Phyre Home Retrieve Phyre Job Id
Emaill.a.kelley@imperial.ac.uk
DescriptionC1P601
DateThu Jan 5 10:55:53 GMT 2012
Unique Job IDadce3219c5c88ace

Summary 

Top model
Image coloured by rainbow N → C terminus
Model (left) based on template d1sxma_
Top template information
Fold:Knottins (small inhibitors, toxins, lectins)
Superfamily:Scorpion toxin-like
Family:Short-chain scorpion toxins
Confidence and coverage
Confidence: 22.9% Coverage: 13%
11 residues ( 13% of your sequence) have been modelled with 22.9% confidence by the single highest scoring template.
You may wish to submit your sequence to Phyrealarm. This will automatically scan your sequence every week for new potential templates as they appear in the Phyre2 library.
Please note: You must be registered and logged in to use Phyrealarm.
3D viewing
Interactive 3D view in Jmol

Sequence analysis 

Secondary structure and disorder prediction 

   1........10.........20.........30.........40.........50.........60
Sequence  MRNRNLLKFLPGLLICLIVLTSCVPKQKNMPYALTQRSIPQILPLPSEAKQPKPPKECSP
Secondary structure 

























SS confidence 



























































Disorder  ?????

















?







?










????????????



Disorder confidence 



























































 
   .........70.........80....
Sequence  TCSEILQQKLSFMLKLLTNATSQE
Secondary structure 

SS confidence 























Disorder 

















??????
Disorder confidence 























 

Confidence Key
High(9)                    Low (0)
?Disordered
Alpha helix
Beta strand

Domain analysis 

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

RankAligned region

PDB 1sxm chain A

3D model

Region: 55 - 65
Aligned: 11
Modelled: 11
Confidence: 22.9%
Identity: 55%
Fold: Knottins (small inhibitors, toxins, lectins)
Superfamily: Scorpion toxin-like
Family: Short-chain scorpion toxins

Phyre2

PDB 1zll chain E

3D model

Region: 13 - 20
Aligned: 8
Modelled: 8
Confidence: 11.6%
Identity: 75%
PDB header:membrane protein/signaling protein
Chain: E: PDB Molecule:cardiac phospholamban;
PDBTitle: nmr structure of unphosphorylated human phospholamban2 pentamer

Phyre2

PDB 1jli chain A

3D model

Region: 66 - 84
Aligned: 19
Modelled: 19
Confidence: 9.5%
Identity: 47%
Fold: 4-helical cytokines
Superfamily: 4-helical cytokines
Family: Short-chain cytokines

Phyre2

PDB 2cs3 chain A domain 1

3D model

Region: 23 - 43
Aligned: 21
Modelled: 21
Confidence: 9.5%
Identity: 38%
Fold: RING/U-box
Superfamily: RING/U-box
Family: Variant RING domain

Phyre2

PDB 3h0d chain B

3D model

Region: 22 - 37
Aligned: 14
Modelled: 16
Confidence: 8.4%
Identity: 50%
PDB header:transcription/dna
Chain: B: PDB Molecule:ctsr;
PDBTitle: crystal structure of ctsr in complex with a 26bp dna duplex

Phyre2

PDB 2b0j chain A domain 2

3D model

Region: 52 - 58
Aligned: 7
Modelled: 7
Confidence: 7.0%
Identity: 86%
Fold: NAD(P)-binding Rossmann-fold domains
Superfamily: NAD(P)-binding Rossmann-fold domains
Family: 6-phosphogluconate dehydrogenase-like, N-terminal domain

Phyre2

PDB 3f46 chain A

3D model

Region: 52 - 58
Aligned: 7
Modelled: 7
Confidence: 6.0%
Identity: 86%
PDB header:oxidoreductase
Chain: A: PDB Molecule:5,10-methenyltetrahydromethanopterin hydrogenase;
PDBTitle: the crystal structure of c176a mutated [fe]-hydrogenase (hmd)2 holoenzyme from methanocaldococcus jannaschii

Phyre2

PDB 2cv4 chain A domain 1

3D model

Region: 55 - 65
Aligned: 11
Modelled: 11
Confidence: 5.9%
Identity: 27%
Fold: Thioredoxin fold
Superfamily: Thioredoxin-like
Family: Glutathione peroxidase-like

Phyre2
1

d1sxma_
2

c1zllE_
3

d1jlia_
4

d2cs3a1
5

c3h0dB_
6

d2b0ja2
7

c3f46A_
8

d2cv4a1



Detailed template information 

#
Template Alignment Coverage3D Model Confidence
% i.d. Template Information
1d1sxma_



22.9 55 Fold:Knottins (small inhibitors, toxins, lectins)
Superfamily:Scorpion toxin-like
Family:Short-chain scorpion toxins
2c1zllE_



11.6 75 PDB header:membrane protein/signaling protein
Chain: E: PDB Molecule:cardiac phospholamban;
PDBTitle: nmr structure of unphosphorylated human phospholamban2 pentamer
3d1jlia_



9.5 47 Fold:4-helical cytokines
Superfamily:4-helical cytokines
Family:Short-chain cytokines
4d2cs3a1



9.5 38 Fold:RING/U-box
Superfamily:RING/U-box
Family:Variant RING domain
5c3h0dB_



8.4 50 PDB header:transcription/dna
Chain: B: PDB Molecule:ctsr;
PDBTitle: crystal structure of ctsr in complex with a 26bp dna duplex
6d2b0ja2



7.0 86 Fold:NAD(P)-binding Rossmann-fold domains
Superfamily:NAD(P)-binding Rossmann-fold domains
Family:6-phosphogluconate dehydrogenase-like, N-terminal domain
7c3f46A_



6.0 86 PDB header:oxidoreductase
Chain: A: PDB Molecule:5,10-methenyltetrahydromethanopterin hydrogenase;
PDBTitle: the crystal structure of c176a mutated [fe]-hydrogenase (hmd)2 holoenzyme from methanocaldococcus jannaschii
8d2cv4a1



5.9 27 Fold:Thioredoxin fold
Superfamily:Thioredoxin-like
Family:Glutathione peroxidase-like

Binding site prediction 

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite



Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
 
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
 
© Structural Bioinformatics Group
Imperial College London
Lawrence Kelley, Benjamin Jefferys
Disclaimer
Terms and Conditions
Component software
Template detection: HHpred 1.51
Secondary structure prediction: Psi-pred 2.5
Disorder prediction: Disopred 2.4
Transmembrane prediction: Memsat_SVM
Multi-template modelling and ab initio: Poing 1.0