Email l.a.kelley@imperial.ac.uk Description A6X974 Date Sun Jul 8 11:45:02 BST 2012 Unique Job ID 796354625ff4354a

Summary

Top model

Image coloured by rainbow N → C terminus Close Jmol

Model (left) based on template c2kyjA_ Top template information PDB header:toxin Chain: A: PDB Molecule:litx; PDBTitle: structure of the scorpion toxin u1-liotoxin-lw1a Confidence and coverage Confidence: 32.1% Coverage: 13% 13 residues ( 13% of your sequence) have been modelled with 32.1% confidence by the single highest scoring template. You may wish to submit your sequence to Phyrealarm. This will automatically scan your sequence every week for new potential templates as they appear in the Phyre2 library. Please note: You must be registered and logged in to use Phyrealarm. 3D viewing Interactive 3D view in Jmol

Sequence analysis

Secondary structure and disorder prediction

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 2kyj chain A Region: 73 - 85 Aligned: 13 Modelled: 13 Confidence: 32.1% Identity: 54% PDB header:toxin Chain: A: PDB Molecule:litx; PDBTitle: structure of the scorpion toxin u1-liotoxin-lw1a Phyre2 PDB 3e3u chain A Region: 44 - 71 Aligned: 28 Modelled: 28 Confidence: 10.7% Identity: 21% PDB header:hydrolase Chain: A: PDB Molecule:peptide deformylase; PDBTitle: crystal structure of mycobacterium tuberculosis peptide2 deformylase in complex with inhibitor Phyre2 PDB 1yfz chain A domain 1 Region: 49 - 71 Aligned: 23 Modelled: 23 Confidence: 10.2% Identity: 30% Fold: PRTase-like Superfamily: PRTase-like Family: Phosphoribosyltransferases (PRTases) Phyre2 PDB 1yfz chain A Region: 49 - 71 Aligned: 23 Modelled: 23 Confidence: 10.2% Identity: 30% PDB header:transferase Chain: A: PDB Molecule:hypoxanthine-guanine phosphoribosyltransferase; PDBTitle: novel imp binding in feedback inhibition of hypoxanthine-guanine2 phosphoribosyltransferase from thermoanaerobacter tengcongensis Phyre2 PDB 3o7m chain D Region: 49 - 64 Aligned: 16 Modelled: 16 Confidence: 9.7% Identity: 25% PDB header:transferase Chain: D: PDB Molecule:hypoxanthine phosphoribosyltransferase; PDBTitle: 1.98 angstrom resolution crystal structure of a hypoxanthine-guanine2 phosphoribosyltransferase (hpt-2) from bacillus anthracis str. 'ames3 ancestor' Phyre2 PDB 2c4v chain A domain 1 Region: 55 - 71 Aligned: 17 Modelled: 17 Confidence: 8.8% Identity: 35% Fold: Flavodoxin-like Superfamily: Type II 3-dehydroquinate dehydratase Family: Type II 3-dehydroquinate dehydratase Phyre2 PDB 1hgx chain A Region: 49 - 64 Aligned: 16 Modelled: 16 Confidence: 8.8% Identity: 19% Fold: PRTase-like Superfamily: PRTase-like Family: Phosphoribosyltransferases (PRTases) Phyre2 PDB 1g9s chain A Region: 49 - 64 Aligned: 16 Modelled: 16 Confidence: 8.5% Identity: 19% Fold: PRTase-like Superfamily: PRTase-like Family: Phosphoribosyltransferases (PRTases) Phyre2 PDB 1pzm chain A Region: 49 - 73 Aligned: 22 Modelled: 25 Confidence: 8.3% Identity: 27% Fold: PRTase-like Superfamily: PRTase-like Family: Phosphoribosyltransferases (PRTases) Phyre2 PDB 1ei5 chain A domain 2 Region: 43 - 55 Aligned: 13 Modelled: 13 Confidence: 8.2% Identity: 62% Fold: Streptavidin-like Superfamily: D-aminopeptidase, middle and C-terminal domains Family: D-aminopeptidase, middle and C-terminal domains Phyre2 PDB 1j8r chain A Region: 13 - 67 Aligned: 44 Modelled: 55 Confidence: 8.1% Identity: 43% Fold: Common fold of diphtheria toxin/transcription factors/cytochrome f Superfamily: Bacterial adhesins Family: PapG adhesin receptor-binding domain Phyre2 PDB 1tc1 chain A Region: 49 - 64 Aligned: 16 Modelled: 16 Confidence: 7.7% Identity: 19% Fold: PRTase-like Superfamily: PRTase-like Family: Phosphoribosyltransferases (PRTases) Phyre2 PDB 3kb8 chain A Region: 49 - 71 Aligned: 23 Modelled: 23 Confidence: 7.3% Identity: 26% PDB header:transferase Chain: A: PDB Molecule:hypoxanthine phosphoribosyltransferase; PDBTitle: 2.09 angstrom resolution structure of a hypoxanthine-guanine2 phosphoribosyltransferase (hpt-1) from bacillus anthracis str. 'ames3 ancestor' in complex with gmp Phyre2 PDB 1stm chain A Region: 20 - 47 Aligned: 28 Modelled: 28 Confidence: 6.7% Identity: 39% Fold: Nucleoplasmin-like/VP (viral coat and capsid proteins) Superfamily: Satellite viruses Family: Satellite viruses Phyre2 PDB 2ywt chain A Region: 49 - 64 Aligned: 16 Modelled: 16 Confidence: 6.4% Identity: 13% PDB header:transferase Chain: A: PDB Molecule:hypoxanthine-guanine phosphoribosyltransferase; PDBTitle: crystal structure of hypoxanthine-guanine2 phosphoribosyltransferase with gmp from thermus3 thermophilus hb8 Phyre2 PDB 1p17 chain B Region: 49 - 73 Aligned: 22 Modelled: 25 Confidence: 6.3% Identity: 27% Fold: PRTase-like Superfamily: PRTase-like Family: Phosphoribosyltransferases (PRTases) Phyre2 PDB 2uyg chain F Region: 57 - 71 Aligned: 15 Modelled: 15 Confidence: 5.5% Identity: 33% PDB header:lyase Chain: F: PDB Molecule:3-dehydroquinate dehydratase; PDBTitle: crystallogaphic structure of the typeii 3-dehydroquinase2 from thermus thermophilus Phyre2 PDB 1tf3 chain A domain 1 Region: 80 - 85 Aligned: 6 Modelled: 6 Confidence: 5.4% Identity: 67% Fold: beta-beta-alpha zinc fingers Superfamily: beta-beta-alpha zinc fingers Family: Classic zinc finger, C2H2 Phyre2 PDB 2xlk chain B Region: 15 - 48 Aligned: 28 Modelled: 34 Confidence: 5.4% Identity: 29% PDB header:hydrolase/rna Chain: B: PDB Molecule:csy4 endoribonuclease; PDBTitle: crystal structure of the csy4-crrna complex, orthorhombic form Phyre2 PDB 1gyt chain A domain 2 Region: 47 - 62 Aligned: 16 Modelled: 16 Confidence: 5.1% Identity: 31% Fold: Phosphorylase/hydrolase-like Superfamily: Zn-dependent exopeptidases Family: Leucine aminopeptidase, C-terminal domain Phyre2 1 c2kyjA_ 2 c3e3uA_ 3 d1yfza1 4 c1yfzA_ 5 c3o7mD_ 6 d2c4va1 7 d1hgxa_ 8 d1g9sa_ 9 d1pzma_ 10 d1ei5a2 11 d1j8ra_ 12 d1tc1a_ 13 c3kb8A_ 14 d1stma_ 15 c2ywtA_ 16 d1p17b_ 17 c2uygF_ 18 d1tf3a1 19 c2xlkB_ 20 d1gyta2 21 22

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0