosphatase 1;
PDBTitle: crystal structure of rat protein tyrosine phosphatase eta catalytic2 domain
21c2oc3A_



not modelled 100.0 35 PDB header:hydrolase
Chain: A: PDB Molecule:tyrosine-protein phosphatase non-receptor type
PDBTitle: crystal structure of the catalytic domain of human protein2 tyrosine phosphatase non-receptor type 18
22c2c7sA_



not modelled 100.0 40 PDB header:hydrolase
Chain: A: PDB Molecule:receptor-type tyrosine-protein phosphatase kappa;
PDBTitle: crystal structure of human protein tyrosine phosphatase2 kappa at 1.95a resolution
23c2qdmA_



not modelled 100.0 38 PDB header:hydrolase
Chain: A: PDB Molecule:tyrosine-protein phosphatase non-receptor type 7;
PDBTitle: crystal structure of the heptp catalytic domain c270s/d236a/q314a2 mutant
24c2qcjB_



not modelled 100.0 41 PDB header:hydrolase
Chain: B: PDB Molecule:tyrosine-protein phosphatase non-receptor type
PDBTitle: native structure of lyp
25d1rpma_



not modelled 100.0 42 Fold:(Phosphotyrosine protein) phosphatases II
Superfamily:(Phosphotyrosine protein) phosphatases II
Family:Higher-molecular-weight phosphotyrosine protein phosphatases
26d1larb1



not modelled 100.0 41 Fold:(Phosphotyrosine protein) phosphatases II
Superfamily:(Phosphotyrosine protein) phosphatases II
Family:Higher-molecular-weight phosphotyrosine protein phosphatases
27d1yfoa_



not modelled 100.0 42 Fold:(Phosphotyrosine protein) phosphatases II
Superfamily:(Phosphotyrosine protein) phosphatases II
Family:Higher-molecular-weight phosphotyrosine protein phosphatases
28c2bijA_



not modelled 100.0 40 PDB header:hydrolase
Chain: A: PDB Molecule:tyrosine-protein phosphatase, non-receptor type 5;
PDBTitle: crystal structure of the human protein tyrosine phosphatase2 ptpn5 (step, striatum enriched enriched phosphatase)
29c3jrlA_



not modelled 100.0 61 PDB header:hydrolase
Chain: A: PDB Molecule:oncogenic tyrosine phosphatase shp2;
PDBTitle: crystal structure of the oncogenic tyrosine phosphatase shp2 complexed2 with a salicylic acid-based small molecule inhibitor
30c2hy3A_



not modelled 100.0 42 PDB header:hydrolase
Chain: A: PDB Molecule:receptor-type tyrosine-protein phosphatase gamma;
PDBTitle: crystal structure of the human tyrosine receptor phosphate gamma in2 complex with vanadate
31d1l8ka_



not modelled 100.0 38 Fold:(Phosphotyrosine protein) phosphatases II
Superfamily:(Phosphotyrosine protein) phosphatases II
Family:Higher-molecular-weight phosphotyrosine protein phosphatases
32c1l8kA_



not modelled 100.0 38 PDB header:hydrolase
Chain: A: PDB Molecule:t-cell protein-tyrosine phosphatase;
PDBTitle: t cell protein-tyrosine phosphatase structure
33c2h04A_



not modelled 100.0 43 PDB header:hydrolase
Chain: A: PDB Molecule:protein tyrosine phosphatase, receptor type, b,;
PDBTitle: structural studies of protein tyrosine phosphatase beta2 catalytic domain in complex with inhibitors
34c2b49A_



not modelled 100.0 40 PDB header:hydrolase
Chain: A: PDB Molecule:protein tyrosine phosphatase, non-receptor type 3;
PDBTitle: crystal structure of the catalytic domain of protein tyrosine2 phosphatase, non-receptor type 3
35c2qepA_



not modelled 100.0 39 PDB header:hydrolase
Chain: A: PDB Molecule:receptor-type tyrosine-protein phosphatase n2;
PDBTitle: crystal structure of the d1 domain of ptprn2 (ia2beta)
36c2i75A_



not modelled 100.0 39 PDB header:hydrolase
Chain: A: PDB Molecule:tyrosine-protein phosphatase non-receptor type 4;
PDBTitle: crystal structure of human protein tyrosine phosphatase n4 (ptpn4)
37c2g59B_



not modelled 100.0 39 PDB header:hydrolase
Chain: B: PDB Molecule:receptor-type tyrosine-protein phosphatase o;
PDBTitle: crystal structure of the catalytic domain of protein2 tyrosine phosphatase from homo sapiens
38c3m4uB_



not modelled 100.0 31 PDB header:hydrolase
Chain: B: PDB Molecule:tyrosine specific protein phosphatase, putative;
PDBTitle: crystal structure of trypanosoma brucei protein tyrosine phosphatase2 tbptp1
39d1lara2



not modelled 100.0 42 Fold:(Phosphotyrosine protein) phosphatases II
Superfamily:(Phosphotyrosine protein) phosphatases II
Family:Higher-molecular-weight phosphotyrosine protein phosphatases
40c1g4wR_



not modelled 100.0 18 PDB header:signaling protein
Chain: R: PDB Molecule:protein tyrosine phosphatase sptp;
PDBTitle: crystal structure of the salmonella tyrosine phosphatase2 and gtpase activating protein sptp
41c4az1B_



not modelled 100.0 31 PDB header:hydrolase
Chain: B: PDB Molecule:tyrosine specific protein phosphatase;
PDBTitle: crystal structure of the trypanosoma cruzi protein tyrosine2 phosphatase tcptp1, a potential therapeutic target for chagas'3 disease
42d1p15a_



not modelled 100.0 40 Fold:(Phosphotyrosine protein) phosphatases II
Superfamily:(Phosphotyrosine protein) phosphatases II
Family:Higher-molecular-weight phosphotyrosine protein phosphatases
43d1lyva_



not modelled 100.0 21 Fold:(Phosphotyrosine protein) phosphatases II
Superfamily:(Phosphotyrosine protein) phosphatases II
Family:Higher-molecular-weight phosphotyrosine protein phosphatases
44d1g4us2



not modelled 100.0 22 Fold:(Phosphotyrosine protein) phosphatases II
Superfamily:(Phosphotyrosine protein) phosphatases II
Family:Higher-molecular-weight phosphotyrosine protein phosphatases
45c3gqiB_



not modelled 100.0 31 PDB header:transferase/transferase inhibitor
Chain: B: PDB Molecule:phospholipase c-gamma-1;
PDBTitle: crystal structure of activated receptor tyrosine kinase in complex2 with substrates
46c2oq1A_



not modelled 100.0 29 PDB header:transferase
Chain: A: PDB Molecule:tyrosine-protein kinase zap-70;
PDBTitle: tandem sh2 domains of zap-70 with 19-mer zeta1 peptide
47c4fl2A_



not modelled 100.0 33 PDB header:transferase
Chain: A: PDB Molecule:tyrosine-protein kinase syk;
PDBTitle: structural and biophysical characterization of the syk activation2 switch
48c2ozoA_



not modelled 100.0 30 PDB header:transferase
Chain: A: PDB Molecule:tyrosine-protein kinase zap-70;
PDBTitle: autoinhibited intact human zap-70
49c1a81E_



not modelled 100.0 29 PDB header:complex (transferase/peptide)
Chain: E: PDB Molecule:syk kinase;
PDBTitle: crystal structure of the tandem sh2 domain of the syk kinase bound to2 a dually tyrosine-phosphorylated itam
50c3or8A_



not modelled 100.0 20 PDB header:transcription
Chain: A: PDB Molecule:transcription elongation factor spt6;
PDBTitle: a tandem sh2 domain in transcription elongation factor spt6
51c2xp1A_



not modelled 100.0 19 PDB header:transcription
Chain: A: PDB Molecule:spt6;
PDBTitle: structure of the tandem sh2 domains from antonospora locustae2 transcription elongation factor spt6
52d1rxda_



not modelled 99.9 25 Fold:(Phosphotyrosine protein) phosphatases II
Superfamily:(Phosphotyrosine protein) phosphatases II
Family:Dual specificity phosphatase-like
53d1v3aa_



not modelled 99.9 19 Fold:(Phosphotyrosine protein) phosphatases II
Superfamily:(Phosphotyrosine protein) phosphatases II
Family:Dual specificity phosphatase-like
54d2shpa2



not modelled 99.9 69 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
55c1x6cA_



not modelled 99.9 45 PDB header:signaling protein
Chain: A: PDB Molecule:tyrosine-protein phosphatase, non-receptor type
PDBTitle: solution structures of the sh2 domain of human protein-2 tyrosine phosphatase shp-1
56c3rz2B_



not modelled 99.9 23 PDB header:hydrolase
Chain: B: PDB Molecule:protein tyrosine phosphatase type iva 1;
PDBTitle: crystal of prl-1 complexed with peptide
57c3hizB_



not modelled 99.9 25 PDB header:transferase/oncoprotein
Chain: B: PDB Molecule:phosphatidylinositol 3-kinase regulatory subunit
PDBTitle: crystal structure of p110alpha h1047r mutant in complex with2 nish2 of p85alpha
58d2oq1a1



not modelled 99.9 24 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
59c2y3aB_



not modelled 99.9 27 PDB header:transferase
Chain: B: PDB Molecule:phosphatidylinositol 3-kinase regulatory subunit beta;
PDBTitle: crystal structure of p110beta in complex with icsh2 of p85beta and2 the drug gdc-0941
60d3c7ia1



not modelled 99.9 26 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
61c2eobA_



not modelled 99.9 24 PDB header:hydrolase
Chain: A: PDB Molecule:1-phosphatidylinositol-4,5-bisphosphate
PDBTitle: solution structure of the second sh2 domain from rat plc2 gamma-2
62d2shpa3



not modelled 99.9 77 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
63c2ci8A_



not modelled 99.9 33 PDB header:translation
Chain: A: PDB Molecule:cytoplasmic protein nck1;
PDBTitle: sh2 domain of human nck1 adaptor protein - uncomplexed
64c2hdxB_



not modelled 99.9 20 PDB header:signaling protein
Chain: B: PDB Molecule:sh2-b ph domain containing signaling mediator 1
PDBTitle: crystal structure of the src homology-2 domain of sh2-b in2 complex with jak2 ptyr813 phosphopeptide
65d1ayaa_



not modelled 99.9 50 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
66c2lqnA_



not modelled 99.9 19 PDB header:signaling protein
Chain: A: PDB Molecule:crk-like protein;
PDBTitle: solution structure of crkl
67c2fo0A_



not modelled 99.9 25 PDB header:transferase
Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase abl1 (1b isoform);
PDBTitle: organization of the sh3-sh2 unit in active and inactive forms of the2 c-abl tyrosine kinase
68d1a81a1



not modelled 99.9 29 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
69c2eo6A_



not modelled 99.9 25 PDB header:signaling protein
Chain: A: PDB Molecule:b-cell linker protein;
PDBTitle: solution structure of the sh2 domain from mouse b-cell2 linker protein blnk
70c2gsbA_



not modelled 99.9 27 PDB header:signaling protein
Chain: A: PDB Molecule:ras gtpase-activating protein 1;
PDBTitle: solution structure of the second sh2 domain of human ras2 gtpase-activating protein 1
71d2oq1a2



not modelled 99.9 29 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
72c2dlzA_



not modelled 99.9 24 PDB header:signaling protein
Chain: A: PDB Molecule:protein vav-2;
PDBTitle: solution structure of the sh2 domain of human protein vav-2
73d1fhsa_



not modelled 99.9 31 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
74d1a81e1



not modelled 99.9 27 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
75d1nrva_



not modelled 99.9 33 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
76c2crhA_



not modelled 99.9 24 PDB header:signaling protein
Chain: A: PDB Molecule:vav proto-oncogene;
PDBTitle: solution structure of the sh2 domain of human proto-2 oncogene protein vav1
77c2dlyA_



not modelled 99.9 31 PDB header:transferase
Chain: A: PDB Molecule:fyn-related kinase;
PDBTitle: solution structure of the sh2 domain of murine fyn-related2 kinase
78d1rjaa_



not modelled 99.8 36 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
79d1pica_



not modelled 99.8 26 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
80c3s4oB_



not modelled 99.8 18 PDB header:structural genomics, unknown function
Chain: B: PDB Molecule:protein tyrosine phosphatase-like protein;
PDBTitle: protein tyrosine phosphatase (putative) from leishmania major
81c2lctA_



not modelled 99.8 26 PDB header:signaling protein
Chain: A: PDB Molecule:proto-oncogene vav;
PDBTitle: solution structure of the vav1 sh2 domain complexed with a syk-derived2 doubly phosphorylated peptide
82c2ysxA_



not modelled 99.8 35 PDB header:signaling protein
Chain: A: PDB Molecule:signaling inositol polyphosphate phosphatase
PDBTitle: solution structure of the human ship sh2 domain
83d1a81a2



not modelled 99.8 28 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
84d1qada_



not modelled 99.8 30 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
85d1a81e2



not modelled 99.8 33 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
86c1oplA_



not modelled 99.8 25 PDB header:transferase
Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase;
PDBTitle: structural basis for the auto-inhibition of c-abl tyrosine2 kinase
87d1blja_



not modelled 99.8 37 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
88d1jyra_



not modelled 99.8 30 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
89c2ge9A_



not modelled 99.8 28 PDB header:transferase
Chain: A: PDB Molecule:tyrosine-protein kinase btk;
PDBTitle: solution structures of the sh2 domain of bruton's tyrosine2 kinase
90d1lkka_



not modelled 99.8 36 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
91c1y57A_



not modelled 99.8 26 PDB header:transferase
Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase src;
PDBTitle: structure of unphosphorylated c-src in complex with an inhibitor
92c1k9aB_



not modelled 99.8 27 PDB header:transferase
Chain: B: PDB Molecule:carboxyl-terminal src kinase;
PDBTitle: crystal structure analysis of full-length carboxyl-terminal2 src kinase at 2.5 a resolution
93d2izva2



not modelled 99.8 22 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
94d1d4ta_



not modelled 99.8 27 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
95c2ablA_



not modelled 99.8 32 PDB header:transferase
Chain: A: PDB Molecule:abl tyrosine kinase;
PDBTitle: sh3-sh2 domain fragment of human bcr-abl tyrosine kinase
96d1qcfa2



not modelled 99.8 34 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
97d1bkla_



not modelled 99.8 30 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
98d1opka2



not modelled 99.8 31 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
99c1ka6A_



not modelled 99.8 25 PDB header:immune system
Chain: A: PDB Molecule:sh2 domain protein 1a;
PDBTitle: sap/sh2d1a bound to peptide n-py
100d1o48a_



not modelled 99.8 30 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
101c2eo3A_



not modelled 99.8 31 PDB header:signaling protein
Chain: A: PDB Molecule:crk-like protein;
PDBTitle: solution structure of the sh2 domain from human crk-like2 protein
102d1jwoa_



not modelled 99.8 31 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
103c2kk6A_



not modelled 99.8 27 PDB header:transferase
Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase fer;
PDBTitle: solution structure of sh2 domain of proto-oncogene tyrosine-2 protein kinase fer from homo sapiens, northeast structural3 genomics consortium (nesg) target hr3461d
104d1csya_



not modelled 99.8 27 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
105d2qmsa1



not modelled 99.8 32 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
106d1g83a2



not modelled 99.8 32 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
107c2el8A_



not modelled 99.8 18 PDB header:signaling protein
Chain: A: PDB Molecule:signal-transducing adaptor protein 2;
PDBTitle: solution structure of the human stap2 sh2 domain
108c2vifA_



not modelled 99.8 27 PDB header:signaling protein
Chain: A: PDB Molecule:suppressor of cytokine signalling 6;
PDBTitle: crystal structure of socs6 sh2 domain in complex with a c-kit2 phosphopeptide
109d1f2fa_



not modelled 99.8 29 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
110d1r1qa_



not modelled 99.8 37 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
111c2h8hA_



not modelled 99.8 26 PDB header:transferase
Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase src;
PDBTitle: src kinase in complex with a quinazoline inhibitor
112d1i3za_



not modelled 99.8 34 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
113c2augB_



not modelled 99.8 33 PDB header:signaling protein
Chain: B: PDB Molecule:growth factor receptor-bound protein 14;
PDBTitle: crystal structure of the grb14 sh2 domain
114d1luia_



not modelled 99.8 34 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
115d1ohea2



not modelled 99.8 26 Fold:(Phosphotyrosine protein) phosphatases II
Superfamily:(Phosphotyrosine protein) phosphatases II
Family:Dual specificity phosphatase-like
116c3nhnA_



not modelled 99.8 35 PDB header:transferase
Chain: A: PDB Molecule:tyrosine-protein kinase hck;
PDBTitle: crystal structure of the src-family kinase hck sh3-sh2-linker2 regulatory region
117c1x27F_



not modelled 99.8 36 PDB header:signaling protein
Chain: F: PDB Molecule:proto-oncogene tyrosine-protein kinase lck;
PDBTitle: crystal structure of lck sh2-sh3 with sh2 binding site of2 p130cas
118d1xa6a2



not modelled 99.8 32 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
119d1k9aa2



not modelled 99.8 29 Fold:SH2-like
Superfamily:SH2 domain
Family:SH2 domain
120c2dcrA_



not modelled 99.8 26 PDB header:transferase
Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase fes/fps;
PDBTitle: fully automated solution structure determination of the fes2 sh2 domain

Binding site prediction 

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